Patents Examined by W. Catchpole
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Patent number: 4999200Abstract: A psyllium composition in tablet form is provided having a wetting agent, a disintegrant and a binding agent. In one embodiment, the wetting agent is polysorbate 80, the binding agent is polyvinyl pyrrolidone and the dry binding agent and disintegrant is microcrystalline cellulose. Calcium carbonate may also be added to serve as a disintegrant in HCL. The tablets are manufactured by mixing the psyllium powder with a solution of povidone and polysorbate 80. Microcrystalline cellulose may be added either during or after granulation. After mixing, the composition is compressed into tablet form. The mixing of the ingredients in specific quantities allows a tablet to be manufactured that is both resistant to fracture and at the same time disintegrates easily and quickly in the gastrointestinal tract of the patient.Type: GrantFiled: December 9, 1987Date of Patent: March 12, 1991Assignee: Marion LaboratoriesInventor: Angel Casillan
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Patent number: 4978678Abstract: Novel 12-halogenated forskolin derivatives, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: August 7, 1989Date of Patent: December 18, 1990Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventor: Gregory M. Shutske
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Patent number: 4966726Abstract: The new compounds produced from a molecular structural element with two chirality centers and at least one mesogenic structural element are defined by the general formula (I) ##STR1## in which the symbols have the following meaning: Y.sup.1 =H, (C.sub.1 -C.sub.10)alkyl, MC--CH.sub.2 or MC--CO, MC denoting the molecular radical of a mesogenic carboxylic acid after splitting off a COOH group,Y.sup.2 =(C.sub.1 -C.sub.10)alkyl, MC--CH.sub.2 or MC--CO, it being possible for Y.sup.1 and Y.sup.2 to jointly represent a MC--CH group, which is then part of a dioxolane ring,X=COOR.sup.1, CONH.sub.2, CONR.sup.2 R.sup.3 or C.tbd.N,R.sup.1 =(C.sub.1 -C.sub.10)alkyl or MC--CH.sub.2, andR.sup.2, R.sup.3 =H and (C.sub.1 -C.sub.4)alkyl or, independently of each other, (C.sub.1 -C.sub.4)alkyl.Said esters preferably find application as dopants in twistable liquid crystal phases in which they produce temperature compensation and twisting.Type: GrantFiled: July 18, 1988Date of Patent: October 30, 1990Assignee: Hoechst AktiengesellschaftInventors: Gunter Scherowsky, Manel Gunaratne
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Patent number: 4966754Abstract: A cosmetic composition containing a dermatologically acceptable carrier or vehicle and certain essential oils as a preservative. The essential oil provides antimicrobial assurance against Apergillus niger, Candida albicans, Staphylococcus aureus and Pseudomonas aeruginosa. A method of preparing the preserved cosmetic composition is also described.Type: GrantFiled: August 8, 1988Date of Patent: October 30, 1990Assignee: Aveda CorporationInventors: Prakash C. Purohit, Lal G. Ramdeen
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Patent number: 4963531Abstract: A method of use of azithromycin or derivatives of azithromycin in the treatment of infection caused by Toxoplasma gondii in mammals is disclosed.Type: GrantFiled: August 16, 1988Date of Patent: October 16, 1990Assignee: Pfizer Inc.Inventor: Jack S. Remington
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Patent number: 4963667Abstract: There are disclosed novel ivermectin compounds and a process for preparing them, the novel ivermectin compounds containing straight chain or branched fatty acid residues of from about C.sub.2 to about C.sub.Type: GrantFiled: December 19, 1989Date of Patent: October 16, 1990Assignee: Merck & Co., Inc.Inventors: Shuet-Hing L. Chiu, Josephine R. Carlin, Rae Taub
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Patent number: 4961933Abstract: The invention features a medicament for simple relief of aches and pains. An aqueous solution of cayenne, alcohol and copper oxide in solution is applied to affected, aching joints and muscles by topical application. After drying, the solution imparts a soothing warmth and heating to the pained areas.Type: GrantFiled: December 14, 1987Date of Patent: October 9, 1990Inventor: Longino S. Campos Pino
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Patent number: 4957730Abstract: A nail varnish comprising a water-insoluble film-forming substance and an antimycotic compound which is a 1-hydroxy-2-pyridone I of the general formula ##STR1## in which R.sup.1 is a hydrocarbon group which contains from 6 to 9 carbon atoms, but is free from olefinic and acetylenic bonds, one of the groups R.sup.2 and R.sup.4 is hydrogen and the other is hydrogen, methyl or ethyl and R.sup.3 is alkyl having up to two carbon atoms, said antimycotic ingredient being present in free form or in the form of a salt.Type: GrantFiled: December 17, 1986Date of Patent: September 18, 1990Assignee: Hoechst AktiengesellschaftInventors: Manfred Bohn, Walter Dittmar, Heinz G. Peil, Eberhard Futterer, Karl Kraemer
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Patent number: 4956353Abstract: Kojic acid and its esters have been found to be more effective synergists for pyrethroid and carbamate insecticides on H. zea and S. frugiperda. Thus they may serve as replacements for the widely used methylene dioxyphenyl compounds such as piperonyl butoxide.Type: GrantFiled: June 16, 1988Date of Patent: September 11, 1990Assignee: The United States of America as represented by the Secretary of AgricultureInventor: Patrick F. Dowd
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Patent number: 4954484Abstract: Novel compounds of formula ##STR1## in which A is a ##STR2## group wherein R.sub.1 is hydrogen or an OH-protecting group, and R.sub.11 is hydrogen, an OH-protecting group, or an alkyl, cycloalkyl or acyl group,R.sub.2 is methyl, ethyl, isopropyl, sec.-butyl or a --C(CH.sub.3).dbd.CH--E group wherein E is methyl, ethyl or isopropyl,R.sub.3 and R.sub.4 together represent a bond between the two carbon atoms to which they are bonded, or together represent a --C(X')(Z')-- group wherein X' and Z' each represents, independently of the other, hydrogen or halogen, andX and Z each represents, independently of the other, hydrogen or halogen,the preparation of the novel compounds and the use thereof for controlling parasites of productive livestock and for controlling harmful insects.Type: GrantFiled: March 24, 1988Date of Patent: September 4, 1990Assignee: Ciba-Geigy CorporationInventor: Jean-Claude Gehret
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Patent number: 4946681Abstract: A process for the production of stable azadirachtin solutions comprising extracting ground neem seeds with a solvent having azadirachtin solubility to produce an aqueous-containing azadirachtin extract solution and then adding an effective amount of 3-4 Angstrom molecular sieves to selectively remove water from the extract to yield a storage-stable azadirachtin solution having less than 5% water by volume.Type: GrantFiled: June 26, 1989Date of Patent: August 7, 1990Assignee: W. R. Grace & Co.-Conn.Inventor: James F. Walter
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Patent number: 4938963Abstract: Methods and compositions are provided for alleviating xerostomia. The compositions are formulated from Yerba Santa extract and sweetener, and may be in aqueous solution or in gum or lozenge form. The compositions may additionally contain a stimulator compound effective to stimulate salivary gland secretion, e.g., citric acid, ascorbic acid, or both. Preservatives, flavoring agents, coloring agents, emulsifiers, and the like may be included in the compositions as well. The Yerba Santa-based compositions of the invention are orally administered to an affected patient to alleviate the symptoms of dry mouth.Type: GrantFiled: November 22, 1988Date of Patent: July 3, 1990Assignee: Parnell Pharmaceuticals, Inc.Inventor: Francis W. Parnell
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Patent number: 4931575Abstract: Enantiomerically pure glycerol derivatives, e.g. S-1,2-O-isopropylidene, S-1,2-O-benzylidene, and R-1,2-O-dibenzyl glycerol, have been prepared from 1,2R-O-protected erythritols in high yields. The latter compounds are easily obtained from erythorbic acid and are useful building blocks in the synthesis of a host of optically active compounds having biological activity.Type: GrantFiled: March 13, 1987Date of Patent: June 5, 1990Assignee: The Board of Governors for Higher Education, State of Rhode Island and Providence PlantationsInventor: Elie Abushanab
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Patent number: 4915946Abstract: Bay salt with Ginkgo, Persimmon, Pine and Bamboo are used to form an initial mixture with bay salt in a ratio of about 200:1 by weight percent. The mixture is placed in a special furnace, and then burned by using firewood of Ginkgo, Persimmon, Pine and Bamboo at a temperature of about 1,000.degree. to 1,3000.degree. C. to produce a solid salt ash. The solid salt ash is then repeatedly burned about 5 to 6 times in accordance with the above method to produce a burned solid salt ash. This burned solid salt ash is the put into a Bamboo tube and further burned with firewood of Ginkgo, Persimmon, Pine and Bamboo at about 1,000.degree. to 1,300.degree. C. Finally, the burned solid salt ash is put into an electric furnace, and heated at a temperature of about 1,3000.degree. C. to manufacture the salt composition.Type: GrantFiled: January 13, 1988Date of Patent: April 10, 1990Inventor: Kwon J. Kang
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Patent number: 4913909Abstract: Extract of tea leaves or (-)-epigallocatechin gallate as the principal ingredient of the extract forms a complex with active aluminum hydroxide. The animal test using rats has established that these complexes have therapeutic effect for gastric ulcers, e.g. pylorus-ligated ulcer and indomethacin-induced ulcer, when orally administered. Tests were also undertaken for the effect on the secretion of gastric juice and acute toxicity of these complexes using rats and mice as the test animals.Type: GrantFiled: October 2, 1986Date of Patent: April 3, 1990Assignee: Mitsui Norin Co., Ltd.Inventors: Yukihiko Hara, Hajime Asai, Tadashi Kitamikado, Hajimu Yamamoto, Kazuo Okushio, Kozo Nakamura
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Patent number: 4900543Abstract: An aqueous hair-treatment preparation containing an antistatic additive imparting an antistatic effect to the hair, characterized in that said antistatic additive is at least one cationic polymer produced by the process of (1) epoxidizing 1,3-diene homopolymers or copolymers, (2) amine reacting the epoxide compound so produced with low molecular weight amines selected from the group consisting of primary amines, secondary amines and tertiary amines, and (3) converting the reaction products into the salt form or into polymeric quaternary ammonium salts. The use of these polymeric amine salts or quaternary ammonium salts in cosmetic hair-treatment preparations provides these preparations with antistatic effects.Type: GrantFiled: July 17, 1986Date of Patent: February 13, 1990Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Wolfgang Ritter, Rolf Tenhaef, Horst Hoffkes, Kurt Seidel
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Patent number: 4900544Abstract: An aqueous hair-treatment preparation containing an antistatic additive imparting an antistatic effect to the hair, characterized in that said antistatic additive is at least one cationic polymer produced by the process of (1) epoxidizing 1,3-diene homopolymers or copolymers (2) reacting the epoxide compound so produced with low molecular weight amines selected from the group consisting of primary amines, secondary amines and tertiary amines, and (3) converting the reaction products into the salt form or into polymeric quaternary ammonium salts. The use of these polymeric amine salts or quaternary ammonium salts in cosmetic hair-treatment preparations provides these preparations with antistatic effects.Type: GrantFiled: July 8, 1986Date of Patent: February 13, 1990Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Wolfgang Ritter, Rolf Tenhaef, Horst Hoffkes, Kurt Seidel
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Patent number: 4891213Abstract: Nail enamel compositions, particularly of the nitrocellulose type, have added a small amount of microcrystalline cellulose powder. When the compositions are applied to the nails, the microcrystalline cellulose particles act in lieu of long thin fibers to reinforce and strengthen the enamel coating while some of the particles tend to settle into the valleys between the nail ridges to smooth out the surface of the nails. These enamel compositions can be used without prior application of a filler coat to give a smooth, glossy, reinforced finish to the nails with no fibers visible.Type: GrantFiled: May 15, 1986Date of Patent: January 2, 1990Assignee: Del Laboratories, Inc.Inventors: Harry W. Gordon, Kenneth Chung
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Patent number: 4876277Abstract: Substituted olefinic (allyl) benzene compounds which exhibit important antimicrobial (antibacterial and antifungal) activity, compositions and methods of delivery against pathovars and pathogens, and methods of synthesis from commonly available reactants. The antifungal composition active ingredient is one or more 4,5-substituted 2,3-alkylidenedioxy-1-olefinic benzenes of the formula: ##STR1## where R.sub.1 and R.sub.2 may be the same or different, and are selected from OH, and C.sub.1 -C.sub.5 alkoxy (--OR) or thioalkyl (--SR) groups. R.sub.3 and R.sub.4 are selected from H and C.sub.1 -C.sub.5 alkyl, alkenyl and alkynyl groups, and R.sub.5 is selected from C.sub.3 -C.sub.7 alkyl, alkenyl and alkynyl groups. The preferred compounds are 4,5-substituted-2,3-methylenedioxy-1-allyl benzenes. Where R.sub.1 =OCH.sub.3, R.sub.2 =OH, R.sub.3 and R.sub.4 =H and R.sub.5 =allyl (2',3' propenyl) the compound may be called nor methyl-pseudo-dillapiole. Where R.sub.1 =R.sub.2 =OCH.sub.3, R.sub.3 and R.sub.Type: GrantFiled: May 29, 1987Date of Patent: October 24, 1989Assignee: Plant Cell Research Institute, Inc.Inventors: Basil A. Burke, Muraleedharan G. Nair
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Patent number: 4868289Abstract: O-glycosidic compounds useful for therapy or prophylaxis of a wide variety of diseases, for diagnostic use or as research chemicals. Another object of the present invention is to provide a method for preparing the O-glycosidic compounds.Type: GrantFiled: September 3, 1986Date of Patent: September 19, 1989Assignee: Symbicom AktiebolagInventors: Hans G. Magnusson, Torbjorn Frejd