Patents Examined by W. Catchpole
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Patent number: 4868341Abstract: New bicyclohexyls of the formula IR.sup.1 --Cy--Cy--R.sup.2wherein R.sup.1 and R.sup.2 are each alkyl which has 1-10 C atoms and in which one or two CH.sub.2 group(s) can be replaced by 0 atoms, and Cy is 1,4-cyclohexylene,are suitable for use as the coponents of liquid-crystal dielectrics.Type: GrantFiled: September 15, 1986Date of Patent: September 19, 1989Assignees: Merck Patent Gesellschaft Mit Beschrankter Haftung, The Secretary of State for Defence in Her Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventors: Rudolf Eidenschink, Michael Romer, Georg Weber, George W. Gray, Kenneth J. Toyne
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Patent number: 4855463Abstract: Water soluble glucuronic acid derivatives of vitamin A, including retinoyl .beta.-glucuronide and retinyl .beta.-glucuronide, having in vivo activity comparable to retinoic acid and retinol and methods of their preparation are disclosed.Type: GrantFiled: December 15, 1986Date of Patent: August 8, 1989Assignee: Iowa State University Research Foundation, Inc.Inventors: Arun B. Barua, James A. Olson
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Patent number: 4837336Abstract: A compound of formula (I) ##STR1## is prepared by cyclizing a compound of formula (IIa) or (IIb) or a mixture thereof ##STR2## wherein X is hydroxyl or halogen and R.sup.1 and R.sup.2 independently, represent hydroxy protecting groups) followed by removal of the protecting groups R.sup.1 and R.sup.2.The compound (I) is of use as an intermediate in the stereoselective preparation of (.+-.) trans-5-fluoro-2,3,3a,9a-tetrahydro-1H-[1,4]benzodioxino[2,3-c] pyrrole, which is a selective .beta..sub.2 -adrenoreceptor antagonist and is thus of potential value, in particular, for the treatment or prevention of depression.Type: GrantFiled: October 23, 1986Date of Patent: June 6, 1989Assignee: Glaxo Group LimitedInventors: David F. Hayman, Alastair C. Brodie, Panayiotis A. Procopiou
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Patent number: 4820828Abstract: The present invention relates to cinnamohydroxamic acids. These compounds inhibit 5-lipoxygenase and are useful as bronchodilators.Type: GrantFiled: March 4, 1987Date of Patent: April 11, 1989Assignee: Ortho Pharmaceutical CorporationInventors: James P. Demers, William V. Murray, Richard B. Sulsky
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Patent number: 4816479Abstract: Xanthone derivatives of the formula (I): ##STR1## wherein W, X, Y and Z which may be the same or different represent a hydrogen atom, a halogen atom or a lower alkyl group having 1 to 4 carbon atoms; A is a hydrogen atom B is a hydroxymethyl group, a lower alkoxycarbonyl group having 1 to 4 carbon atoms, or a carboxyl group, provided that a --O--CH.sub.2 --B group is bonded to the 2- or 3-position of the xanthone ring and that there is no case in which X, Y, and Z are each a hydrogen atom concurrently; as well as intoxic salts thereof when B is a carboxyl group, and a process for preparing the same are disclosed.The compounds of formula (I) in accordance with the present invention are useful as diuretics having uricosuric activity and can be used in the treatment of edema or hypertension.Type: GrantFiled: December 2, 1986Date of Patent: March 28, 1989Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroshi Koga, Takashi Mori, Takashi Dan, Michitaka Akima
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Patent number: 4814468Abstract: New intermediate, an optically active (1S,5R)-7,7-alkylenedioxy-2-alkoxycarbonylbicyclo[3.3.0]octan-3-one which is useful for the synthesis of an optically active carbacyclin. This intermediate is prepared, as a non-reduced compound, from a racemic compound, (1SR,5RS)-7,7-alkylenedioxy-2-alkoxycarbonyl-cis-bicyclo[3.3.0]octane-3-on e, by treatment of the racemic compound with a microorganism. The microorganism has an ability of specifically reducing the keto group of the (1R,5S) epimer of the racemic compound.Type: GrantFiled: May 30, 1986Date of Patent: March 21, 1989Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Kenji Mori, Masahiro Tsuji
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Patent number: 4812160Abstract: Cyclohexenone derivative of the formula ##STR1## where A is oxygen or NOR.sup.8, where R.sup.8 is alkyl, alkenyl, alkynyl, haloalkyl or haloalkenyl, chlorothienyl or alkoxyalkylB is O, S, SO or SO.sub.2,X is hydrogen or methoxycarbonyl,R.sup.1 is hydrogen, carbonylalkyl, benzoyl or a cation,R.sup.2 is alkyl,R.sup.3 and R.sup.4 are hydroxyl, chlorine, bromine, thioalkylcarboxyl, thiocarbonylalkyl, alkylcarbonyloxy, alkoxy, or alkylthio, or R.sup.3 and R.sup.4 together epoxy,R.sup.5 and R.sup.6 are hydrogen or methyl or R.sup.5 and R.sup.6 are together methyleneoxyethylene, andR.sup.7 is hydrogen or methyl,and herbicides containing these compounds.Type: GrantFiled: December 24, 1986Date of Patent: March 14, 1989Assignee: BASF AktiengesellschaftInventors: Dieter Jahn, Michael Keil, Dieter Kolassa, Ulrich Schirmer, Bruno Wuerzer, Norbert Meyer, Johann Jung, Wilhelm Rademacher
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Patent number: 4808614Abstract: A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.Type: GrantFiled: June 4, 1987Date of Patent: February 28, 1989Assignee: Eli Lilly and CompanyInventor: Larry W. Hertel
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Patent number: 4806604Abstract: The present invention discloses a new class of calcium chelating compounds which have a decreased affinity for calcium following illumination. These new compounds contain a photolabile nitrobenzyl derivative coupled to a tetracarboxylate Ca.sup.2+ chelating parent compound having the octacoordinate chelating groups characteristic of EGTA or BAPTA. However unlike EGTA or BAPTA-like compounds, in which the two halves of the chelator are linked by a simple 1,2-ethanediyl moiety, the compounds of the present invention modify the stereochemical conformation of this linkage by adding bulky substituents or incorporating the linkage into a carbocyclic or heterocyclic ring. In a first form, the new compounds are comprised of a BAPTA-like chelator coupled to a single 2-nitrobenzyl derivative, which in turn is a photochemical precursor of a 2-nitrosobenzophenone.Type: GrantFiled: May 13, 1987Date of Patent: February 21, 1989Assignee: Regents of the University of CaliforniaInventors: Roger Yonchien Tsien, Stephen R. Adams
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Patent number: 4806659Abstract: The invention herein disclosed provides a tannin especially effective as antipsychotic drug for mental disorders such as acute and chronic schizophrenia. This tannin composition is represented by the following general formula: ##STR1## wherein l is an integer from 0 to 6, m is 0 or 1, n is an integer from 0 to 6, l+n+m=6;R.sub.1 is hydrogen or G, G representing the galloyl group ##STR2## X is ##STR3## R.sub.2 is OH, . . . OG, or . . . OH; filled dots mean bonding sites, there being no possibility to bond between the mutual fourth positions in each unit; there is only one bonding between the fourth and the sixth position; and there is a total of three galloyl groups in the tannin.Type: GrantFiled: November 7, 1986Date of Patent: February 21, 1989Assignee: Kabushiki Kaisha Tsumura JuntendoInventors: Nishioka Itsuo, Nonaka Genichiro, Fujiwara Michihiro, Ueki Showa
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Patent number: 4803290Abstract: Substituted 5'-nonanol/5'-nonene compounds which exhibit important antimicrobial and antifungal activity, compositions and methods of delivery against pathovars and pathogens, and methods of synthesis from commonly available reactants. The antimicrobial composition active ingredient is one or more substituted 1,2-alkylidenedioxybenzene compounds of the formula: ##STR1## where R.sub.3 is selected from 5'-nonanol and 5'-nonene, and R.sub.1 and R.sub.2 are selected from H and C.sub.1 -C.sub.5 alkyl, alkenyl and alkynyl groups. The preferred compounds are 5-(5'-hydroxy- 5'- nonanyl)-1,1-methylenedioxybenzene and 4-(5'-non-4'-enyl)-1,2-methylenedioxybenzene. Compositions including these compounds exhibit antimicrobial activity against a variety of pathogens and pathovars, e.g., Xanthomonas campestris spp. bacteria, antifungal activity against a variety of fungi and bacteria, and are highly specific, e.g.Type: GrantFiled: May 29, 1987Date of Patent: February 7, 1989Assignee: PCRI, Inc.Inventors: Basil A. Burke, Muraleedharan Nair