Patents Examined by William R. A. Jarvis
  • Use
    Patent number: 6399617
    Abstract: The invention provides a method of treatment or prophylaxis of obesity, comprising administering to a patient in need of such treatment a therapeutically effective amount of an aryl sulfonamide compound of formula (I) or formula (II) wherein the substituents are as described in the specification.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: June 4, 2002
    Assignee: Biovitrum AB
    Inventors: Patrizia Caldirola, Sukhwinder Jossan, Kjell S. Sakariassen, Jan Svartengren
  • Method of treating dermatoses using avermectin compound
    Patent number: 6399651
    Abstract: A method for treating dermatoses including transient acantholytic dermatitis, acne miliaris necrotica, acne varioliformis, perioral dermatitis, and acneiform eruptions is disclosed. The method includes topical application of a dermatological composition containing an avermectin compound to the affected areas of a patient.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: June 4, 2002
    Inventor: L. Dean Parks
  • Method of treating acne vulgaris using avermectin compound
    Patent number: 6399652
    Abstract: Methods for treating acne vulgaris are disclosed. The treatment includes topical application of a dermatological composition containing an avermectin compound to the affected areas of a patient alone, or in conjunction with other conventional methods of treating acne vulgaris. The dermatological composition contains an avermectin compound in a pharmaceutically acceptable carrier, including water, glycols, alcohols, lotions, creams, gels, emulsions, sprays, soaps, body washes, facial cleansers, and facial masks.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: June 4, 2002
    Inventor: L. Dean Parks
  • Method of providing an antihistaminic effect in a hepatically impaired patient
    Patent number: 6399632
    Abstract: The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of a compound of the formula wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A and B is hydrogen or hydroxy with the proviso that at least one of A or B is hydrogen; or a pharmaceutically acceptable salt and individual isomers thereof.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: June 4, 2002
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: James K. Woodward, Richard A. Okerholm, Mark G. Eller, Bruce E. McNutt
  • N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
    Patent number: 6399648
    Abstract: This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-Oxides of heterocyclic esters, amides, thioesters, or ketones
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: June 4, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
    Patent number: 6395746
    Abstract: Methods of treating or preventing ophthalmic, otic, and nasal infections and attendant inflammation are described. The methods utilize ophthalmic, otic, and nasal compositions containing a new class of antibiotics (e.g. trovafloxacin). The compositions also contain one or more anti-inflammatory agents (e.g. dexamethasone). The compositions are utilized to treat ophthalmic, otic, and nasal conditions by topically applying the compositions to the affected tissues.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: May 28, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Gerald Cagle, Robert L. Abshire, David W. Stroman, John M. Yanni
  • Calcitonin mimetics
    Patent number: 6395740
    Abstract: Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: May 28, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Nand Baindur, Virender Labroo, Steven Stroop, Stephanie Beigel, Theresa Martinez, Charles R. Petrie, Mark W. Orme, Patricia A. Mckernan, Emma E. Moore
  • Compositions and methods for the treatment of anorectal disorders
    Patent number: 6395736
    Abstract: Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2−) scavengers, &bgr;-adrenergic agonists, cAMP-dependent protein kinase activators, &agr;1-adrenergic antagonists, L-type Ca2+ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: May 28, 2002
    Assignee: Cellegy Pharmaceuticals, Inc.
    Inventors: Thomas P. Parks, Vivien Mak, Jung-Chung Lee, Charles Lee
  • Small molecule carbamates or ureas for vision and memory disorders
    Patent number: 6395758
    Abstract: This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using small molecule carbamates and ureas.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: May 28, 2002
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • Compositions and methods for the treatment of anorectal disorders
    Patent number: 6391869
    Abstract: Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2−) scavengers, &bgr;-adrenergic agonists, cAMP-dependent protein kinase activators, &agr;1-adrenergic antagonists, L-type Ca2+ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: May 21, 2002
    Assignee: Cellergy Pharmaceuticals, Inc.
    Inventors: Thomas P. Parks, Vivien Mak, Jung-Chung Lee, Charles Lee
  • Reboxetine for treatment obsessive compulsive disorders and panic disorder
    Patent number: 6391876
    Abstract: This invention relates to the use of reboxetine in the treatment of Obsessive Compulsive Disorders and Panic Disorders.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: May 21, 2002
    Assignee: Pharmacia and Upjohn Company
    Inventors: Adriana Dubini, John Michael McCall, Duncan Paul Taylor, Philip F. Von Voigtlander, Erik Ho Fong Wong
  • Use of serotonin agonists to alleviate disordered breathing episodes in a mammal
    Patent number: 6387907
    Abstract: The invention includes compositions for alleviating or preventing a disordered breathing episode. The composition of the invention comprises a serotonin re-uptake inhibitor, a TRH agonist and an agent selected from the group consisting of a serotonin precursor and a serotonin agonist.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: May 14, 2002
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Joan C. Hendricks, Leszek Kubin, Allan I. Pack, Sigrid C. Veasey
  • Highly purified EPA for treatment of schizophrenia and related disorders
    Patent number: 6384077
    Abstract: A pharmaceutical preparation comprising EPA in an appropriately assimilable form where of all the fatty acids present in the preparation at least 90%, and preferably at least 95%, is in the form of EPA and where less than 5%, and preferably less than 3%, is in the form of DHA is provided for the treatment of a psychiatric or central nervous disorder. The preparation may be administered with conventional drugs to treat psychiatric or central nervous disorders to improve their efficacy or reduce their side effects.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: May 7, 2002
    Assignee: Laxdale Limited
    Inventors: Malcolm Peet, Krishna S Vaddadi
  • Systemic use of 5-HT3 receptor antagonists against rheumatic inflammatory processes
    Patent number: 6384042
    Abstract: The present invention relates to a new use for compounds having 5-HT3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for the systemic treatment of an inflammatory rheumatic or rheumatoid disease other than crystal induced arthritis and other than living pathogen induced inflammatory diseases as long as the living pathogen is still present.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: May 7, 2002
    Inventors: Lothar Färber, Wolfgang Müller, Thomas Stratz
  • Methods of alleviating pain sensations of the denuded eye with opioid analgesics
    Patent number: 6384043
    Abstract: A method of alleviating pain sensations in a denuded eye comprising the step of applying topically to the eye an analgesic solution with the analgesic solution comprising an opioid analgesic is disclosed.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: May 7, 2002
    Inventors: Gholam A. Peyman, Mohamad H. Rahimy
  • Heterocyclic thioesters or ketones for vision and memory disorders
    Patent number: 6384056
    Abstract: This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic thioesters and ketones.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: May 7, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • Use of 40-O-(2-hydroxy)ethylrapamycin for treatment of restenosis and other disorders
    Patent number: 6384046
    Abstract: This invention relates to the use of 40-O-(2-hydroxy)ethyl-rapamycin for the prevention or treatment of neointimal proliferation and thickening, restenosis, and vascular occlusion following vascular injury.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: May 7, 2002
    Assignee: Novartis AG
    Inventors: Walter Schuler, Hendrik J. Schuurman, Gisbert Weckbecker, Hans-Günter Zerwes
  • R-hydroxynefazodone
    Patent number: 6384037
    Abstract: The R-isomer of the hydroxy metabolite of nefazodone, R-hydroxynefazodone, is an effective treatment for depression which does not give rise to the adverse effects associated with nefazodone. R-hydroxynefazodone is also useful in the treatment of migraine headaches, panic disorders, post traumatic stress disorder and sleep disorders.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: May 7, 2002
    Assignee: Sepracor Inc.
    Inventors: Timothy J. Barberich, Paul D. Rubin, William E. Yelle
  • Fast-acting antimicrobial lotion with enhanced efficacy
    Patent number: 6383505
    Abstract: An antimicrobial lotion for topical use comprises an oil-in-water emulsion with a dispersant of emollient droplets in an oil phase and an antimicrobial agent in a water phase. The emollients moisturize the skin. Antimicrobial agents have a more rapid antimicrobial effect in an aqueous solution than in the oil phase. A combination of anionic and nonanionic surfactants stabilize the emulsion and maintain a cationic antimicrobial agent primarily in the water phase. The resulting lotion is gentle on the skin while providing more rapid antimicrobial effect than conventional lotions. With longer lasting antimicrobial agents, such as chlorhexidene, the lotion is rubbed into the skin and left on to continue moisturizing and killing microbes for up to 12 hours.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: May 7, 2002
    Assignee: Steris Inc
    Inventors: Nancy E. Kaiser, Denise K. Pretzer, Kevin A. Tibbs
  • Silicone gel containing salicylic acid
    Patent number: 6384023
    Abstract: The present invention relates to a silicone gel comprising a volatile liquid, a silicone polymer, and salicylic acid; compositions comprising the silicone gel; and methods of using such gel and composition for the prevention and treatment of acne or seborrhea.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: May 7, 2002
    Assignee: Neutrogena Corporation
    Inventors: Laura C. Singleton, Carol J. Collins, Frederick W. Woodin, Jr.