Patents Examined by Xiaoyun R Xu
  • Patent number: 10921259
    Abstract: An example peripheral device to be placed over an image sensor and a light source of a portable computing device to assist the portable computing device in reading a reaction area on a test strip in the peripheral device is disclosed. The peripheral device includes a light guide to direct light from the light source to the test strip, and an alignment feature to aid placement of the peripheral device relative to the image sensor and the light source on the portable computing device.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: February 16, 2021
    Inventors: Tungmeng Tsai, Yenyu Chen, Chieh Hsiao Chen
  • Patent number: 10914741
    Abstract: Disclosed are 13C and 15N derivatization reagents and their use for gas chromatography-mass spectroscopy and liquid chromatography/mass spectroscopy chemical identification and quantification.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: February 9, 2021
    Assignee: Albert Einstein College of Medicine
    Inventors: Irwin J. Kurland, Yunping Qiu
  • Patent number: 10908165
    Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: February 2, 2021
    Assignees: Purdue Research Foundation, AMGEN INC.
    Inventors: Stephen T. Ayrton, Robert Graham Cooks, Tawnya Flick, Da Ren
  • Patent number: 10900972
    Abstract: The present invention provides methods for improved label-free absolute quantification of relatively low abundant polypeptides by liquid chromatography/mass spectrometry analysis of peptide products obtained from simple or complex polypeptide mixtures. The methods for absolute quantification include MS signals from a set of qualified ions of peptide products of a relatively high abundant polypeptide to improve quantification of a relatively low abundant polypeptide.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: January 26, 2021
    Assignee: GENZYME CORPORATION
    Inventors: Martha Stapels, Michelle Busch
  • Patent number: 10895578
    Abstract: A method includes applying distinct isobaric tags to each of a plurality of samples; combining the samples; performing a separation of species within the combined samples; isolating and fragmenting labeled parent ions within a m/z range to produce a plurality of reporter ions, each reporter ion corresponding to one of the isobaric tags; determining intensities of the plurality of reporter ions and ions representative of a parent species at a plurality of points along a peak; and fitting the intensity of the ions representative of a parent species and the plurality of reporter ions at the plurality of points to obtain a relative abundance of the parent species in each of the plurality of samples.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: January 19, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventor: Michael W. Senko
  • Patent number: 10883972
    Abstract: Embodiments of the disclosure generally relate to a system, apparatus and method for testing a coating over a semiconductor chamber component. In one embodiment, a test station comprises a hollow tube, a sensor coupled to a top end of the tube and a processing system communicatively coupled to the sensor. The hollow tube has an open bottom end configured for sealingly engaging a coating layer of the semiconductor chamber component. The sensor is configured to detect the presence of a gaseous byproduct of a reaction between a reagent disposed in the hollow tube and a base layer disposed under the coating layer. The processing system is configured to determine exposure of the base layer through the coating layer in response to information about the presence of the gaseous byproduct. In another embodiment, the processing system is communicatively coupled to each sensor of a plurality of test stations.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: January 5, 2021
    Assignee: Applied Materials, Inc.
    Inventors: Tasnuva Tabassum, Mats Larsson, Kevin A. Papke
  • Patent number: 10866219
    Abstract: This invention provides a method that is capable of detecting a trifluridine-related substance and a tipiracil-related substance contained in a sample containing trifluridine or a salt thereof and tipiracil or a salt thereof using the same procedure. The method is for detecting a trifluridine-related substance or a tipiracil-related substance or both, the method comprising the step of subjecting a sample containing trifluridine or a salt thereof and tipiracil or a salt thereof to high-performance liquid chromatography using a mobile phase composed of an organic phase and an aqueous phase.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: December 15, 2020
    Assignee: TAIHO PHARMACEUTICAL CO., LTD.
    Inventor: Yoshinori Tokimitsu
  • Patent number: 10859569
    Abstract: This disclosure is directed to methods of conducting dynamic single-molecule fluorescence studies such as smFRET on a membrane protein which permits observation and quantification of conformational dynamics of a membrane protein. Also disclosed herein are mutant membrane proteins in which one or more mutations have been introduced for affixing a fluorophore, as well as reagents and kits containing such mutant membrane proteins for conducting dynamic single-molecule fluorescence studies. The methods and compositions disclosed herein can be used in screening for compounds that enhance or reduce the activity of a membrane protein, useful for treating diseases associated with the malfunction of the membrane protein or alterations in membrane protein conformation.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: December 8, 2020
    Assignees: Cornell University, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Scott Blanchard, Harel Weinstein, Jonathan Javitch
  • Patent number: 10852306
    Abstract: Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed allowing ions having similar unmodified mass-to-charge ratios to be separated before further isolation, fragmentation or analysis.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: December 1, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Joshua J. Coon, Michael S. Westphall
  • Patent number: 10837904
    Abstract: The present invention relates to enhancement of detectable emissions from carbon nanodots or variants thereof by using the techniques of MEF to further enhance carbon nanodot brightness, photostability, and thus, potentially detectability in biological imaging applications by using plasmon supporting materials, such as silver island films and positioning of the carbon nanodots an optimal distance from the plasmon supporting materials.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: November 17, 2020
    Inventor: Chris D. Geddes
  • Patent number: 10832801
    Abstract: The present invention concerns a method for sequencing oligosaccharides, which makes it possible to identify the primary sequence of an oligosaccharide of unknown structure, including its monosaccharide composition, the position (regiochemistry) and configuration (stereochemistry) of glycosidic bonds, the nature and position of functional modifications, and its branched structure, particularly including the identification of the reducing end.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: November 10, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ CLAUDE BERNARD LYON 1
    Inventors: Isabelle Compagnon, Baptiste Schindler
  • Patent number: 10832895
    Abstract: Provided is an analytical device including: a self-flowing microfluidic system, having a sample extraction location, at least one sample preparation location, and at least one sample analytical chamber; wherein the sample extraction location, the sample preparation location, and the at least one sample analytical chamber are interconnected by at least one microfluidic channel on a first substrate; and a signal readout system, having at least one sample analysis elements, and a data gathering and processing element.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: November 10, 2020
    Assignee: Plasmotica, LLC
    Inventors: Nedal Saleh, Waqas Khalid, Faisal Saleh
  • Patent number: 10823744
    Abstract: Described herein are sets of metabolite and lipid (e.g., fatty acid) markers that can be used in the detection of early stage colorectal cancer and/or early development of adenomatous polyps. Presented herein are illustrative pathology-linked panels. In certain embodiments, the markers presented herein (or subsets thereof) are used as a panel for detecting either colorectal cancer or adenomatous polyps at the same time. The markers presented herein include metabolites and lipids (e.g., fatty acid) freely detectable and accurately quantifiable in human serum. In certain embodiments, the sample may be plasma, urine, saliva, whole blood, dried blood spot or dried serum spot.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: November 3, 2020
    Assignee: Universal Diagnostics, S.L.
    Inventors: Marko Bitenc, Kristi Kruusmaa, Paola Hurtado Castillo, Ana María Jiménez Girón, Rosa Argamasilla Martinez, Andreu Fabregat Rossell, Antonio Jesus Adsuar Gomez, Juan Martinez-Barea, Christian Hense, Patricia Rodríguez Gómez, Ángela Peralbo Molina, Jorge Casado Agrelo, Alejandro Sánchez Brotons, Cristina Pavón Solís, Rosa María Delgado Sánchez
  • Patent number: 10815520
    Abstract: Methods for diagnosis or prognosis of a cancer in a subject include isolating one or more nanovesicles from a biological sample obtained from the subject, determining the amount in the biological sample of the one or more nanovesicles, and comparing the amount of the one or more nanovesicles to a control level to thereby diagnose the cancer. The one or more nanovesicles are obtained by depleting the biological sample of exosomes prior to the isolation of the nanovesicles. Methods for identifying a tumor metastasis in a subject are also provided and include fractionating a biological sample from a subject to obtain a fraction including one or more exosomes and one or more nanovesicles having a diameter of about 8-12 nm, and then isolating the one or more nanovesicles to diagnose the tumor metastasis.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: October 27, 2020
    Assignee: University of Louisville Research Foundation, Inc.
    Inventor: Huang-Ge Zhang
  • Patent number: 10816560
    Abstract: The present invention relates to a method to analyse the ability of a substance (3) to cross a bilayer membrane comprising the following steps: (i) providing in a hydrophobic medium (1) a first droplet D1 of an aqueous solution AS1, wherein the droplet D1 is surrounded by a monolayer of amphiphilic molecules (2), (ii) providing in the said hydrophobic medium (1) a second droplet D2 of an aqueous solution AS2 containing the substance (3) to be analysed, wherein the droplet D2 is surrounded by a monolayer of amphiphilic molecules (2), (iii) putting the first droplet D1 and the second droplet D2 into contact so as to form a bilayer of amphiphilic molecules (2) in the contact area and to have a contact angle 2? between the two droplets D1 and D2 comprised between 10° and 180°, (iv) adding to the hydrophobic medium (1) a solvent capable of separating the droplets D1 and D2 put into contact, (v) collecting the droplet D1, and (vi) analysing the content of the droplet D1 in order to determine the presence or not of
    Type: Grant
    Filed: July 4, 2017
    Date of Patent: October 27, 2020
    Assignees: Paris Sciences Et Lettres—Quartier Latia, Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventor: Abdou Rachid Thiam
  • Patent number: 10809267
    Abstract: Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed allowing ions having similar unmodified mass-to-charge ratios to be separated before further isolation, fragmentation or analysis.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: October 20, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Joshua J. Coon, Michael S. Westphall
  • Patent number: 10787660
    Abstract: Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic channels of a capillary structure. The methods and apparatuses can include providing at least one capillary barrier that positions a meniscus of the first liquid at a fluid-interface region using capillary forces within the capillary structure. Additionally, a path is provided along one of the channels for the second liquid to flow toward the fluid-interface region. Additionally, gas pressure is released, via a gas-outflow port, from the fluid-interface region while flow of the first liquid is arrested. Further, the first liquid and the second liquid contact in the fluid-interface region with the capillary barrier holding the first liquid at the fluid-interface region.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: September 29, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Juan G. Santiago, Lewis A. Marshall, Anita Rogacs
  • Patent number: 10772831
    Abstract: Provided according to embodiments of the invention pharmaceutical capsules that include a capsule body and a capsule cap, wherein the capsule cap envelops an open end of the capsule body to form a capsule core; and an adherence sheath that envelops a portion of the capsule core. Related capsules and methods of making such capsules are also provided herein.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: September 15, 2020
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Donn Dennis
  • Patent number: 10775359
    Abstract: Embodiments of the present invention relate to a method to determine formation measurements, the method comprising placing a sample in a reservoir, removing aliquots from the reservoir containing the sample or continuously monitoring the reservoir or headspace as the sample and reservoir equilibrate and analyzing the aliquots or readings sufficient to provide diffusion measurements.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: September 15, 2020
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Christopher Michael Jones, Louis W. Elrod
  • Patent number: 10777397
    Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: September 15, 2020
    Assignee: Micromass UK Limited
    Inventors: Zoltán Takáts, Júlia Balog, Steven Derek Pringle, Tamás Karancsi, Michael Raymond Morris, Lajos Gödörhazy, Dániel Szalay, Dániel Simon