Patents Examined by Xiaozhen Xie
  • Synthetic arginine substituted peptides and their use
    Patent number: 8815812
    Abstract: The present invention relates to new arginine substituted peptides designed based on the sequence of human lactoferrin and to use thereof, in particular for treatment and/or prevention of infections, inflammations, tumors, pain, wounds and/or scars.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: August 26, 2014
    Assignee: Inger Mattsby-Baltzer
    Inventors: Inger Mattsby-Baltzer, Gunnar Dolphin
  • Use of liposomal Wnt composition to enhance osseointegration
    Patent number: 8809272
    Abstract: Methods and compositions are provided for the therapeutic use of Wnt proteins, for enhancing bone growth and regeneration, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: August 19, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Jill Helms
  • Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis
    Patent number: 8796212
    Abstract: A composition comprising a synthetic growth factor analog comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analog is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: August 5, 2014
    Assignee: BioSurface Engineering Technologies, Inc.
    Inventors: Paul O. Zamora, Brent Lee Atkinson, Xinhua Lin, Louis A. Pena
  • BMP10 propeptides and related methods
    Patent number: 8772234
    Abstract: In certain aspects, the present invention provides BMP10 propeptides for use in treating a variety of disorders including heart disorders and other disorders associated with unwanted activity of the mature BMP10 polypeptide. The present invention also provides methods of screening compounds that modulate activity of BMP10.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: July 8, 2014
    Assignee: Acceleron Pharma, Inc.
    Inventors: Jasbir Seehra, John Knopf
  • Use of calcitonin in osteoarthritis
    Patent number: 8765675
    Abstract: The present invention relates to a novel use of calcitonin in osteoarthritis, and to methods of treating and/or preventing osteoarthritis in mammals, particularly humans.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: July 1, 2014
    Assignee: Novartis AG
    Inventors: Moise Azria, Claus Christiansen, Simon David Bateman, Shoufeng Li
  • Stabilized preparation containing protein
    Patent number: 8765124
    Abstract: Protein formulations containing a poloxamer as a surfactant, and methods for maintaining the biological activity in protein formulations without adding an antioxidant and for inhibiting the formation of foreign insoluble matters by adding a poloxamer as a surfactant.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: July 1, 2014
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Akihiko Saito, Eiichi Miyauchi
  • GDF3 propeptides and related methods
    Patent number: 8765670
    Abstract: In certain aspects, the present invention provides compositions and methods for regulating body weight, in particular, for treating obesity and obesity-associate disorders. The present invention also provides methods of screening compounds that modulate activity of GDF3. The compositions and methods provided herein are also useful in treating diseases associated with abnormal activity of GDF3.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: July 1, 2014
    Assignee: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra
  • Methods for promoting wound healing and/or reducing scar formation
    Patent number: 8765673
    Abstract: The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: July 1, 2014
    Assignee: Arizona Board of Regents
    Inventors: Colleen Brophy, Alyssa Panitch, Catherine Parmiter, Elizabeth Furnish, Padmini Komalavilas
  • Interleukin-B30 proteins
    Patent number: 8765914
    Abstract: Purified genes encoding a cytokine referred to as interleukin-B30 (IL-B30) from a mammal, and reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: July 1, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: J. Fernando Bazan
  • Methods for treating inflammatory bowel disease
    Patent number: 8728475
    Abstract: Methods of treating inflammatory disorders, such as rheumatoid arthritis, by modulating TWEAK and TNF-? are disclosed, as are other methods.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: May 20, 2014
    Assignee: Biogen Idec MA Inc.
    Inventors: Linda C. Burkly, Timothy Zheng
  • Implant depots to deliver growth factors to treat osteoporotic bone
    Patent number: 8728509
    Abstract: The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat osteoporotic bone, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate it's implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased bone mineral density in the osteoporotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: May 20, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Epitopes
    Patent number: 8715663
    Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: May 6, 2014
    Assignee: Amgen Inc.
    Inventors: Christopher J. Paszty, Hsieng Sen Lu
  • Method of intervertebral disc treatment using articular chondrocyte cells
    Patent number: 8697139
    Abstract: Harvesting articular chondrocyte cells from a non-critical location of a patient and growing additional cells for transplantation into a damaged or diseased disc of the patient.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: April 15, 2014
    Inventor: Frank Martin Phillips
  • Flowable paste and putty bone void filler
    Patent number: 8653029
    Abstract: The present invention provides a composition that may be used as an implant or a bone graft substitute or extender for filling voids and/or promoting fusion of osseous tissues. The implant may comprise ceramic granules such as calcium phosphate granules and one or more polysaccharide excipients, and may be in the form of a putty or flowable paste. Optionally, the implant may also comprise a growth factor such as a bone morphogenetic protein.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: February 18, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Scott Mitchell Vickers, Jeffrey L. Scifert
  • Method for purifying bone morphogenetic protein
    Patent number: 8648178
    Abstract: The present invention relates to a method for purifying a protein belonging to the TGF-?, superfamily, preferably BMP, and more preferably BMP-2. According to the invention, the number of purification steps is reduced and the purification process is simplified, compared to the conventional BMP-2 purification method. Thus, the time required for purification can be shortened and the cost can be reduced. In addition, the invention solves the problem that as the time for purification increases and the number of purification steps increases, BMP-2 is degraded by protease or lost during purification steps, resulting in a decrease in the final yield of BMP-2. Thus, the invention increases the final yield of BMP-2.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: February 11, 2014
    Assignee: Korea Bone Bank Co., Ltd.
    Inventors: Young-Bock Shim, Yeong-Schick Kim, Yon-Rak Choi, Ju-Woong Jang
  • Modulation of the activity and differentiation of cells expressing the osteoclast-associated receptor
    Patent number: 8642728
    Abstract: This invention relates to the finding that collagen peptides bind to the osteoclast-associated receptor (OSCAR) and stimulate the activation and/or differentiation of OSCAR expressing cells, such as osteoclasts and osteoclast precursor cells. Collagen peptides are described which may be useful in the modulation of the differentiation and/or activation of OSCAR expressing cells, for example in the treatment of bone defects and disorders characterized by altered differentiation and/or activation of OS-CAR expressing cells.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: February 4, 2014
    Assignee: Cambridge Enterprise Ltd.
    Inventors: John Trowsdale, Alexander Barrow, Richard Farndale
  • Affinity peptides toward BMP-2
    Patent number: 8629106
    Abstract: We have disclosed affinity peptides toward BMP-2. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable polymer. The affinity biomatrix is useful in preparing controlled release devices for BMP-2.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: January 14, 2014
    Assignee: Janssen Biotech, Inc.
    Inventors: John Kehoe, Daphne A. Salick, Carrie H. Fang, Chunlin Yang, Abla Creasey
  • Antigenic GM-CSF peptides and antibodies to GM-CSF
    Patent number: 8623364
    Abstract: Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 7, 2014
    Assignee: Morphotek, Inc.
    Inventors: Philip M. Sass, Nicholas C. Nicolaides, Luigi Grasso, Jian Li, Qimin Chao, Eric Routhier, Wolfgang Ebel
  • Use of cytokine receptors as biomarkers and therapeutic targets in human cancer
    Patent number: 8617844
    Abstract: Nucleic acids encoding erythropoietin receptor isoforms are described, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: December 31, 2013
    Assignee: Duke University
    Inventors: Murat O. Arcasoy, Zishan A. Haroon
  • Carbon nanotube composite scaffolds for bone tissue engineering
    Patent number: 8614189
    Abstract: The present invention provides biocompatible composite materials that can be fabricated into a scaffold having properties suitable for bone repair and regeneration. These scaffolds have sufficient mechanical strength to be useful for the repair and regeneration of cortical bone.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: December 24, 2013
    Assignee: University of Connecticut
    Inventors: Cato T. Laurencin, Syam Prasad Nukavarapu, Sangamesh G. Kumbar