Patents Examined by Xiaozhen Xie
  • Local treatment of bone defects
    Patent number: 8318674
    Abstract: A method of local treatment of specific bone defects such as osteoporosis or bone cysts comprises the step of local administration of a formulation comprising a fusion peptide containing a first domain comprising PTH or BMP 2 or BMP 7, and a second domain comprising a covalently crosslinkable substrate domain; and a material suitable of forming a biodegradable matrix suitable for cellular growth or in-growth, wherein the fusion peptide is covalently linked to the matrix. In one embodiment, the matrix contains one or more contrast agents, and is preferably formed in the absence of a growth factor. The matrix may be used in the treatment of fluid-filled cysts such as Tarlov cysts, ovarian cysts, arachnoid cysts, aneurysmal bone cysts or hepatic cysts.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: November 27, 2012
    Assignee: Kuros Biosurgery AG
    Inventors: Jason Schense, John Watson, Isabelle Arrighi
  • Spacer with a coating thereon for use with an implant device
    Patent number: 8309521
    Abstract: The present invention relates to a spacer, such as a polymeric spacer, for use with an implant device, e.g., a bone plate, for splinting a fracture of a bone. The spacer includes a body defining a bone healing surface, wherein at least a portion of the bone healing surface has a coating which includes a therapeutic agent, a polymeric carrier, and a buffer medium to stimulate bone growth and/or promote fracture healing. A kit is also disclosed which includes one or more of the spacers, at least one bone plate, and optionally one or more bone screws for securing the bone plate to bone. A method for promoting fracture healing in bone is further disclosed which includes securely situating a coated portion of the spacer adjacent bone.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: November 13, 2012
    Assignee: Zimmer, Inc.
    Inventors: Kai Zhang, Daniel Buehler, Hallie E. Brinkerhuff, Michael E. Hawkins, Ralf Klabunde
  • Therapeutic formulations of keratinocyte growth factor
    Patent number: 8304387
    Abstract: The present invention provides long-term stable formulations of lyophilized keratinocyte growth factor and methods for making a lyophilized composition comprising keratinocyte growth factor.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: November 6, 2012
    Assignee: Swedish Orphan Biovitrum AB (publ)
    Inventors: Michael J. Treuheit, Vasumathi Dharmavaram, Judith Purtell, Suzanne E. Roy
  • GDF3 antibodies and related methods
    Patent number: 8293238
    Abstract: The application describes compositions and methods for regulating body weight, in particular, for treating obesity and obesity-associate disorders. The application also provides methods of screening compounds that modulate activity of GDF3. These compositions and methods are also useful in treating diseases associated with abnormal activity of GDF3.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: October 23, 2012
    Assignee: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra
  • Ceramic composition for filling bone defects
    Patent number: 8288344
    Abstract: The invention is directed toward a sterile formable implant composition for application to a bone defect site comprising bioactive glass particles in an aqueous carrier solution, the bioactive glass particles being added to a viscous carrier at a concentration ranging from about 68% to about 76% (w/w), the carrier comprising a mixture of glycerol and polyethylene glycol ranging from 24% to 32% (w/w) with the ratio of glycerol to polyethylene glycol ranging from about 45:55 to about 65:35.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: October 16, 2012
    Assignee: Musculoskeletal Transplant Foundation
    Inventor: Carl Alexander DePaula
  • BMP10 antibodies and related methods
    Patent number: 8287868
    Abstract: In certain aspects, the present invention provides BMP10 propeptides for use in treating a variety of disorders including heart disorders and other disorders associated with unwanted activity of the mature BMP10 polypeptide. The present invention also provides methods of screening compounds that modulate activity of BMP10.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: October 16, 2012
    Assignee: Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, John Knopf
  • Use of cytokine receptors as biomarkers and therapeutic targets in human cancer
    Patent number: 8273551
    Abstract: Nucleic acids encoding erythropoietin receptor isoforms are described, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: September 25, 2012
    Assignee: Duke University
    Inventors: Murat O. Arcasoy, Zishan A. Haroon
  • Antibodies to human IL-1?
    Patent number: 8273350
    Abstract: An IL-1? binding molecule, in particular an antibody to human IL-1?, especially a human antibody to human IL-1? is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis and other inflammatory arthritides.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: September 25, 2012
    Assignee: Novartis AG
    Inventors: Hermann Gram, Franco E Di Padova
  • P-selectin ligand protein
    Patent number: 8232252
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: July 31, 2012
    Assignee: Genetics Institute, LLC
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw
  • IL-B30 antibodies
    Patent number: 8182810
    Abstract: Purified genes encoding cytokine referred to as interleukin-B30 (IL-B30) from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: May 22, 2012
    Assignee: Schering Corporation
    Inventor: J. Fernando Bazan
  • Treatment of osteolytic disorders and cancer using CSF1R extracellular domain fusion molecules
    Patent number: 8183207
    Abstract: Methods of using colony stimulating factor receptor (CSF1R) extracellular domain (ECD) fusion molecules for treating osteolytic bone loss, cancer metastasis, cancer metastasis-induced osteolytic bone loss, and tumor growth are provided. CSF1R ECD fusion molecules, polynucleotides encoding CSF1R ECD fusion molecules, and methods of making CSF1R ECD fusion molecules are also provided.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: May 22, 2012
    Assignee: Five Prime Therapeutics, Inc.
    Inventors: Haishan Lin, Li Long
  • Synthetic peptide materials for joint reconstruction, repair and cushioning
    Patent number: 8119598
    Abstract: In joint reconstruction, repair and cushioning applications, a synthetic polypeptide material is useful that contains cross-linked polypeptides that are modeled on human elastin or other fibrous proteins. The polypeptides comprise at least three consecutive beta-sheet/beta-turn structures and at least one amino acid residue that participates in cross-linking.
    Type: Grant
    Filed: May 6, 2008
    Date of Patent: February 21, 2012
    Assignees: Hospital For Sick Children, Elastin Specialties, Inc.
    Inventors: Fred Keeley, Aser Rothstein, Steven Rothstein, Kimberly Woodhouse
  • Modified defensins and their use
    Patent number: 8106006
    Abstract: This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. Methods are provided for modulating an antimicrobial activity and for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: January 31, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Joel Moss, Rodney L. Levine, Akihiro Wada, Toshiya Hirayama, Gregorino Paone
  • Methods of treating arthritis using IL-1? binding molecules
    Patent number: 8105587
    Abstract: This invention relates to methods employing IL-1?-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1? ligand-IL-1 receptor interaction, IL-1? antibodies or IL-1 receptor antibodies, e.g. IL-1? binding molecules as described herein, e.g. antibodies disclosed herein, e.g. IL-1? binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1? ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: January 31, 2012
    Assignees: Novartis AG, Novartis Pharma GmbH
    Inventors: Phil Lowe, Hermann Gram, Thomas Jung, Timothy Wright, Trevor Mundel
  • Use of immunogens to treat or prevent, in malignant tumors, the immune or vascular disorders induced by extracellular factors
    Patent number: 8101165
    Abstract: The invention concerns vaccines comprising as an active principle an immunogen which is a cytokinetic factor or a cell regulating factor particularly transcriptional or another type of factor with immunosuppressive/apoptotic/angiogenic properties abnormally released in the extracellular (stromal) environment by cancer or stromal cells of malignant tumors, and a pharmaceutically acceptable carrier for inducing a systemic or mucosal immune response with secretory formation of class IgC or IgA neutralizing antibodies directed against the native factor, or which is derived from such a factor and the use of said immunogen to obtain a medicine for use as anticancer drug.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: January 24, 2012
    Assignee: Neovacs
    Inventors: Jean Francois Zagury, Bernard Bizzini, Helene Le Buanec, Daniel Zagury
  • Methods for promoting wound healing and/or reducing scar formation
    Patent number: 8101572
    Abstract: The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: January 24, 2012
    Assignee: Arizona Board of Regents, A Corporate Body Organized Under Arizona Law
    Inventors: Coleen Brophy, Alyssa Panitch, Catherine Parmiter, Elizabeth Furnish, Padmini Komalavilas
  • Biocompatible materials containing stable complexes method of TSG-6 and hyaluronan and method of using same
    Patent number: 8093365
    Abstract: The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable complexes of TNF-stimulated gene protein (TSG-6) and hyaluronan.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: January 10, 2012
    Assignees: New York University, Polytechnic Institute of NYU
    Inventors: Hans-Georg Wisniewski, Mary K. Cowman, Philip Band
  • Synthetic single domain polypeptides mimicking apolipoprotein E and methods of use
    Patent number: 8084423
    Abstract: The present invention is directed to a synthetic apolipoprotein-E mimicking polypeptide consisting of a single domain. The invention is also directed to nucleic acid encoding the polypeptide, vectors including the nucleic acid, antibodies specific for the polypeptide, and compositions comprising the same and methods of using the same.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: December 27, 2011
    Assignee: UAB Research Foundation
    Inventors: Gattadahalli M. Anantharamiah, David W. Garber, Geeta Datta
  • Processes and systems for loading medical implants with simulative growth agents
    Patent number: 8080060
    Abstract: Methods and systems for providing an improved apparatus and packaging system to more expeditiously hydrate or reconstitute medical grafts and to effectively and uniformly seed the medical grafts with biological components and cells. The systems generally comprise a container comprising entry port, at least one substrate cavity, and top, side and bottom walls defining an inner surface. The entry port is configured to receive the biological solution. The cavity is in communication with the entry port and includes the porous substrate maintained under negative pressure. The container volume is substantially the same as a volume of the porous substrate. The side and bottom walls are configured to promote a laminar flow of the biological solution received through the entry port.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: December 20, 2011
    Assignee: Alphatec Spine, Inc.
    Inventors: Amit Govil, Neil Irvin Thompson, Christian Gabriel Gamboa, Sudhanshu Somasundar
  • Processes and systems for hydrating and seeding medical implants with biological components
    Patent number: 8070740
    Abstract: Methods and systems for providing an improved apparatus and packaging system to more expeditiously hydrate or reconstitute medical grafts and to effectively and uniformly seed the medical grafts with biological components and cultured cells. The systems generally comprise a container comprising entry port, at least one substrate cavity, and top, side and bottom walls defining an inner surface. The entry port is configured to receive the biological solution. The cavity is in communication with the entry port and includes the porous substrate maintained under negative pressure. The container volume is substantially the same as a volume of the porous substrate. The side and bottom walls are configured to promote a laminar flow of the biological solution received through the entry port.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: December 6, 2011
    Assignee: Alphatec Spine, Inc.
    Inventors: Amit Govil, Christian Gamboa