Abstract: The present invention provides a stable, aqueous injectable solution comprising epinephrine or its pharmaceutically acceptable salt, a sulfite antioxidant, butylated hydroxyl anisole, an organic acid and a chelating agent, wherein the solution is free of an inorganic acid and an inorganic base. The invention also provides a method of treating the septic shock by intravenous administration of stable aqueous injectable solution comprising epinephrine or its pharmaceutically acceptable salt, a sulfite antioxidant, butylated hydroxyl anisole, an organic acid and a chelating agent, wherein the solution is free of an inorganic acid and an inorganic base.

Abstract: The invention provides compositions including epinephrine fine particles, including epinephrine nanoparticles or nanocrystals and epinephrine microparticles or microcrystals, and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine fine particles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required.

Abstract: The present invention generally relates to compositions and methods for forming droplets and/or emulsions. In some embodiments, the compositions and methods comprise two or more components miscible at a first temperature and immiscible at a second temperature, dispersed in an outer phase.

Abstract: The present invention relates to a method for preparing a composition comprising one or more omega-3 fatty acid salt(s), the composition obtainable or obtained by this method, and also the use of this composition for the preparation of foodstuffs, food supplements or pharmaceutical products.

Abstract: Methods and compositions related to molecules and formulations comprising antibiofilm materials are provide, including new formulations of Deep Eutectic Solvents (DES) that are chemically related to choline geranate. Specifically, geranic acid (a component of choline geranate DES) is a molecule from the isoprenoid/terpene family of compounds. Other members of this family as DES components include isoprenoid acids and chemical derivatives thereof.

Abstract: A preservative composition is described that may be used in personal care products and other products for protecting the products against bacteria and fungus during production and during use. The composition can about 3 to about 15% by weight of an organic acid; about 3 to about 15% by weight of a C8-C18 fatty alcohol; about 30 to about 60% by weight of an aromatic alcohol; and about 30 to about 60% by weight of an organic solvent.

Abstract: A device for attracting a rodent includes a housing for receiving the rodent and a composition adjacent to or included within the housing. The composition includes one or more of androstenone, testosterone, progesterone, or estrogen. The one or more of androstenone, testosterone, progesterone, or estrogen are isolated, purified, synthetic, or a combination thereof. The composition may also include at least one of a lethal agent or a chemosterilant. The device may also include a trap configured to trap or kill the rodent.

Abstract: The present invention primarily relates to novel fragrance compositions suitable for enhancing the mood of a subject, preferably a human, novel products containing the same as well as novel uses and methods of such compositions and products.

Abstract: A solid material adapted to kill bacteria in planktonic, spore and biofilm states is lethal toward a wide spectrum of gram positive and gram negative bacteria as well as other microbes. The solid material includes a significant amount of one or more surfactants entrained in a crosslinked polymeric network.

Abstract: The purpose of the present invention is to provide a water-in-oil emulsion cosmetic that, while having an excellent hair-styling effect, exhibits a strong ability to moisturize the coated tissue, provides a smooth finger manipulation sense unlike that of a cream or wax, and does not produce stickiness on the hands and hair. The water-in-oil emulsion cosmetic according to the present invention is characterized by containing (A) a crosslinked siloxane elastomer, (B) a solid oil component, (C) a liquid oil component, and (D) at least 55 mass % water, wherein the ratio of component (B) to component (C) ((B)/(C)) is 0.25 to 1.5.

Abstract: A composition for providing a film on keratin fibres, the composition comprising: a film-forming aminosilicone polymer; a silicone resin; an ether of a water-soluble polyhydric alcohol; a thickening system comprising a deposition enhancer and a thickening polymer; one or more coloured materials or one or more pigments; water; 2-phenoxyethanol and/or phenylmethanol; wherein the composition is substantially free of esters of parahydroxybenzoic acid; and wherein the composition is substantially free of isothiazolinone compounds. Also, associated methods, kits and uses.

Abstract: The present invention relates to a bis phenyl hexa triene derivative, a preparation method thereof and a composition for skin whitening comprising the same as an active ingredient. The said derivative inhibits the expression of tyrosinase, TRP 1 (tyrosinase-related protein 1), TRP 2 (tyrosinase-related protein 2) or MITF (microphthalmia-associated transcription factor) gene which produces a precursor necessary for the generation of melanin, suppresses the activity of tyrosinase, eventually inhibits the biosynthesis of melanin, is safe due to low cytotoxicity, and has less side effects and excellent antioxidative effect, so that it can be effectively used as a composition for skin whitening.

Abstract: An improved microparticle or lyophilized or otherwise reconstitutable microparticle composition thereof for medical therapy, including ocular therapy.

Abstract: The present application relates to GHB formulations and methods for manufacturing the same.

Abstract: Glycan Composites and methods for rendering glycan composites for the treatment of photosynthetic organisms, including the steps of formulating branched glycan deglycosylates into coordination complex compositions resulting in water-borne availability; stability during storage; applying a suitable volume of the resulting mixture to one or more photosynthetic organisms; delivery to photosynthetic organisms; metabolically based growth of crops; enhanced qualities and increased quantities of crops; and systems and compositions for the same.

Abstract: Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training.

Abstract: The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.

Abstract: A rodenticide composition is described along with a method for using the same to exterminate rodents. The composition features a mixture of a dehydrant for causing dehydration in a rodent, a water-absorbent, hygromorphic carrier for absorbing water and expanding after consumption by the rodent, and a flavoring composition. The carrier can be a source of cellulose or a non-cellulosic material. After consumption of the composition by a rodent, the dehydrant and carrier cause the rodent to experience dehydration. The rodenticide composition may also include an irritant that causes digestive stress to the rodent, which further stresses and dehydrates the rodent. Once the rodenticide composition is prepared, it may be placed in areas frequented by or infested with rodents so as to kill the rodents once they consume the composition. One or more flavorings, coloring agents, and weather resistant materials may also be added to the composition.

Abstract: The present invention provides active compositions that contain an aluminum system active, a buffer comprising urea or an amino acid in free or salt form; and a calcium ion source. The compositions are stable at high pH; i.e., at a pH above 4 or 5, reaching neutral or basic pH.

Abstract: Composition and method for treatment of Alzheimer's disease that includes ANAVEX2-73. Method of treatment of Alzheimer's disease using pharmaceutical compositions comprising ANAVEX2-73 according to an intermittent dosage regimen.