Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.
Type:
Grant
Filed:
February 21, 2019
Date of Patent:
December 29, 2020
Assignee:
Capsugel Belgium, NV
Inventors:
Dominique Nicolas Cade, Xiongwei David He
Abstract: The present invention relates to the novel use of the pyrazole carboxylic acid amide derivative Pydiflumetofen, compositions comprising this compound and its use in methods for the reduction of mycotoxin contamination in plants. Pydiflumetofen is also useful in increasing yield, in particular in cereals eg. wheat.
Type:
Grant
Filed:
October 7, 2016
Date of Patent:
December 22, 2020
Assignee:
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors:
Peter Dahmen, Pierre-Yves Coqueron, Ingo Wetcholowsky
Abstract: Aspects of the invention include sunscreen formulations that include uniform, rigid, spherical nanoporous calcium phosphate particles. Also provided are methods of making the sunscreen formulations. The sunscreen formulations find use in sunblocking applications.
Type:
Grant
Filed:
October 10, 2018
Date of Patent:
December 8, 2020
Assignee:
Laboratory Skin Care, Inc.
Inventors:
Zahra Mansouri, Rodica-Tatiana Canelide, Douglas Thomas, Tetsuro Ogawa
Abstract: The present disclosure relates to methods and devices for controlling arthropods, including insects and arachnids in an environment. The methods generally comprise: generating a near-ideal gas Purified Hydrogen Peroxide Gas (PHPG) that is substantially non-hydrated (e.g., in the form of water in solution or water in solution or water molecules bonded by covalence, van der Waals forces, or London forces) and substantially free of, e.g., ozone, plasma species, and/or organic species; and directing the gas comprising primarily PHPG into the environment such that the PHPG acts to control arachnids in the environment. In certain aspects, the arachnids may be totally or partially killed.
Abstract: This invention relates to compositions and methods for treating, ameliorating and preventing the toxic effects of venom poisoning. In particular, the invention provides compositions comprising carbon monoxide releasing molecules (CORM) or compositions comprising CORM and iron releasing molecules (IRM) for one or more of enhancing coagulation, reducing fibrinolysis, and/or inactivating venom related metalloproteinase activity in a subject suffering from or at risk of suffering from venom poisoning.
Type:
Grant
Filed:
April 30, 2019
Date of Patent:
November 10, 2020
Assignee:
Arizona Board of Regents on Behalf of the University of Arizona
Abstract: A composition for oral administration of a bioactive agent to aquatic or terrestrial species includes particles each of which includes a bioactive agent dispersed in oil droplets, the oil droplets being dispersed in a matrix including an enteric coating polymer, wherein the particles each further include a mucoadhesive polymer. Methods of making and using the composition are also provided.
Abstract: Disclosed is use of a composition for preventing or treating an inflammatory disease and a metabolic disease. The composition includes hyaluronic acid nanoparticles formed in such a way that 5?-cholanic acid or polycaprolactone binds to a hydrophobic moiety of hyaluronic acid through self-assembly in an aqueous solution state.
Type:
Grant
Filed:
September 28, 2017
Date of Patent:
October 20, 2020
Assignee:
AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Inventors:
Wook Kim, Hwa Seung Han, Jae Hyung Park, Jun Gi Rho, Juhwan Yoon
Abstract: The present invention relates to a cosmetic composition using a mannosylerythritol lipid, which is a kind of glycolipid, as a stabilizer in order to prevent kojyl methylenedioxycinnamate, which is an active ingredient having various skin effects such as antiaging, whitening and antioxidation, from causing crystallization inside a dosage form. Even if the cosmetic composition according to the present invention contains a high concentration of an active ingredient, crystal precipitation does not occur in various dosage forms, and thus the functionality of the active ingredient is maximized, skin delivery is increased and the texture during use is improved.
Type:
Grant
Filed:
March 1, 2019
Date of Patent:
October 6, 2020
Assignee:
AMOREPACIFIC CORPORATION
Inventors:
Yu Jung Kim, Hyeon Chung Kim, Jae Won Yoo, Yong Jin Kim, Do Hoon Kim, Sung Il Park
Abstract: The present invention relates to a composition for reshaping keratin fibers, preferably the hair, having a specific range of a pH and including at least one specific active compound in an amount of 8% by weight or more relative to the total weight of the composition. The composition according to the present invention is preferably a cosmetic composition, for keratin fibers, such as hair, and can be used for a process for reshaping the keratin fibers with heat. The process according to the present invention can be used to deform or reshape keratin fibers, preferably hair, and can provide the keratin fibers with sufficient reshaping efficiency such as strong wave intensity of the curled keratin fibers and excellent hair conditioning effects (less damage to the keratin fibers), in a relatively short period of time as compared to a conventional process which uses a reducing agent and an oxidizing agent.
Abstract: The present invention includes compositions and methods for the treatment, softening and removal of ear wax by administering to the ear a solution of a semi-fluorinated alkane according to the formula: RFRH or RFRHRF, wherein RF is a perfluorinated hydrocarbon segment with 20 or less carbon atoms, and RH is a non-fluorinated hydrocarbon segment with 3 to 20 carbon atoms.
Abstract: Described herein are drug delivery systems for delivering biologically active agents comprising primary or secondary amines, or a ring nitrogen atom of an azaheteroaryl ring, pharmaceutically acceptable salts thereof, drug delivery reagents related thereto, pharmaceutical compositions comprising the drug delivery systems, and the use of the drug delivery systems as sustained release therapeutics.
Type:
Grant
Filed:
April 19, 2018
Date of Patent:
August 25, 2020
Assignee:
Novartis AG
Inventors:
Christopher M. Adams, Myriam April, Tanzina Fazal, Cornelia Jutta Forster, Edward Charles Hall, Cameron Chuck-munn Lee
Abstract: A process of preparing an adhesive haemostatic product is provided. The process comprises: (a) coating a porous solid substrate with a coating liquid that comprises an electrophilically activated polyoxazoline (EL-POX) and a solvent to produce a coated substrate; and (b) removing the solvent from the coated substrate. The EL-POX comprises at least 2 reactive electrophilic groups. The process enables the application of an EL-POX coating that leaves the pore structure of the substrate largely intact so that the ability of the porous substrate to absorb body fluids, such as blood, remains essentially unaffected. The EL-POX coated haemostatic product obtained by the present process has excellent adhesive properties due to the presence of electrophilic reactive groups that are capable of reacting with e.g. amine groups that are naturally present in tissue, under the formation of covalent bonds.
Type:
Grant
Filed:
December 19, 2018
Date of Patent:
August 25, 2020
Assignee:
GATT TECHNOLOGIES B.V.
Inventors:
Johannes Caspar Mathias Elizabeth Bender, Marcel Alexander Boerman
Abstract: An aqueous surfactant composition containing one or more alpha-sulfo fatty acid disalts (A) of the general formula (I), R1CH(SO3M1)COOM2??(I) in which the radical R1 is a linear or branched alkyl or alkenyl radical with 6 to 16 carbon atoms and the radicals M1 and M2—independently of one another—are selected from the group H, Li, Na, K, Ca/2, Mg/2, ammonium and alkanolamine, one or more alkyl glycosides (B) of the general formula (II), R2O-[G]p??(I) in which R2 is an alkyl and/or alkenyl radical with 8 to 18 carbon atoms, G is a sugar radical with 5 or 6 carbon atoms and p is numbers between 1 and 10, and water are disclosed. The composition has excellent foaming ability and is suitable for use in cosmetic products.
Abstract: A stick-shaped cosmetic contains a wax composition including (A) polyethylene wax having an average molecular weight of 600 or more and (B) carnauba wax. Additionally, the stick-shaped cosmetic includes: (C) film-forming agent; (D) volatile silicone oil agent; and (E) powder. The content of the wax composition is 4% to 13% by mass with respect to the total amount of the stick-shaped cosmetic, and the content of (A) polyethylene wax having an average molecular weight of 600 or more in the wax composition is 50% to 95% by mass with respect to the total amount of wax composition.
Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
September 6, 2018
Date of Patent:
July 7, 2020
Assignee:
The Research Foundation for the State University of New York
Inventors:
Marvin Cohen, Susanne Cohen, Robert G. Flynn
Abstract: Methods for use of structures based on graphene-related materials are disclosed. These structures can be utilized for manipulating the cell transmembrane potential in various biomedical applications.
Abstract: This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (PCR). Methods for preparing the modified detergents are also described.
Type:
Grant
Filed:
December 19, 2018
Date of Patent:
June 9, 2020
Assignee:
Life Technologies Corporation
Inventors:
Parul Angrish, Zhiwei Yang, Jonathan Wang
Abstract: Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB). Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.
Abstract: The present disclosure relates to pharmaceutically acceptable complex formulae comprising complexes of Abiraterone acetate and pharmaceutically acceptable excipients, process for the preparation thereof and pharmaceutical compositions containing them. The complex formulae of the present disclosure have improved physicochemical properties which results in reduced food effect which allows significant dose reduction and the abandoning of the requirement of taking the drug on an empty stomach.
Type:
Grant
Filed:
October 17, 2018
Date of Patent:
June 2, 2020
Assignee:
NanGenex Nanotechnology Incorporated
Inventors:
Réka Angi, Tamás Jordán, Orsolya Basa-Dénes, Tamás Solymosi, Zsolt Ötvös, Hristos Glavinas, Genovéva Filipcsei