Abstract: A method for on-line monitoring of deprotection reaction in a peptide automated synthesizer comprising UV detector is disclosed. A UV source, detector, electronics, and housing are integrated with a line or tube through which liquid reactants flow for periodic measurements in the peptide synthesizer. The method includes determining the progression of the reaction, completion point of the reaction, and the modification of the reaction times and repetitions in real time.
Type:
Grant
Filed:
September 30, 2010
Date of Patent:
September 17, 2013
Assignee:
Protein Technologies, Inc.
Inventors:
Mahendra S. Menakuru, Robert William Hensley, Joseph B. E. Blais
Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.
Abstract: Disclosed herein is a method involving the steps of (a) precipitating an amount of asphaltenes from a liquid sample of a first hydrocarbon-containing feedstock having solvated asphaltenes therein with one or more first solvents in a column; (b) determining one or more solubility characteristics of the precipitated asphaltenes; (c) analyzing the one or more solubility characteristics of the precipitated asphaltenes; and (d) correlating a measurement of feedstock reactivity for the first hydrocarbon-containing feedstock sample with a mathematical parameter derived from the results of analyzing the one or more solubility characteristics of the precipitated asphaltenes.
Type:
Grant
Filed:
June 6, 2012
Date of Patent:
September 10, 2013
Assignee:
The University of Wyoming Research Corporation
Inventors:
John F. Schabron, Joseph F. Rovani, Jr.
Abstract: A method and apparatus for rapidly and accurately determining the fat and oil content of a sample using microwave drying and NMR analysis is disclosed. The method and apparatus incorporate a low mass, porous, hydrophilic and lipophilic sample pad that ensures that the entire sample is subjected to NMR analysis. The method and apparatus according to the invention are suitable for rapidly determining the fat and oil content of samples collected during a production process and for process or quality control.
Abstract: A monitoring system is presented. The monitoring system may include a first chemical vessel containing a first chemical mixture and a second chemical vessel containing a second chemical mixture. The monitoring system may further include a sensor configured to selectively receive a first sample flow of the first chemical mixture from the first chemical vessel and a second sample flow of the second chemical mixture from the second chemical vessel. The sensor may be configured to measure a first sample attribute value of the first sample flow and a second sample attribute value of the second sample flow. By multiplexing multiple sample flows through a sensor, the monitoring system may monitor attributes of multiple chemical mixtures without requiring separate sensors for each chemical mixture monitored by the system. In an embodiment, the monitoring system is preferably configured to control an attribute of a chemical mixture.
Type:
Grant
Filed:
February 28, 2007
Date of Patent:
August 27, 2013
Assignee:
Advanced Micro Devices, Inc.
Inventors:
Mark A. Campbell, Phuong-Anh Tang, Gary R Anderson
Abstract: Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.
Type:
Grant
Filed:
January 19, 2011
Date of Patent:
August 27, 2013
Assignee:
Schlumberger Technology Corporation
Inventors:
Li Jiang, Oliver C. Mullins, Gale H. Gustavson, Christopher Harrison, Bhavani Raghuraman, Ronald E. G. Van Hal, Jimmy Lawrence, Kosta Ladavac, Albert Ballard Andrews, Timothy Gareth John Jones, Rogerio Tadeu Ramos
Abstract: Methods and processes for quantitatively determining the ratio of the metallic to semiconductor tubes in the sample single-wall carbon nanotubes is provided. The single-walled carbon nanotubes can be sonicated to debundle the bulk material. The debundled SWNTs can be coated with a polymer, such as sulfonated polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene (SDPS), and the coated SWNTs can be deposited on a substrate. The total number of tubes can be determined by atomic force microscopy (AFM). The semiconducting nanotubes can be determined by photoluminescence spectroscopy. The combination of photoluminescence and AFM measurements provides a quantitative ratio of the metallic to semiconductor tubes in the sample.
Abstract: When an atomic absorption spectrophotometer (AAS) or inductively coupled plasma (ICP) is used, samples must be introduced in a liquid state. Thus, sample decomposition by acids must be performed. Methods for decomposing samples using beakers or microwaves have caused several problems such as loss of volatile elements, excessive use of acids, emission of harmful gases, limitation of sample capacity and amount, and inconvenience of cleaning up. However, the present invention can treat many samples with one acid injection through gas condensation by both heating of a reaction container and air cooling of a collection pipe, wherein the reaction container is made of fluororesin (Teflon) or quartz. Also, if there are many samples, the samples can be treated at once. Furthermore, since the present invention can treat the samples with a conventional heating plate, the invention can be used at inexpensive costs.
Abstract: The present invention generally relates to water-soluble, highly fluorescent polyhedral oligomeric silsesquioxane (POSS) compounds useful for sensing and bioimaging applications.
Abstract: A method of normalizing surface tension of a sample fluid on a clinical analyzer is disclosed. The method comprises aspirating a portion of a sample fluid into a metering tip, the metering tip having a lower end through which the sample fluid is aspirated and an upper end; sealing the lower end of the metering tip, forming a cuvette for the portion of the sample fluid; pre-treating a micro-tip with a surface tension-normalizing agent, and then dispensing the surface tension-normalizing agent into the sample fluid in the cuvette; mixing the surface tension-normalizing agent and the sample fluid in the cuvette using the micro-tip to create a mixture of the sample fluid and the surface tension-normalizing agent, the mixture having a normalized surface tension; and using the mixture for testing on the clinical analyzer.
Type:
Grant
Filed:
August 14, 2007
Date of Patent:
August 13, 2013
Assignee:
Ortho-Clinical Diagnostics, Inc.
Inventors:
Merrit Jacobs, Ed Graham, Karen Vavra, Chuck Noeson, Susan Danielson, Terri Fazio
Abstract: A method to produce an assay is provided. The method includes introducing into a channel having a peripheral wall a first fluid having a first acoustic contrast, and introducing into a substantially peripheral portion of the channel a second fluid having a second acoustic contrast that is different from the first acoustic contrast, the substantially peripheral portion reaching from within the channel to the peripheral wall of the channel, wherein the second fluid is a biological fluid. The method further includes applying acoustic radiation pressure to the channel, and acoustically reorienting the second fluid based upon the difference between the first acoustic contrast and the second acoustic contrast such that the acoustically reoriented second fluid is translated from the substantially peripheral portion of the channel to a substantially internal portion of the channel that does not reach the peripheral wall of the channel.
Type:
Grant
Filed:
June 14, 2012
Date of Patent:
August 13, 2013
Assignee:
Life Technologies Corporation
Inventors:
Michael D. Ward, Carleton C. Stewart, Gregory Kaduchak
Abstract: Systems and methods of sample (1) and staining processing including compression and dynamic movement of liquids (3) in a fluidically moving substantially contained liquid bridge (6) perhaps between a hydrophobic wand (4) and a hydrophilic sample support element (2). Embodiments may include low volume reagent and perhaps even low volume buffer wash in sample processing. In addition, antibodies can be conjugated with nanoparticles (64) and can be used in sample processing. Exposing a sample with or without movement to AC, DC, or even a permanent magnet field may improve staining. Staining with nanoparticle reagents could be quantified using a microscope with a magnetometer below the slide viewing area. The detection of nanoparticles attached to the chemistry may facilitate the quantification of cancerous cells stained in the tissue.
Abstract: An example system for detecting an analyte in a sample of a bodily fluid comprises a test chamber having at least one sidewall and configured to contain at least a portion of a bodily fluid sample, an excitation electromagnetic energy source configured to direct an energy source into the test chamber through the at least one sidewall and to induce a thermoelastic expansion in the one or more analytes, and a sensor configured to detect said thermoelastic expansion in the bodily fluid sample in the test chamber, the sensor configured to measure changes in optical reflectance that result from the thermoelastic expansion.
Type:
Grant
Filed:
December 31, 2008
Date of Patent:
August 6, 2013
Assignee:
The Curators of the University of Missouri
Inventors:
John A. Viator, Paul S. Dale, Ryan M. Weight, Peter Sutovsky
Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges is a wavelength-tunable cartridge in which different light sources, excitation filters, and/or emission filters may be selected. Tuning is further accomplished by tilting the excitation or emission filters at desired angles relative to a beam of exciting light or emitted light.
Abstract: Apparatus and method for producing electrically conducting nanostructures by means of electrospinning, the apparatus having at least a substrate holder (1), a spinning capillary (2), connected to a reservoir (3) for a spinning liquid (4) and to an electrical voltage supply (5), an adjustable movement unit (6, 6?) for moving the spinning capillary (2) and/or the substrate holder (1) relative to one another, an optical measuring device (7) for monitoring the spinning procedure at the outlet of the spinning capillary (2), and a computer unit (8) for controlling the drive of the spinning capillary (2) relative to the substrate holder (1) in accordance with the spinning procedure.
Type:
Grant
Filed:
August 27, 2008
Date of Patent:
July 30, 2013
Inventors:
Stefan Bahnmüller, Andreas Greiner, Joachim H. Wendorff, Roland Dersch, Jacob Belardi, Max Von Bistram, Stefanie Eiden, Stephan Michael Meier
Abstract: Surface Enhanced Spectroscopy-Active Composite Nanoparticles (SACN) comprising: core/shell nanoparticles comprising nanoparticle cores covered with shells, wherein the cores and the shells may comprise the same or different materials; at least one Raman-active reporter molecule associated with said core/shell nanoparticle; and an SiO2 encapsulant which encapsulates the core/shell nanoparticle and the at least one Raman-active reporter molecule, are described.
Type:
Grant
Filed:
April 25, 2005
Date of Patent:
July 30, 2013
Assignee:
Becton, Dickinson and Company
Inventors:
Michael J. Natan, Sharron Gaynor Penn, R. Griffith Freeman, Gabriela Chakarova, William E. Doering, Ian D. Walton
Abstract: An ozone gas concentration measurement method that can easily measure the concentration of ozone gas. A process gas containing ozone gas is produced from a raw gas containing oxygen gas. The number of moles of gas molecules contained in the process gas is measured. The concentration of the ozone gas contained in the process gas is calculated based on the number of moles of gas molecules contained in the process gas.
Abstract: Disclosed herein is a method involving the steps of (a) precipitating an amount of asphaltenes from a liquid sample of a first hydrocarbon-containing feedstock having solvated asphaltenes therein with one or more first solvents in a column; (b) determining one or more solubility characteristics of the precipitated asphaltenes; (c) analyzing the one or more solubility characteristics of the precipitated asphaltenes; and (d) correlating a measurement of feedstock fouling tendency for the first hydrocarbon-containing feedstock sample with a mathematical parameter derived from the results of analyzing the one or more solubility characteristics of the precipitated asphaltenes.
Type:
Grant
Filed:
August 30, 2012
Date of Patent:
July 23, 2013
Assignee:
The University of Wyoming Research Corporation
Inventors:
John F. Schabron, Joseph F. Rovani, Jr.
Abstract: The present invention provides a novel integrated valve system for a fuel cell stack, in which an air shut-off valve for preventing the inflow of air when a fuel cell shuts down and a dry gas purge valve for improving cold startability are coaxially coupled to each other so that the air shut-off valve and the dry gas purge valve simultaneously open or close.