Abstract: A sensory material with high sensitivity, selectivity, and photostability has been developed for vapor probing of organic amines. The sensory material is a perylene-3,4,9,10-tetracarboxyl compound having amine binding groups and the following formula where A and A? are independently chosen from N—R1, N—R2, and O such that both A and A? are not O, and R1 through R10 are amine binding moieties, solubility enhancing groups, or hydrogen such that at least one of R1 through R10 is an amine binding moiety. This perylene compound can be formed into well-defined nanofibers. Upon deposition onto a substrate, the entangled nanofibers form a meshlike, highly porous film, which enables expedient diffusion of gaseous analyte molecules within the film matrix, leading to a milliseconds response for vapor sensing.

Abstract: Polydentate polycyclic compounds of various formulas are disclosed herein. The compounds are useful for ratiometric luminescence. Significantly, the compounds will luminesce at different wavelengths/colors, depending on the analyte (metal ion, acid, or boron-containing compound) it is combined with. Thus, a single compound can provide different luminescent outputs based on the analyte, rather than requiring an entire set of structurally different compounds to detect each analyte or to generate a desired color output.

Abstract: Systems and methods are provided for identifying missing product ions after demultiplexing product ion spectra produced by overlapping precursor ion transmission windows in sequential windowed acquisition tandem mass spectrometry. Overlapping sequential windowed acquisition is performed on a sample. A first precursor mass window and the corresponding first product ion spectrum are selected from a plurality of overlapping stepped precursor mass windows and their corresponding product ion spectra. A product ion spectrum is demultiplexed for each overlapped portion of the first precursor mass window producing two or more demultiplexed first product ion spectra for the first precursor mass window. The two or more demultiplexed first product ion spectra are added together producing a reconstructed summed demultiplexed first product ion spectrum.

Abstract: The present invention provides methods and apparatus for measuring a property of an sample, the apparatus can manipulate, detect, and analyze the sample composed of single molecules, single small particles or single small samples of matter by drawing the sample into a nanofluidic channel and stretching the sample within the channel, passing the stretched sample through a gap having a width of less than or equal to 20 nm of a nanogap detector positioned inside or adjacent to the nanofluidic channel and measuring an output from the nanogap detector representative of the property of the sample.

Abstract: A visualization kit includes (i) a cyanoacrylate and (ii) a fluorescent agent containing at least one tetrazine of formula 1: wherein X and Y represent independently a nonionic, electron-withdrawing group selected from halogens, azide, cyano and O-A-R, in which A represents a single bond or a C1-C4 alkyldiyl and R is alkyl, alkenyl, alkynyl, cycloalkyl or epoxyalkyl, or an aziridine group, which is optionally substituted by alkyl or aryl. A method of cofugation and a method of visualizing traces on a substrate utilizing these components are also presented.

Abstract: Systems and methods for controlling the temperature of items such as a sample in a vessel or a specimen, in a thermal bath using thermally efficient pellets as the thermal media. The pellets are typically oblong metallic or oblong metallic-coated pellets with rounded edges, a hardened surface, a smooth polished finish, and characteristics that enable efficient thermal communication between the bath's thermal source, the pellets, and the items that are inserted into the mass of pellets. Further, the pellets are dry and moisture and gas impermeable, and they resist microbial growth and are readily decontaminated by several methods including applying an antimicrobial compound to the pellets. The thermal source is controlled to achieve the desired temperature of the items inserted into the pellets.

Abstract: The present invention provides a method for studying transport of an agent across a membrane comprising the steps a) providing at least one surface with a bilayer structure tethered to the surface, said bilayer structure comprising a detection volume, b) contacting the bilayer with at least one agent to be analyzed, and c) detecting a change in refractive index in the detection volume resulting from transportation of the agent across the membrane. Further there is provided a device comprising a) at least one surface, b) at least one bilayer structure tethered to the surface, and c) at least one sensor capable of detecting a change in refractive index in a detection volume, wherein the bilayer structure encloses a first volume of the detection volume and wherein the volume not enclosed by the bilayer structure but within the detection volume is a second volume and wherein the ratio between the first volume and second volume is above about 0.001.

Abstract: A liquid handling device that determines a position of a tray utilizing light reflected from structural features of the tray.

Abstract: A system for analyzing a content of a sample material is presented. The system includes a fiber sensitized to a first substance, and at least one electrode configured to expose the fiber to an electric field. The system includes an optical sensor configured to detect a displacement of the fiber when the fiber is exposed to the electric field, and a processor configured to use the displacement of the fiber to characterize a content of the sample material.

Abstract: In the present invention a controllable acoustic source (14) in connection with the process fluid (10) emits a signal (18) into the fluid (10), consisting of a suspension of particles (12), being volumes of gas, liquid or solid phase. The controllable acoustic signal (18) is allowed to interact, with the particles (12), and the acoustic (pressure) signals (22) resulting from such an interaction is measured preferably via a sensor (24). A spectrum is measured. The spectrum is used to predict properties, content and/or size of the particles (12) and/or used to control a process in which the process fluid (10) participates. The prediction is performed in the view of the control of the acoustic source (14). The used acoustic signal has preferably a frequency below 20 kHz.

Abstract: An indexer adapted to index a test sensor from a test-sensor cartridge. The indexer includes an indexer face having a first aperture formed generally through the center thereof. The indexer further includes a retention pin extending through the first aperture and a flexible pawl positioned near an edge of the indexer face. The indexer is adapted to be rotated in a first direction and a second generally opposite direction about the retention pin. The flexible pawl is configured to bend when the indexer is rotated in the second direction. The flexible pawl is configured to assist in rotating the test-sensor cartridge.

Abstract: Techniques, apparatus and systems are described for using parameters including chain length, number of double bonds and number of double-double bonds of a complex, magnetic resonance imaging (MRI)-generated fat spectrum to determine the composition and properties of fat and to perform various diagnostic functions. In one aspect, a method using MRI to characterize fat includes acquiring a magnetic resonance (MR) image that includes MR data from a target, determining fat characterization parameters based on the acquired MR data, and using the determined fat characterization parameters to produce a relationship between regions of fat and/or water in the MR image.

Abstract: An analyzing device has a main body and is configured to draw a sample liquid from a spot application section of the main body and transfer the sample liquid to a measurement chamber via a microchannel structure formed inside the main body by a centrifugal force. The spot application section has an inlet. The analyzing device includes a supplying capillary channel formed within the spot application section. The supplying capillary channel has an end connected to the inlet of the spot application section. The analyzing device also includes a holding chamber connected to another end of the supplying capillary channel and having a thickness sized to generate a capillary force to move the sample liquid. The holding chamber is formed between a first side wall and a second side wall. The first side wall and the second side wall define the holding chamber.

Abstract: The present invention provides for the surface plasmon-enhancement of long lived luminescent compounds, thereby providing for methods and systems having enhanced and controllable rates of the radiative emission of such relaxation of long lived luminescent compounds. The present invention achieves acceleration of the radiative processes by the interaction of the long lived luminescent compounds with surface plasmons of the metal surfaces.

Abstract: A method of manufacturing a glatiramer acetate drug product is described. The method entails measuring one or both of alpha helical content of the glatiramer acetate and random coil content of the glatiramer acetate in the batch and manufacturing a glatiramer acetate drug product using at least a portion of the glatiramer acetate when the alpha helical content and or random coil content meets certain criteria.

Abstract: High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.

Abstract: The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.

Abstract: The present disclosure relates to the identification of components in a sample based on the chemical nature of the component. In particular, although not exclusively, the present disclosure relates to the identification of hydrophobic and hydrophilic components using a mass spectrometric technique. The present invention also relates to kits and products used in the identification of the components, as well as other subject matter.

Abstract: Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed allowing ions having similar unmodified mass-to-charge ratios to be separated before further isolation, fragmentation or analysis.

Abstract: The present invention provides a sensor or a system comprising gold nanoparticles coated with specific organic coatings for diagnosing, staging or monitoring chronic kidney disease.