Patents Examined by Yevegeny Valenrod
  • Patent number: 10555929
    Abstract: The present invention relates to methods for treating a disease associated with insulin resistance selected from a nonalcoholic fatty liver disease (NAFLD) and its sequelae, a lipodystrophic syndrome or a combination thereof with the selective PPAR? agonist, INT131 and optionally vitamin E or compositions thereof. NAFLDs that may be treated with methods and compositions of the present invention include, but are not limited to, simple nonalcoholic fatty liver and nonalcoholic steatohepatitis (NASH). Lipodystrophic syndromes that may be treated with the methods and compositions of the present invention include, but are not limited to, generalized lipodystrophy including congenital generalized lipodystrophy and acquired generalized lipodystrophy and/or partial lipodystrophy, including congenital partial lipodystrophy and acquired partial lipodystrophy, all of which may or may not include hyperlipidemia and/or hyperglycemia and may or may not include NAFLD.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: February 11, 2020
    Assignee: Coherus Biosciences, Inc.
    Inventor: Christos Mantzoros
  • Patent number: 10287242
    Abstract: The present invention is related to synthesis of highly pure cationic surfactant products by eliminating or reducing impurities generation that has beset prior art. This is achieved through the N-acylation of ester of amino acid and its inorganic salts or its organic salts (e.g. amino acid or hydrochloride of amino acid or sulfate of amino acid or acetate of amino acid etc.) in non-hydrolytic or nearly non-hydrolytic reaction conditions involving mono or biphasic reaction system with fatty acid halide (C4 to C20), under moderate uniform basic condition yielding high purity N-acyl substituted amino acid ester, particularly ethyl lauroyl arginate. The present process achieves pH control through process strategy rather than the measurement and control steps. This ambient temperature process is stable through a range of temperature variation eliminating rigid low temperature control.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: May 14, 2019
    Assignee: ORGANISTRY, LLC
    Inventors: Dilip S. Mehta, Mayank Shastri
  • Patent number: 10035759
    Abstract: A means of isolating specific stereoisomers and enantiomers from a complex mixture containing a possibility of 32 different stereoconfigurations, thus concentrating the stereoisomer or enantiomer to a high degree of purity.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: July 31, 2018
    Assignee: THE PROCTER & GAMBLE COMPANY
    Inventors: Steven Hamilton Hoke, Qingxin Lei, Safa Motlagh, John Christian Haught, Michael Reilly, Koti Tatachar Sreekrishna, Yakang Lin
  • Patent number: 10016402
    Abstract: Embodiments of the present invention are directed to methods for treatment of melanoma using an inhibitor of dihydroorotate dehydrogenase (DHODH) and to combination therapies that involve administering to a subject an inhibitor of oncogenic BRAF (e.g. BRAF(V600E)), as well as an inhibitor of dihydroorotate dehydrogenase (DHODH). Assays for identifying compounds useful for the treatment of melanoma are also provided. The methods comprise screening for compounds or agents that inhibit neural crest progenitor formation in a zebra fish model of melanoma.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: July 10, 2018
    Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Leonard Zon, Richard M. White
  • Patent number: 9931303
    Abstract: The present invention relates generally to abuse-deterrent formulations containing dextroamphetamine sulfate.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: April 3, 2018
    Assignee: Alcobra Ltd.
    Inventors: Yaron Daniely, David Baker, Hanna Ron, David Siner
  • Patent number: 9926246
    Abstract: Disclosed herein are methods and systems for the simultaneous production of oxo-alcohols comprising n-butanol, isobutanol, and 2-ethylhexanol. Also disclosed are methods and systems for simultaneous production of plasticizers using the disclosed oxo-alcohols.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: March 27, 2018
    Assignee: SAUDI BASIC INDUSTRIES CORPORATION
    Inventors: Syed Azhar Hashmi, Flaiyh Al-Anazi, Abdullah Al-Nafissa
  • Patent number: 9925170
    Abstract: Provided herein are pharmacologically active compositions suitable for topical application or injection directly for fat treatment without the need for surgical intervention.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: March 27, 2018
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Serge Lichtsteiner, Alain Vasserot, Neil Poloso
  • Patent number: 9913821
    Abstract: The present invention discloses a novel form of ferric organic compounds, including a form of ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. The ferric organic compounds of the present invention can be delivered effectively by oral route with better delivery to treat patients suffering from hyperphosphatemia, metabolic acidosis and other disorders responsive to ferric organic compound therapy.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: March 13, 2018
    Assignee: Panion & BF Biotech Inc.
    Inventors: David W. K. Kwok, Nikolay Mintchev Stoynov
  • Patent number: 9902689
    Abstract: A process for preparing alkanesulfonic acids from sulfur trioxide and an alkane, wherein sulfur trioxide, the alkane and dialkylsulfonoyi peroxide (DASP) react as components, characterized in that the following steps are performed: a) sulfur trioxide is charged in a high-pressure reactor in a condensed phase; b) a temperature of at least 25° C. is set; c) the gaseous alkane is introduced to the high-pressure reactor until a pressure of at least 10 bar is reached; d) dialkylsulfonoyi peroxide (DASP) is added; and e) after a duration of at least 5 hours, the produced alkanesulfonic acid is withdrawn.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: February 27, 2018
    Assignee: Grillo Chemie GMBH
    Inventors: Timo Ott, Ingo Biertümpel, Klaus Bunthoff, Alan Richards
  • Patent number: 9884842
    Abstract: The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I), Formula (II), and Formula (V) are provided.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: February 6, 2018
    Assignee: BIOVENTURES, LLC
    Inventors: Narsimha Reddy Penthala, Peter Crooks, Vijayakumar Sonar
  • Patent number: 9884839
    Abstract: Provided herein are non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 and type 2 (17?-HSD1 and 17?-HSD2) inhibitors, their production and use, especially for the treatment and for prophylaxis of hormone-related diseases.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: February 6, 2018
    Assignee: ElexoPharm GmbH
    Inventors: Rolf Hartmann, Martin Frotscher, Ahmed Saad Abdelsamie Ahmed, Emmanuel Bey, Chris J. van Koppen, Sandrine Oberwinkler-Marchais, Carsten Börger, Lorenz Siebenbürger, Victor Hernández Olmos
  • Patent number: 9872847
    Abstract: The present invention provides a pharmaceutical composition for preventing and/or treating a movement disorder comprising the phenyl carbamate compound as an active ingredient, and a use of the phenyl carbamate compound for preventing and/or treating movement disorder.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: January 23, 2018
    Assignee: Bio-Pharm Solutions Co., Ltd.
    Inventor: Yong Moon Choi
  • Patent number: 9872908
    Abstract: The present disclosure provides for a composition which may be used for the solublization of an agent or the oral administration of an agent, the composition comprising, a lyosphosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lyosphosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lyosphosphatidyl compound, a monoglyceride and a free fatty acid.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: January 23, 2018
    Assignee: Avanti Polar Lipids, Inc.
    Inventors: Walter A Shaw, Stephen W Burgess, Shengrong Li
  • Patent number: 9871213
    Abstract: The present invention relates to the use of aromatic boronic acid or borinic acid derivatives in organic electronic devices, in particular electroluminescent devices.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: January 16, 2018
    Assignee: Merck Patent GmbH
    Inventors: Philipp Stoessel, Esther Breuning, Arne Buesing, Amir Hossain Parham, Holger Heil, Horst Vestweber
  • Patent number: 9861626
    Abstract: The present invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: January 9, 2018
    Assignee: RIKEN
    Inventors: Akira Wada, Hiroki Hayase, Nobumoto Watanabe, Hiroyuki Osada, Takeshi Shimizu, Konstanty Wierzba
  • Patent number: 9862671
    Abstract: This invention relates to a process for obtaining highly pure aliphatic dialkyl esters of saturated dicarboxylic acids from vegetable oils, which can advantageously be used in polymerization. The process comprises the steps of reacting with an aliphatic alcohol a triglycerides mixture containing at least one triglyceride of at least one saturated dicarboxylic acid in the presence of one or more catalysts capable of catalyzing the esterification and transesterification reactions, and separating the dialkyl esters of saturated dicarboxylic acids from the reaction mixture thus obtained.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: January 9, 2018
    Assignee: NOVAMONT S.P.A.
    Inventors: Catia Bastioli, Luigi Capuzzi, Francesca Digioia
  • Patent number: 9862677
    Abstract: An acrylic or methacrylic compound having N-alkoxyalkyl group; and a method for producing the compound. An acrylic or methacrylic compound having N-alkoxyalkyl group, of Formula [1]: [where R1 is a hydrogen atom or methyl group; R2 is a C2-20 alkylene group etc.; R3 is an r-valent C2-20 aliphatic group etc.; R4 is a C1-20 alkyl group etc.; Z is >NCOO— or —OCON< (where “-” is a bond, “>” and “<” each have two bonds, and any one of “>” and “<” is bonded to —CH2OR4); and r is a natural number of 2 or more and 9 or less].
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: January 9, 2018
    Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Yoshikazu Harada, Mitsumasa Kondo, Shojiro Yukawa
  • Patent number: 9855204
    Abstract: A treatment method including: (a) identifying a subject in need of treatment for androgenic alopecia (AGA), and (b) orally administering a physiologically effective amount of cepharanthine (CEP) to the subject according to a dosage regimen.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: January 2, 2018
    Inventor: Moshe Rogosnitzky
  • Patent number: 9856209
    Abstract: Xylylene dicarbamate contains impurities represented by formulas (1) to (4) below at a ratio of less than 100 ppm as a total amount thereof on a mass basis. (In the above-described formulas (1) to (4), R represents a monovalent hydrocarbon group.).
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: January 2, 2018
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Koji Takamatsu, Hideki Sone, Masaaki Sasaki
  • Patent number: 9850196
    Abstract: The present invention relates to a reverse wavelength dispersion compound, a reverse wavelength dispersion composition including the same, and an optically anisotropic body including the same. The reverse wavelength dispersion composition according to the present invention can provide a stronger and more stable reverse wavelength dispersion property, and makes it possible to provide an optically anisotropic body having excellent optical properties.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: December 26, 2017
    Assignee: LG CHEM, LTD.
    Inventors: Min Hyung Lee, Sung-Ho Chun, Kyung Chang Seo, Jung Hyun Kim, Mi Ra Hong, Hyeong Bin Jang, Jeong Wook Mun