Patents Examined by Yevegeny Valenrod
  • Method for adjunctive treatment of cancer metastasis by using lycogen
    Patent number: 9675563
    Abstract: The present invention relates to a method for adjunctive treatment of cancer by using a Lycogen composition to inhibit metastasis, comprising administering a Lycogen composition to the subject, wherein the Lycogen composition comprises an effective amount of a Lycogen extract, wherein the Lycogen extract comprises active ingredients selected from ?-carotene, neurosporene, spheroidenone, methoxyneurosporene or a combination thereof.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: June 13, 2017
    Assignee: ASIA-PACIFIC BIOTECH DEVELOPING, INC.
    Inventors: Wen-Sheng Liu, Fu-Hsin Chang, Ya-Fen Hsiao
  • Methods for integrated natural gas purification and products produced therefrom
    Patent number: 9676695
    Abstract: A method is disclosed of coupling and integrating natural gas recovery and separation along with chemical conversion. The method can comprise extracting at least one natural gas component. Non-limiting examples of the extracted component include ethane, propane, butanes, and pentanes. The method can also comprise contacting a natural gas stream with a catalyst under conditions that selectively convert at least one component into at least one product, such as ethylene, acetic acid, polyethylene, vinyl acetate, ethylene vinyl acetate, ethylene oxide, ethylene glycol, and their derivatives, propylene, polypropylene, propylene oxide, propylene glycol, acrylates, acrolein, acrylic acid, butenes, butadiene, methacrolein, methacrylic acid, methacrylates, and their derivatives, which can then be separated from the remaining components.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: June 13, 2017
    Inventors: Mark Allen Nunley, Madan Mohan Bhasin, William George Etzkorn, George Ernest Keller, II, Parvez H. Wadia
  • Methods of makng high-purity dibasic acid compositions
    Patent number: 9670125
    Abstract: High-purity dibasic acid compositions are generally disclosed. In some embodiments, the dibasic acid compositions are solutions or suspensions. In some other embodiments, the compositions are solid-state compositions. In some such embodiments, the solid-state compositions comprise a dibasic acid as a crystalline solid and further comprise a low quantity of certain impurities, such as monobasic acids, various esters, and the like. Methods and systems for making such high-purity dibasic acid compositions are also disclosed.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: June 6, 2017
    Assignee: Elevance Renewable Sciences, Inc.
    Inventors: Alpeshkumar K. Patel, Yenamandra Viswanath
  • Intermediate of tapentadol
    Patent number: 9663456
    Abstract: The present invention relates to novel carbamate intermediate of formula (II), process for its preparation and process for its conversion into 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol, tapentadol and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: May 30, 2017
    Assignee: SUN PHARMA ADVANCED RESEARCH COMPANY
    Inventors: Anil Kumbhani, Biswajit Samanta, Kilaru Srinivasu, Thennati Rajamannar
  • Use of bucillamine in the treatment of gout
    Patent number: 9662305
    Abstract: Disclosed are pharmaceutical compositions comprising, bucillamine, including bucillamine and allopurinol or colchicine, or pharmaceutically acceptable salts or solvates thereof, together with one or more pharmaceutically acceptable carriers, diluents and excipients. Methods for use of the said compositions in the treatment of gout and metabolic syndrome are also disclosed.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: May 30, 2017
    Assignee: Revive Therapeutics Inc.
    Inventor: Michael L. Selley
  • Method of treating or preventing tumors using 1-(alkylsulfinyl)-2-isothiocyanatoalkyl-1-alkene
    Patent number: 9655875
    Abstract: A method of treating or preventing human or mammalian cancer and tumor including administering to a patient or an animal in need thereof a pharmaceutical composition, a health product, or a food additive, including 1-(alkylsulfinyl)-2-isothiocyanatoalkyl-1-alkene.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: May 23, 2017
    Assignee: BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY
    Inventors: Qipeng Yuan, Ming Yang, Hao Liang
  • Pharmaceutical compositions comprising perillyl alcohol derivatives
    Patent number: 9657026
    Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: May 23, 2017
    Assignee: NeOnc Technologies Inc.
    Inventors: Thomas Chen, Daniel Levin, Satish Pupalli
  • Quinoline-substituted compound
    Patent number: 9650386
    Abstract: An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: May 16, 2017
    Assignee: Taiho Pharmaceutical Co., Inc.
    Inventors: Takao Uno, Katsumasa Nonoshita, Tadashi Shimamura
  • Itraconazole analogues and methods of use thereof
    Patent number: 9650365
    Abstract: Disclosed herein are analogs of itraconazole that are both angiogenesis and hedgehog signaling pathway inhibitors. The compounds are expected to be useful in the treatment of cancer, particularly cancers that are dependent upon the hedgehog signaling pathway such as basal cell carcinoma and medulloblastoma.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: May 16, 2017
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Matthew Kyle Hadden, Upasana Banerjee
  • Antifungal drugs
    Patent number: 9642846
    Abstract: The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. The methods of the invention also relates to the administration of pharmaceutical compositions comprising compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. Subjects suffering from fungal infection and immunocompromised subjects may particularly benefit from the methods and compositions of the invention.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 9, 2017
    Assignee: Georgetown University
    Inventors: Richard A. Calderone, Nuo Sun
  • Layered double hydroxides
    Patent number: 9642919
    Abstract: The invention relates to layered double hydroxide (LDH) materials and in particular to new methods of preparing improved LDH materials which have intercalated active anionic compounds (improved LDH-active anion materials). The improved LDH-active anion materials are characterized by their high degree of robustness, demonstrated by their high Particle Robustness Factor values, and by their ability to retain substantially all of the intercalated active anionic compound, in the absence of ion exchange conditions and/or at pH>4.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: May 9, 2017
    Assignee: OXFORD PHARMASCIENCE LIMITED
    Inventors: Claire Thompson, Marcelo Leonardo Bravo Cordero, Dermot Michael O'Hare
  • Process for hydrolyzing 1,2,4-trihalobenzene
    Patent number: 9643909
    Abstract: The present invention relates to a process for providing a compound of formula (I): wherein Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal sulfite of the formula X2SO3 and an alkali metal hydroxide of the formula YOH, wherein X and Y are independently selected from an alkali metal.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: May 9, 2017
    Assignee: BASF SE
    Inventors: Gerald Schmelebeck, Junmin Ji, Eric George Klauber, Michael Rack, Thomas Zierke, Nicole Holub, David Cortes
  • Cross-linked carbon nanotube networks
    Patent number: 9643149
    Abstract: The present invention relates to a method for the production of cross-linked carbon nanotube network which are selected from aerogels and xerogels with improved performance and characteristics thereof. The invention is also concerned with carbon nanotube networks which are selected from aerogels and xerogels produced by such processes and uses thereof.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: May 9, 2017
    Assignees: The Bio Nano Centre Limited, King Abdulaziz University
    Inventors: Milo Shaffer, Garcia Gallastegui Ainara, Abdullah Asiri, Shaeel Althabaiti
  • Benzene polycarboxylic acid compounds and their use as drug
    Patent number: 9644074
    Abstract: The present invention relates to new benzene polycarboxylic acids compound, which is prepared by alkaline oxidation of hydrolyzed lignin. The present invention also relates to the use of the new benzene polycarboxylic acids compound as part of a composite substance, where the composite substance is prepared by complexing or encapsulating the new benzene polycarboxylic acid compounds with a metal cation. The present invention also relates to a method for preparing the new benzene polycarboxylic acids compound and for its use in cosmetic, nutraceutical and pharmaceutical compositions.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: May 9, 2017
    Assignee: RINNOVATION APS
    Inventors: Valery Pavlovich Shipov, Evgeny Sergeevich Pigarev, Elena I. Fedoros
  • Xylylene dicarbamate, method for producing xylylene diisocyanate, xylylene diisocyanate, and method for reserving xylylene dicarbamate
    Patent number: 9624165
    Abstract: Xylylene dicarbamate contains impurities represented by formulas (1) to (4) below at a ratio of less than 100 ppm as a total amount thereof on a mass basis. (In the above-described formulas (1) to (4), R represents a monovalent hydrocarbon group.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: April 18, 2017
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Koji Takamatsu, Hideki Sone, Masaaki Sasaki
  • Substituted piperidinyltetrahydroquinolines
    Patent number: 9624198
    Abstract: The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: April 18, 2017
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Eva Maria Becker-Pelster, Philipp Buchgraber, Anja Buchmüller, Karen Engel, Volker Geiss, Andreas Göller, Herbert Himmel, Raimund Kast, Andreas Knorr, Dieter Lang, Gorden Redlich, Carsten Schmeck, Hanna Tinel, Frank Wunder
  • Process for the preparation of ingenol-3-angelate from 20-deoxy-ingenol
    Patent number: 9624157
    Abstract: The present invention provides a method for preparing ingenol-3-angelate.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: April 18, 2017
    Assignee: LEO Laboratories Limited
    Inventor: Xifu Liang
  • Substituted bipiperidinyl derivatives
    Patent number: 9624199
    Abstract: The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: April 18, 2017
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Eva Maria Becker-Pelster, Philipp Buchgraber, Anja Buchmüller, Karen Engel, Andreas Göller, Herbert Himmel, Raimund Kast, Joerg Keldenich, Carsten Schmeck, Hanna Tinel, Frank Wunder
  • IDO inhibitors
    Patent number: 9624188
    Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention. Formula (I).
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: April 18, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: James Aaron Balog, Audris Huang, Bin Chen, Libing Chen, Weifang Shan
  • Creatine prodrugs, compositions and methods of use thereof
    Patent number: 9617230
    Abstract: The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: April 11, 2017
    Assignee: FARMINGTON PHARMA DEVELOPMENT
    Inventor: William F. Brubaker