Abstract: A system for identifying and optionally treating biological material is provided. The system includes a coherent light source for irradiating the biological material and device for collecting light waves reflected from the biological material and transforming the light waves to nanoplasmonic waves. The system also includes a processing module for extracting phase and amplitude information from the nanoplasmonic waves to identify the biological material based on the phase and amplitude information.

Abstract: In part, the disclosure relates to computer-based methods, and systems suitable for evaluating a subject to determine the appropriate diagnostic tools for assessing coronary arteries. This can include assessing various blood pressure values during a resting state (without inducing hyperemia). These systems and methods can assess a patient and identify coronary dominance on per patient basis. In turn, this assessment can be used to recommend whether a resting index is appropriate or if another index such as FFR or others such be obtained diagnostic metric such as a pressure value-based ratio.

Abstract: Localization array position determination in a treatment room coordinate system is described. A method may include imaging, using an imaging system, a position of one or more markers integrated with a localization array in a treatment room and transforming the position of the one or more markers to a treatment room coordinate system. The method also includes determining the position of the localization array in the treatment room coordinate system based on the transforming.

Abstract: An ultrasonic diagnostic device includes: a probe including a plurality of elements; a transmission unit that transmits an ultrasonic beam by performing transmission focusing in a first direction from the plurality of elements; a reception unit that generates element data by processing reception signals output from the plurality of elements that has received an ultrasonic echo generated by the transmitted ultrasonic beam; an element data processing unit that generates reflection component removal data by removing a reflection component generated from the first direction from the element data; an image generation unit that generates an ultrasonic image by performing reception focusing for the element data; and a control unit that controls the image generation unit to generate an image signal along a second direction different from the first direction by performing reception focusing in the second direction for the reflection component removal data generated by the element data processing unit.

Abstract: A modular fluoro-navigation instrument including a base made of a substantially radiotransparent material. The base is intended to be rigidly secured to a patient's bone and a tracker rigidly attachable to the base. The instrument has a registration phantom separate from the tracker which includes a plurality of radiopaque fiducials. The base and the registration phantom includes respective attachment members for reproducibly attaching the registration phantom to the base.

Abstract: A virtual beam's-eye view of a planning target volume is generated based on volumetric image data acquired immediately prior to radiation therapy by a radiation therapy system. The virtual beam's-eye view can then be displayed to confirm that, with the patient disposed in the current position, the planned beam-delivered treatment extends beyond the surface of the skin. In some embodiments, the virtual beam's-eye view can be displayed in conjunction with a beam's-eye view that is generated based on volumetric image data acquired during treatment planning, to create a blended beam's-eye view. In some embodiments, a field outline of a treatment beam can be superimposed on the blended beam's-eye view, thereby illustrating whether the planned beam-delivered treatment extends beyond the surface of the skin of the patient. The blended beam's-eye view can facilitate a manual confirmation process that verifies the planned beam-delivered treatment extends beyond the surface of the skin.

Abstract: An ultrasonic diagnostic device includes: a probe including a plurality of elements; a transmission unit that transmits an ultrasonic beam by performing transmission focusing in a first direction from the plurality of elements; a reception unit that generates element data by processing reception signals output from the plurality of elements that has received an ultrasonic echo generated by the transmitted ultrasonic beam; an element data processing unit that generates reflection component removal data by removing a reflection component generated from the first direction from the element data; an image generation unit that generates an ultrasonic image by performing reception focusing for the element data; and a control unit that controls the image generation unit to generate an image signal along a second direction different from the first direction by performing reception focusing in the second direction for the reflection component removal data generated by the element data processing unit.

Abstract: An electronic device including optical sensing with a concentric architecture and methods for operation thereof is disclosed. The concentric architecture can include light detector(s) arranged in a concentric manner around light emitter(s). In some examples, at least one light emitter can be located in the center of the device, and each light detector can be located the same separation distance from the light emitter. Each light detector can be arranged such that the separation distance from the centrally located light emitter can be greater than the separation distance from another light emitter. Examples of the disclosure further include a selective transparent layer overlaying the light detector(s). The selective transparent layer can include section(s) transparent to a first wavelength range and non-transparent to a second wavelength ranges. In some examples, the selective transparent layer can further include section(s) transparent to the second wavelength range.

Abstract: Light is irradiated to a finger of a subject and received from the finger of the subject to extract a pulse wave signal, generates an optimized pulse wave signal in a desired type by sampling the extracted pulse wave signal according to a predetermined sampling condition and normalizes the generated pulse wave signal, the entire segment of the normalized pulse signal is divided into a plurality of window segments to detect a pulse wave amplitude value with respect to a pulse wave signal for each window, a first eigenvector for each subject corresponding to a pulse wave amplitude value of the entire window segment is extracted by using a linear discriminant analysis and then the first eigenvector per subject is compared with a threshold, determines distribution of eigenvectors for each subject compared to the threshold and thus a characteristic of the corresponding subject is diagnosed.

Abstract: A fluoro-navigation system for navigating a tool relative to a medical image. The system includes a motorized X-ray imaging system for acquiring a plurality of images of a region of interest of a patient, the position of each image being known. Also included is a localization system, a registration phantom with a plurality of radiopaque fiducials, a tracker for being tracked by the localization system, a processor for receiving the plurality of images and for reconstructing a 3D medical image from the images using radiopaque fiducials visible in the plurality of images. Also included is base made of a substantially radiotransparent material, to be rigidly secured to a patient's bone and having a reproducible fixation system for attaching the registration phantom and/or tracker.

Abstract: An apparatus for the ultrasound guided refilling of a drug delivery pump includes an ultrasound imaging transducer having a nosepiece and a support device coupled to the nosepiece of the ultrasound imaging transducer. The support device can have two support holes whose centers are positioned along a horizontal axis of the support device. A marker can be placed in each of the two support holes. The vertical axis of the ultrasound imaging transducer coincides with the vertical axis of the support device. When imaging using this apparatus and the port inlet of the pump is visualized using the ultrasound transducer, two primary marks on skin can be created by inserting a marker into the support holes. The apparatus can then be rotated around its vertical axis, and a marker again inserted into the support holes to create two secondary marks. The inlet port of the pump is then marked at the intersection of lines which connects the primary marks and respectively the secondary marks.

Abstract: Described herein are methods, systems, and software for monitoring blood pressure. In some embodiments, a using a mobile device is used. The blood pressure monitoring system utilizes heart rate measurements at two separate locations on the body to calculate a differential pulse arrival time which is used to estimate blood pressure. The heart rate measurements can be taken simultaneously, or they can be taken sequentially while simultaneously taking ECG measurement. If taken sequentially, the heart rate measurements are aligned with the ECG to determine the differential. Accurate, inexpensive, and discreet blood pressure monitoring is thus provided.

Abstract: A system and method for planning surgical procedure including a treatment zone setting view presenting at least one slice of a 3D reconstruction generated from CT image data including a target. The treatment zone setting view presenting a treatment zone marker defining a location and a size of a treatment zone and configured to adjust the treatment zone marker in response to a received user input. The system and method further including a volumetric view presenting a 3D volume derived from the 3D reconstruction and a 3D representation of the treatment zone marker relative to structures depicted in the 3D volume.

Abstract: An ultrasound probe is described that comprises a transducer for transmitting and receiving ultrasound. The probe also includes a coupling element, such as a spherical ball of self-lubricating or hydrogel material, for contacting and acoustically coupling to an object to be inspected. The ultrasound probe also includes an analyser that is arranged to analyse the ultrasound signal received by the transducer and thereby determine if there is contact between the coupling element, and the surface of an object. The probe can thus be used for internal (ultrasound) inspection of objects as well as measuring the position of points on the surface of the object. The probe may be mountable to a coordinate measuring machine or other moveable platforms.

Abstract: A heartbeat measurement device includes a transmitter configured to transmit a transmission signal from a transmission antenna to a person to be measured, a receiver configured to receive a signal reflected from the person to be measured as a reception signal using a reception antenna, and an orthogonal detection circuit configured to generate an I signal that is an in-phase component of the transmission signal and the reception signal and a Q signal that is a quadrature component of the transmission signal and the reception signal. The heartbeat measurement device further includes a Fourier transform unit configured to calculate a spectrum in positive and negative frequency domains on the basis of the I signal and the Q signal and a signal processing unit configured to compare positive and negative frequency components in the spectrum to extract a heartbeat component.

Abstract: A method for ultrasound image acquisition for tracking an object of interest in ultrasound image information includes receiving X-ray image information and ultrasound image information, determining, before the tracking, a spatial relationship between the X-ray image information and the ultrasound image information, detecting an object of interest in the X-ray image information and steering two-dimensional ultrasound image acquisition such that the object of interest is within an ultrasound image plane.

Abstract: A combined optical coherent tomography (OCT) pressure sensor system includes an optical cable comprising a single-mode core and a multi-mode core. An OCT optical imaging sensor near a distal end of the optical cable can be inserted into a lumen of a living being. First light exiting a distal end of the single-mode core illuminates an interior of the lumen. The OCT optical imaging sensor acquires image information about the interior of the lumen and transmits an optical signal carrying the image information into the distal end of the single-mode core, toward a proximal end of the single-mode core. An optical pressure sensor attached near the OCT optical imaging sensor receives second light from the distal end of the optical cable, senses ambient pressure within the lumen and transmits an optical signal indicative of the ambient pressure into a distal end of the multi-mode core, toward a proximal end of the multi-mode core.

Abstract: An array of CMUT cells has a DC bias voltage (VB) coupled to the membrane and floor electrodes of the cells to bias the electrode to a desired collapsed or partially collapsed state. The low voltage or ground terminal of the DC bias supply is coupled to the patient-facing membrane electrodes and the high voltage is applied to the floor electrodes. An ASIC for controlling the CMUT array is located in the probe with the array. The ASIC electronics are electrically floating relative to ground potential of the ultrasound system to which the CMUT probe is connected. Control and signal lines are coupled to the CMUT probe by level shifters which translate signals to the floating potential of the ASIC and provide DC isolation between the CMUT probe and the ultrasound system.

Abstract: An elongate medical device may include an elongate body having a proximal end portion and a distal end portion and defining a longitudinal axis extending from the proximal end portion to the distal end portion. The elongate medical device may further include a basket assembly coupled to the distal end portion comprising a plurality of ablation elements, each of the ablation elements configured to ablate a respective target, the basket assembly disposed on a radial exterior of the elongate body. The elongate medical device may further include an imaging transmitter disposed radially-inward of the ablation elements and configured to project imaging energy towards at least one of the respective targets.

Abstract: A method and apparatus to non-invasively measure instantaneous blood pressure using pulse wave velocity are disclosed. A measurement component is affixed to a patient proximate to a blood vessel. One or more sensors, such as an ultrasound sensor, is included in the measurement component. The measurement component substantially simultaneously measures the pulse wave velocity of the vessel and the instantaneous blood velocity within the vessel. The measurement component computes the instantaneous blood pressure of the vessel using, for example, the water hammer equation. The one or more sensors may be contained in a disposable patch or collocated with another sensor, such as a patient-monitor sensor, or the like.