Patents Examined by Yong Pak
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6806072
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: October 19, 2004
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • D-pantolactone hydrolase and gene encoding the same
    Patent number: 6794171
    Abstract: A novel enzyme which is useful in the optical resolution of D,L-pantolactone via D-selective asymmetric hydrolysis and a gene encoding the the same are provided. The invention discloses the gene coding for a natural D-pantolactone hydrolase (for example, one originating in Fusarium oxysporum) or proteins having an activity substantially equivalent thereto; host cells transformed with DNA containing a nucleotide sequence coding for said protein, processes for producing said protein via using said host cells and uses of said proteins and host cells.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: September 21, 2004
    Assignee: Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Keiji Sakamoto, Hideaki Yamada, Sakayu Shimizu, Michihiko Kobayashi
  • Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
    Patent number: 6783965
    Abstract: A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: August 31, 2004
    Assignee: Mountain View Pharmaceuticals, Inc.
    Inventors: Merry R. Sherman, Mark G. P. Saifer, L. David Williams
  • 22438, 23553, 25278, and 26212 novel human sulfatases
    Patent number: 6767727
    Abstract: The present invention relates to newly identified human sulfatases. In particular, the invention relates to sulfatase polypeptides and polynucleotides, methods of detecting the sulfatase polypeptides and polynucleotides, and methods of diagnosing and treating sulfatase-related disorders. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: July 27, 2004
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Maria Alexandra Glucksmann, Mark Williamson, Fong Ying Tsai, Laura A. Rudolph-Owen
  • Human secretory type phospholipase a2
    Patent number: 6756219
    Abstract: This invention relates to a gene encoding human secretory type phospholipase A2 (PLA2). According to the invention, an expression vector having this gene, and a transformant having the expression vector are obtainable. The PLA2 protein can be produced by the culture of the transformant.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: June 29, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Jun Ishizaki, Noriko Suzuki, Kohji Hanasaki
  • Nucleic acids and polypeptides
    Patent number: 6743619
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: June 1, 2004
    Assignee: Nuvelo
    Inventors: Y. Tom Tang, Ping Zhou, Ryle Goodrich, Chenghua Liu, Vinod Asundi, Feiyan Ren, Jie Zhang, Qing A. Zhao, Yonghong Yang, Aidong J. Xue, Tom Wehrman, Jian-Rui Wang, Dunrui Wang, Radoje T. Drmanac
  • Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
    Patent number: 6716614
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: April 6, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • DNA glycosylases and their use
    Patent number: 6713294
    Abstract: Novel cytosine-, thymine- and uracil-DNA glycosylases, subcellular localization peptides, nucleic acid molecules containing the same, methods of identifying such enzymes and their use in various methods including mutagenesis, cell killing and DNA sequencing and modification, are described.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: March 30, 2004
    Inventors: Hans E. Krokan, Geir Slupphaug, Bodil Kavli, John A. Tainer, Clifford D. Mol
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Patent number: 6689598
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: February 10, 2004
    Assignee: Applera Corporation
    Inventors: Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Nucleotide sequences which encode plsC gene
    Patent number: 6680186
    Abstract: The present invention relates to polynucleotides corresponding to the plsC gene and which encode 1-acyl-SN-glycerol-3-phosphate acyltransferase, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having 1-acyl-SN-glycerol-3-phosphate acyltransferase activity.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: January 20, 2004
    Assignees: Degussa AG, Forschungszentrum Juelich GmbH
    Inventors: Madhavan Nampoothiri, Brigitte Bathe, Lothar Eggeling, Hermann Sahm
  • Plant polyphenol oxidase homologs
    Patent number: 6680185
    Abstract: This invention relates to an isolated nucleic acid fragment encoding a polyphenol oxidase enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the polyphenol oxidase enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the polyphenol oxidase enzyme in a transformed host cell.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: January 20, 2004
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rebecca E. Cahoon, Saverio Carl Falco, Anthony J. Kinney, Guo-Hua Miao
  • 38692 and 21117, novel dual specificity phosphatase molecules and uses therefor
    Patent number: 6664089
    Abstract: The invention provides isolated nucleic acids molecules, designated 38692 or 21117 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38692 or 21117 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 38692 or 21117 gene has been introduced or disrupted. The invention still further provides isolated 38692 or 21117 proteins, fusion proteins, antigenic peptides and anti-38692 or 21117 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: December 16, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Rachel A. Meyers
  • Canine cox-2 nucleic acid molecules and uses thereof
    Patent number: 6638744
    Abstract: The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit COX-2 activity, as well as the use of such therapeutic compositions to treat animals.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: October 28, 2003
    Assignee: Heska Corporation
    Inventors: Nancy Wisnewski, Kevin S. Brandt
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Patent number: 6638747
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: October 28, 2003
    Assignee: Applera Corporation
    Inventors: Ellen M Beasley, Chunhua Yan, Valentina Di Francesco
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6630336
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: October 7, 2003
    Assignee: Applera Corporation
    Inventors: Jane Ye, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Human glucose-6-phosphatase molecules and uses thereof
    Patent number: 6627425
    Abstract: The invention provides isolated nucleic acids encoding human pancreatic islet-specific glucose-6-phosphatase proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides, and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: September 30, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Hong Chen
  • 21481, a novel dehydrogenase molecule and uses therefor
    Patent number: 6627423
    Abstract: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: September 30, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Rachel Meyers, William James Cook, Mark Williamson, Laura A. Rudolph-Owen, Ruth Gimeno
  • Isolated human enzyme, nucleic acid molecules encoding human enzyme, and uses thereof
    Patent number: 6613554
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: September 2, 2003
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Chunhua Yan, Valentina DiFrancesco, Ellen M. Beasley
  • 32142, 21481, 25964, 21686, novel human dehydrogenase molecules and uses therefor
    Patent number: 6613555
    Abstract: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: September 2, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Rachel Meyers, William James Cook, Mark Williamson, Laura A. Rudolph-Owen
  • Nucleic acids encoding IKR-2, a protein kinase related to the I kappa B kinases
    Patent number: 6605456
    Abstract: The invention is directed to purified and isolated kappa B kinase-related kinases 1 and 2 (IKR-1 and IKR-2) polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: August 12, 2003
    Assignee: Immunex Corporation
    Inventors: Timothy A. Bird, G. Duke Virca