Patents Examined by Younus Meah
  • Method for producing hydroxylated adaivjantane using cytochrome P450
    Patent number: 8383381
    Abstract: Disclosed is a method for producing a hydroxylated form of a compound having an adamantane skeleton, which is useful as an intermediate for functional resins and pharmaceutical products, with high yield and at low cost. Specifically, a hydroxylated form of a compound having an adamantane skeleton can be obtained by using cytochrome P450. More specifically, an N-(5-hydroxy-2-adamantyl)-benzamide derivative can be produced by hydroxylating an N-(2-adamantyl)-benzamide derivative.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: February 26, 2013
    Assignee: Shjonogi & Co., Ltd.
    Inventors: Taijiro Tomikawa, Yuuichi Mitsuda
  • Method for producing serine derivative and protein used for the same
    Patent number: 8372607
    Abstract: The present invention describes a method for generating a serine derivative and an optically active isomer thereof by a convenient technique, and an enzyme and the like useful in the method. In the presence of the following protein (A) and/or (B) having an enzymatic activity, an ?-amino acid is reacted with an aldehyde to form a serine derivative: (A) a protein comprising the amino acid sequence of SEQ ID NO:5, and (B) a protein comprising an amino acid sequence of SEQ ID NO: 5, but which includes substitution, deletion, insertion and addition of one or more amino acids and is able to catalyze the reaction to form the serine derivative.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: February 12, 2013
    Assignee: Ajinomoto Co., Inc.
    Inventors: Shinji Kuroda, Masakazu Sugiyama, Kunihiko Watanabe, Shunichi Suzuki, Kenzo Yokozeki, Tatsuki Kashiwagi
  • Production of peracids using an enzyme having perhydrolysis activity
    Patent number: 8367728
    Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: February 5, 2013
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Robert DiCosimo, John E. Gavagan, Mark Payne, Frederick B. Cooling, III
  • Process for producing sugars and ethanol using corn stillage
    Patent number: 8367378
    Abstract: A process for producing sugars from lignocellulosic materials such as corn stover by the addition of corn stillage as a carbon source is disclosed. The sugars are formed by treating the combination of the corn stillage and the lignocellulosic materials with hydrolytic enzymes. The sugars can be fermented to ethanol, and the process improves ethanol production economies with an increased sugar yield from the lignocellulosic materials.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: February 5, 2013
    Assignee: Board of Trustees of Michigan State University
    Inventors: Venkatesh Balan, Shishir Chundawat, Leonardo Sousa, Bruce Dale
  • Glucose dehydrogenase and method for producing the dehydrogenase
    Patent number: 8367385
    Abstract: A DNA encoding a glucose dehydrogenase enzyme having high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is described. Cells transformed with the DNA encoding the glucose dehydrogenase enzyme may be used to produce the glucose dehydrogenase by culturing the transformants to produce glucose dehydrogenase as an expression product of the DNA, and collecting the product.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: February 5, 2013
    Inventor: Koji Sode
  • Bifidobacterial gene sequences and their use
    Patent number: 8361756
    Abstract: This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria. The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: January 29, 2013
    Assignee: The Regents of the University of California
    Inventors: David A. Mills, Carlito B. Lebrilla, J. Bruce German, David Sela
  • Method of preparing a dough-based product
    Patent number: 8361526
    Abstract: Dough with a high sucrose content (such as cake dough) tends to inhibit the activity of an anti-staling amylase such as Novamyl®, making it less effective to prevent the staling of dough-based products with high sucrose content such as cakes. A good anti-staling effect in cakes can be achieved by using a carefully selected anti-staling amylase with certain properties. Analysis of a 3D structure of Novamyl® shows that sucrose may inhibit by binding in the active site. Sucrose docks into the active site of Novamyl® differently from the substrate or inhibitor in published models 1QHO and 1QHP. This finding is used to design sucrose-tolerant variants.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: January 29, 2013
    Assignee: Novozymes A/S
    Inventors: Lars Beier, Esben Peter Friis, Henrik Lundqvist, Peter Kamp Hansen, Tina Spendler
  • L-amino acid-producing bacterium and a method for producing L-amino acids
    Patent number: 8354255
    Abstract: A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the ?-glucoside PTS activity, and collecting the L-amino acid from the medium or cells.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: January 15, 2013
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takuji Ueda, Yuji Joe
  • Methods and compositions for identifying a cell phenotype
    Patent number: 8343733
    Abstract: A method of staining or pre-staining at least one cell is provided. The method comprising contacting the at least one cell with a staining agent selected from the group consisting of an extract of a Ficus elastica plant, a C23H44O4 and a proanthocyanidin, thereby staining or pre-staining the at least one cell. Also provided are methods of detecting cells of different differentiation stages and methods of diagnosing cancer and metabolic diseases.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: January 1, 2013
    Assignee: Zetiq Technologies Ltd.
    Inventors: Dan Jacob Gelvan, Lev Goltsman, Alexander Chausovsky
  • Production of peracids using an enzyme having perhydrolysis activity
    Patent number: 8329441
    Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: December 11, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert Dicosimo, John Edward Gavagan, Mark Scott Payne, Frederick B. Cooling, III
  • Enone reductases
    Patent number: 8329438
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: December 11, 2012
    Assignee: Codexis, Inc.
    Inventors: Christopher Savile, Vesna Mitchell, Xiyun Zhang, Gjalt Huisman
  • Enhanced promoter and method for producing L-lysine using the same
    Patent number: 8329434
    Abstract: The present invention provides a nucleic acid molecule having enhanced promoter activity, which is operably linked to a gene encoding aspartate aminotransferase and derived from Corynebacterium glutamicum, a vector comprising the nucleic acid molecule, a transformant transformed with the vector, and a method for producing L-lysine using the transformant.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: December 11, 2012
    Assignee: CJ Cheiljedang Corporation
    Inventors: Do Hyun Kwon, Hyung Joon Kim, Jae Woo Jang, Jun Ok Moon, Sang Jo Lim
  • Process for the enantioselective enzymatic reduction of secodione derivatives
    Patent number: 8323936
    Abstract: The invention relates to a process for the enantioselective enzymatic reduction of secodione derivatives. The secodione derivative is reduced with an oxidoreductase/dehydrogenase in the presence of NADH or NADPH as a cofactor. The secodione derivative is used in the reaction batch at a concentration of ?10 g/l and the oxidized cofactor NAD or NADP formed by the oxidoreductase/dehydrogenase is regenerated continuously.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: December 4, 2012
    Assignee: IEP GmbH
    Inventors: Antje Gupta, Anke Tschentscher, Maria Bobkova
  • Use of fructanases in feed of hoofed animals, preferably to prevent diseases
    Patent number: 8309079
    Abstract: Laminitis is defined as an inflammation of the sensitive laminae of the hoof, especially in horses. It has been surprisingly found that fructanases such as 2,1-?-D-fructan hydrolase are highly effective as therapeutic and prophylactic agents against laminitis in horses. The fructanases may be used as enzyme compositions in horse feed, as additives for horse feed or as oral preparations for the therapy and prophylaxis of laminitis. Because of its effectiveness in hydrolyzing fructans, which seem to play an important role in the aetiology of laminitis, the administration of fructanases in combination with an increased intake of fructans or with an increased availability of fructans is particularly advantageous.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: November 13, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Jeppe Wegener Tams, Petra Philipps
  • Polypeptides having endoglucanase activity and polynucleotides encoding same
    Patent number: 8309338
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: November 13, 2012
    Assignee: Novozymes A/S
    Inventors: Katja Salomon Johansen, Keith Gibson, Preben Nielsen, Helle Outtrup
  • Method for production of erythro-or threo-2-amino-3-hydroxypropionic acid ester, novel carbonyl reductase, gene for the reductase, vector, transformant, and method for production of optically active alcohol using those
    Patent number: 8304216
    Abstract: The present invention has its object to provide a method of producing an erythro- or threo-2-amino-3-hydroxypropionic acid ester, and so forth. The present invention relates to: a method of asymmetrically reducing an N-2-amino-3-oxopropionic acid ester by allowing cells of a microorganism to act thereon; a polypeptide having an activity of asymmetrically reducing a carbonyl compound to give an optically active alcohol, which is isolated from a microorganism belonging to genus Brevundimonas; a DNA coding for the polypeptide; and a transformant producing the polypeptide. The invention also relates to a method of producing an optically active alcohol by reducing a carbonyl compound with the help of the polypeptide or the transformant.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: November 6, 2012
    Assignee: Kaneka Corporation
    Inventors: Tozo Nishiyama, Yoshihiko Yasohara
  • Gluconacetobacter strain having cellulose producing activity
    Patent number: 8304215
    Abstract: Disclosed herein is a novel gluconacetobacter strain having cellulose producing activity. Specifically, the present invention relates to a novel gluconacetobacter strain producing nano-structured cellulose in a highly efficient manner. The cellulose produced by the strain, due to its superb thermodynamic properties, can be characterized as nano-structured bacterial cellulose and therefore utilized as a bio-nano-fiber. Particularly, the cellulose can be impregnated with a resin to form a cellulose-based resin which can be effectively adapted for a substrate for a liquid crystal display (LCD).
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: November 6, 2012
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jong-Seong Kim, Woo-jae Lee, Nam-Seok Roh, Sang-IL Kim, Min-Ho Yoon, Young Tak Song, Tae Jin Kang, Suk Heung Oh, Seung-Jae Lee, Hye Jin Kim, Jin Ju Yu, Dong Hyun Yu, Young Sik Yoon, Jong Hwan Lee
  • Production of peracids using an enzyme having perhydrolysis activity
    Patent number: 8298808
    Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: October 30, 2012
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Robert DiCosimo, John Edward Gavagan, Mark Scott Payne, Frederick B. Cooling
  • Purine-derived substance-producing bacterium and a method for producing purine-derived substance
    Patent number: 8298791
    Abstract: A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in the medium or the bacterial cells, and can be collected from the medium or the bacterial cells.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: October 30, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kiyoshi Matsuno, Yukiko Mori, Takayuki Asahara
  • Microorganism and method for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using the novel microorganism
    Patent number: 8293518
    Abstract: This invention relates to a novel microorganism that efficiently produces a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. As a result of concentrated studies, a plurality of novel microorganisms having properties of interest that are not classified as conventional microorganisms were isolated and identified. The novel microorganism of the present invention belongs to Ascomycetes and has the ability of producing a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. Such microorganism of Ascomycetes represents a new finding and it can be effective for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan and an intermediate thereof.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: October 23, 2012
    Assignee: Kao Corporation
    Inventors: Kazuaki Igarashi, Shuichi Takizawa, Norihiko Higaki, Hiroshi Hagihara