Patents Examined by Younus Meah
  • Enzymic production of neoagarobiose
    Patent number: 8795989
    Abstract: The present invention is directed to methods and systems of producing neoagarobiose, useful in whitening melanoma cells and in cosmetics, using polypeptides having neoagarobiosebiohydralase activity, including Aga86E from Saccharophagus degradans. The reaction can be enhanced by including other agarases, including Aga16B, also from S. degradans.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: August 5, 2014
    Assignee: University of Maryland
    Inventors: Steven W. Hutcheson, Ronald M. Weiner, Nathan A. Ekborg
  • L-amino acid oxidase with cytotoxic activity from
    Patent number: 8784813
    Abstract: The present invention relates to a cytotoxic polypeptide which is an L-amino acid oxidase isolated from the ink of the sea hare Aplysia punctata.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: July 22, 2014
    Inventors: Daniel Butzke, Sigrid Goedert, Michael Dittrich, Thomas Rudel, Thomas Meyer
  • Process for producing prenyl alcohols
    Patent number: 8759046
    Abstract: A method of producing a prenyl alcohol(s) by culturing a mutant cell into which a fusion gene of farnesyl diphosphate synthase gene and geranylgeranyl diphosphate synthase gene has been introduced and recovering the prenyl alcohol(s) from the resultant culture.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: June 24, 2014
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Chikara Ohto, Shusei Obata
  • Biocatalytic production of ambroxan
    Patent number: 8759043
    Abstract: The invention relates to a process for the biocatalytic production of ambroxan by means of a polypeptide with the activity of a homofarnesol-ambroxan cyclase, which are a novel class of enzymes.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: June 24, 2014
    Assignee: BASF SE
    Inventors: Michael Breuer, Andrea Hörster, Bernhard Hauer
  • CDK9 as modifier of the IGF pathway and methods of use
    Patent number: 8758994
    Abstract: Human CDK9 genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF, comprising screening for agents that modulate the activity of CDK9 are provided.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: June 24, 2014
    Assignee: Exelixis, Inc.
    Inventors: Mark E. Maxwell, Michael Martin Ollmann, Timothy S. Heuer, Lynn Margaret Bjerke
  • Protease comprising one or more combinable mutations
    Patent number: 8753861
    Abstract: The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and methods for using the same are also provided.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: June 17, 2014
    Assignee: Danisco US Inc.
    Inventors: Luis G. Cascao-Pereira, David A. Estell, James T. Kellis, Jr.
  • Lyase enzymes, nucleic acids encoding them and methods for making and using them
    Patent number: 8735107
    Abstract: This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. X?NO2, Cl, Br, NH2, OH, H, alkyl at one or several o, m, and p positions R?H or alkyl.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: May 27, 2014
    Assignee: Verenium Corporation
    Inventors: David P. Weiner, Alexander Varvak, Toby Richardson, Mircea Podar, Ellen Burke, Shaun Healey
  • CAB molecules
    Patent number: 8728470
    Abstract: The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: May 20, 2014
    Assignee: Danisco US Inc.
    Inventors: Judith A. Fox, Fiona A. Harding, Rashid M. Harunur, Volker Schellenberger
  • Process for producing hydroxycarboxylic acid
    Patent number: 8728780
    Abstract: An object of the invention is to produce a microorganism which yields high amounts in a short time of a hydroxycarboxylic acid reduced in impurity content. This invention further provides a process for producing a hydroxycarboxylic acid, including glycolic acid, using the microorganism. This process enables a hydroxycarboxylic acid having high purity to be supplied at low cost.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: May 20, 2014
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Mitsufumi Wada, Daisuke Mochizuki, Hitoshi Takahashi, Takashi Morishige, Katsuyuki Takahashi
  • Glycosyltransferase, novel glycosyltransferase gene, and novel sugar donor compound
    Patent number: 8722868
    Abstract: An object of the present invention is to provide a sugar donating reagent comprising a sugar donor compound other than a sugar nucleotide and an enzyme capable of catalyzing a glycosyl transfer reaction using a sugar donor compound other than a sugar nucleotide. The present invention provides the following: a sugar donating reagent containing a compound of formula (A): wherein R1 is independently selected from hydrogen, or C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO2, and SO2, n is 0, 1, 2, 3, 4 or 5, m is 0 or 1, and X represents a monosaccharide bound via a ? bond on its anomeric carbon; a glycosyltransferase capable of catalyzing a glycosyl transfer reaction using the sugar donor; and a glycosyltransferase gene comprising DNA encoding the glycosyltransferase.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: May 13, 2014
    Assignee: National University Corporation Tokyo University of Agriculture and Technology
    Inventors: Yoshihiro Ozeki, Nobuhiro Sasaki, Kazuo Nagasawa, Masayuki Tera, Yuki Matsuba, Haruka Nakamura, Yutaka Abe
  • Glucose dehydrogenase and method for producing the dehydrogenase
    Patent number: 8715990
    Abstract: A glucose dehydrogenase, having high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is obtained by culturing a microorganism belonging to the genus Burkholderia, particularly Burkholderia cepacia. The glucose dehydrogenase produced by the microorganism is collected from the medium and/or from the cells of the microorganism.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: May 6, 2014
    Inventor: Koji Sode
  • Enzymatically catalyzed method of preparing mono-acylated polyols
    Patent number: 8715970
    Abstract: The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacylglycerol lipase mutants, as for example derived from Candida antarctica lipase B (CALB); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of a mutated triacylglycerol lipase in a method of preparing mono-acylated polyols. The invention also provides novel mutants, coding sequences thereof, and recombinant microorganisms carrying said coding sequences.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: May 6, 2014
    Assignee: BASF SE
    Inventors: Bernhard Hauer, Cecilia Kvarnström Branneby, Karl Hult, Anders Magnusson, Anders Hamberg
  • Alkane oxidation by modified hydroxylases
    Patent number: 8715988
    Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: May 6, 2014
    Assignee: California Institute of Technology
    Inventors: Frances Arnold, Peter Meinhold, Matthew W. Peters, Rudi Fasan, Mike M. Y. Chen
  • Glucose dehydrogenase and method for producing the dehydrogenase
    Patent number: 8715989
    Abstract: A glucose dehydrogenase, having high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is obtained by culturing a microorganism belonging to the genus Burkholderia, particularly Burkholderia cepacia. The glucose dehydrogenase produced by the microorganism is collected from the medium and/or from the cells of the microorganism.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: May 6, 2014
    Inventor: Koji Sode
  • Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
    Patent number: 8669080
    Abstract: A D-aminotransferase can be modified so as to efficiently produce (2R,4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by mutating the amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:4.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: March 11, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Masakazu Sugiyama, Kunihiko Watanabe, Tatsuki Kashiwagi, Ei-ichiro Suzuki
  • Enhanced pyruvate to acetolactate conversion in yeast
    Patent number: 8669094
    Abstract: A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having acetolactate as an upstream intermediate benefit from the increased conversion of pruvate to acetolactate in the described strains.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: March 11, 2014
    Assignee: Butamax™ Advanced Biofuels LLC
    Inventors: Larry Cameron Anthony, Lori Ann Maggio-Hall
  • Polypeptide
    Patent number: 8663966
    Abstract: We disclose a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises substitutions at the following positions: G121D, 134, 141, 157, 223, 307 and 334 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: March 4, 2014
    Assignee: Dupont Nutrition Biosciences APS
    Inventors: Karsten Matthias Kragh, Bo Spange Sørensen
  • Enzymatic peracid generation for use in oral care products
    Patent number: 8663616
    Abstract: Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening, disinfecting, destaining, deodorizing, decreasing or removing biofilm, and combinations thereof. The peracid is enzymatically generated from a carboxylic acid ester substrate using a CE-7 carbohydrate esterase having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a peptidic component having affinity for an oral cavity surface, either directly or through an optional linker, may be used to target the perhydrolytic activity to the oral cavity surface.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: March 4, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Lisa A. Butterick, Scott D. Cunningham, Robert DiCosimo, Kari A. Fosser, Tanja Maria Gruber, Sharon L. Haynie, Mark S. Payne, Pierre E. Rouviere, Hong Wang
  • Gluconacetobacter strain having cellulose producing activity
    Patent number: 8658399
    Abstract: Disclosed herein is a novel gluconacetobacter strain having cellulose producing activity. Specifically, the present invention relates to a novel gluconacetobacter strain producing nano-structured cellulose in a highly efficient manner. The cellulose produced by the strain, due to its superb thermodynamic properties, can be characterized as nano-structured bacterial cellulose and therefore utilized as a bio-nano-fiber. Particularly, the cellulose can be impregnated with a resin to form a cellulose-based resin which can be effectively adapted for a substrate for a liquid crystal display (LCD).
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: February 25, 2014
    Assignee: Samsung Display Co., Ltd.
    Inventors: Jong-Seong Kim, Woo-jae Lee, Nam-Seok Roh, Sang-Il Kim, Min-Ho Yoon, Young Tak Song, Tae Jin Kang, Suk Heung Oh, Seung-Jae Lee, Hye Jin Kim, Jin Ju Yu, Dong Hyun Yu, Young Sik Yoon, Jong Hwan Lee
  • Targeted perhydrolases
    Patent number: 8652455
    Abstract: Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: February 18, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Robert DiCosimo, Scott D. Cunningham, Stephen R. Fahnestock, Tanja Maria Gruber, Mark S. Payne, Pierre E. Rouviere, Linda Jane Solomon, Hong Wang