Patents Examined by Yvonne Eyler
  • Formation of self-assembled monolayers of redox SAMs on silicon for molecular memory applications
    Patent number: 7348206
    Abstract: This invention provides a new method of forming a self-assembling monolayer (SAM) of alcohol-terminated or thiol-terminated organic molecules (e.g. ferrocenes, porphyrins, etc.) on a silicon or other group IV element surface. The assembly is based on the formation of an E-O— or an E-S— bond where E is the group IV element (e.g. Si, Ge, etc.). The procedure has been successfully used on both P- and n-type group IV element surfaces. The assemblies are stable under ambient conditions and can be exposed to repeated electrochemical cycling.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: March 25, 2008
    Assignees: The Regents of the University of California, The North Carolina State University
    Inventors: David F. Bocian, Werner G. Kuhr, Jonathan S. Lindsey, Rajeeve Balkrishna Dabke, Zhiming Liu
  • Cost effective method for synthesis of triarylamine compounds from an aniline and an arylchloride
    Patent number: 7345203
    Abstract: A process for forming a triarylamine compound, including reacting an aniline and an arylchloride in the presence of a ligated palladium catalyst and a base.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: March 18, 2008
    Assignee: Xerox Corporation
    Inventors: Timothy P. Bender, Jennifer A. Coggan
  • Method for making an energetic material
    Patent number: 7345208
    Abstract: A method for making trinitrotoluene is described, and which includes the steps of providing a source of aqueous nitric acid having a concentration of less than about 95% by weight; mixing a surfactant with the source of aqueous nitric acid so as to dehydrate the aqueous nitric acid to produce a source of nitronium ions; providing a supercritical carbon dioxide environment; providing a source of an organic material to be nitrated to the supercritical carbon dioxide environment; and controllably mixing the source or nitronium ions with the supercritical carbon dioxide environment to nitrate the organic material and produce trinitrotoluene.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: March 18, 2008
    Assignee: Battelle Energy Alliance, LLC
    Inventor: Robert V. Fox
  • Cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
    Patent number: 7345174
    Abstract: The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, —O—, —S—, —NH—, or —CH2—; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
    Type: Grant
    Filed: June 22, 2006
    Date of Patent: March 18, 2008
    Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New York
    Inventors: Ronald Breslow, Sandro Belvedere, Leland Gershell, Thomas A. Miller, Paul A. Marks, Victoria M. Richon, Richard A. Rifkind
  • Process for the preparation of adapalene
    Patent number: 7345189
    Abstract: A process for the preparation of a compound of formula (I), or a salt thereof wherein R is H, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; comprising the reaction between a compound of formula (II) wherein R1 and R2 are independently hydrogen, C1-C8 alkyl, aryl, aryl-C1-C8 alkyl, or R1 and R2, taken together, form a —(CH2)m—V—(CH2)n— group, in which V is NR3 or C(R3)2 wherein R3 is hydrogen, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; and m and n, which can be the same or different, are 1 or 2; with a compound of formula (III) in which R4 and R5 are independently C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; in the presence of a Ni (II) salt, an organic ligand and a basic agent, to obtain a compound of formula (I) wherein R is C1-C8 alkyl, aryl or aryl-C1-C8 alkyl and, if desired, its conversion to a compound of formula (I) wherein R is hydrogen or to a salt thereof.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: March 18, 2008
    Assignees: Dipharma S.p.A., Lundbeck Pharmaceuticals, Italy
    Inventors: Graziano Castaldi, Pietro Allegrini, Gabriele Razzetti, Mauro Ercoli
  • Process for the synthesis of 2,5-dihydroxyterephthalic acid
    Patent number: 7345194
    Abstract: 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: March 18, 2008
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Joachim C. Ritter
  • Process for the synthesis of 2,5-dihydroxyterephthalic acid
    Patent number: 7345195
    Abstract: 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: March 18, 2008
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Joachim C. Ritter
  • Multistage continuous preparation of cycloaliphatic diisocyanates
    Patent number: 7339074
    Abstract: The invention relates to a multistage process for continuous and phosgene-free preparation of cycloaliphatic diisocyanates.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: March 4, 2008
    Assignee: Degussa AG
    Inventors: Stephan Kohlstruk, Manfred Kreczinski, Rainer Elm, Hans-Werner Michalczak
  • Catalytic method of producing alkyl mercaptans by adding hydrogen sulphide to an olefin
    Patent number: 7339083
    Abstract: The process for preparing a mercaptan from an olefin and hydrogen sulphide is carried out in the presence of hydrogen and a catalyst composition comprising a strong acid, such as a heteropolyacid, and at least one metal belonging to group VIII of the Periodic Table.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: March 4, 2008
    Assignee: Arkema France
    Inventors: Georges Fremy, Nadine Essayem, Michel Lacroix, Elodie Zausa
  • Ligand synthesis
    Patent number: 7339075
    Abstract: Ligand synthesis methods for the preparation of ligands having the formula wherein Q is selected from phosphorus, arsenic and antimony; wherein X1, X2 and X3 are carbon anions; and, wherein R15 is selected from —SO3, —SO2N(R18), —CO2, —PO3, —AsO3, —SiO2, —C(CF3)2O; where R18 is selected from a hydrogen, a halogen, a hydrocarbyl group and a substituted hydrocarbyl group, are disclosed. Also disclosed are methods of complexing the ligands with late transition metals to form catalyst complexes that catalyze polymerization reactions and/or Heck coupling reactions.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: March 4, 2008
    Assignee: Rohm and Haas Company
    Inventors: Nathan Tait Allen, Brian Leslie Goodall, Thomas Cleveland Kirk, Lester Howard McIntosh, III
  • Process for the synthesis of 2,5-dihydroxyterephthalic acid
    Patent number: 7339076
    Abstract: 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: March 4, 2008
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Joachim C. Ritter
  • Process for producing mercaptoorganyl (alkoxysilane)
    Patent number: 7339067
    Abstract: The invention concerns a process for producing mercaptoorganyl(alkoxysilanes), wherein bis(alkoxysilylorganyl)polysulfides are hydrogenated at temperatures of <190° C. and pressures of <100 bar with hydrogen and a transition metal catalyst without the addition of water, alcohol or H2S.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: March 4, 2008
    Assignee: Evonik Degussa GmbH
    Inventors: Karsten Korth, Philipp Albert, Dorit Wolf, Steffen Seebald, Reimund Pieter, Alfreg Alig
  • Process for the synthesis of hydroxy aromatic acids
    Patent number: 7335791
    Abstract: Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: February 26, 2008
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Joachim C. Ritter
  • Method for producing onium salt derivatives, and novel onium salt derivatives
    Patent number: 7335787
    Abstract: The invention provides a high-yield method for producing onium salt derivatives useful as agents, such as acid-generators, employed in chemically amplified resists; and to provide novel onium salt derivatives. Reaction of an onium salt derivative containing a halide anion or a carboxylate anion with a sulfonic acid ester derivative or a phosphoric acid derivative provides an onium sulfate derivative or an onium phosphate derivative at high yield.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: February 26, 2008
    Assignee: Toyo Gosei Kogyo Co., Ltd.
    Inventors: Kyoichi Tomita, Shinji Ishii
  • Polycyclic aromatic carbon based solid strong acid
    Patent number: 7335790
    Abstract: A composite solid strong acid comprising, a solid acid and a carbon material, wherein said solid acid is obtained by heat treating of polycyclic aromatic hydrocarbons or polycyclic aromatic hydrocarbons to which the carbon material is blended in concentrated sulfuric acid or fuming sulfuric acid, transforming said polycyclic aromatic hydrocarbons to a solid acid which is insoluble in a polar solvent by condensation and sulfonation further compositing with said carbon material.
    Type: Grant
    Filed: September 8, 2003
    Date of Patent: February 26, 2008
    Assignee: Japan Science and Technology Agency
    Inventors: Kazunari Domen, Michikazu Hara
  • Polyesters based upon dimer acid in personal care
    Patent number: 7335720
    Abstract: The present invention is related to the cosmetic utilization of a series of polyesters based upon the reaction of dimer acid, dimer alcohol and Guerbet alcohol. The resulting polyester is a high molecular weight product that is well tolerated by the skin and has outstanding emolliency. The Guerbet alcohol, being mono hydroxyl is a capper portion of the polymer, the dimer alcohol is a chain extender having two hydroxyl groups and the dimer acid is a diacid that reacts with the hydroxyl groups on the Guerbet and dimer alcohol to make the polyester.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: February 26, 2008
    Assignee: ZeniTech Corporation
    Inventor: Anthony J. O'Lenick, Jr.
  • Michael-adduct fluorochemical silanes
    Patent number: 7335786
    Abstract: Fluorochemical silane compounds and coating compositions derived therefrom are described. The compounds and compositions may be used in treating substrates, in particular substrates having a hard surface such as ceramics or glass, to render them water, oil, stain, and soil repellent.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: February 26, 2008
    Assignee: 3M Innovative Properties Company
    Inventors: Suresh Iyer, Oscar S. Benz, Thomas P. Klun, Wayne W. Fan
  • Process for the preparation of tolterodine
    Patent number: 7335793
    Abstract: A novel process prepares tolterodine, i.e. (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation. Tolterodine free base may be prepared by reacting diisopropyl-(3-phenyl-3-p-tolyloxy-propyl)-amine and 60% aqueous sulfuric acid for three hours under stirring at room temperature. The reaction mixture is then poured over ice/water and then alkalized with 50% NaOH.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: February 26, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Gabriele Razzetti, Simone Mantegazza, Roberto Rossi, Pietro Allegrini
  • Process for the preparation of mercaptoorganyl (alkoxysilanes)
    Patent number: 7332619
    Abstract: The invention relates to a process for the preparation of mercaptoorganyl(alkoxysilanes), wherein bis(alkoxysilylorganyl)polysulfides are hydrogenated with hydrogen and a transition metal catalyst in a solvent without the addition of alcohols, H2S or water.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: February 19, 2008
    Assignee: Degussa AG
    Inventors: Karsten Korth, Philipp Albert, Dorit Wolf, Steffen Seebald, Reimund Pieter, Alfreg Alig
  • Multistage continuous preparation of cycloaliphatic diisocyanates
    Patent number: 7329776
    Abstract: A multistage process for continuous and phosgene-free preparation of cycloaliphatic diisocyanates.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: February 12, 2008
    Assignee: Degussa AG
    Inventors: Stephan Kohlstruk, Manfred Kreczinski, Rainer Elm, Hans-Werner Michalczak