Patent number: 7202238
Abstract: The present invention relates to a group of unique diazabicyclo alkane derivatives having interesting neurokinin-NK1 receptor antagonistic activity represented by the general formula (1) wherein: R1 represents phenyl, 2-indolyl, 3-indolyl, 3-indazolyl or benzo[b]thiophen-3-yl, which groups may be substituted with halogen or alkyl (1–3C), R2 and R3 independently represent halogen, H, OCH3, CH3 and CF3, R4, R5 and R6 independently represent H, OH, O-alkyl(1–4C), CH2OH, NH2, dialkyl(1–3C)N, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or morpholin-4-yl substituted with one or two methyl or methoxymethyl groups, morpholin-4-ylamino, morpholin-4-ylmethyl, imidazol-1-yl, thiomorpholin-4-yl, 1,1-dioxothiomorpholin-4-yl or 3-oxa-8-azabicyclo[3.2.
Type:
Grant
Filed:
April 2, 2003
Date of Patent:
April 10, 2007
Assignee:
Solvay Pharmaceuticals B.V.
Inventors:
Dirk de Boer, Hein K. A. C. Coolen, Mayke B. Hesselink, Wouter I. Iwema Bakker, Gijsbert D. Kuil, Jan H. van Maarseveen, Andrew C. McCreary, Gustaaf J. M. van Scharrenburg