Patents Examined by Zohreh Fay
  • Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use
    Patent number: 10493006
    Abstract: The object of the present invention is an injectable sterile aqueous formulation, ready-to-use, resorbable, used for aesthetic purposes as a particulate, cohesive, viscoelastic gel comprising i) crosslinked hyaluronic acid, or one of its salts, at a concentration of between 1% and 4% (mass/volume); the crosslinking carried out providing the possibility of obtaining a gel based on crosslinked hyaluronic acid with a so-called cohesive structure, and ii) hydroxyapatite, at a concentration of between 5% and 60% (mass/volume), said hydroxyapatite being in the form of particles with an average size of less than or equal to 200 ?m; said injectable sterile aqueous formulation having viscoelastic properties such that tan ? at the frequency of 1 Hz is less than or equal to 0.60.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: December 3, 2019
    Assignee: ANTEIS S.A.
    Inventor: Samuel Gavard Molliard
  • Two-component anti-cancer composition
    Patent number: 10494391
    Abstract: Gold(I) complexes and gold(I) dithiocarbamate polymers as anticancer therapeutics. The Au(I) ion within the gold(I) complexes is coordinated to two phosphine ligands. The repeating unit formed by Au(I) ion coordinating to dithiocarbamte ligands are connected by Au(I)-Au(I) interactions within the gold(I) dithiocarbamate polymers. Also disclosed are methods of synthesis, pharmaceutical compositions incorporating the gold(I) complexes, pharmaceutical compositions incorporating the gold(I) dithiocarbamate polymers, and methods of treating cancer.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: December 3, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Anvarhusein A. Isab, Muhammad Altaf, Adam Ahmed Abdallah Seliman
  • Xanthophyll composition containing macular pigments and a process for its preparation
    Patent number: 10485833
    Abstract: A xanthophyll composition that contains macular pigments including trans-lutein and zeaxanthin isomers, namely, (R,R)-zeaxanthin and (R,S)-zeaxanthin, derived from the plant extract/oleoresin containing xanthophylls/xanthophylls esters which is safe for human consumption and useful for nutrition and health care. The composition has at least 80% by weight that is total xanthophylls, of which the ratio of trans-lutein and zeaxanthin isomers being in the range of about 4:1 to about 6:1 and the ratio of the isomers of zeaxanthin being in the range of about 80 to 20:20 to 80.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: November 26, 2019
    Assignee: OmniActive Health Technologies Limited
    Inventors: Sunil Kumar T. K., Sherena P. Abdulkadir
  • Use of geninstein
    Patent number: 10471041
    Abstract: Use of genistein for the treatment and prevention of dry eye syndrome or LKC and corresponding compositions containing it.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: November 12, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Kevin Prudence, Christoph Riegger, Wolfgang Schalch
  • Compositions and methods to treat vision disorders
    Patent number: 10471076
    Abstract: The present invention provides sterols and uses thereof to treat vision disorders. In one embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat and/or prevent vision disorders in a subject. In another embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat cataract or blindness/impaired vision in a subject. In yet another embodiment, composition comprising lanosterol is used to dissolve amyloid-like fibrils of crystallin proteins.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: November 12, 2019
    Assignees: YOUHEALTH BIOTECH, LIMITED, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kang Zhang, Rui Hou, Huimin Cai
  • Mascara compositions comprising a bimodal acrylic polymer and anionic, water-dispersible polyester and an aliphatic tackifier
    Patent number: 10470995
    Abstract: A mascara composition includes a vehicle comprising water; a bimodal acrylic polymer including cationic functionality and anionic functionality; an anionic, water-dispersible polyester; and an aliphatic tackifier having a weight average molecular weight less than about 10,000 daltons. Methods of making up the eyelashes are also provided.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: November 12, 2019
    Assignee: L'OREAL
    Inventors: Christine Marie Crane, Angeles Clara Fonolla-Moreno
  • Tissue fusion agent
    Patent number: 10463761
    Abstract: A tissue fusion agent includes a particulate and/or fibrous flock material, wherein the fibrous flock material includes monofilament flock fibers and has a fiber length of 100 ?m to 3 mm. A discharge device can contain the tissue fusion agent and a surgical system can includes the tissue fusion agent or the discharge device and a tissue fusion instrument.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: November 5, 2019
    Assignee: Aesculap AG
    Inventors: Christof Merckle, Erich Odermatt
  • Hair composition
    Patent number: 10456344
    Abstract: Disclosed is an oral or topical composition comprising a nuclear factor erythroid-2 related factor 2 agonist and a liver X receptor agonist, wherein the amounts of each of the nuclear factor erythroid-2 related factor 2 agonist and the liver X receptor agonist produce a synergistic benefit of hair fiber growth, wherein the oral or topical composition comprises ?9, preferably ?8% w/w ?-sitosterol, wherein when the oral or topical composition comprises a catechin, the oral or topical composition comprises 0.001 to 90, preferably 0.005 to 70, most preferably 0.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: October 29, 2019
    Assignee: CONOPCO, INC.
    Inventors: Ranjit Kaur Bhogal, Gail Jenkins, Magdalena Sawicka, Linda Jane Wainwright
  • Tissue fusion agent
    Patent number: 10456507
    Abstract: A tissue fusion agent includes a supporting element and a flock material. A surgical system includes the tissue fusion agent and a tissue fusion instrument. A method of producing the tissue fusion agent includes a) coating a supporting element with an adhesive, and b) flocking the adhesive-coated supporting element with a flock material while the adhesive is moist, adhesive or tacky, or after activation of the adhesive.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: October 29, 2019
    Assignee: Aesculap AG
    Inventors: Christof Merckle, Erich Odermatt
  • Methods for treating HCV
    Patent number: 10456414
    Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: October 29, 2019
    Assignee: Gilead Pharmasset LLC
    Inventors: William E. Delaney, IV, John O. Link, Hongmei Mo, David W. Oldach, Adrian S. Ray, William J. Watkins, Cheng Yong Yang
  • Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use
    Patent number: 10434040
    Abstract: The object of the present invention is an injectable sterile aqueous formulation, ready-to-use, resorbable, used for aesthetic purposes as a particulate, cohesive, viscoelastic gel comprising i) crosslinked hyaluronic acid, or one of its salts, at a concentration of between 0.1% and 4% (mass/volume); the crosslinking carried out providing the possibility of obtaining a gel based on crosslinked hyaluronic acid with a so-called cohesive structure, and ii) hydroxyapatite, at a concentration of between more than 70% and 140% (mass/volume), said hydroxyapatite being in the form of particles with an average size of less than or equal to 200 ?m; said injectable sterile aqueous formulation having viscoelastic properties such that tan ? at the frequency of 1 Hz is less than or equal to 0.60.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: October 8, 2019
    Assignee: ANTEIS S.A.
    Inventor: Samuel Gavard Molliard
  • Use of ergot alkaloids as an anthelmintic agent
    Patent number: 10426772
    Abstract: Methods for preventing, inhibiting or treating parasitic flatworm infection in a vertebrate are provided that include administering an effective amount of a composition comprising one or more ergot alkaloids, one or more lysergic acid amides, or one or more dimethoxyisoquinoline derivatives.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: October 1, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Jonathan Stephen Marchant, John David Chan
  • Oral formulation and suspension of an oncology drug
    Patent number: 10426781
    Abstract: Dry powder formulations for inhalation and their use in the treatment diseases and conditions. The formulation contains a uniform blend of a first spray-dried powder and a second spray-dried powder. The first spray-dried powder contains spray-dried particles of a therapeutically active ingredient dispersed in a pharmaceutically acceptably hydrophobic excipient. The second spray-dried powder contains spray-dried particles formed from a pharmaceutically acceptable hydrophobic excipient but are substantially free of any therapeutically active ingredient. The active ingredient in the first spray-dried powder is loaded sufficiently high to compensate for the second spray-dried powder being substantially free of any active ingredient. A process for preparing such formulations is also described.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: October 1, 2019
    Assignee: Sun Pharma Global FZE
    Inventors: Celine Decaudin, Vincent Rogue
  • Methods and compositions for the treatment of acne
    Patent number: 10420743
    Abstract: The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: September 24, 2019
    Assignee: SOL-GEL TECHNOLOGIES LTD
    Inventors: Ofer Toledano, Ori Nov
  • Oral delivery compositions for treating dermatitis disorders in mammals
    Patent number: 10406232
    Abstract: A composition for treating atopic dermatitis in animals containing active compositions of ceramides for skin barrier protection, omega 3 and omega 6 fatty acids for reducing pruritus and botanical extracts for inhibiting 5-lipoxygenase activity, histamine release while modulating the immune system. The active compositions are placed in a soft dough oral delivery system.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: September 10, 2019
    Assignee: VETS PLUS, INC.
    Inventors: Daniel J. DuBourdieu, Rajiv Lall, Ajay Srivastava
  • Solid oral formulation of fenretinide
    Patent number: 10406127
    Abstract: Amorphous solid dispersions suitable for oral delivery comprising fenretinide or an analog thereof and at least one matrix polymer, and processes for making the dispersions, are disclosed. Also disclosed are solid oral formulations comprising the amorphous solid dispersions, as well as uses thereof for the prevention and/or treatment of diseases or conditions treatable by fenretinide, including but not limited to cancers, conditions associated with a lipid imbalance, cystic fibrosis, osteoporosis, conditions associated with inflammation or opportunistic infections, and other diseases such as diabetes, obesity, dry-form age-related macular degeneration.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: September 10, 2019
    Assignee: LAURENT PHARMACEUTICALS
    Inventors: Aimesther Betancourt, Marc Lemieux, Roch Thibert
  • Hydrogel compositions and drug delivery systems comprising the same
    Patent number: 10398647
    Abstract: A hydrogel composition is provided. The hydrogel composition includes polyglutamic acid (PGA) containing maleimide groups, and polyethylene glycol (PEG) containing terminal thiol groups, wherein the hydrogel composition has a pH value ranging from 4.0 to 6.5. A drug delivery system is also provided. The drug delivery system includes the above-mentioned hydrogel composition, and a pharmaceutically active ingredient encapsulated in the hydrogel composition.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: September 3, 2019
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Wen-Hsuan Chiang, Yu-Wen Lo, Felice Cheng, Maggie Lu, Ya-Ling Chiu
  • Multimodal ultrasound and photoacoustic contrast agent based on polymeric microparticles
    Patent number: 10391185
    Abstract: The invention provides a multimodal ultrasound and photoacoustic contrast agent based on polymeric microparticles having a gas core and carrying at least one photoacoustic agent in its shell that stabilizes the gas core, for use in ultrasound and photoacoustic imaging. Such multimodal ultrasound and photoacoustic contrast agent is also suitable as a carrier of drugs and for use in photodynamic therapy, and for tissue imaging ex vivo.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: August 27, 2019
    Assignees: Fujifilm VisualSonics, Inc., RWTH Aachen
    Inventors: Fabian Kiessling, Twan Lammers, Stanley Fokong Nyongamsen, Katrin Suppelt
  • Oral rapamycin nanoparticle preparations and use
    Patent number: 10391059
    Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer, neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: August 27, 2019
    Assignee: Rapamycin Holdings, Inc.
    Inventors: Neal K Vail, Dana M Vaughn
  • Skin lightening cosmetic composition and preparation method thereof
    Patent number: 10383813
    Abstract: A cosmetic composition for whitening skin and a preparation method thereof. The composition comprises the following components: pearl powder, pearl extract, glycyrrhiza glabra aqueous solution, hydrolyzed conchiolin protein and pea extract. The contents of the pearl powder and the pearl extract are not both zero, and the glycyrrhiza glabra aqueous solution contains 0.5 to 5.0% of the glycyrrhiza glabra extract.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: August 20, 2019
    Assignee: OSM Biology Co., Ltd.
    Inventors: Gang Huo, Xueyang Deng, Ping Ma