Abstract: Methods of operating a surgical instrument are disclosed herein.

Abstract: The disclosure provides antibodies that bind human ITGAv/B1 and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an anti-ITGAv/B1 antibody.

Abstract: Provided herein are compounds, compositions, and methods for treating disorders (e.g., opioid addiction) using compounds disclosed herein, which are selective agonists of the cannabinoid 2 receptor (CB2R).

Abstract: A method and apparatus for a horticultural light fixture that utilizes a metallic extrusion with multiple heat pipes to distribute heat to multiple heat sink fins. The heat sink fins utilize a geometrical shape that facilitates increased air flow into an interior of the horticultural light without the use of forced air.

Abstract: Provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Still further provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol.

Abstract: Described herein is a multilayer microporous film or membrane that may exhibit improved properties, including improved dielectric break down and strength, compared to prior monolayer or tri-layer microporous membranes of the same thickness. The preferred multilayer microporous membrane comprises microlayers and one or more lamination interfaces or barriers. Also disclosed is a battery separator or battery comprising one or more of the multilayer microporous films or membranes. The inventive battery and battery separator is preferably safer and more robust than batteries and battery separators using prior monolayer and tri-layer microporous membranes. Also, described herein is a method for making the multilayer microporous separators, membranes or films described herein.

Abstract: A system determines a baseline cyberthreat-risk score for a user, and displays the baseline cyberthreat-risk score via a user interface. The system presents at least one cyberthreat-education activity via the user interface, and receives, via the user interface, at least one user input associated with the presented at least one cyberthreat-education activity. The system generates an updated cyberthreat-risk score at least in part by updating the baseline cyberthreat-risk score based at least in part on the user input, and displays the updated cyberthreat-risk score via the user interface.

Abstract: A system and method for removing a backing from a ply of composite material is disclosed. The system includes a roller having a roller axis and a roller surface that circumscribes the roller axis. The system also includes an adhesion feature disposed on the roller surface. The system further includes a roller drive to move the roller along a travel path that is perpendicular to the roller axis and to rotate the roller about the roller axis.

Abstract: Various cannulated bone implants and methods of using the cannulated bone implant are disclosed. The cannulated bone implant can include a proximal portion, a proximal end, a distal portion, a distal end, a transition portion, a threaded portion, a finned portion and a central passage. The transition portion can comprise a bend positioned between the proximal portion and the distal portion. The threaded portion can be positioned along the proximal portion between the proximal end and the transition portion. The threaded portion can be configured to secure the implant into a bone of a patient. The finned portion can be positioned along the distal portion between the transition portion and the distal end. The finned portion can be configured to prevent migration and/or rotation of the implant in use. The central passage can extend linearly from the proximal end of the implant to the distal end of the implant.

Abstract: A surgical system may include tiered-access features. The surgical system may be used to analyze at least a portion of a surgical field. Based on a control parameter, the system may scale up or down various capabilities, such as visualization processing, endocutter communication, endocutter algorithm updates, smart cartridge connectivity, smart motor control for circular stapler, smart energy control, cloud analytics, hub connectivity control, and/or hub visualization and control interactions. The control parameter may include system aspects such as processing capability or bandwidth for example and/or the identification of an appropriate service tier.

Abstract: A system and method for removing a backing from a ply of composite material is disclosed. The system includes a roller having a roller axis and a roller surface that circumscribes the roller axis. The system also includes an adhesion feature disposed on the roller surface. The system further includes a roller drive to move the roller along a travel path that is perpendicular to the roller axis and to rotate the roller about the roller axis.

Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: A pressure bleed-off system. The system includes a fluid bypass line having an inlet and an opposing outlet, wherein the inlet is in fluid communication with a high pressure frac line for a hydraulic fracturing operation. The system also includes a high-pressure transducer located proximate the fluid inlet, a first plug valve residing along the fluid bypass line, and a first electric actuator residing on the first plug valve. The actuator is configured to rotate the first plug valve between close and open positions in response to command signals from a controller. The controller, in turn, sends the command signals in response to control signals delivered by an operator, remotely. Preferably, the command signals are wireless signals sent from outside of the red zone. The system may also include a second plug valve along the bypass line.

Abstract: Techniques and apparatuses directed to improved pawl-latching devices are described in this document. The disclosed techniques and apparatuses provide pawl-latching devices with pawls structured to avoid the sinking and warping problems present in some conventional injection molding processes. In aspects, the pawl-latching devices include a pawl having at least one of a pivot member including a notch, a release feature on the pawl spaced apart from the front and sides of the pawl, a recess defined in the top of the pawl, and/or a recess defined in the bottom of the pawl.

Abstract: Disclosed is a surgical instrument for treating tissue in a surgical procedure. The surgical instrument comprises an end effector, comprising an anvil, and a staple cartridge. The surgical instrument further comprises a drive train operably coupled to the end effector, a motor configured to motivate the drive train based on a default control algorithm to affect a tissue treatment motion of the end effector, and a sensor configured to monitor an independent parameter of the surgical procedure. The independent parameter is independent of the motion of the end effector. The surgical instrument further comprises a control circuit coupled to the motor and the sensor. The control circuit is configured to receive an input from the sensor indicative of the independent parameter, and adjust the default control algorithm based on the independent parameter.

Abstract: A surgical instrument system comprising a motor system and a control circuit is disclosed. The motor system comprises a motor and a drive train coupleable to the motor and configured to actuate a firing member through a staple firing stroke. The control circuit is coupled to the motor, wherein the control circuit comprises a motor controller configured to control the motor, and wherein, during the staple firing stroke, the control circuit is configured to actuate the firing member through the staple firing stroke, monitor a parameter of the motor system during the staple firing stroke, identify when the firing member is within an active adjustment portion of the staple firing stroke; and automatically adjust, at a frequency, tuning parameters of the motor controller with based on the monitored parameter of the motor system during the active adjustment portion of the staple firing stroke.

Abstract: A surgical instrument is disclosed including an end effector configurable between an open state and a clamped state, a firing member movable from an unfired position toward a fired position during a firing stroke, a manually-driveable closure system, a motor-powered firing system, and a control system. The motor-powered firing system is configured to drive the firing member through the firing stroke. The control system is configured to detect, at a first time point, the end effector reaching the clamped state with the manually-driveable closure system, detect, at a second time point, the actuation of the motor-powered firing system, set a firing motion parameter of the motor-powered firing system based on an elapsed time from the first time point to the second time point, and drive the firing member through the firing stroke with the motor-powered firing system using the firing motion parameter.

Abstract: A surgical instrument system comprising a drive train and a control circuit is disclosed. The drive train comprises a motor and a shaft actuatable by the motor to actuate a function of an end effector. The control circuit is coupled to the motor, wherein the control circuit is configured to determine a relative excess capacity of the drive train, compare the relative excess capacity to a predetermined shifting threshold, and increase the speed of the motor based on the relative excess capacity exceeding the predetermined shifting threshold.

Abstract: Disclosed is a surgical system for use with a surgical device. The surgical system comprises a remote processing device comprising a device control circuit and a surgical hub configured to communicably couple to the remote processing device and the surgical device. The surgical hub comprises a hub control circuit, wherein the hub control circuit and the device control circuit perform distributed processing. The surgical hub control circuit is configured to transmit a synchronization feature to the remote processing device, transmit a first subset of data associated with the surgical device to the remote processing device, perform a second analysis on a second subset of the data, determine a second result based on the second analysis, receive a first result from the remote processing device and synchronization data of the first result, assess a synchronicity of the first result and the second result based on the synchronization data.

Abstract: A surgical stapling system includes an anvil, a blade, a motor and gear assembly, a motor power supply, and a motor controller. A method of controlling the motor includes receiving first and second data indicative of operations of the motor under first and second conditions, respectively, and adjusting a motor control signal based on a difference between the first and second data. Another method includes receiving initial manufacture motor and gear assembly data from a manufacture and operational data during an initial use of the system, and adjusting parameters of the control signal based on a difference between the manufacture data and the operational data. Another method includes controlling a pulse-width modulated (PWM) motor control signal, receiving data regarding an interaction between the blade and a tissue clamped by the anvil, and adjusting a frequency of the PWM signal based on the data related to the interaction.