Abstract: An electro-optically controlled active-matrix system comprises a system substrate, row wires extending in a row direction disposed on the system substrate, a row controller providing a row electrical signal to each row wire, column light-pipes extending in a column direction disposed on the system substrate, a column controller providing a column optical signal to each column light-pipe, and pixels disposed over the system substrate. Each pixel can comprise a pixel circuit that is uniquely responsive to a row wire and to a column light-pipe, the pixel circuit receiving the row electrical signal from the row wire and receiving the column optical signal from the column light-pipe. In some embodiments, column wires carrying column electrical signals extend in a column direction over the system substrate and the pixel circuit is capacitively coupled to the row wire, the column wire, or both.

Abstract: A package substrate is disclosed. The package substrate includes a die package in the package substrate located at least partially underneath a location of a power delivery interface in a die that is coupled to the surface of the package substrate. Connection terminals are accessible on a surface of the die package to provide connection to the die that is coupled to the surface of the package substrate. Metal-insulator-metal layers inside the die package are coupled to the connection terminals.

Abstract: Systems, devices, and methods are disclosed herein for ultraviolet saunas. Systems include a plurality of walls of an enclosure, the enclosure being a sauna enclosure configured to accommodate a user. The systems further include a plurality of heating elements coupled to the plurality of walls, a plurality of emissive elements configured to generate ultraviolet (UV) light, and a controller coupled to the plurality of heating elements and the plurality of emissive elements. The controller includes one or more processors configured to generate activation properties for each of the plurality of heating elements and the plurality of emissive elements, activate at least one of the plurality of heating elements based on the plurality of activation properties, and activate the at least one emissive element based on the plurality of activation properties.

Abstract: The present invention provides antibodies that bind to the T-cell co-inhibitor programmed death-1 (PD-1) protein, and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that bind to PD-1. In certain embodiments, the present invention provides multi-specific antigen-binding molecules comprising a first binding specificity that binds to PD-1 and a second binding specificity that binds to an autoimmune tissue antigen, another T-cell co-inhibitor, an Fc receptor, or a T-cell receptor. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing PD-1 activity, thus providing a means of treating a disease or disorder such as cancer or a chronic viral infection. In other embodiments, the antibodies are useful for enhancing or stimulating PD-1 activity, thus providing a means of treating, for example, an autoimmune disease or disorder.

Abstract: Provided are compounds of the Formula (IVB): or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.

Abstract: The present disclosure is directed to network traffic management and load balancing at a cloud-based secure access service accessible to remotely connected user devices. In one example, a cloud-based secure service system includes a network controller configured to receive network traffic from one or more user devices remotely connected to the controller; parse the network traffic into flow data and contextual information associated with the network traffic; determine that the network traffic is to be serviced by a target firewall service at the cloud-based secure service system based on the flow data and the contextual information; and direct the network traffic to the target firewall service to be serviced.

Abstract: Devices and techniques related to landfill gas extraction are disclosed. A technique for controlling extraction of landfill gas from a landfill through a gas extraction system is described. The method may include measuring a plurality of values indicating conditions associated with the landfill; computing, based at least in part on the plurality of values and on a model of the landfill, a predicted future state of the landfill; determining, based at least in part on the predicted future state of the landfill, one or more control parameters for one or more respective control devices configured to control operation of the gas extraction system; applying the one or more control parameters to the one or more respective control, and with 10 the one or more control devices, controlling extraction of the landfill gas from the landfill based, at least in part, on the one or more respective control parameters.

Abstract: The embodiments of the present disclosure provide an aircraft assembly. The aircraft assembly includes an aircraft structure comprising a component with a plurality of wire openings. A plurality of high voltage wires are disposed in the wire openings in the component such that each wire opening receives one high voltage wire, and the each wire opening has an opening size larger than a size of the one high voltage wire, the opening size being smaller than a size of a connector attached to an end of the one high voltage wire. The high voltage wires are installed in the wire openings before curing the aircraft structure.

Abstract: Described herein are systems, devices, methods, and media providing emergency data to public safety answering points (PSAPs). Also provided are systems, methods, and media for utilizing location data and geofences to provide emergency data to PSAPs and interactive graphical displays to efficiently display relevant emergency data.

Abstract: In a shaving instrument having one or more blades, each with a single exposed cutting, each blade is clamped between clamping parts hinged to one another in a unitary molded blade clamp. Following insertion of the blade or blades, the blade clamp is inserted into an end of an elongated slot in a head attached to a handle. The slot is shaped to allow movement of the blade clamp only along the direction of its insertion. The blades are secured against sliding in the blade clamp by engagement with protrusions formed on interior surfaces of clamping parts. The blades can be replaced when worn, but the clamping elements can be reused.

Abstract: Gas dispensing control systems that use a gas expansion chamber with a plunger in fluid communication with both a vacuum pump and a nitrogen supply with a controller that calculates and dispenses standard volumes of gas based, at least in part, on local environmental conditions. The dispensed gas can be hyperpolarized 129Xe for MRI imaging.

Abstract: Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9.

Abstract: A connector assembly includes housing for storing components of the connector assembly. The connector assembly further includes a cable including a cable center conductor, wherein the cable center conductor is configured as a signal conductor. The connector assembly also includes a first dielectric and an alignment dielectric. Each of the first dielectric and the alignment dielectric includes a path to guide the cable center conductor through an angle to a printed circuit board as the cable is axially inserted into the housing.

Abstract: A determination is made whether a requested transaction of a certain type or class is available (i.e., suitable for execution or queueing) within a processing environment. In the case that a transaction of the certain type or class is not available, the request to be rejected is enabled, thus avoiding queuing of the requested transaction. Embodiments may thus provide a mechanism to protect a processing environment by avoiding the overhead of creating and removing specific transactions of the certain type or class.

Abstract: A system having components coupled to an aircraft in operation processes sensor-derived data, performs a localization cross-checking procedure, and dynamically generates updated analyses of the position and orientation of the aircraft. Based on the updated analyses, the system can generate instructions for flight control of the aircraft and can update flight control instructions as new data is received and processed. The system functions to reduce the “worst-case” bounds on a localization estimate for the aircraft to a low enough level that is appropriate for completing a flight operation.

Abstract: A device that includes a microphone may be worn in or on an ear of a user. A microphone signal generated by the microphone may be processed to determine a heart activity of a user. An indication of a heart pathology may be detected by applying a predictive algorithm to at least the heart activity. Other aspects are described.

Abstract: Combined solar power generation and agricultural material dispersion system having a system module comprising a solar power generation panel having a solar energy collection surface opposite a base surface; a barrier panel; at least two coupling elements extending between and coupled to the power generation panel base surface and a first surface of the barrier panel for forming a cavity there between to enable an electrical cable to be disposed therein; and at least one liquid conduit coupled to the barrier panel. The liquid conduit for conveying agricultural dispersion material or fire-retardant chemicals. The system module attached to a tiltable mount that, in turn is attached to at least one post having an end specifically adapted for securing to at least one footing, wherein the electronically-controllable tiltable mount is specifically adapted to enable system module tilting to at least one of a substantially vertical position or horizontal position.

Abstract: A mesh to flexible screen frame laminator includes a first table with a horizontal surface and an alignment fence, a second table that is lower than the first table and a first pair of selectively driven heater rollers which are shiftable between a raised position and a lowered position relative to the first table. A cradle is located adjacent the first table and above the second table and at least a portion of the cradle is shiftable between a raised position and a lowered position, the raised position being substantially coplanar with the first table. A second pair of selectively driven heater rollers is shiftable between a raised position and a lowered position relative to the second table and is oriented transversely to the first pair of heater rollers. A third table is located adjacent the second table and at a height substantially coplanar with the second table.

Abstract: A ring for facilitated aspiration of a syringe is provided. The ring is preferably worn on the thumb of a user, but may be used on other fingers. An opening slot is located along the perimeter of the ring. The opening slot has a curved passageway, formed by the first end and the second end of the ring being curved. The opening slot secures a portion of a syringe. A v-shaped slit on the second end of the ring receives and secures various sized syringes.

Abstract: A rolled material dispenser; including a roll supporting structure that supports a plurality of rolls of material, each roll of material having a width and a long axis, the roll supporting structure supporting the rolls of material with the long axes parallel and with a free end of the rolled material extending downwardly from each of the of rolls. The dispenser includes a pinch roller assembly located beneath the roll supporting structure. The pinch roller assembly is movable in a direction perpendicular to the long axes of the rolls of material and the pinch rollers have a second long axis oriented parallel to the first long axis. A conveyor is positioned below the pinch roller assembly and a material cutter assembly facilitates cutting the rolled material.