Abstract: A method of aligning a wire with a pathway inlet includes directing a feeding end of a wire toward a pathway inlet of a feed pathway, creating a pressure differential between the pathway inlet and a pathway outlet of the feed pathway thus creating a pressure-driven gas flow around the wire and into the pathway inlet. The wire is urged along the feed pathway toward the pathway outlet via the shear force of the gas flow created by the pressure differential. A method of preventing stiction of a wire with an inner wall of a thin pathway includes creating a pressure differential between a pathway inlet and a pathway outlet thus creating a pressure-driven gas flow around a feeding end of the wire and into the pathway inlet of the pathway, and inducing one of a flutter or vibration in the wire at the feeding end of the wire.

Abstract: Systems and methods are directed to a pull-through winding method, and a manufacturing fixture, or mandrel, that guides the layup of material in the pull-through winding method, for fabrication of a three-dimensional load bearing structure. These systems and methods allow fibers of material of the 3D load bearing structure to be pulled as straight as possible during winding, and maintained as straight as possible during curing, to take full advantage of properties associated with the fiber or filament-based materials used in these structures, including, for example, carbon fiber material. The manufacturing fixture includes a plurality of pull-through slots at end portions thereof, that provide for the pulling of the fiber-based material, and the application and maintenance of tension in the material that maintains the alignment of the fibers as the material is wound, cured and hardened.

Abstract: Disclosed herein are methods for detecting and producing PoMV. Further, disclosed herein are immunogenic and/or vaccine compositions and methods for treating or preventing PoMV. The compositions and methods include immunogenic portions of PoMV including entry proteins. In at least particular cases, a mutated version of a portion of the PoMV is utilized, such as a deglycosylated, or amino acid substituted mutant of the spike protein.

Abstract: The present invention relates to the use of hypoxia-inducible factor (HIF) inhibitors in cancer immunotherapy. Specifically, the disclosure provides methods of treating a cancer in a subject in need of cancer immunotherapy, comprising administering a HIF-1a inhibitor to the subject and a second cancer immunotherapeutic agent to the subject, wherein the HIF-1a inhibitor comprising echinomycin, and wherein the second cancer immunotherapeutic agent comprising an anti-CTLA-4 antibody including Ipilimumab or Tremelimumab.

Abstract: Internally reheated sweep gas-aided membrane gas separation module in which the sweep gas is expanded retentate that is warmed through heat exchange with non-expanded retentate within the module.

Abstract: A medical instrument system comprises an instrument manipulator configured to control a position of a medical instrument with respect to a base. The instrument manipulator comprises an instrument carriage comprising a medical instrument connector configured to engage the medical instrument. The instrument carriage is configured to translate along a linear axis to advance or retract the medical instrument with respect to the base. The medical instrument system also comprises an insertion stage slideably engaged with the instrument carriage along the linear axis. The insertion stage has a drive assembly comprising a drive belt and a drive motor configured to drive the drive belt. The base is fixedly coupled to the drive belt. The medical instrument system also comprises a connecting element having a distal end fixedly coupled to the drive belt and a proximal end fixed to the instrument carriage.

Abstract: In one aspect, authentication information is received from a first processing device in a second processing device, and a digital signature is generated in the second processing device by signing data that incorporates at least a portion of the received authentication information. The received authentication information is generated at least in part from a secret seed stored in the first processing device. The received authentication information may be combined with the digital signature generated by the second processing device to form a joint signature that is transmitted to an authentication server. In an illustrative embodiment, the received authentication information comprises a tokencode and the digital signature is generated by signing data that incorporates the tokencode. The data that is signed to generate the digital signature may comprise an electronic document having the tokencode appended thereto.

Abstract: One or more implementations of a multi-film thermoplastic bag with a grab zone of contact areas positioned in a high-touch area of the bag. For example, the multi-film thermoplastic bag includes one or more regions of a first film in contact with a second film at one or more contact areas. The grab zone regions of one or more contact areas are located in visible and high-touch areas to provide visual and tactile cues of strength and durability. Moreover, the grab zone regions of one or more contact areas serve to distribute pull and lift forces across a wider area in order to avoid common failures in high-touch areas such as over stretching, punctures, tears, and rips.

Abstract: Disclosed herein are methods and apparatus for making a determination about an eye comprising detecting light reflected out of an eye of a subject from a retina of the eye of the subject and making a determination about the eye of the subject based upon the reflected light, wherein the light is adjusted for color temperature when making the determination about the eye.

Abstract: An oscillating roller system for a beverage can decorator is driven back and forth by a cam follower. A cam body having a cam is mounted to a frame of the inker system. Three oscillating cam roller assemblies are positioned about the cam body. Rotation of the cam oscillates the cam followers for each one of the oscillating rollers. Bearings of the oscillating roller assemblies includes an inlet gallery and outlet gallery for a closed loop lubrication system. The rollers are water cooled.

Abstract: Disclosed herein are methods and apparatus for making a determination about a cataract in an eye in ambient lighting conditions.

Abstract: A processor circuit receives a sports wager entry including a predetermined number of base wagers and a predetermined number of available points. Separately, for each base wager of the predetermined number of base wagers, the processor circuit receives a base wager selection, the base wager selection associated with a predetermined point value. The processor circuit receives a point value adjustment selection and adjusts the predetermined point value by the selected point value adjustment to generate an adjusted point value, wherein a sum of the selected point value adjustments for the predetermined number of base wagers does not exceed the predetermined number of available points. The processor circuit displays, at the display device, an indication of the adjusted point value. The processor circuit stores a sports wager entry record comprising the base wager selections and the adjusted point values for the sport wager entry.

Abstract: Illustrative embodiments disclose systems for sharing, among a group of consumers, data provided by a contributor. Some embodiments are well-suited for real-time distribution of data developing from ongoing incidents, and may be useful, for example, for emergency management. Illustrative embodiments provide a cloud-based system having tenants that are data contributors and data consumers. The system receives, from each contributor, both data and sharing rules that dictate whether and how that data may be shared, and with whom (which consumer or consumers), and then provide data to such consumer or consumers according to the sharing rules.

Abstract: Exemplary embodiments are disclosed of systems and methods for remotely controlling locomotives with gestures. In an exemplary embodiment, a system is configured for allowing an operator(s) to remotely control operation of a locomotive with gesture(s) made by an operator(s). The system includes at least one processor configured to be operable for visually recognizing gesture(s) made by an operator(s) in one or more images captured by at least one camera. A locomotive control unit is configured to be operable for controlling the operation of the locomotive according to the visually recognized gesture(s) made by the operator(s).

Abstract: A method for creating or modifying a PDF file includes inserting or identifying a barcode in the PDF file and adding metadata to, or modifying metadata in, the PDF file for the barcode, wherein the metadata includes a position of the barcode on at least one page, a symbology of the barcode, and data represented by the barcode. A method for locating, modifying, or replacing a barcode of a PDF file includes identifying metadata in the PDF file corresponding to the barcode, wherein the metadata includes a position of the barcode on at least one page, a symbology of the barcode, and data represented by the barcode and locating, modifying, or replacing the barcode in the PDF file using the metadata.

Abstract: Enhancements to existing gaming controllers facilitating expedient response time and fine-tuned accuracy are described. The enhancements comprise the internal modification of the stock resistance force supplied by the analog stick centering spring mechanism. Through modification, the force of resistance supplied may be increased to over 200 grams of force, or down to 40 grams of force, while maintaining full function of the analog stick mechanism. A second primary enhancement replaces the stock triggers, conventionally equipped with progressive resistance sensors, to a momentary ‘snap-action’ two-way switch, minimizing trigger pull distance, and removing the analog nature of the trigger to achieve optimal performance.

Abstract: The present invention is directed to a gypsum panel and a method of making such gypsum panel. For instance, in one embodiment, the gypsum panel comprises a gypsum core and a first facing material and a second facing material sandwiching the gypsum core, wherein the gypsum core includes gypsum and one or more components of a reclaim gypsum panel, such as reclaimed gypsum and reclaimed facing material. The methods of the present invention are directed to making the aforementioned gypsum panels by providing the first facing material, providing a gypsum slurry comprising gypsum, water, and one or more components of a reclaim gypsum panel, such as reclaimed gypsum and reclaimed facing material, onto the first facing material, and providing a second facing material on the gypsum slurry.

Abstract: A trailer towable compact telehandler having an operator cab with an internal width greater than 700 mm and a curbside weight less than 2950 kg. Also included is a telehandler having a side-mounted engine which extends through a side wall of the chassis and under a lifting arm of the telehandler. Also included is a compact tool carrier having a reduced fore-aft dimension between an attachment plane and a principal pivot member.

Abstract: Provided herein are methods for the production of activated CD26high T cells by co-stimulation with inducible coactivator (ICOS). Further provided are methods for treatment of cancer by administration of the of activated CD26high T cells as an adoptive T cell therapy.