Abstract: Novel compositions and methods are provided for the treatment of cancer employing monoclonal antibodies (MoAbs) conjugated to a toxin. According to the present invention, MoAbs defining epitopes on either a tumor associated glycoprotein antigen of about 72 kD m.w. or on carcinoembryonic antigen conjugated to a ribosomal inhibiting protein, or the like, are employed either alone or in combination as cytotoxic agents in the treatment of various cancers including, but not limited to, colorectal carcinoma, ovarian carcinoma and osteogenic sarcoma. For some of these compositions, an enhanced or potentiated efficacy is observed when the conjugates are administered along with a related, unconjugated monoclonal antibody.Hybridomas XMMCO-791 and XMMCO-228 were deposited with the A.T.C.C. on Aug. 14, 1986 and given A.T.C.C. Accession Nos. HB 9173 and HB 9174, respectively. Hybridoma XMMBR-B14 was deposited with the A.T.C.C. on Jan. 14, 1987 and given A.T.C.C. Accession No. HB 9308.

Abstract: A system using appliances in the form of sectional mirrors allows drivers wide-angle viewing of approaching traffic to the rear and on both side of the system equipped vehicle. The system appliances include an in-vehicle mirror having as sections a convex upper mirror portion and a flat lower mirror portion. The in-vehicle mirror is used individually or in cooperation with one or more outside mirrors of similar structure. The flat lower mirror portions allow regular rear viewing and the convex upper mirror portions provides wide angle viewing to the rear and on both sides of the system equipped vehicle. A preset tilting of the convex mirror surfaces outwardly at the top and inwardly at the bottom in an adjusted relationship to the flat mirror surfaces allows the driver to see a reduced version in a wider plane in the convex mirror surfaces of the same image reflected in the flat mirror surface.

Abstract: Certain substituted hexahydroarylquinolizines and pharmaceutically acceptable salts thereof are peripherally selective .alpha..sub.2 -adrenoceptor antagonists. The compounds are adapted to be employed for the treatment of certain pathological disorders such as hypertension, diabetes, disorders involving platelet aggregation and the like without side effects attributable to effect on the central nervous system.

Abstract: Novel compositions and methods are provided for the treatment of cancer employing monoclonal antibodies (MoAbs) conjugated to a toxin. According to the present invention, MoAbs defining epitopes on either a tumor associated glycoprotein antigen of about 72 kD m.w. or on carcinoembryonic antigen conjugated to a ribosomal inhibiting protein, or the like, are employed either alone or in combination as cytotoxic agents in the treatment of various cancers including, but not limited to, colorectal carcinoma, ovarian carcinoma and osteogenic sarcoma.Hydridomas XMMCO-791 and XMMCO-228 were deposited with the A.T.C.C. on Aug. 14, 1986 and given A.T.C.C. Accession Nos. HB 9173 and HB 9174, respectively.

Abstract: A notebook with selectively changeable, removable and replaceable information carriers, comprising: (a) a plurality of notebook pages of glossy paper having alignment indicia printed thereon to divide said pages into multiple label-support zones; (b) a series of information carriers in the form of pressure-sensitive labels; (c) said labels including preprinted information, designations and space for inclusion by hand of further information; (d) whereby each of said labels may be selectively moved and replaced to and from any of said label-support zones; and, (e) book cover means binding said pages together.

Abstract: 7,8-Dihydro-4-(1-piperazinyl)-6H-thiopyranopyrimidines have .beta.-adrenergic blocking properties and are thus useful in the treatment of cardiovascular ailments known to be amenable to .beta.-blocker therapy. Certain of the compounds are useful in the treatment of elevated intraocular pressure by topical ocular administration.

Abstract: The present invention relates to an apparatus used by the handicapped, feeble or elderly sepecially in the process of dressing. An upright wheel support structure is provided and includes a handle about an upper portion thereof. A suction device is disposed about the lower part of the structure and acts to grip the floor so as to anchor the entire apparatus. While anchored an individual can grasp the handle and support him or herself while being dressed.

Abstract: A stylus contains a switch which makes contact in response to slight radial motion of the stylus tip relative to the stylus housing. Means for emitting radiation operates in response to switch closure, thereby emitting a beam of radiation out the tip. The stylus includes an internal power source, such as one or more batteries, for operation of the means for emitting radiation. When such internal power source is capable of being recharged, the stylus may include means for external connection to the recharging supply. In another embodiment, the stylus is capable of emitting more than one type of radiation which are distinguishable, such as by wavelength, modulation type, or other convenient means. In this manner, the stylus can be controlled by the user to emit different signals, which may be interpreted by a receiving device, for example, as different colors, or as a write signal versus an erase signal. In one embodiment, such an erase signal is emitted from the opposite end of the stylus as the write signal.

Abstract: 1-Aryloxy-3-(substituted alkylamino)-2-propanols having the general information: ##STR1## and their pharmaceutically acceptable salts exhibit cardioselective .beta.-adrenergic blocking activity, and are useful as antihypertensive, cardioprotective, antiarrhythmic and, antianginal agents.

Abstract: Novel immunoassay which utilizes an enzyme linked ligand or receptor wherein the enzyme is bacterial luciferase; mercantile kit useful in performing said immunoassay; and compounds utilized in performing said assay.

Abstract: A sailboard is disclosed of the type having a mast pivotally connected to a board, a boom connected at one end to the mast and a sail tensioned by out haul and down haul lines. A down haul tie down mechanism is provided for receiving and securing the down haul line at a location adjacent to the sailboard pivot. A cup with a special release mechanism is provided for releasably connecting the mast to the pivot. Release mechanisms for releasably interconnecting other sailboard components, such as boom sections and boom extensions, are also disclosed.

Abstract: A power supply for an arc lamp. It includes a DC converter which has an input, an output, and a circuit for increasing the voltage received at the input and for supplying the increased voltage to its output. A current sensing circuit is provided for controlling the amount of current delivered to the output. An output "H" bridge is coupled to the output of the DC converter for generating a squarewave in response thereto. The power supply is capable of quickly igniting and re-igniting arc lamps, is relatively inexpensive to manufacture and is relatively light in weight. The power supply can accept either an AC or DC source over a wide voltage range and increases or decreases the input voltage compared to the output voltage.

Abstract: A power supply for an arc lamp. It includes a DC to DC converter which has an input, an output, and a circuit for increasing the voltage received at the input and for supplying the increased voltage to its output. A current sensing circuit is provided for controlling the amount of current delivered to the output. The power supply is capable of quickly igniting and re-igniting arc lamps, is relatively inexpensive to manufacture and is relatively light in weight. The power supply can accept either an AC or DC source over a wide voltage range and increases or decreases the input voltage compared to the output voltage.

Abstract: There are disclosed certain 2-substituted-4-substituted 6H-7,8-dihydrothiapyrano[3,2-d]pyrimidines which have oral hypoglycemic activity and with such ability to lower blood sugar are useful in the treatment of type II diabetes and/or obesity with associated insulin resistance. Processes for the preparation of such compounds and compositions containing such compounds as the active ingredient thereof are also disclosed. The compounds are also .beta.-adrenergic blocking agonists or .alpha.-adrenergic blocking agents and act as ocular antihypertensives and are useful for the treatment of glaucoma and other eye disorders.

Abstract: A high energy density capacitor comprises a plurality of individual capacitor chips connected in parallel circuit to achieve a unit with improved series resistance and inductance and having the capability of delivering its stored energy in extremely short discharge times and providing high energy electrical pulses with extremely short rise times. The chips are fabricated of a ceramic material of the ABO.sub.3 perovskite type where A belongs to a divalent cationic species such as Mg, Ca, Ba, and Sr; B belongs to a quadrivalent species such as Ti, Sn, Pb, and Zr; and O represents oxygen. The perovskite material is preferably prepared from oxides, carbonates, oxalates and the like materials. A novel method of fabrication of the capacitive chips includes a first sintering step followed by hot isostatic pressing under predetermined times, temperatures, pressures and gaseous mixtures which are related to the particular material compositions being procesed.

Abstract: An identification system to identify objects from a remote interrogation station may be used with moving objects such as railroad cars. The system remotely programs and stores information on an object and remotely retrieves information from the object. An information and identity storage device is located on the object and at least one interrogation station is located remotely from the object.

Abstract: An invertable tray/vial package assembly is disclosed formed of separable interlockably connected top and bottom vial holding and locating tray sections which tray enables and effects holding and spatial positioning of a plurality of vials therein for selective external access to the vials at their respective opposite fluid content filling ends and fluid serving ends, for ease of vial filling, closing, handling, labeling and visual identification of vial contents, and for dispensing of the vials and serving the fill content of a vial to a patient. The tray has vial holding and spatially positioning pockets formed on one of its separable sections, with fluid-fill enabling openings formed in the bottom end of each of the pockets, and which are effectively registrable with closeable fill openings of vials disposed therein.

Abstract: A method is provided of determining saturation values corresponding to particular locations in a sample of a porous media, whereby such saturation values can be used in conjunction with corresponding capillary pressures to derive a capillary pressure curve. The method of the invention involves the use of nuclear magnetic resonance (NMR) imaging to obtain NMR intensity values corresponding to the locations of interest. Intensity is related to saturation by an appropriate function which is employed to determine the saturation values from the intensity values.

Abstract: A syringe infusion or other patient health care fluid delivery arrangement or system having a substantially constant force syringe holder/driver for a fluid-dispensing, preferably disposable, syringe to which an on-off valve and effectively bendably flexible tube connecting set are connected. The outside diameter of the tubing of an available flow-rate assortment of suitably identifiably marked tube connecting sets is formed of a desired single size by extrusion addition of a plastic outer overcoat layer over the inner fluid-carrying tubing, enabling interchangeable accommodation and securing thereon of standard single-size conventional or other desired connectors, whereby a single health care professional may fill a syringe with a prescribed dosage and concentration of health care fluid, and may also preselect and fix the delivery rate for the fluid, by selecting and assembling a given syringe holder/driver, fluid-filled syringe and tube connecting set.