Abstract: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.

Abstract: The present invention relates to the radioimmuno detection of cancers by detecting tumor associated antigens and comprising the following steps:(i) preparing samples of hybridoma XMMCO-791 as herein described,(ii) separating and purifying the associated antibody produced by XMMCO-791 hybridomas to obtain the IgG2b isotype,(iii) labelling the antibody thus obtained with a radio active label,(iv) preparing composition containing an effective concentration of said labelled antibody(v) administering said antibody composition to a patient and(vi) thereafter screening said patient to detect concentrations of radioactivity thereby indicating a concentration of antibody.Hybridoma cell line XMMCO-791 was deposited with the American Type Culture Collection (A.T.C.C.), Rockville, MD 20852-1776, on Aug. 14, 1986, and given A.T.C.C. Accession No. HB 9173.

Abstract: An elevator cab in which emergency lighting is concealed until it is required to be utilized. When the normal electrical power supply to the cab fails, the emergency lighting is automatically pivoted from a concealed position behind an inconspicuous wall plate to an exposed position which projects the lens of the emergency lighting fixture into the cab through the opening previously closed by the inconspicuous wall plate. In the exposed position, the emergency lighting is energized by an emergency power supply, with the emergency power supply also automatically becoming available when the normal power supply fails. In a preferred embodiment, the emergency lighting is located in the return, directly above the car station, and below the transom.

Abstract: An improved halogenated butyl rubber wherein the polymer has a conjugated diene content of less than 0.25 mole % and a halogen content of at least 0.6 wt. %; at least 20 mole % of the halogen being in a primary allylic configuration.

Abstract: A process for reducing the sulfur oxide content of flue gases produced by combustion of sulfur-containing coal containing cations of alkali metals, alkaline earth metals or both, in ion exchangeable form. Flue gases containing sulfur oxides are recycled to contact coal awaiting combustion. Sulfur oxides are absorbed on the coal during the contact step, which is conducted in the presence of water. Sulfur oxides react with alkali and alkaline earth metal cations, and are oxidized to form sulfate reaction products. When the treated coal is burned, these sulfate reaction products are retained in the coal ash.

Abstract: A washer for utensils, such as baking pans and trays, having a spray chamber containing a movably mounted utensil rack and spray nozzles arranged to impinge upon articles stacked in the rack; a source for supplying wash and rinse water under pressure to the spray nozzles, and a water motor for moving the rack relative to the spray nozzles, the water motor comprising a waterwheel rotatably journaled in a housing, the waterwheel having a plurality of radially extending blades driven by additional spray nozzles mounted on the housing and positioned to direct jets of water onto the blades adjacent their outer ends, the additional spray nozzles for driving the waterwheel being connected to the source supplying wash and rinse water to the spray nozzles utilized to spray the articles being cleaned, the waterwheel mounting drive mechanism for moving the rack relative to the spray chamber so as to obtain complete and efficient washing of all surface of the articles being cleaned.

Abstract: An athletic monitoring device for attachment to a portion of an athlete'body or to athletic equipment. The device measures a predetermined parameter of the motion of the device while in use and compares the measured parameter to a predetermined range. Intensity of acceleration is measured by taking the square root of the sum of the squares of acceleration data for each of the three axes of motion. This value is compared to a threshold value. If greater than the threshold value, the square root value is stored and added to a second measured intensity value. In this manner, a sum of intensity values throughout a stroke is calculated. If the sum of intensities is above or below a predetermined range, appropriate signalling will so indicate.

Abstract: An elevator cab, and method of assembling same, including upstanding wall members on a platform, with the upstanding wall members having upper edges which support a canopy. The canopy is constructed of at least two metallic panel members having adjacent edges which are bent into complementary bend configurations which form an interlocking joint when one bend configuration is pivoted about the other bend configuration.

Abstract: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.6 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, antidiabetics, antiobesity and platelet aggregation inhibitors.

Abstract: A tuned exhaust manifold is provided for attachment to an engine having a plurality of exhaust ports. The manifold includes an inner and outer shell joined together to form an exhaust chamber and an inwardly-opening flange-receiving space at a split line defined by the union of the inner and outer shells. Captive tuning baffles are dropped in place and positioned in the exhaust chamber to isolate individual engine exhaust ports for engine performance tuning. Each baffle includes a flange trapped in the space between the inner and outer shells to retain the baffle in a predetermined position within the exhaust chamber. The baffles are arranged in a predetermined pattern within the exhaust manifold to define separate passgeways extending from exhaust inlet openings formed in the inner shell toward one or more exhaust openings of the manifold. Tuning is accomplished by configuring and placing the baffles to control the flow of exhaust from each engine exhaust port through the exhaust manifold.

Abstract: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, antiobesity and platelet aggregation inhibitors and modifiers of gastrointestinal motility.

Abstract: Heterocyclic aminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.

Abstract: Improved halogenated butyl rubbers are prepared by isomerizing the polymers so that a significant mole fraction of the halogen is in the primary allylic position. The isomerization is carried out utilizing as a catalyst either a Friedel Crafts catalyst or HBr.

Abstract: Prodrugs of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formula (I): ##STR1## the amido ester moiety of which is in the L-configuration, and pharmaceutically acceptable salts thereof are disclosed.

Abstract: There are disclosed novel diazapines and derivatives thereof which are useful in the treatment of cardiovascular disorders.

Abstract: Aromatic sulfonamides with a saturated heterocycle fused thereto are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.

Abstract: Pharmaceutical compositions of specific substituted pyrimidines and methods of treatment of certain cardiovascular disorders are disclosed. Also disclosed are novel substituted acrylated pyrimidines which are useful as calcium channel blockers.

Abstract: 6.beta.-(L-.alpha.-Aminoadipoyl)-2.alpha.-vinyl-2.beta.-methylpenam-3-carbo xylic acid is provided in an enzymatic process converting .delta.-(L-.alpha.-aminoadipoyl)-L-cysteinyl-D-.gamma.,.delta.-didehydrois oleucine with isopenicillin N synthetase. The 2.alpha.-vinylpenam product is converted by known methods to the 6.beta.-amino-2.alpha.-vinyl-2.beta.-methylpenam-3-carboxylic acid nucleus and the latter is N-acylated to provide corresponding 6.beta.-acylaminopenams.

Abstract: Hydroxyalkyl-phenoxy-propan-2-olamines and novel esters thereof are oculoselective .beta.-blockers useful in the treatment of elevated intraocular pressure with little or no effect on the pulmonary or cardiovascular system.

Abstract: Novel metal-working process and aqueous metal-working fluids are provided. The aqueous metal-working fluids contain at least one N,N'-dilactam disulfide as an extreme pressure (EP) additive.