Abstract: Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: A popcorn funnel assembly for directing popcorn from a popcorn bag includes an inlet end having an inlet opening that is arranged to fit a popcorn bag and an outlet end having an outlet opening suitable for conveying popped popcorn into the mouth of a person who is eating popcorn. The funnel assembly includes a funnel portion and a sleeve portion. The funnel portion includes a transversely oriented inwardly curved lower wall that is adjacent to the outlet end of the funnel portion and that presents a transversely arranged pattern of holes that are pear shaped with wider lower portions and that are of a suitable size for rejecting popped popcorn and for receiving un-popped kernels and directing them out of the funnel portion and into a receiving space for retaining kernels, the receiving space being enclosed by the inwardly curved wall of the funnel portion and the sleeve portion.

Abstract: A cyberthreat detection system queries a content database for unstructured content that contains a set of keywords, clusters the unstructured content into clusters based on topics, and determines a cybersecurity cluster utilizing a list of vetted cybersecurity phrases. The set of keywords represents a target of interest such as a newly discovered cyberthreat, an entity, a brand, or a combination thereof. The cybersecurity cluster thus determined is composed of unstructured content that has the set of keywords as well as some percentage of the vetted cybersecurity phrases. If the size of the cybersecurity cluster, as compared to the amount of unstructured content queried from the content database, meets or exceeds a predetermined threshold, the query is saved as a new classifier rule that can then be used by a cybersecurity classifier to automatically, dynamically and timely identify the target of interest in unclassified unstructured content.

Abstract: In various embodiments, portable bathroom facilities disclosed herein can employ various features that can use data from one or more sensors, devices, etc. to provide enhanced bathroom management and user experience.

Abstract: Methods and systems are provided for managing, tracking, and storing vehicle ownership data in a decentralized, distributed vehicle management system. In an embodiment, a decentralized, distributed vehicle management system comprises a blockchain; a streaming service configured to provide event data in real time to a contract executing virtual machine (VM) embedded in the blockchain; and a non-transitory memory storing instructions that when executed by a processor of the vehicle management system, cause the vehicle management system to manage ownership data of a vehicle of the vehicle management system, including changes in ownership of the vehicle, via smart contracts that execute automatically in response to real-time event data streamed by the streaming service, wherein the smart contracts are created by various users of the vehicle management system linked to or associated with the vehicle.

Abstract: Consumer needs for life insurance benefits change over time, yet traditional individual insurance policies have a fixed death benefit. Embodiments disclosed herein are directed to a user interface that facilitates forecasting future benefits and premiums under user-defined assumptions to optimize the policy application process and coverage, and to system and method for administering life insurance policies with death benefits that are automatically, periodically adjusted, without requiring new underwriting, based on third-party data linked to the insured's specific life insurance need. Embodiments disclosed herein facilitate the alignment of life insurance benefits with an individual's need as those needs change over time regardless of their changing health status, ensuring coverage when the need increases while saving money on unnecessary premiums when the need is declining.

Abstract: Disclosed are compositions, devices, kits, and methods for treatment of Enterobacteriaceae infection. Aspects of the present disclosure are directed to bacteriophage compositions comprising one or more of ES17, ES19, HP3, HP3.1, and HP3.2. Certain aspects of the disclosure are directed to compositions comprising (a) bacteriophage ES17 or bacteriophage ES19, (b) bacteriophage HP3, and (c) bacteriophage HP3.1. Also disclosed are compositions comprising bacteriophage HP 3.2. Further disclosed are devices and kits comprising such compositions and methods for use of such compositions in treatment and prevention of pathogenic E. coli infection.

Abstract: The disclosure relates to systems, methods, and devices for managing traffic through a road segment and/or intersection. The traffic management system may place traffic objects in a collaboration group for coordinating movements in the road segment and/or intersection in response to a received indication that an emergency vehicle has a planned route that includes the road segment and/or intersection. The traffic management system may determine a movement plan for each traffic object in the collaboration group based on received measurements about the road segment and the planned route of the emergency vehicle. The traffic management system may control a transmitter to send the movement plan to each traffic object in the collaboration group.

Abstract: Disclosed is a retainer assembly to securely couple a fastener to a component, the retainer assembly having a sleeve and a retainer. The sleeve includes a tube, a first flange, a second flange and a collar. The sleeve defines a central passage having a central longitudinal axis. The first flange and the second flange are separated by a tube. The collar includes one or more external ribbed features formed in or on an exterior surface of the collar and configured to press into and retain in the component. The collar is configured to reside within the opening and to provide compression limiting to the component. The retainer is positioned within the central passage and is securely positioned between an interior surface of the sleeve and an outer surface of the fastener.

Abstract: Systems and methods for amenity management are described. An amenity management system can include a plurality of amenities and an amenity manager communicatively coupled to the plurality of amenities. The amenity manager can implement a user authentication module configured to generate a user profile including user authentication data and an access status, selectively provide access to the plurality of amenities based on the access status, and update the user profile to include amenity use data for each instance a particular amenity of the plurality of amenities is accessed by the user profile, an amenity status tracking module configured to receive cleanliness data of each of the plurality of amenities, and a user management module configured to update the access status of the user profile based on the user authentication data, the amenity use data, and the cleanliness data.

Abstract: A method includes: generating a manifest of assets during the target time interval; labeling each asset in the manifest of assets with a set of attributes exhibited by the asset during the target time interval; defining a first attribute category exhibiting a first combination of attributes; assigning a first action to the first attribute category; identifying a subset of assets in the manifest of assets matching the first attribute category, each asset in the subset of assets exhibiting a set of attributes including the first combination of attributes; and executing the first action on the first subset of assets.

Abstract: A recorded event presentation system, including a camera that is adapted to capture and provide a video stream at a resolution. An originating client is adapted to receive the video stream from the camera at the resolution and provide the entire video stream at the resolution across a network at a variable bandwidth. When the bandwidth is relatively larger, then the video stream is provided at the resolution at a relatively faster speed. When the bandwidth is relatively smaller, then the video stream is provided at the resolution at a relatively slower speed. A server is adapted to receive the video stream from the originating client, and provide the video stream to a viewing client.

Abstract: Systems and methods of 3D ultrasound imaging with one or more “thick-slice” 3D ultrasound imaging zones and one or more 2D ultrasound zones using a multi-zone, multi-frequency image reconstruction scheme with subzone blending. The first zone can be a thick-slice imaging zone and the second and third zones are 2D imaging zones. The first zone and the second zone can be thick-slice imaging zones and the third zone can be a 2D imaging zone. The first zone can be a 2D imaging zone, the second zone can be a thick-slice imaging zone and the third zone can be a 2D imaging zone. A method includes imaging a first zone using plane wave imaging, a second zone using tissue harmonic imaging, and a third zone using fundamental and subharmonic deep imaging. The depth of each zone can vary based on the ultrasonic array and the F# used for imaging the zone.

Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.

Abstract: Three dimensional x-ray imaging systems are described in this application. In particular, this application describes a 3D dental intra-oral imaging (3DIO) system that collects a series of 2D image projections. The x-ray imaging system comprises a housing, an x-ray source attached to a articulating or motion gantry configured to move the source within the housing to multiple positions, an x-ray detector array located on an opposite side of an object to be imaged from the x-ray source, where the detector array is synchronized with the x-ray source to capture 2D images of the object when the x-ray source is located in multiple imaging positions, and a processor configured to accept the 2D images and reconstruct a 3D image. The multiple imaging positions can be located on a plane substantially parallel to the x-ray detector array. Other embodiments are described.

Abstract: A wearable spatial audio device is provided. The wearable spatial audio device includes one or more audio speakers, one or more processors, and a storage machine holding instructions executable by the one or more processors. Map data is obtained for a real-world environment that includes one or more dynamic audio objects. A device-specific subset of audio tracks is obtained, and a device-specific spatialized audio mix of the device-specific subset of audio tracks that is based on the map data is obtained. An indication of a change in an environmental condition relative to one or more of the dynamic audio objects is received. The device-specific spatialized audio mix is adjusted based on the change in the environmental condition.

Abstract: Improved systems and methods for securing license plates are disclosed herein. In the preferred embodiments discussed, the systems and methods are applied to the securing of dealer license plates. There are numerous problems with the unauthorized or illegal use of these types of license plates, and the machine and software combination disclosed herein may provide solutions to at least some of these problems.

Abstract: The present disclosure is directed to rubber compositions comprising at least one rubber, at least one reinforcing carbon black filler, and a whey protein component. The whey protein component is in an amount sufficient to provide about 0.1 to about 10 phr whey protein. The present disclosure is also directed to methods of preparing such rubber compositions and to tire components containing the rubber compositions disclosed herein.

Abstract: In one example in accordance with the present disclosure, an attention analysis system is described. The attention analysis system includes a database. The database includes 1) images indicative that users are paying attention to corresponding computing devices and 2) images indicative that users are not paying attention to corresponding computing devices. The system also includes an analyzer to extract multiple user position characteristics from a stream of images of a user disposed in front of a computing device. A comparer of the system determines, by comparing the stream of images of the user to the images in the database, whether the user is paying attention to the computing device.

Abstract: Cladding of the interior of a component part of a pressure vessel is shown. A lining which conforms to at least a portion of the interior geometry of the component is positioned in the interior of the component. The lining is then pressed into the component past its yield strength. The lining is then fused to the component.