Abstract: The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network Activation State (NAS) or a Network Inhibition State (NIS) for the cells using a computational model of the cellular network. The response of the cells to treatment is then predicted124 based on the NAS or NIS value that has been computed. The invention also comprises predictive methods for cellular responsiveness in which computation of a NAS or NIS value for the cells (e.g., tumor cells) is combined with use of a statistical classification algorithm. Biomarkers for predicting responsiveness to treatment with a therapeutic agent that targets a component within the ErbB signaling pathway are also provided.

Abstract: An apparatus is provided for forming, cutting and stamping a dough sheet into a plurality of uniformly stamped, imprinted dough pieces. The apparatus engages a leading portion of a dough sheet as it travels along a conveyor. The apparatus includes a drum rotatably disposed relative to the conveyor, a plurality of cutter molds disposed on the rotatable drum and a plurality of pattern imprinters formed within internal cavities defined by the plurality of cutter molds. Each of the cutter molds simultaneously cuts a dough piece received in the internal cavity and imprints on the dough piece to form a rounded edge roll. The pattern imprinter preferably has a star configuration for stamping the dough to form Kaiser-type rolls.

Abstract: A dump cart comprises a bed, a bed adapter, a frame, and a lift adapter. The bed is configured to carry a load. The bed adapter is configured to receive a bottom wall of the bed and includes a left adapter rail and a right adapter rail. The frame includes a left frame rail pivotally coupled to the left adapter rail and a right frame rail pivotally coupled to the right adapter rail. These connections allow the bed to dump the load to the rear of the dump cart. The lift adapter assists in lifting an object and includes left and right cradle arms that are configured to couple to one or more features of the object and a stabilizer leg that is configured to contact the ground so as to support a portion of the weight of the object.

Abstract: A method and system for producing documents with which the quality of a template conversion is increased by presenting to an operator associations of template elements between a source document template and a destination document template and allowing the operator to correct any erroneous association during the conversion. This includes providing a source document template, parsing the source document template into source parsed elements, converting at least some of the source parsed elements that require conversion for a destination document template and thereby providing destination template elements. This further includes presenting to an operator the source parsed elements and the destination template elements with their association and accepting operator input to correct at least some of the destination template elements.

Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, and autoimmune conditions.

Abstract: The current invention describes processes for obtaining of concentrates of esters of eicosapentaenoic acid and docosahexaenoic acid for their use in massive and regular human consumption either as a pharmaceutical ingredient or as a food ingredient, which are characterized by having neutral and stable organoleptic properties, free of side effects, which are typical from marine oils derivatives, and with low content of Persistent Organic Pollutants (POP).

Abstract: Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein L is —C(R12a)R12b—C(R13a)R13b—, wherein the carbon atom bonded to R12a and R12b is also bonded to the carboxamide nitrogen atom in Formula 1; or 1,2-phenylene optionally substituted with up to 4 substituents independently selected from halogen and C1-C2 alkyl; and A, Z, R1, R2, n, G and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention. Also disclosed are methods for controlling a phytophagous nematode comprising contacting the nematode or its environment with a nematocidally effective amount of a compound of Formula 1 wherein L is —C(R12a)R12b—C(R13a)R13b; and A, Z, R1, R2, n, G and Q are as defined in the disclosure.

Abstract: The present invention is a process and the product produced by that process for solid, particulate animal feed premixes, characterized by having a certain particle size range, physical stability, hardness range, and rapid dissolution, wherein the premixes contain various drugs and other, pharmaceutically and nutritionally acceptable diluents, binders and formulation aids as needed, or desired.

Abstract: A plastic article having a thickness of about 2 mm to about 3.2 mm is disclosed. The article is formed from a thermoplastic composition that includes a first polymer that is a polycarbonate, a second polymer that is a polyphthalatecarbonate, a perfluoroakyl sulfonate salt; and a cyclic siloxane compound. The thermoplastic has a light transmittance at a thickness of 3.2 mm of at least 86% according to ASTM D1003-11E1, a UL94 flammability rating of V0, a notched Izod impact strength at a thickness of 3.2 mm of at least 500 ?m according to ASTM D256-05 with a 2.27 kg weight at a, and a heat deflection temperature at a thickness of 3.2 mm of at least 160° C. according to ASTM D648-06 under a load of 0.45 MPa.

Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.

Abstract: A method of making a nanocomposite permanent magnet is provided. The method comprises applying an extreme shear deformation to hard magnetic phase nanoparticles and soft magnetic phase nanoparticles to align at least a portion of the hard phase magnetic particles and to produce a nanocomposite permanent magnet.

Abstract: An electrical stimulation method for the reduction of joint compression is disclosed. In a preferred embodiment, the method utilizes an electrical stimulation device that includes a plurality of channels of electrodes each of which includes at least a first and second electrode positioned in electrical contact with tissue of at least two muscles crossing a joint. Agonist/antagonist muscles involved in abduction/adduction, flexion/extension, supination/pronation, protraction/retraction, and/or eversion/inversion of body regions via joint movement are stimulated with a patterned series of electrical pulses through channels of electrodes in accordance with a procedure for reducing joint compression.

Abstract: Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.

Abstract: A gaming method for providing a poker-style game on a gaming device includes selecting at least one player card to form at least part of a player hand, selecting at least one machine card to form at least part of a machine hand. A prize schedule payable to the player if the player were to win a completed hand is calculated based on the selected cards. The player decides whether to continue play of the game utilising their hand, after being provided with the calculated prize schedule.

Abstract: An object carrying device comprising a body harness and an object carrying portion disposed on the body harness, the object carrying portion comprising a support member for supporting an object thereon.

Abstract: The invention relates to a cassette for a milling cutter having a cutter carrier and a clamping part, which together constitute a generally rectangular cassette, the cutter carrier and the clamping part being loosely placed on each other and together delimiting a fastening opening for a fastening screw by means of which the cassette can be fastened in a receiver of a milling cutter, the cutter carrier having a seat for a cutting insert. The invention additionally relates to a milling cutter having at least one receiver for a cassette and having at least one such cassette. A gap, S, between the cutter carrier and the clamping part is located below the cutting tip of the cutting insert to prevent chips from being lodged in the gap, S.

Abstract: A tissue interface module has an applicator chamber on a proximal side of the tissue interface module and a tissue acquisition chamber on a distal side of the tissue interface module. The applicator chamber may include: an opening adapted to receive the applicator; an attachment mechanism positioned in the applicator chamber and adapted to attach the tissue interface module to the applicator; a sealing member positioned at a proximal side of the applicator chamber; and a vacuum interface positioned at a proximal side of the applicator chamber and adapted to receive a vacuum inlet positioned on a distal end of the applicator. The invention also includes corresponding methods.

Abstract: Embodiments of apparatuses and methods including virtual address memory range registers are disclosed. In one embodiment, a processor includes a memory interface, address translation hardware, and virtual memory address comparison hardware. The memory interface is to access a system memory using a physical memory address. The address translation hardware is to support translation of a virtual memory address to the physical memory address. The virtual memory address is used by software to access a virtual memory location in the virtual memory address space of the processor. The virtual memory address comparison hardware is to determine whether the virtual memory address is within a virtual memory address range.

Abstract: The present invention provides a process for reducing static charge in a polycarbonate part involving combining a polycarbonate and a diphosphite to form a composition and molding a part from the composition, wherein the part exhibits reduced static charge compared to a part made without addition of the diphosphite.

Abstract: An inertial lockout mechanism is coupled to a latch mechanism, such that, during a collision event, the inertial lockout mechanism will move to an interference position such that the latch mechanism will be retained in a locked position as an inertial force is realized on the latch mechanism. Specifically tailored compression spring configurations ensure that the inertial lockout mechanism will move to the interference position before the latch mechanism can move to the unlocked position.