Abstract: Apparatus and methods for detecting onset of cardiac arrest utilizing a perfusion monitor. Detecting cardiac arrest comprises transmitting a signal toward a user to interact with the skin of the user, receiving a reflection of the signal, generating a photoplethysmogram, and processing the photoplethysmogram to detect whether the user is experiencing cardiac arrest.

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: An inverter device intended to convert a DC voltage into three phases of a polyphase AC voltage with a predetermined frequency, the inverter device comprising three single-phase inverters, each of the three single-phase inverters being able to deliver one of the three phases.

Abstract: A method for sterilising a platelet lysate in the liquid state comprising at least the endogenous growth factors TGF-beta 1, EGF, PDGF-AB, IGF-1, VEGF and bFGF. The method comprising freezing the liquid platelet lysate in order to obtain a frozen platelet lysate, and irradiating the frozen platelet lysate with ionising radiation in order to obtain a sterilised platelet lysate, the irradiation being adapted so as to preserve at least 80% of the concentration of at least one of the endogenous growth factors chosen from the group consisting of TGF-beta 1, EGF, PDGF-AB, IGF-1 and VEGF.

Abstract: Described are platforms, systems, and methods for determining quantifiable measures of dyadic ties. In one aspect, a method comprises receiving contextual data for a user from at least one data source; processing the contextual data through a first machine-learning model to determine quantifiable measures of dyadic ties between the user and each of a plurality of individuals, the first machine-learning model trained with previously received contextual data of a plurality of other users; determining a grouping for the user based on the determined quantifiable measures, the grouping comprising at least one of the individuals; and providing, through a user-interface, access to the determined quantifiable measures to members of the grouping.

Abstract: An implantable device for the treatment of hydrocephalus using a stent having a peripheral wall and an interior passageway and wherein a plurality of microneedles project outwardly from the peripheral and each needle includes a microneedle passageway from an aperture adjacent a distal end of the microneedle to a proximal end of the microneedle adjacent the peripheral wall. A corresponding plurality of one-way microvalves is positioned at the proximal ends of the microneedle and wherein the microneedle passageway is in fluid communication with the interior passageway whenever the one-way microvalve is open. When the stent is implanted in the superior sagittal sinus with the distal end of the plurality of microneedles positioned within the subarachnoid space and at least one of the plurality of microvalves is open, the stent permits cerebrospinal fluid to pass from the subarachnoid space to the superior sagittal sinus.

Abstract: An implant for repairing an articular cartilage defect site including an implant fixation portion with an upper segment and at least one bone interfacing segment and a top articulating portion with an articulating surface and an engagement surface. The upper segment includes a supporting plate with a first locking mechanism segment. The engagement surface includes a second locking mechanism segment. The first locking mechanism segment with at least two channels is structured to couple to the second locking mechanism segment with at least two protrusions. The at least one bone interfacing segment structured for insertion into the articular cartilage defect site. An implant including an implant fixation portion, a top articulating portion, and a locking mechanism with a first locking segment coupled to the upper segment and a second locking segment coupled to the at least one engagement surface and structured to couple to the first locking segment.

Abstract: A method includes applying laser pulses along a direction to a side of a wafer to create first and second stealth damage regions at respective first and second depths in the wafer and to create cracks that extend in the wafer from the respective stealth damage regions and that are spaced apart from one another along the direction, applying a compressive and retractive cyclical force to the wafer along the third direction to propagate and join the cracks from the respective stealth damage regions together, and expanding the wafer to separate individual dies from the wafer.

Abstract: A roof assembly for a work vehicle includes a roof panel having a vertical peak positioned longitudinally between a forward end and a rearward end of the roof panel. In addition, the roof panel includes a forward surface extending from the vertical peak to the forward end of the roof panel, and the roof panel includes a rearward surface extending from the vertical peak to the rearward end of the roof panel. The roof panel also includes a ridge extending around a periphery of the roof panel. The ridge has a first gap positioned at the rearward end of the roof panel, a second gap positioned at the forward end of the roof panel, and a third gap positioned at a first lateral end of the roof panel. In addition, the roof panel does not include a channel extending along the roof panel.

Abstract: A computer-implemented method of predicting phenotypic shift in response to usage of a plurality of drugs on a plurality of phenotypes of a cohort of individuals with a plurality of confounders. The cohort of individuals has associated phenotype measurements, covariate measurements, and drug usage patterns for two separate time points. The phenotype measurements for the first and second time points are covariate-corrected and drug-usage corrected through the use of biostatistics.

Abstract: The present invention relates to a diagnostic peptide and methods, kits and systems for the in vitro diagnostic of an infection in a subject. The methods using the peptide of the invention comprise the steps of: i) providing a bodily fluid sample, ii) contacting the bodily fluid sample with a peptide comprising a fluorescent agent having an emission wavelength of 650-900 nm and a non-fluorescent agent having an absorption wavelength of 650-900 nm, for quenching said emission of said fluorescent agent, and a cleavage site located between said fluorescent agent and first non-fluorescent agent, the cleavage site being specific for a viral protease, iii) monitoring the fluorescence in the range of 650-900 nm from the peptide in step ii), wherein an increase in fluorescence in the range of 650-900 nm is indicative for the presence of a viral protease in the sample.

Abstract: A roof assembly for a work vehicle includes a grab rail and a grab rail support coupled to the grab rail. The grab rail support is configured to couple to a roof structure of the roof assembly, the grab rail support is configured to support the grab rail on the roof structure, the grab rail support has a hollow passage configured to facilitate passage of a wire, and the grab rail support has an inlet to the hollow passage configured to be positioned at an interior of the roof structure to enable the wire to extend from the interior of the roof structure into the hollow passage.

Abstract: Systems, methods, and apparatuses relating efficient exception handling in trusted execution environments are described. In an embodiment, a hardware processor includes a register, a decoder, and execution circuitry. The register has a field to be set to enable an architecturally protected execution environment at one of a plurality of contexts for code in an architecturally protected enclave in memory. The decoder is to decode an instruction having a format including a field for an opcode, the opcode to indicate that the execution circuitry is to perform a context change. The execution circuitry is to perform one or more operations corresponding to the instruction, the one or more operations including changing, within the architecturally protected enclave, from a first context to a second context.

Abstract: A billiard ball rack for racking 3 or more billiard balls is provided, comprising a base arm and two side arms configured to enable the billiard ball rack to be foldable and self-aligning. The inner surfaces of the base arms and the side arms are tapered at an angle relative to a top surface of the billiard ball rack, and the arms are pivotally connected to one another and configured such that when the billiard rack is positioned around a set of billiard balls and downward pressure is applied, the base arm and side arms of the billiard rack automatically adjust to form an equilateral triangle. The billiard ball rack is also configured to be folded compactly to fit within standard pool cue cases while the arms remain interconnected. Methods of using the billiard ball rack for racking billiard balls are also provided.

Abstract: This disclosure describes techniques and apparatuses directed to defining a layout (100) and drawing elements for display by a graphical user interface (810) on a display screen (808) of a computing device (802). The process of laying out a drawing area occurs in floating point, but drawing occurs aligned to pixel boundaries of the display screen. Drawing may also occur relative to pixel offsets with respect to the display screen and the layout. This layout process occurs in floating point to avoid accumulating errors. However, drawing occurs pixel-aligned, optionally relative to pixel offsets, to improve visual results including the centering of nested layouts and sharp element edges.

Abstract: The present invention relates to a method for charging an electrochemical cell of a rechargeable battery with charging pulse control (PL), the pulses (PL) being driven in voltage control mode in the form of voltage steps (Pt) of variable amplitude. According to the invention, the method consists in calculating the value (Ut+1) of each voltage step (Pt+1) with respect to the value (Ut) of the preceding voltage step (Pt) and according to a progression variable representative of the variation in the internal resistance of the cell (d(R)/dt), for a period ending on the preceding step (Pt), with respect to a predetermined tolerated variation threshold (?), where Var=d(R)/dt??. The method applies to high-voltage electric battery charging protocols for electromobility or stationary applications, or portable device batteries, for example.

Abstract: A modular power distribution system includes using power extension modules and power distribution modules. The power extension modules are configured to route inputted power to another power extension module or a power distribution module. The power distribution modules are configured to route power from a power extension module to one or more racks or cabinets in a data center.

Abstract: A transient voltage suppressor is disclosed that includes an electrode, a substrate disposed on the electrode, the substrate having a first doping, an epitaxial layer disposed on the substrate, the epitaxial layer having a second doping that is different from the first doping, a channel formed in the epitaxial layer having a width W, a length L and a plurality of curved regions, the channel forming a plurality of adjacent sections, the channel having a third doping that is different from the first doping and the second doping and a metal layer formed on top of the channel and contained within the width W of the channel.

Abstract: An interventional hysteroscope includes a shaft, an optical imaging element, an ultrasonic imaging element and a treatment element, such as an ablation needle. The shaft has a distal end, a proximal end, and a longitudinal axis therebetween, and the optical imaging element is disposed at the distal end of the shaft. The ultrasonic imaging element is also disposed at the distal end of the shaft and is configured to image along a laterally oriented image path. The treatment element is configured to be deployed from the shaft along a laterally oriented treatment path, and the imaging path and the treatment path intersect at an intersectional location spaced laterally away from the shaft. A display is configured to present both an optical image from the optical imaging element and an ultrasonic image from the ultrasonic imaging element and to present a marker on the ultrasonic image at a location corresponding to the intersectional location.