Abstract: Provided herein are compositions, methods and uses involving antibodies that specifically bind to MET, a receptor tyrosine kinase, and modulate the expression and/or activity of MET. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. In one aspect, provided herein is a monoclonal antibody or antigen-binding fragment thereof that binds to the Sema/PSI domain of human MET. Also provided herein is a kit comprising an antibody or antigen-binding fragment provided herein. Also provided herein is a method of managing, protecting against, or treating cancer in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment provided herein.

Abstract: A processing device includes a first counter having a first count value of a number of child pages among a plurality of child pages present in an enclave memory of a first virtual machine (VM). The plurality of child pages are associated with a parent page in the enclave memory. The processing device includes a second counter having a second count value of a number of child pages among the plurality of child pages not present in the enclave memory and being shared by a second VM, wherein the second VM is different from the first VM. A non-zero value of at least one of the first counter or the second counter prevents eviction of the parent page from the enclave memory.

Abstract: A monitoring apparatus includes a housing configured to be positioned within an ear of a subject, and a sensor module. The sensor module includes an optical emitter and detector, and an optical filter overlying at least a portion of the detector. The sensor module also includes a motion sensor, an interference filter, and a processor. The optical filter attenuates time-varying environmental light interference caused by sunlight and/or ambient light. The interference filter removes effects of time-varying environmental interference from a signal output from the optical detector and produces a processed energy response signal associated with a physiological condition of the subject. The processor controls operations of the optical emitter, the optical detector, the motion sensor, and the interference filter. The processor utilizes an output signal from the motion sensor to remove motion artifacts from the energy response signal, and extracts at least one physiological property from the energy response signal.

Abstract: Federated systems for issuing playback certifications granting access to technically protected content are described. One embodiment of the system includes a registration server connected to a network, a content server connected to the network and to a trusted system, a first device including a non-volatile memory that is connected to the network and a second device including a non-volatile memory that is connected to the network. In addition, the registration server is configured to provide the first device with a first set of activation information in a first format, the first device is configured to store the first set of activation information in non-volatile memory, the registration server is configured to provide the second device with a second set of activation information in a second format, and the second device is configured to store the second set of activation information in non-volatile memory.

Abstract: This disclosure generally relates to antibodies or antibody fragments which specifically bind to M-CSF. In particular antibodies and antibody fragments are disclosed which bind to M-CSF and which inhibit binding of M-CSF to the M-CSF receptor with an IC50 of 10 pM or less. The invention also relates to nucleic acids, vectors and host cells capable of expressing the antibodies or fragments thereof of the invention, pharmaceutical compositions comprising the antibodies or fragments thereof and uses of said antibodies or fragments thereof and compositions for treatment of specific diseases.

Abstract: A delayed return mechanism, such as for a door latch, including a housing having a hole with an axis, a cavity in the housing at least partially filled with a fluid media, a hub disposed in the cavity including a spindle hole coaxial with the hole in the housing including teeth within the spindle hole to engage a spindle, the hub being rotatable about the axis and having a fin extending radially outward in the cavity, and a channel through which the fluid media passes during rotation of the hub to control flow of the fluid media about the cavity.

Abstract: A solar shade-energy device comprising a solar shade having a photovoltaic solar panel and a support structure; a means of mounting said solar shade; an energy storage-distribution module having a housing, an energy storage device, power conditioning circuitry, and one-or-more energy distribution ports; a means of detachably mounting said energy storage-distribution module onto said solar shade; and a disconnectable electrical interface means between said energy storage-distribution module and said photovoltaic solar panel is disclosed. A method of using said solar shade-energy device is also disclosed.

Abstract: A terminology marker system integrates a terminology analytical component for quantifying the amount of linguistic noise found in the translation output as measured against a dictionary; further, correlating the noise measured on a continuous basis enables the analytical component to build terminology predictive models used in a feedback loop to upstream components of the supply chain to improve future translation of new content. The system also provides a smart terminology assessment component for assessing linguistic assets and improving the quality of those assets to assist in translation. The system also provides a smart terminology evaluation component that is able to analyze MT output to make smart decisions on reducing the amount of post editing corrections needed for delivering a persistent level of translation quality.

Abstract: Methods, apparatus, and systems to create, output, and use animation programs comprising keyframes, objects, object states, and programming elements. Objects, object states, and programming elements may be created through image analysis of image input. Animation programs may be output as videos, as non-linear interactive experiences, and/or may be used to control electronic actuators in articulated armatures.

Abstract: Devices and methods related to embedded sensors for dynamic error vector magnitude corrections. In some embodiments, a power amplifier (PA) can include a PA die and an amplification stage implemented on the PA die. The amplification stage can include an array of amplification transistors, with the array being configured to receive and amplify a radio-frequency (RF) signal. The PA can further include a sensor implemented on the PA die. The sensor can be positioned relative to the array of amplification transistors to allow sensing of an operating condition representative of at least some of the amplification transistors. The sensor can be substantially isolated from the RF signal.

Abstract: A target system includes a lower rod configured to be removably inserted, at a lower end, into the ground; and an upper rod assembly. The upper rod assembly includes an upper rod configured to be coupled, at a lower end, to an upper end of the lower rod. The upper rod assembly also includes a mounting assembly coupled to an upper end of the upper rod and configured to hold a target.

Abstract: The present invention relates to pharmaceutical compositions comprising Akt protein kinase inhibitors with therapeutic activity against diseases such as cancer as well as processes for their preparation and their use as medicament.

Abstract: Self-dispensing poultry and small animal feeder dispenses feed from a hopper into a catch dish on demand by action of the bird pecking at the feed in the catch dish or small animal feeding at the catch dish. Interchangeable regulating disks have respective different size center apertures, and a groove seating a cross-bar of a trigger rod on which the catch dish is supported. A spade or paddle at the upper end of the trigger rod moves when the trigger rod wiggles or shifts, and this causes feed to fall through the regulator disk center aperture to replenish the feed in the catch dish.

Abstract: A treatment mixture for treating biofilms on a human or animal is provided. The treatment mixture comprises: an effective amount of a salt of alkyleth sulfate defined by Formula I: R1—(OCHR2CH2)n—OSO3X1 ??Formula I wherein: R1 is a branched or unbranched alkyl of 8-24 carbons; R2 is hydrogen or methyl; n is an integer of 2 to 30; and each X1 is independently a counter ion; an effective amount of at least one surfactant selected from the group consisting of a salt of alkyl sulfoacetate defined by Formula II: R4OC(O)CH2SO3X2 ??Formula II wherein R4 is a branched or unbranched alkyl of 8-24 carbons; and X2 is a counter ion; and an effective amount of a salt of an alkyl sulfosuccinate defined by Formula III: wherein: R3 is the branched or unbranched alkyl group of an alkyl alcohol with the alcohol hydrogen replaced with the sulfosuccinate wherein the alkyl has of 8-24 carbons, more preferably 10-18 carbons and most preferably 12-14 carbons; and X is a counter ion.

Abstract: A gas turbine engine includes a spool configured to rotate about an axial centerline. The spool includes a fan rotor and a cold turbine rotor. The fan rotor is rotatably driven by the cold turbine rotor. A cold turbine inlet passage is configured to direct an airflow along a radial inward trajectory to the cold turbine rotor.

Abstract: A system for providing a multi-technology visual environment for management of issues. A Topic Model is trained via a text corpus for each issue via Topic Model Trainer, also known as the Topic Modeler. Then, incoming discourse texts (such as tweets) are classified to issues organizations care about and are thus relevant, or classified as irrelevant via a Classification Module. Finally, the resulting list of relevant discourse surrounding the issues is scored via a Scoring Module. The modules are configured accordingly. A topic training module configured to allow an user to specify a text corpus representing the discourse surrounding an issue. A topic classification module configured to analyze the data to remove non-material information and classify the text discourse data based on topic. A scoring module configured to assign numerical scores to the classified discourse text based on the issue it is about and the type of entity that created the discourse text for an identified period of time.

Abstract: A steerable catheter system may include a flexible elongate catheter body, a drive mechanism at the proximal end of the catheter body, and at least one group of pullwires extending along a length of the catheter body. The catheter body may include a distal articulating section and a proximal non-articulating section. Each group of pullwires includes at least two pullwires, and each of the pullwires is anchored at a first end to the distal end of the catheter body and at a second end to the drive mechanism. The pullwires of each group are positioned close to one another in the catheter wall to concentrate the forces and cause deflection along the articulating section of the catheter body and diverge away from one another to reach a more separated distribution around a circumference of the catheter body to distribute the forces and prevent deflection along the non-articulating section.

Abstract: A method for a cellular telecommunications network includes performing a modulo operation on a physical cell identifier (PCI) of a target cell to determine a first PCI mod value, determining first tier neighbors of the target cell, determining that at least one of the first tier neighbors uses a PCI that has a PCI mod value that is the same as the first PCI mod value, comparing a number of handover attempts between the target cell and the at least one first tier neighbor with the first PCI mod value to a first threshold value, and when the number of handover attempts exceeds the threshold value, replacing the PCI of the target cell with a PCI with a second PCI mod value different from the first PCI mod value.

Abstract: The present disclosure is directed towards systems and methods for assisting with legal research and for aiding in the discovery of information and documents relevant to a user's research focus. The inventive systems receive identifications of relevant documents explicitly or implicitly from a user's research session and, based on issues relevant to those documents and other connections to those documents, recommends similar documents to the user for their consideration. Recommendations may be ranked and filtered and the recommendations and their ranking may be based at least in part on aggregated research session information from previous research sessions.

Abstract: Devices for detecting biomarkers in a sample and methods for detecting such biomarkers are discussed. The biomarkers may be associated with a particular disease such as breast cancer or another health condition. The devices may contain a disc including a plurality of microfluidic channels extending in a radial direction of the disc, the microfluidic channels pre-loaded with a plurality of capture molecules specific to at least one biomarker. The methods may include introducing a fluid sample into at least one microfluidic channel of a disc, rotating the disc, such that the fluid sample flows radially outward through the at least one microfluidic channel to combine with capture molecules specific to at least one biomarker, and detecting a signal from the disc indicative of a presence of the at least one biomarker contained in the fluid sample.