Abstract: This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

Abstract: A computing system is described that determines a location of a first computing device at a particular time. Responsive to determining that a second computing device is located within a threshold distance of the location of the first computing device at the particular time, the computing system identifies, based on contextual information associated with a user of the first computing device and contextual information associated with a user of the second computing device, at least one data file that the user of the first computing device is likely to access at the particular time. The computing system then outputs, for transmission to the first computing device, an indication of the at least one data file.

Abstract: A gas turbine engine according to an example of the present disclosure includes, among other things, a fan shaft drivingly connected to a fan with the fan having fan blades. A fan shaft support that supports the fan shaft and a gear system connected to the fan shaft. The gear system includes a ring gear defining a ring gear lateral stiffness and a ring gear transverse stiffness, a gear mesh defining a gear mesh lateral stiffness and a gear mesh transverse stiffness, and a reduction ratio greater than 2.3. At least one of the ring gear lateral stiffness and the ring gear transverse stiffness is less than 12% of a respective one of the gear mesh lateral stiffness the ring gear transverse stiffness.

Abstract: A fuel delivery pump for delivering fuel, having an electric motor and having a pump impeller that is driven by means of the electric motor, wherein the pump impeller is connected by means of a shaft to a rotor of the electric motor such that a rotational movement of the rotor is transmitted via the shaft to the pump impeller, wherein the shaft is mounted by means of an axial bearing in an axial direction and/or by means of a radial bearing in a radial direction relative to a pump stage in which the pump impeller is arranged, wherein an electrical insulation element is arranged between the axial bearing and the pump stage, and/or an electrical insulation element is arranged between the radial bearing and the pump stage.

Abstract: A welding-type helmet includes a cover with a channel recessed from an external surface of the cover, the channel being configured to house a removable light source within the channel.

Abstract: Various embodiments relate generally to autonomous vehicles and associated mechanical, electrical and electronic hardware, computer software and systems, and wired and wireless network communications to provide an autonomous vehicle fleet as a service. More specifically, systems, devices, and methods are configured to initiate modification of trajectories to influence navigation of autonomous vehicles. In particular, a method may include receiving a teleoperation message via a communication link from an autonomous vehicle, detecting data from the teleoperation message specifying an event associated with the autonomous vehicle, identifying one or more courses of action to perform responsive to detecting the data specifying the event, and generating visualization data to present information associated with the event to a display of a teleoperator computing device.

Abstract: A surgical instrument includes an ultrasonic waveguide extending through a body assembly. An ultrasonic blade connects to the ultrasonic waveguide. A clamp arm assembly of the surgical instrument is able to move from an opened position for receiving a tissue toward a closed position for clamping the tissue. The clamp arm assembly includes a clamp body and a clamp pad facing the ultrasonic blade. A clamp arm actuator of the surgical instrument is able to move from a first position toward a second position to direct the clamp arm assembly from the opened position toward the closed position. A modular coupling of the surgical instrument connects to the clamp pad such that at least the clamp pad can be disconnected relative to the ultrasonic blade for replacement thereof.

Abstract: Methods for treating hyperaldosteronism with therapeutic renal neuromodulation and associated systems and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods that at least partially inhibit sympathetic neural activity in renal nerves proximate a renal blood vessel of a human patient. One or more measurable physiological parameters corresponding to hyperaldosteronism of the patient can thereby be improved. Moreover, central sympathetic drive in the patient can be reduced in a manner that treats the patient for hyperaldosteronism. Renal sympathetic nerve activity can be modulated along the afferent and/or efferent pathway. The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the renal nerve.

Abstract: An apparatus includes a processor and a storage storing instructions causing the processor to: maintain a federated area; receive a request to perform a job flow with a data set from a remote device; retrieve a job flow definition specifying the tasks of the job flow from the federated area; determine whether there is an instance log in the federated area generated by a previous performance of the job flow with the data set; in response to there being such an instance log, retrieve the version specified in the instance log of each task routine for each task from the federated area; in response to there being no such instance log, retrieve the most recent version of each task routine; perform the job flow with the retrieved versions of the task routines and the data set to generate a result report; and provide the result report to the remote device.

Abstract: A temperature sensor (1) has a pressure sensor (10), the distal end of which is inserted in a sealed chamber (2) filled with a liquid. The pressure sensor has a light guide (4), a cavity (14) at a distal end of the light guide, a diaphragm (11) forming a wall of the cavity and being configured to deflect with applied pressure, and a detector to detect changes in light reflection due to deflection of the diaphragm. The liquid (3) which changes volume in response to temperature changes and this volume change is sufficient to change the pressure applied on the diaphragm (11), and the a interrogation system processes pressure data and/or light reflection data to generate an output indicating temperature of the fluid in the chamber.

Abstract: A processing device includes a cache implementing a set of at least three cache slices. Each cache slice is to store a corresponding set of cache lines. The cache further includes cache control logic coupled to the set of at least three cache slices. The cache control logic is to map addresses of an address space to the cache such that each address within the address space maps to a corresponding strict subset of two or more cache slices of the set of cache slices.

Abstract: A crimping system (1) for a timepiece (6) or jewelry item comprising: a crimping support (3); a precious stone (2) mounted in or on the crimping support (3); and a flexible element (5) fastened to the crimping support (3) in such a way as to flexibly link the crimping support (3) to said item (6), such that the stone (2) can oscillate axially and radially relative to an axis of symmetry (15), following a movement of the item (6); the crimping system (1) further comprising a stop (18, 22) that is more rigid than the flexible element (5), the stop (18, 221, 241) being capable of cooperating with the crimping support (3), in such a way as to limit the range of axial and/or radial movement of the stone (2) when the latter oscillates. In particular, the crimping system (1) has the advantage, relative to the prior art, of allowing much easier and more reliable mounting of the stone (2) and of being better suited to the use of stones (2) of small dimensions.

Abstract: The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

Abstract: The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.

Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides.

Abstract: A gas turbine engine has a compressor section, a compressor case substantially surrounding the compressor section, and a diffuser case attached at an attachment interface to the compressor case. The attachment interface is between a forward and an aft end of the compressor. A geared turbofan is also disclosed.

Abstract: A sensor for use in lithographic apparatus of an immersion type and which, in use, comes into contact with the immersion liquid is arranged so that the thermal resistance of a first heat path from a transducer of the sensor to a temperature conditioning device is less than the thermal resistance of a second heat flow path from the transducer to the immersion liquid. Thus, heat flow is preferentially towards the temperature conditioning device and not the immersion liquid so that temperature-induced disturbance in the immersion liquid is reduced or minimized.

Abstract: Representative implementations of devices and techniques provide reinforcement for a carrier or a package. A reinforcement layer is added to a surface of the carrier, often a bottom surface of the carrier that is generally under-utilized except for placement of terminal connections. The reinforcement layer adds structural support to the carrier or package, which can be very thin otherwise. In various embodiments, the addition of the reinforcement layer to the carrier or package reduces warpage of the carrier or package.

Abstract: A mounting system for a gas turbine engine includes a low pressure turbine section, a first bearing, a mid-turbine frame, and a rear mount. The first bearing supports at least a portion of the low pressure turbine section. The mid-turbine frame supports the first bearing. The rear mount is connected to the mid-turbine frame and is configured to react loads from the gas turbine engine.