Abstract: A method for presenting measurements of properties of a subsurface material to a user includes: conveying a carrier through a borehole penetrating the subsurface material; performing a plurality of measurements of multiple properties of the subsurface material at multiple depths in the borehole using a plurality of downhole tools disposed at the carrier; constructing, with a processor, a three-dimensional mathematical model of the subsurface material using the plurality of measurements, the model having data from the plurality of measurements of the multiple properties; receiving, with the processor, an input from a user directing the processor to generate a three-dimensional image of the subsurface material as seen from a virtual viewer-window viewing the model, the input having a three-dimensional position and three-dimensional viewing direction of the virtual-viewer window within the model; generating the three-dimensional image with the processor; and displaying the generated three-dimensional image on a

Abstract: The present disclosure provides pharmaceutical compositions of statins and polyunsaturated fatty acids (PUFAs), in which the statins are dissolved in the PUFAs, the PUFA species being present substantially in the free acid form. Also provided are oral unit dosage forms of the disclosed pharmaceutical compositions and methods of treating blood lipid disorders using the compositions and oral unit dosage forms.

Abstract: Methods of identifying subjects who are resistant to antiplatelet therapy, such as therapy with clopidogrel, are presented. The methods comprise determining is whether the subject is an efficient converter of medium chain polyunsaturated fatty acids to long-chain polyunsaturated fatty acids. Also provided are methods of treating resistance to antiplatelet therapy in subjects who are efficient converters of medium chain polyunsaturated fatty acids to long-chain polyunsaturated fatty acids, comprising adjunctively administering to the subject an effective amount of a composition comprising omega-3 long chain polyunsaturated fatty acids. Improved methods of antiplatelet therapy are provided, wherein the improvement comprises adjunctive administration of a composition comprising omega-3 long chain polyunsaturated fatty acids in free acid form.

Abstract: The invention provides a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cell, and (b) introducing into a progenitor cell two or more network elements within said network to induce a predetermined series of cis regulatory network interactions resulting in a specified regulatory state of said progenitor cell. Also provided is a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cellular state, and (b) introducing into a progenitor cell two or more network elements within said network to induce a predetermined series of cis regulatory network interactions resulting in a specified regulatory state of said progenitor cell.

Abstract: The present invention is a method for secure and flexible key schedule generation, which includes loading a key schedule algorithm and a cryptographic algorithm into a cryptographic engine. The method further includes loading the cryptographic algorithm, when selected, into a cryptographic co-processor. The method further includes loading the key schedule algorithm into a separate virtual machine.

Abstract: A system for monitoring and controlling a batch process. The system includes a control system that is operable to control the batch process and to receive measured process variables of the batch process. An analyzer analyzes a material sample from the batch process and generates array data representative of the composition of the material sample. An analyzer controller is operable to collect the array data from the analyzer and the measured process variables from the control system. A software data server running on a computer is operable to retrieve the array data and the measured process variables from the analyzer controller. A software information management system running on the computer is operable to receive the measured process variables and the array data from the data server and to store the measured process variables and the array data in a database in an associated manner.

Abstract: A computational method is described which uses the process of cis-regulatory module evolution to identify conserved sequence patches which exhibit suppression of change by snp/indel occurrence, including determining sequence similarities significantly greater than random expectation on selected genome sequences from two or more species in sequences that lie outside of protein coding regions, sorting the similarities for conserved patches of single nucleotide polymorphisms (SNPs) and insertion/deletions (indels). and selecting such patches to identify cis-regulatory modules. Further, the disclosed method is practiced in the absence of having to execute multiple interspecific sequence comparison analysis, where such identified cis-regulatory modules are used to produce libraries and arrays containing such cis-regulatory modules.

Abstract: The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes' label codes. Methods, computers, and computer program products for identifying target-specific sequences for inclusion in the probes are also provided, as are methods of making and using such probes. The probes can be used in diagnostic, prognostic, quality control and screening applications.

Abstract: The invention provides a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cell, and (b) introducing into a progenitor cell two or more network elements within said network to induce a predetermined series of cis regulatory network interactions resulting in a specified regulatory state of said progenitor cell. Also provided is a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cellular state, and (b) introducing into a progenitor cell two or more network elements within said network to induce a predetermined series of cis regulatory network interactions resulting in a specified regulatory state of said progenitor cell.

Abstract: A system for monitoring and controlling a batch process. The system includes a control system that is operable to control the batch process and to receive measured process variables of the batch process. An analyzer analyzes a material sample from the batch process and generates array data representative of the composition of the material sample. An analyzer controller is operable to collect the array data from the analyzer and the measured process variables from the control system. A software data server running on a computer is operable to retrieve the array data and the measured process variables from the analyzer controller. A software information management system running on the computer is operable to receive the measured process variables and the array data from the data server and to store the measured process variables and the array data in a database in an associated manner.

Abstract: A system for the distribution of flavors is disclosed. The system includes a plurality of consumer workstations linked to a central processing hub. The central processing hub includes means for providing consumers with information regarding flavors. The means for providing includes a flavor search system through which a consumer may identify desired flavor based upon a series of input criteria.

Abstract: A composite structural reinforcement device to be applied to structural members by wrapping in successive overlying layers includes a body formed of a first ply of resin impregnated high tensile strength material, a second ply of resin impregnated high tensile strength material, a magnetically detectable ply disposed and bonded between the first and second plies, an interlock means for mechanically interlocking successive layers as the device is applied to a structural member, and an alignment means for aligning successive layers of the device in overlying relation. Various alternative embodiments and various combinations of features are disclosed.

Abstract: The invention provides a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cell, and (b) introducing into a progenitor cell two or more network elements within said network to induce a predetermined series of cis regulatory network interactions resulting in a specified regulatory state of said progenitor cell. Also provided is a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cellular state, and (b) introducing into a progenitor cell two or more network elements within said network to induce a predetermined series of cis regulatory network interactions resulting in a specified regulatory state of said progenitor cell.

Abstract: Disclosed herein are methods for identifying and developing safe and effective nutritional supplement formulations; associated regimens for administering such formulations; and methods for distributing such formulations. The nutritional supplement formulations and associated regimens are adapted to prevent and/or treat specific medical or health conditions. Also disclosed herein are methods for prescribing and supplying nutritional supplement formulations to patients according to appropriate regimens. Particular embodiments of the invention relate to safe and effective nutritional supplement formulations and associated regimens for the prevention and/or treatment of cardiovascular disease (“CVD”). Various embodiments of the invention provide advantages over the prior art in areas such as patient safety, medical effectiveness, physician supervision, patient compliance, and consumer costs.

Abstract: Described is a process for augmenting, enhancing or imparting an aroma or taste of or to a consumable material which can be: (i) a calcium supplement; (ii) a foodstuff; (iii) a beverage; (iv) a chewing gum; (v) a toothpaste; or (vi) an oral care such as a mouthwash, by adding to the consumable material a tastand composition obtained from Saccharum officinarum leaves (sugarcane leaves) by means of carrying out a sequence of physical separation unit operations on a plurality of such leaves, macerates thereof or mixtures of leaves and macerates thereof, whereby the tastand composition is separated and isolated from the remainder of the plurality of leaves, macerates thereof or mixtures of leaves and macerates thereof; and then spray-drying or freeze-drying the resulting product.

Abstract: Described are flavored calcium supplement compositions, beverage (e.g., coffee, milk, cocoa and citrus/whey protein), foodstuff, chewing gum and oral care (e.g., toothpaste and mouthwash) compositions and articles comprising flavored calcium supplements, foodstuff, beverage, chewing gum and oral care base compositions and intimately admixed therewith an aroma or taste augmenting, enhancing or imparting quantity and concentration of one or more freeze-dried or spray-dried tastand compositions containing tastands produced from Saccharum officinarum leaves (sugarcane leaves) by means of carrying out one or more physical separation unit operations on a plurality of such leaves, macerates thereof or mixtures of leaves and macerates thereof whereby one or more natural food additives, chewing gum additives or oral care additives is separated and isolated from the remainder of the plurality of leaves, macerates thereof or mixtures of leaves end macerates thereof.

Abstract: The present invention is directed to methods and compositions useful for altering the transcriptional expression of genes in eukaryotic cells. The invention employs novel antibody derivative molecules which function to recognize and bind to specific cis-regulatory DNA sequence elements of a eukaryotic gene. When two antibody derivative molecules are bound to adjacent cis-regulatory DNA sequence elements of a gene, those molecules may interact to form an antibody binding site which is capable of recognizing and binding to a transcription factor protein for the target gene, thereby affecting the functionality of that transcription factor protein and, in turn, the transcriptional activity of the gene. Also provided herein are isolated nucleic acids encoding the novel antibody derivative molecules of the present invention and expression vectors comprising those nucleic acids.

Abstract: The present invention is directed to methods and compositions useful for altering the transcriptional expression of genes in eukaryotic cells. The invention employs novel antibody derivative molecules which function to recognize and bind to specific cis-regulatory DNA sequence elements of a eukaryotic gene. When two antibody derivative molecules are bound to adjacent cis-regulatory DNA sequence elements of a gene, those molecules may interact to form an antibody binding site which is capable of recognizing and binding to a transcription factor protein for the target gene, thereby affecting the functionality of that transcription factor protein and, in turn, the transcriptional activity of the gene. Also provided herein are isolated nucleic acids encoding the novel antibody derivative molecules of the present invention and expression vectors comprising those nucleic acids.