Patents by Inventor A. H. Davidson
A. H. Davidson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5712379Abstract: The present invention is directed to methods and compositions useful for altering the transcriptional expression of genes in eukaryotic cells. The invention employs novel antibody derivative molecules which function to recognize and bind to specific cis-regulatory DNA sequence elements of a eukaryotic gene. When two antibody derivative molecules are bound to adjacent cis-regulatory DNA sequence elements of a gene, those molecules may interact to form an antibody binding site which is capable of recognizing and binding to a transcription factor protein for the target gene, thereby affecting the functionality of that transcription factor protein and, in turn, the transcriptional activity of the gene. Also provided herein are isolated nucleic acids encoding the novel antibody derivative molecules of the present invention and expression vectors comprising those nucleic acids.Type: GrantFiled: June 7, 1996Date of Patent: January 27, 1998Assignee: California Institute of TechnologyInventor: Eric H. Davidson
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Patent number: 5688025Abstract: A two level convertible child car seat comprising a frame adapted to be releasably secured to an automobile seat using an existing seat belt, the frame defining a seat to receive a child, and a selectively retractable seat hinged to the frame back the retractable seat folding into and out of a recess. The frame comprises a base, an angled back and a pair of opposite facing sides extending between the base portion and the back portion. A resilient shell is disposed over the frame or the frame and shell is formed from a single piece. The shell defines a child receptive seating area which is padded. The seating area defines a recess which receives the retractable seat when folded. A harness comprised of a torso plate and a set of straps secures the child in the seat.Type: GrantFiled: December 11, 1996Date of Patent: November 18, 1997Inventor: Timothy H. Davidson
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Patent number: 5530161Abstract: Compounds of general formula I: ##STR1## wherein: R.sup.1 represents a C.sub.1 -C.sub.6 alkyl, phenyl, thiophenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.6)alkyl, heterocyclyl, (C.sub.1 -C.sub.6)alkylcarbonyl phenacyl or substituted phenacyl group; or, when n=O, R.sup.1 represents SR.sup.x, wherein R.sup.x represents a group: ##STR2## R.sup.2 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl(C.sub.1 -C.sub.6)alkyl, cycloalkyl(C.sub.1 -C.sub.6)alkyl or cycloalkenyl(C.sub.1 -C.sub.6)alkyl group;R.sup.3 represents an amino acid residue with R or S stereochemistry or a C.sub.1 -C.sub.6 alkyl, benzyl, (C.sub.1 -C.sub.6 alkoxy)benzyl or benzyloxy(C.sub.1 -C.sub.6 alkyl) group;R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group;R.sup.5 represents a hydrogen atom or a methyl group;n is an integer having the value 0, 1 or 2; andA represents a C.sub.1 -C.sub.6 hydrocarbon chain, optionaly substituted with one or more C.sub.1 -C.sub.Type: GrantFiled: February 14, 1994Date of Patent: June 25, 1996Assignee: British Bio-technology LimitedInventors: Colin Campion, Alan H. Davidson, Jonathan P. Dickens, Michael J. Crimmin
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Patent number: 5514677Abstract: Compounds of general formula I: ##STR1## wherein: A represents the group --NH.sub.2, a substituted acyclic amine or a heterocyclic base;have collagenase inhibition activity and are useful in the management of disease involving tissue degradation and/or the promotion of wound healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumour invasion.Type: GrantFiled: April 18, 1994Date of Patent: May 7, 1996Assignee: British Biotech Pharmaceuticals LimitedInventors: Alan H. Davidson, Jonathan P. Dickens, Michael J. Crimmin
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Patent number: 5453438Abstract: Compounds of general formula I: ##STR1## are presented that have collagenase inhibition activity and are useful in the management of disease involving the tissue degradation and the promotion of would healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumor invasion.Type: GrantFiled: January 16, 1992Date of Patent: September 26, 1995Assignee: British Biotech Pharmaceuticals LimitedInventors: Colin Campion, Alan H. Davidson, Jonathan P. Dickens, Michael J. Crimmin
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Patent number: 5428168Abstract: The invention encompasses compounds of general formula I: ##STR1## wherein W represents an imidazo[4,5-c]pyridyl group, optionally substituted with one or more substituents selected from C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, CF, and CN; and Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 are variables. These compounds are useful as antagonists of platelet activating factor.Type: GrantFiled: October 23, 1992Date of Patent: June 27, 1995Assignee: British Biotech Pharmaceuticals LimitedInventors: Mark Whittaker, Alan H. Davidson, Zoe M. Spavold, Stephen A. Bowles
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Patent number: 5412145Abstract: Compounds of general formula I: ##STR1## Wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are variables. These compounds have collagenase inhibition activity and are useful in the management of disease involving collagen degradation. Its uses include rheumatoide arthritis, corneal ulceration, osteoporosis, periodontitis, gingivitis and tumor invasion.Type: GrantFiled: December 23, 1993Date of Patent: May 2, 1995Assignee: British Bio-Technology LimitedInventors: M. J. Crimmin, A. H. Davidson, R. P. Beckett
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Patent number: 5314880Abstract: Compounds of general formula I: ##STR1## wherein: each of R.sup.1 -R.sup.8, k, and V represent disclosed functional groups that have been chosen such that all disclosed variations of compound I and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or disorders mediated by PAF.Type: GrantFiled: September 30, 1991Date of Patent: May 24, 1994Assignee: British Bio-technology LimitedInventors: Mark Whittaker, Christopher D. Floyd, Jonathan P. Dickens, Alan H. Davidson
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Patent number: 5310763Abstract: Compounds of general formula I: ##STR1## wherein: R.sup.1 represents a C.sub.1 -C.sub.6 alkyl, phenyl, thiophenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.6)alkyl, heterocyclyl, (C.sub.1 -C.sub.6)alkylcarbonyl phenacyl or substituted phenacyl group; or, when n=O, R.sup.1 represents SR.sup.x, wherein R.sup.x represents a group: ##STR2## R.sup.2 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl(C.sub.1 -C.sub.6)alkyl, cycloalkyl(C.sub.1 -C.sub.6)alkyl or cycloalkenyl(C.sub.1 -C.sub.6)alkyl group;R.sup.3 represents an amino acid residue with R or S stereochemistry or a C.sub.1 -C.sub.6 alkyl, benzyl, (C.sub.1 -C.sub.6 alkoxy)benzyl or benzyloxy(C.sub.1 -C.sub.6 alkyl) group;R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group;R.sup.5 represents a hydrogen atom or a methyl group;n is an integer having the value 0, 1 or 2; andA represents a C.sub.1 -C.sub.6 hydrocarbon chain, optionaly substituted with one or more C.sub.1 -C.sub.Type: GrantFiled: April 14, 1993Date of Patent: May 10, 1994Assignee: British Bio-technology LimitedInventors: Colin Campion, Alan H. Davidson, Jonathan P. Dickens, Michael J. Crimmin
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Patent number: 5308864Abstract: Compounds of either of general formulae (I) and (II), wherein: R.sup.1 represents a C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl(C.sub.1-8)alkyl, C.sub.2-8 alkenyl, or C.sub.1-6 alkyl substituted phenyl group; R.sup.2 represents a C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl group or a C.sub.1-5 alkyl, C.sub.2-5 alkenyl or C.sub.2-5 alkynyl group substituted with a substituted phenyl group; R.sup.3 represents a hydrogen atom or a substituent R.sup.4 or M; R.sup.4 represents a C.sub.1-5 alkyl group, or C.sub.1-5 alkyl group substituted with a group chosen from substituted phenyl, dimethylamino and acetylamino; R.sup.5 represents a hydrogen atom or a methyl or ethyl group except that when R.sup.2 is methyl then R.sup.5 is not methyl; M represents a cation capable of forming a pharmaceutically acceptable salt; Q represents C.dbd.Type: GrantFiled: October 15, 1991Date of Patent: May 3, 1994Assignee: British Bio-Technology LimitedInventors: Christopher N. Lewis, Alan H. Davidson, Christopher D. Floyd, Jonathan P. Dickens
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Patent number: 5304604Abstract: Compounds of general formula I: ##STR1## wherein: R.sup.1 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl, phenyl(C.sub.1 -C.sub.6)alkyl, C.sub.1 -C.sub.6 alkylthiomethyl, phenylthiomethyl, substituted phenylthiomethyl, phenyl(C.sub.1 -C.sub.6)alkylthiomethyl or heterocyclylthiomethyl group; or R.sup.1 represents --SR.sup.x wherein R.sup.x represents a group ##STR2## R.sup.2 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl(C.sub.1 -C.sub.6)alkyl, cycloalkyl(C.sub.1 -C.sub.6)alkyl, or cycloalkenyl(C.sub.1 -C.sub.6)alkyl;R.sup.3 represents an amino acid residue with R or S stereochemistry or a C.sub.1 -C.sub.6 alkyl, benzyl, (C.sub.1 -C.sub.6)alkoxybenzyl or benzyloxy(C.sub.1 -C.sub.6)alkyl group;R.sup.4 represents a hydrogen atom or a methyl group;n is an integer from 1 to 6; andA represents the group --NH.sub.Type: GrantFiled: April 15, 1991Date of Patent: April 19, 1994Assignee: British Bio-technology LimitedInventors: Alan H. Davidson, Jonathan P. Dickens, Michael J. Crimmin
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Patent number: 5300524Abstract: Compounds of general formula I; ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are variables.These compounds are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or disorders mediated by PAF.Type: GrantFiled: September 16, 1991Date of Patent: April 5, 1994Assignee: British Bio-Technology LimitedInventors: Alan H. Davidson, Mark Whittaker, Zoe M. Spavold
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Patent number: 5300674Abstract: Compounds of general formula I: ##STR1## Wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are variables.These compounds have collagenase inhibition activity and are useful in the management of disease involving collagen degradation. Its uses include rheumatoide arthritis, corneal ulceration, osteoporosis, periodontitis, gingivitis and tumour invasion.Type: GrantFiled: September 16, 1991Date of Patent: April 5, 1994Assignee: British Bio-Technology LimitedInventors: M. J. Crimmin, A. H. Davidson, R. P. Beckett
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Patent number: 5279540Abstract: A method for reducing the risk of atherosclerosis in a patient at risk of same comprising the steps of removing cholesterol ester transfer protein from blood of the patient to reduce the plasma CETP levels in the patient. In an embodiment, the method includes the step of passing the patient's plasma through an apheresis machine to remove at least some of the plasma cholesterol ester transfer protein.Type: GrantFiled: September 24, 1992Date of Patent: January 18, 1994Inventor: Michael H. Davidson
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Patent number: 5240958Abstract: Compounds of general formula I: ##STR1## wherein: R.sup.1 represents a C.sub.1 -C.sub.6 alkyl, phenyl, thiophenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.6)alkyl, heterocyclyl, (C.sub.1 -C.sub.6)alkylcarbonyl phenacyl or substituted phenacyl group; or, when n=O, R.sup.1 represents SR.sup.x, wherein R.sup.x represents a group: ##STR2## R.sup.2 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl (C.sub.1 -C.sub.6) alkyl, cycloalkyl(C.sub.1 -C.sub.6)alkyl or cycloalkenyl(C.sub.1 -C.sub.6)alkyl group;R.sup.3 represents an amino acid residue with R or S stereochemistry or a C.sub.1 -C.sub.6 alkyl, benzyl, (C.sub.1 -C.sub.6 alkoxy)benzyl or benzyloxy(C.sub.1 -C.sub.6 alkyl) group;R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group;R.sup.5 represents a hydrogen atom or a methyl group;n is an integer having the value 0, 1 or 2; andA represents a C.sub.1 -C.sub.6 hydrocarbon chain, optionaly substituted with one or more C.sub.1 -C.sub.Type: GrantFiled: July 8, 1991Date of Patent: August 31, 1993Assignee: British Bio-Technology LimitedInventors: Colin Campion, Alan H. Davidson, Jonathan P. Dickens, Michael J. Crimmin
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Patent number: 5210228Abstract: Compounds of either of general formulae I and II: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, a, b, c, and d are variables.These compounds are useful in the treatment of hypercholesterolaemia in general and arteriosclerosis, familial hypercholesterolaemia or hyperlipidaemia in particular.Type: GrantFiled: September 16, 1991Date of Patent: May 11, 1993Assignee: British Bio-Technology LimitedInventors: Richard S. Todd, Christopher N. Lewis, Alan H. Davidson, Alan H. Drummond
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Patent number: 5104614Abstract: Superalloy with a nickel base matrix having good mechanical properties when ot in respect of tensile strength, creep resistance, low cycle fatigue and resistance to crack-propagation of which the composition in percentages by weight is as follows: Cr 11 to 13; Co 8 to 17; Mo 6 to 8; Nb less than or equal to 1.5; Ti 4 to 5; Al 4 to 5; Hf less than or equal to 1; C, B, Zr each less than or equal to 500 ppm; Ni remainder to 100. The alloy can be manufactured advantageously by powder metallurgy techniques and used in the manufacture of turbo machine disks.Type: GrantFiled: June 3, 1986Date of Patent: April 14, 1992Assignees: Societe Nationale d'Etude et de Construction de Moteurs d'Aviation "S.N.E.C.M.A.", Association pour la Recherche et le Developpement des Methodes et Processus Industriels - "A.R.M.I.N.E.S.", Tecphy, Office National d'Etudes et de Recherches Aerospatiales - "O.N.E.R.A."Inventors: Christian A. B. Ducrocq, Didier P. A. Lestrat, Bernard Paintendre, James H. Davidson, Michel Marty, Andre Walder
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Patent number: 5092184Abstract: A pipetting system is provided which includes 1) a microtiter plate, 2) a multichannel pipette, and 3) a rack for recieving the microtiter plate and the multichannel pipette. The rack includes multiple rows corresponding to the rows of the microtiter plate. The rack and the multichannel pipette are constructed so that for each row, the pipette can be inserted in the rack in only one left/right orientation. In this way, errors due to misorientations of the pipette with the wells of the microtiter plate are eliminated. Methods for staining cells for flow cytometry using the pipetting system are also disclosed.Type: GrantFiled: December 22, 1989Date of Patent: March 3, 1992Assignee: Medical Research Institute of The Mary Imogene Bassett HospitalInventors: Estelle M. Goodell, Roger H. Davidson, Jr.
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Patent number: 4777139Abstract: Red cells are exposed to an unsaturated aldehyde such as acrolein (propenal) under conditions sufficient to increase the stability of the cells without impairing the ability of a lysing reagent to lyse the cells. After treatment, the treated cells are washed and are suspended in a stabilizing suspension medium.Type: GrantFiled: June 25, 1987Date of Patent: October 11, 1988Assignee: Fisher Scientific CompanyInventors: Show-Chu Wong, Harbans S. Deol, Debra L. Harz, Jill H. Davidson
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Patent number: 4764161Abstract: An apparatus for folding large sheets of thermoplastic film in a U-shaped fold comprising a trapezoidal former or frame which tapers from a relatively wide width to a substantially narrower width about one-half the width of the relatively wide width and which extends downwardly across a flat plane about the width of the narrower width, a tucker bar or V-shaped member mounted on the trapezoidal former for receiving and inwardly folding the edges of the film to be folded, and a top plane mounted on the trapezoidal former just above and substantially parallel to the tucker bar for receiving and guiding the unfolded portion of the plastic film thereover. Means for receiving the sheet of plastic film and guiding the film over the trapezoidal former and a means for receiving the plastic film after it has been folded are also provided. Adjustment means are further provided for raising and lowering the tucker bar.Type: GrantFiled: December 2, 1983Date of Patent: August 16, 1988Assignee: Ethyl CorporationInventors: James H. Davidson, deceased, John F. Pollock