Abstract: An apparatus for preventing physical intrusion on a data bus includes a data bus state sensor coupled to the data bus for monitoring a state of the data bus, a power circuit for generating multiple voltages supplied to functional circuitry in the apparatus, and a variable override circuit. The variable override circuit receives one or more voltages from the power circuit and selectively gates the voltages onto the data bus as a function of one or more control signals. A controller coupled to the variable override circuit, the power circuit and the state sensor receives state information from the state sensor and generates the control signals in response to detection of physical intrusion on the data bus. The controller controls a voltage level of at least one of the voltages generated by the power circuit for overriding the data bus when physical intrusion is detected on the data bus.

Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.

Abstract: A circuit breaker for an electric load includes first and second terminals; a number of first separable contacts each electrically connected between one of the first terminals and one of the second terminals; a first mechanism to open, close or trip open the first contacts; a number of second separable contacts each electrically connected in series with a corresponding one of the first contacts; a second mechanism to open or close the second contacts; a processor to cause the second mechanism to open or close the second contacts, annunciate through one of the second terminals a power circuit electrical parameter for the electric load, receive from a number of the second terminals a confirmation from or on behalf of the electric load to cause the second mechanism to close the second contacts, and determine a fault state operatively associated with current flowing through the second contacts.

Abstract: Enteral tubes, tube tip detection systems, and methods for detecting tube misplacement are provided. For example, a tube tip detection system comprises an enteral tube having a tip and a first light disposed at the tip that is illuminated as the enteral tube is inserted into a patient to indicate to a user of the system whether the tip is misplaced in the patient's airway. Similarly, enteral tubes are provided that comprise a tip, a length, and a light that is continuously illuminated as the enteral tube is inserted into a patient. Methods for detecting a tube misplacement in a patient's airway include embedding a light into an enteral tube, inserting the enteral tube into the patient through the patient's nose or mouth, and monitoring a location of the light as the enteral tube is inserted into the patient to determine if the tube is traveling into the patient's airway.

Abstract: A vehicle controller programming system is provided for enabling a user to program a vehicle controller for a vehicle that is being retrofitted with the vehicle controller. The system comprises a data storage unit for storing a database of a plurality of configurators and a corresponding database of a plurality of vehicle product portfolios. Each configurator and its corresponding portfolio are associated with a specific vehicle specification. The system also comprises a user interface unit for (i) receiving a set of vehicle characteristics that is associated with the vehicle, (ii) selecting one of the configurators and its corresponding portfolio based upon the set of vehicle characteristics, and (iii) creating a job based upon the selected configurator and its corresponding portfolio to enable a user to execute the job to program the vehicle controller.

Abstract: A calibration monitoring system is provided to automatically monitor the calibration status of tools and other inventory items, such as upon the items being issued from or returned to the automated calibration monitoring system. The system identifies an inventory item, for example a calibrated torque wrench or other calibrated tool identified based on a unique identifying tag attached thereto. The system retrieves a calibration parameter value for the item from a calibration database, and completes a calibration measurement of the item based on the calibration parameter value. In the example, a torque measurement of the calibrated torque wrench can thus be automatically completed. In turn, the system determines a current calibration status of the item based on the calibration measurement, and selectively enables or disables issuance of the inventory item from the system according to the item's status as being in calibration or out of calibration.

Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

Abstract: An inventory control system is described that includes a tool storage device including a drawer or a tray providing a pallet, wherein the pallet includes storage locations for objects; a sensing device configured to form an image of the storage locations; and a data processor configured to determine presence or absence of the pallet and presence or absence of objects within the storage locations of the pallet using the information from the image.

Abstract: The present application describes an automated inventory control system that comprises a storage device, a sensing system, a data storage, and one or more processors. The storage device includes a plurality of storage locations for storing objects. The sensing system is configured to associate the storage device with a first location and with a second location. The data storage is configured to store configurable data of the storage device. The one or more processors are configured to send configurable data corresponding to the first location to the storage device in response to receiving information associating the storage device with the first location from the sensing system. In response to receiving information associating the storage device with the second location from the sensing system, the one or more processors are configured to send configurable data corresponding to the second location to the storage device.

Abstract: A circuit breaker for an electric load includes first and second terminals; a number of first separable contacts each electrically connected between one of the first terminals and one of the second terminals; a first mechanism to open, close or trip open the first contacts; a number of second separable contacts each electrically connected in series with a corresponding one of the first contacts; a second mechanism to open or close the second contacts; a processor to cause the second mechanism to open or close the second contacts, annunciate through one of the second terminals a power circuit electrical parameter for the electric load, receive from a number of the second terminals a confirmation from or on behalf of the electric load to cause the second mechanism to close the second contacts, and determine a fault state operatively associated with current flowing through the second contacts.

Abstract: An apparatus for preventing physical intrusion on a data bus includes a data bus state sensor coupled to the data bus for monitoring a state of the data bus, a power circuit for generating multiple voltages supplied to functional circuitry in the apparatus, and a variable override circuit. The variable override circuit receives one or more voltages from the power circuit and selectively gates the voltages onto the data bus as a function of one or more control signals. A controller coupled to the variable override circuit, the power circuit and the state sensor receives state information from the state sensor and generates the control signals in response to detection of physical intrusion on the data bus. The controller controls a voltage level of at least one of the voltages generated by the power circuit for overriding the data bus when physical intrusion is detected on the data bus.

Abstract: Layers of siloxane tackifying resins that do not contain siloxane fluids, gums or polymers act as adhesion promotion agents. Articles include a substrate layer, a non-tacky siloxane tackifying resin adhesion promotion layer disposed on the surface of the substrate layer, and a crosslinked siloxane layer in contact with the adhesion promotion layer. The crosslinked siloxane layer is not an adhesive layer. The adhesion of the crosslinked siloxane layer to the substrate is greater than the adhesion without the non-tacky siloxane tackifying adhesion promotion layer.

Abstract: A calibration monitoring system is provided to automatically monitor the calibration status of tools and other inventory items, such as upon the items being issued from or returned to the automated calibration monitoring system. The system identifies an inventory item, for example a calibrated torque wrench or other calibrated tool identified based on a unique identifying tag attached thereto. The system retrieves a calibration parameter value for the item from a calibration database, and completes a calibration measurement of the item based on the calibration parameter value. In the example, a torque measurement of the calibrated torque wrench can thus be automatically completed. In turn, the system determines a current calibration status of the item based on the calibration measurement, and selectively enables or disables issuance of the inventory item from the system according to the item's status as being in calibration or out of calibration.

Abstract: Polymeric tubing containing extractable component(s) for use in medical articles include a tube and a vapor-deposited coating of a barrier polymer covering at least a portion of the tube. The barrier polymer is derived from at least one ethylenically unsaturated monomer. The vapor-deposited polymer coating reduces the extraction of extractable component(s) from the tube. The barrier polymer is parylene or a copolymer of parylene. The polymer coated tubing can be used in stethoscopes.

Abstract: Medical diagnostic devices or components thereof are described that comprise a microstructured surface that comprises peak structures and adjacent valleys wherein the valleys have a maximum width ranging from 1 to 1000 microns and the peak structures. In some embodiments (e.g. for improved cleanability) the peak structures of the microstructured surface have a side wall angle of greater than 10 degrees. The peak structures may comprise two or more facets such as in the case of a linear array of prisms or an array of cube-comers elements. The microstructured surface of the medical diagnostic device typically comes in contact with multiple patients during normal use of the device, such as a stethoscope diaphragm. The microstructured surface exhibits better microorganism (e.g. bacteria) removal when cleaned and/or provides a reduction in microbial touch transfer. Also described are methods of making and methods of use.

Abstract: The present application describes an automated inventory control system that comprises a storage device, a sensing system, a data storage, and one or more processors. The storage device includes a plurality of storage locations for storing objects. The sensing system is configured to associate the storage device with a first location and with a second location. The data storage is configured to store configurable data of the storage device. The one or more processors are configured to send configurable data corresponding to the first location to the storage device in response to receiving information associating the storage device with the first location from the sensing system. In response to receiving information associating the storage device with the second location from the sensing system, the one or more processors are configured to send configurable data corresponding to the second location to the storage device.

Abstract: An inventory control system comprises an object storage device, a display device, and one or more processors. The object storage device includes a plurality of compartments, in which each compartment has a plurality of storage locations for storing objects. The display device is configured to display information about the object storage device. The one or more processors are configured to establish a description database of objects configured for storage in the inventory control system. The one or more processors retrieve object keywords corresponding to objects stored in the plurality of storage locations of one of the plurality of compartments. The one or more processors also generate a text block based on the retrieved object keywords. On the display device, the one or more processors display a representation of the plurality of compartments of the object storage device with the text block applied to the one of the plurality of compartments.

Abstract: Passive cooling article (120) includes a plurality of first elements (122) defining a high absorbance in the atmospheric window wavelength range and defining high average reflectance in the solar wavelength range and a plurality of second elements (124) defining a low absorbance in the atmospheric window wavelength range and defining high average reflectance in the solar wavelength range, wherein the plurality of first (122) and second (124) elements are interspersed to form a major structure having a first major surface (130) comprising the first element outer surfaces (126) and the second element outer surfaces (128), wherein the first element outer surfaces (126) face a first direction toward a first end region (136) of the major structure (130) and the second element outer surfaces (128) face a second direction toward a second end region (136) of the major structure. The article (120) may be applied to a substrate (104), for example, on a generally vertical surface of a vehicle or stationary structure.

Abstract: A brush seal is provided that includes a top plate, a back plate, and a bristle pack. The bristle pack is secured at a joint between the top plate and the back plate. The bristle pack includes a first bristle set extending from the joint, a second bristle set extending from the joint, and a sliding backing plate. The sliding backing plate includes a sliding portion and a support portion. The sliding portion is disposed contiguous with the second bristle set. The support portion has an inner face and a support face. The inner face is in contact with a distal end of the second bristle set. The support face is configured to support at least a portion of the first bristle set. The sliding backing plate is configured to slide relative to the second bristle set.

Abstract: Methods and devices are configured for neurointerventional procedures. The methods and devices enable safe and rapid access to the cerebral or intracranial arteries for the introduction of interventional devices such as to treat stroke and/or other disease conditions. The methods and devices include a vascular access and retrograde flow system that can be used safely and rapidly in the neurointerventional procedures.