Abstract: A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.

Abstract: A digital microphone array is configured in an open geometry such as a sphere with a large number of inexpensive microphone elements mounted in opposite-facing pairs. The microphone array with DSP is intended to be placed in a three-dimensional sound field, such as a concert hall or film location, and to completely isolate all sound sources from each other while maintaining their placement in a coherent sound field including reverberance.

Abstract: A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.

Abstract: A microfluidic circuit cartridge for a complete blood count, including analyses of red blood cells. Various parameters of the red blood cells may be attained. The cartridge may have sphering mechanism which has a channel or loop with a configuration for reducing or eliminating cell settling. The channel or loop may incorporate a combination of straight and curve paths in the context of gravity. The channel may alternatively have a hydrophilic or hydrophobic inside surface. Again alternatively, the channel may have an electro-wettable inside surface. Or, the channel may be subject to an electric or magnetic field. There may also be a mechanism for reducing or eliminating clumping of a sample.

Abstract: A cavity ring-down spectroscope includes a ring-down cavity. A trigger detector is optically coupled within the ring-down cavity to generate a signal to indicate a desired radiation level in the ring-down cavity. A controller is coupled to the trigger detector to control light provided to the ring-down cavity. A ring-down time may then be measured.

Abstract: An optical element for conveying scattered and image light to several detectors. The optical element may have the properties of a diffractive beam splitter and imaging lens. The detected light may be from an illuminated target. Further, there may be an optical element for conveying scattered light from a target via several zones to specific detectors, respectively. The latter optical element may include a multiple annular zone diffractive structure on a hybrid lens.

Abstract: A smoke detector having a closed internal optical path can detect airborne particulate matter, such as smoke from a fire, via a light scattering sensor and/or a light absorption sensor. The path can be implemented with a plurality of reflectors, such as piezoelectric minors. Input light can be coupled to the path, on a pulsed basis, for example via one of the minors, in a resonant condition.

Abstract: A cytometer having two or more chambers or regions in a containment structure of sheathing fluid that may be used to provide hydrodynamic focusing of another fluid having particles to be observed. The latter fluid may be a core stream which may have its lateral position in a flow or measurement channel affected by control of at least one of the parameters of the several segments of the sheathing fluid. The lateral position of the core stream may be aligned with a light source and detector for a count and observation of the particles. Electrical signals from the detector may be fed back to a processor which may control one or more parameters of the sheathing fluid in the various chambers or regions via pumps, valves, and flow and pressure sensors. This control of parameters may provide for the positioning of the core stream. This cytometer may be miniaturized.

Abstract: A system for determining particle parameters. The system may, for example, may optically determine parameters common to a hematology analysis. Such parameters may include a red blood cell count, a platelet count, a mean cell volume and a red cell distribution width. A hematocrit parameter may be calculated. Also, a measurement of hemoglobin in a blood sample may be obtained leading to a calculation of a mean mass of hemoglobin in a red blood cell and a mean cell hemoglobin concentration. The system may be implemented in a portable cartridge type cytometer.

Abstract: A system includes a plurality of optical resonators, a light source, an optical fiber that couples the plurality of optical resonators to the light source, and a detector that is coupled to the plurality of optical resonators. The detector is configured to detect an energy in the plurality of optical resonators.

Abstract: A sample analyzer with a removable and/or disposable cartridge for use at the point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.

Abstract: A toxic gas sensor or device which is a cavity ring-down spectroscopy device having two or more mirror components. Each of the mirror components has two Brewster windows attached to it. The Brewster windows are resistant to toxic gases and together with the respective mirror form a hermetically sealed volume for the mirror surface to protect it from the environment or test gases. The Brewster windows may have a heating mechanism to remove contaminants, condensation, and provide temperature stabilization and other beneficial features.

Abstract: A first frequency of electromagnetic radiation and a second frequency of electromagnetic radiation are received at a detector. The first and second frequencies of electromagnetic radiation are transmitted through a medium within a frequency range of approximately 0.1 TeraHertz to approximately 10 TeraHertz. Signals are generated that are proportional to the transmittance of the frequencies of electromagnetic radiation through the medium. A ratio of the of the signals is formed, and one or more of a relative humidity, an absolute humidity, and a water vapor concentration of the medium are calculated as a function of a temperature of the medium, the ratio, and a set of functional parameters associated with the temperature of the medium.

Abstract: A multiplexed set of light sources having outputs of light with various wavelengths which are combined into one beam. The beam may impinge a particle in a flow channel of a cytometer. The light leaving the flow channel may be sensed by a detector and the light distinguished according to wavelength.

Abstract: An optical system having a closed loop light path with a source for providing light in a direction parallel to the normal of an input to the light path. The light may be provided via a refracting mechanism to the input. The system may be a cavity ring-down sensor or some other optical device. The light path may be formed in a laser gyroscope type cavity. A light source may have a beam aligned to a spot, indicator or indicator or mark may be determined in accordance with parameters of the refracting mechanism and/or cavity. A fixture for holding the light source may be secured so that placement of the source in the fixture will automatically result in an aligned light source. Then the refracting mechanism may be inserted to further complete fabrication of the optical system.

Abstract: An invention was developed to improve the performance and survivability of units in a competitive environment. Cryptic Command, Control, and Planning, and Management increases to apparent randomness of a plan from an opponent's perspective without increasing the randomness that is apparent to friendly parties. Friendly systems each carry a keyed pseudo-random or chaotic number generating process and a known method for mapping the numbers to behavioral modifications. Since the opponent does not know the key, the sequence, or the mapping, the result from his point of view is increased randomness and degraded predictive capability. Since friendly systems know each other's key, sequence, and mapping, they can predict each other's behavior or generate compatible controls or plans. This improves coordination of friendly units while forcing the opponent to revert to reactive responses rather than maintaining predictive responses.

Abstract: A spectrometer system for providing information about a target with terahertz radiation. The system may receive incident radiation from the target through fore optics, a slit aperture, secondary optics and a dispersive element which images a slit on an array of terahertz sensitive detectors. The detectors may include uncooled sensors. Each sensor may be connected to its own micro antenna. The array of detectors may be situated proximate to the dispersive element so that radiation from the element may be dispersed according to wavelength to the respective detectors optimally sensitive to the various respective wavelengths. Detector signals indicating the impingement of terahertz radiation may provide information for identifying a material of the target.

Abstract: The invention relates to a method of amplifying one or more nucleic acid templates on a solid support in a nucleic acid amplification reaction, for example by solid-phase PCR using one or more amplification primers attached to the solid support. The method is characterised in that the amplification primers used comprise a template-specific portion which is a sequence of at least 26 consecutive nucleotides and are not capable of annealing to target regions in the template under conditions of the amplification reaction. The method is particularly useful for amplifying human genomic DNA.

Abstract: A first frequency of electromagnetic radiation and a second frequency of electromagnetic radiation are received at a detector. The first and second frequencies of electromagnetic radiation are transmitted through a medium within a frequency range of approximately 0.1 TeraHertz to approximately 10 TeraHertz. Signals are generated that are proportional to the transmittance of the frequencies of electromagnetic radiation through the medium. A ratio of the of the signals is formed, and one or more of a relative humidity, an absolute humidity, and a water vapor concentration of the medium are calculated as a function of a temperature of the medium, the ratio, and a set of functional parameters associated with the temperature of the medium.

Abstract: A radiation sensor that can operate in the THz regime comprising: a micro antenna, which may comprise a two-dimensional patterned thin-film metallizations on a thin dielectric pellicle fabricated by micro machining of a silicon wafer; a thermally isolated microstructure; a coupling mechanism for coupling the energy from the micro antenna to the microstructure, the coupling mechanism providing high thermal isolation between the micro antenna and the microstructure; a temperature signal detector on the microstructure; and signal processing electronics for receiving the temperature signal and processing it into useful data.