Abstract: A shop interface is presented to users in conjunction with presentation of views of an online game, wherein the shop interface is configured to facilitate presentations to users of offers to sell virtual items usable within the game in exchange for consideration. In response to detecting that the online game is systematically unavailable to users, an alternative virtual shop interface is presented to users that is accessed over the Internet separately from the online game, and offers to sell the virtual times usable within the game are presented to users in exchange for less consideration than the offers to sell the virtual items through the shop interface presented in conjunction with the online game.

Abstract: A game provided to users of a game space may include a task to be performed by the users. A plurality of virtual chance items may be composed. Individual ones of the virtual chance items may be configured to be activated by the users in the game space to obtain virtual awards in the game space. The virtual awards may include one or more primary awards and one or more secondary awards. Composing the virtual chance items may include determining probabilities that the individual virtual chance items will provide a primary award and/or a secondary award upon activation. The virtual chance items may be distributed to the users that complete the task responsive to these users completing the task. The virtual awards may be provided to the users in accordance with the probabilities assigned to the virtual chance items in response to the users activating the virtual chance items.

Abstract: An approach to facilitate providing an event space associated with a primary virtual space is provided. An event space is provided to users of a primary virtual space, wherein the event space comprises one or more event objectives. Users of the primary virtual space having primary user accounts have associated event space accounts indicating event user parameters, event game parameters, and event inventory information for the first user. The user may be provided with event virtual items for purchase wherein the event virtual items are used in the event space during the event period. In response to a determination of the progress of the user associated with one or more event objectives an event award is determined for distribution to the user, wherein the event award may be used within the primary virtual space.

Abstract: An approach to facilitating pricing of virtual containers is provided. Item prices associated with obtaining item instances of virtual items in a game space may be determined. Probabilities that container instances of virtual containers will provide individual ones of the item instances of the virtual items upon activation by users in the game space may be determined. Container prices to be associated with obtaining the container instances of the virtual containers may be determined based on the determined item prices and/or the determined probabilities. A store interface may present offers to the users to purchase the container instances of the virtual containers at the determined container prices.

Abstract: A shop interface is presented to users in conjunction with presentation of views of an online game, wherein the shop interface is configured to facilitate presentations to users of offers to sell virtual items usable within the game in exchange for consideration. In response to detecting that the online game is systematically unavailable to users, an alternative virtual shop interface is presented to users that is accessed over the Internet separately from the online game, and offers to sell the virtual times usable within the game are presented to users in exchange for less consideration than the offers to sell the virtual items through the shop interface presented in conjunction with the online game.

Abstract: Provided is method of treating a collection of resin beads (a) comprising the steps of (a) providing the collection of resin beads (a), wherein the resin beads (a) comprise one or more vinyl polymers having quaternary ammonium groups; wherein 90 mole % or more of the quaternary ammonium groups are each associated with a chloride anion; (b) bringing the collection of resin beads (a) into contact with an aqueous solution (b) comprising one or more dissolved (M)nXq to form a mixture (b), (c) separating water and compounds dissolved in the water from the mixture (b), to form resin beads (c) and waste solution (bw); (d) bringing resin beads (c) into contact with an aqueous solution (c) comprising dissolved (M3)(OH)p, to form a mixture (d).

Abstract: An approach to facilitating event-based currency is provided. A first virtual currency usable by users of a game space to purchase in-space benefits may be managed. An event in the game space that is conducted during an event time period may be managed such that, during the event time period, an event virtual currency may be distributed to one or more of the users as a reward for certain operations and/or achievements performed in the game space during the event time period. Exchanges of in-space benefits associated with the event virtual currency may be effectuated for one or more of the users. In some implementations, the event virtual currency may not available to the users after the event time period, while the first virtual currency may be available to the users during and after the event time period.

Abstract: Provided is a collection of polymeric beads, wherein the beads comprise (i) 75 to 99% by weight, based on the weight of the bead, polymerized units of monofunctional vinyl monomer, and (ii) 1 to 25% by weight, based on the weight of the bead, polymerized units of multifunctional vinyl monomer; wherein, within each bead, the average concentration of moles of polymerized units of multifunctional vinyl monomer per cubic micrometer is MVAV; wherein, within each bead, T1000 is a sequence of 1,000 unique connected polymerized monomer units; wherein, within each T1000, MVSEQ is the weight percent polymerized units of multifunctional vinyl monomer, based on the weight of T1000; wherein MVRATIO=MVSEQ/MVAV; and wherein 90% or more of the beads by volume are uniform beads, wherein a uniform bead is a bead in which 90% or more of all T1000 sequences has MVRATIO of 1.5 or less.

Abstract: An approach to facilitating pricing of virtual containers is provided. Item prices associated with obtaining item instances of virtual items in a game space may be determined. Probabilities that container instances of virtual containers will provide individual ones of the item instances of the virtual items upon activation by users in the game space may be determined. Container prices to be associated with obtaining the container instances of the virtual containers may be determined based on the determined item prices and/or the determined probabilities. A store interface may present offers to the users to purchase the container instances of the virtual containers at the determined container prices.

Abstract: An approach to facilitating event-based currency is provided. A first virtual currency usable by users of a game space to purchase in-space benefits may be managed. An event in the game space that is conducted during an event time period may be managed such that, during the event time period, an event virtual currency may be distributed to one or more of the users as a reward for certain operations and/or achievements performed in the game space during the event time period. Exchanges of in-space benefits associated with the event virtual currency may be effectuated for one or more of the users. In some implementations, the event virtual currency may not available to the users after the event time period, while the first virtual currency may be available to the users during and after the event time period.

Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof and an anti-cancer composition.

Abstract: A polymeric bead having radius R wherein the polymer comprises 0.3% to 20% by weight, based on the weight of the polymer, of polymerized units of one or more multifunctional vinyl monomer and 80% to 99.7% by weight, based on the weight of the polymer, of polymerized units of one or more monofunctional vinyl monomer, (a) wherein the polymerized units of multifunctional vinyl monomer have radial distribution factor MR of 0.9 to 1.1, and (b) wherein some of the vinyl groups in the polymerized units of multivinyl monomer are unreacted, and the unreacted vinyl groups have a radial distribution factor VR of 2.5 or higher.

Abstract: Provided is a method of making droplets distributed in an aqueous medium comprising bringing into contact (i) an organic solution comprising 0.002% or more of one or more boronic acids, by weight based on the weight of the organic solution, and (ii) an aqueous solution comprising polyvinyl alcohol.

Abstract: Provided is a composition comprising droplets distributed in an aqueous medium, wherein the droplets comprise one or more boronic acids, and wherein the aqueous medium comprises polyvinyl alcohol.

Abstract: An approach to facilitate providing an event space associated with a primary virtual space is provided. An event space is provided to users of a primary virtual space, wherein the event space comprises one or more event objectives. Users of the primary virtual space having primary user accounts have associated event space accounts indicating event user parameters, event game parameters, and event inventory information for the first user. The user may be provided with event virtual items for purchase wherein the event virtual items are used in the event space during the event period. In response to a determination of the progress of the user associated with one or more event objectives an event award is determined for distribution to the user, wherein the event award may be used within the primary virtual space.

Abstract: The invention provides in certain embodiments a therapeutic regimen comprising (a) an anti-cancer combination of vemurafenib and cobimetinib, or a combination of trametinib and dabrafenib, and (b) a secondary agent comprising L-buthionine-[S,R]-sulfoximine (BSO), or phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof, and chloroquine or hydrochloroquine (HCQ) for the therapeutic treatment of a hyperproliferative disorder.

Abstract: Provided is a method of suspension polymerization comprising (I) providing a composition comprising droplets distributed in an aqueous medium, wherein the droplets comprise one or more boronic acids, one or more monomers, and one or more initiators, and wherein the aqueous medium comprises polyvinyl alcohol; wherein the one or more boronic acids are present in an amount of 0.002% or more, by weight based on the weight of the droplets, and (II) stressing the composition so that the initiator initiates polymerization of the monomer.

Abstract: Provided is a method of regenerating an acrylic resin (B2), comprising (A) providing a collection of particles of acrylic resin (B2) that has calculated Hansch parameter of ?1.0 to 2.5, wherein one or more humic acid, one or more fulvic acid, or a mixture thereof, is adsorbed onto said acrylic resin (B2), and (B) bringing said collection of particles of acrylic resin (B2) into contact with an aqueous solution (RA) having pH of 4 or lower, to form a mixture B2RA, (C) then separating acrylic resin (B3) from said mixture B2RA.

Abstract: Provided is a method of regenerating an acrylic resin (B2), comprising (A) providing a collection of particles of acrylic resin (B2) that has calculated Hansch parameter of ?1.0 to 2.5, wherein one or more humic acid, one or more fulvic acid, or a mixture thereof, is adsorbed onto said acrylic resin (B2), and (B) bringing said collection of particles of acrylic resin (B2) into contact with an aqueous solution (RB) having pH of 10 or higher, to form a mixture B2RB, (C) then separating acrylic resin (B4) from said mixture B2RB.

Abstract: An approach to facilitate providing an event space associated with a primary virtual space is provided. An event space is provided to users of a primary virtual space, wherein the event space comprises one or more event objectives. Users of the primary virtual space having primary user accounts have associated event space accounts indicating event user parameters, event game parameters, and event inventory information for the first user. The user may be provided with event virtual items for purchase wherein the event virtual items are used in the event space during the event period. In response to a determination of the progress of the user associated with one or more event objectives an event award is determined for distribution to the user, wherein the event award may be used within the primary virtual space.