Abstract: A device may receive input data associated with a legal regulation, and may process the input data to generate a record that includes: the input data in a knowledge representation format and a semantic representation format, data identifying a feature, data identifying an industry classification, or data identifying an entity of interest. The device may process the record, with machine learning models, to determine output data that includes: data indicating that the legal regulation is inconsistent, data indicating that the legal regulation is outdated, data indicating a sentiment for the legal regulation, data indicating a prescriptive nature of the legal regulation, data indicating a complexity of the legal regulation, data indicating a misrepresentation in the legal regulation, data indicating a compliance burden associated with the legal regulation, or data indicating an industry performance impact of the legal regulation. The device may perform actions based on the output data.

Abstract: An information handling system and peripheral mouse establish level four security when a preloaded security identification packet is available to securely identify both devices for the exchange of pairing information in a manner that avoids man-in-the-middle attacks. The peripheral advertises with both a BLE protocol packet that supports a conventional level 3 security pairing and a secure identification packet that supports a level four security pairing. When the secure identification packet advertisement is selected by a host, the BLE profile may be populated without performing pairing so that the profile can be used to subsequently pair without risk of a malicious device imitating the BLE interface.

Abstract: The present disclosure provides methods of inhibiting cell proliferation signaling in a cell. The present disclosure further provides compositions for inhibiting cell proliferation signaling in a cell. The methods and compounds have a range of utilities as therapeutics, diagnostics, and research tools.

Abstract: Embodiments disclosed are directed to ensuring resource compliance within a cloud-based environment. The embodiments include steps for performing both pre-provisioning and post-provisioning checks of resources, such as network protocols, prior to and after their deployment within the cloud-based environment. These steps include using bitemporal analysis to determine the impact of deploying resources within the environment through the use of multiple execution timelines where the impact of deploying a resource may be evaluated on an alternative timeline that does not change the current resource scope of the cloud-based environment. The analysis may further include tracking the impact of the resource after it has been deployed to ensure resource compliance.

Abstract: An example method for determining domain name system (DNS) forwarding rules is provided. The method includes training a machine learning model to generate recommended DNS forwarding rules and determine whether a DNS resolver is experiencing an DNS resolver issue. The method further includes receiving a DNS query at the DNS resolver which is one of a plurality of DNS resolvers forming a network of DNS resolvers. The method further includes identifying a chain of DNS resolvers of the network of DNS resolvers based at least in part on the DNS query and a DNS response to the DNS query. The method further includes analyzing the DNS query and the DNS response using the machine learning model to generate a DNS forwarding rule and to identify whether any of the DNS resolvers of the network of DNS resolvers is experiencing the DNS resolver issue.

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in dynamic non-destructive imaging. The non-destructive imaging can be nonlinear ultrasound imaging. There are provided, in some embodiments, nucleic acid compositions encoding gas vesicles (GVs) capable of producing nonlinear ultrasound contrast upon expression in a prokaryotic cell (e.g., a probiotic bacterial cell) or a eukaryotic cell (e.g., a therapeutic mammalian cell).

Abstract: A system for delivering bone cement into a bone is provided. The system can include a hydraulic system actuatable to deliver a bone cement mixture from a bone cement container, through a cannula and into a bone. The hydraulic system can have more than one pressure relief mechanism for decreasing pressure in the hydraulic system to cease delivery (e.g., substantially instantaneously) of the bone cement into the bone.

Abstract: An optical device includes a substrate and an optical transmitter, which is mounted on the substrate and includes an optical emitter, which is configured to emit a beam of optical radiation, and a transmission lens assembly, which is configured to direct the beam along a transmit axis toward a target. An optical receiver is mounted on the substrate alongside the optical transmitter and includes an optical sensor and an objective lens assembly, which is configured to focus the optical radiation that is reflected from the target along a receive axis onto the optical sensor. An optical baffle is disposed asymmetrically relative to the transmit axis and has an asymmetrical shape configured to block preferentially stray radiation emitted from the optical transmitter toward the receive axis.

Abstract: A probe assembly for a surface analysis instrument such as an atomic force microscope (AFM) that accommodates potential thermal drift effects includes a substrate defining a base of the probe assembly, a cantilever extending from the base and having a distal end, and a reflective pad disposed at or near the distal end. The reflective pad has a lateral dimension (e.g., length) between about twenty-five (25) microns, and can be less than a micron. Ideally, the reflective pad is patterned on the cantilever using photolithography. A corresponding method of manufacture of the thermally stable, drift resistant probe is also provided.

Abstract: The present disclosure provides compositions and methods for enhancing immunity (or immune response). The compositions and methods are particularly useful for potentiating immune response of a lymphoid cell. The compositions and methods are applicable for treating cancer and other diseases.

Abstract: A method of treating post-surgical edema includes a step of administering an effective amount of a pharmaceutical composition to a subject identified a risk of post-surgical edema. The pharmaceutic composition include a retinoic acid component selected from the group consisting of 9-cis retinoic acid, geometric isomers of 9-cis retinoic acid, metabolites of 9-cis retinoic acid, substituted derivatives thereof, and combinations thereof. An implantable pellet including the retinoic acid component is also provided.

Abstract: The present disclosure provides compositions and methods for enhancing immunity (or immune response). The compositions and methods are particularly useful for potentiating immune response of a lymphoid cell. The compositions and methods are also applicable for treating cancer and other diseases.

Abstract: Described herein are interactive devices that mimic a portion of a human male and a female genitalia. The male device includes a unique bead drive assembly for providing an extending and retracting motion. Also included on the male device is a massager sub-assembly able to inflate and deflate while being able to slide along a shaft of the male device. The female device includes a clamshell constrictor having an inflation mechanism that is able to provide a squeezing motion as well as being able to slide back and forth within the body of the female device. Also disclosed herein are methods of communication and interaction between a pair of interactive devices or multiple interactive devices. Finally, methods of managing interactive sessions between multiple interactive devices are also described.

Abstract: The present disclosure provides isolated polypeptide comprising an antigen binding unit directed to a cellular targete bound by an exogenous molecule. The polypeptides, cells comprising the same are useful for targeting intracellular targets or intracellular portions of a target. The compositions and methods disclosed herein have a range of utilities as therapeutics, diagnostics, research tools.

Abstract: A method of treating post-surgical edema includes a step of administering an effective amount of a pharmaceutical composition to a subject identified a risk of post-surgical edema. The pharmaceutic composition include a retinoic acid component selected from the group consisting of 9-cis retinoic acid, geometric isomers of 9-cis retinoic acid, metabolites of 9-cis retinoic acid, substituted derivatives thereof, and combinations thereof. An implantable pellet including the retinoic acid component is also provided.

Abstract: A pressure-activated membrane switch and methods of use are provided. The pressure-activated membrane switch includes an electrically-conductive membrane, and a compliant conductive material having an electrically-conductive inner surface, wherein contact between the electrically-conductive membrane and the electrically-conductive inner surface of the compliant material is configured to cause an electrical circuit, of which the switch is a part, to close. The pressure-activated membrane switch further includes a plurality of spacers dispersed between the electrically-conductive membrane and the compliant conductive material. The plurality of spacers form one or more gaps between the electrically-conductive membrane and the compliant conductive material, and, with an application of pressure against the compliant conductive material, the compliant conductive material is configured to deform between the one or more gaps to contact the electrically-conductive membrane.

Abstract: This disclosure relates to a lubricant powder composition that is made from a combination of wax, grease thickener, and additives. The lubricant powder composition exhibits low frictional, and improved mechanical stability in high temperature environments. This disclosure further relates to the use of a lubricant powder composition in a mechanical component.

Abstract: The present disclosure relates to modified release formulations of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-IH-pyrazol-1-propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts thereof, and methods of treatment with the modified release formulations.

Abstract: A converter layer bonding device, and methods of making and using the converter layer bonding device are disclosed. A converter layer bonding device as disclosed herein includes a release liner and an adhesive layer coating the release liner, the adhesive layer is solid and non-adhesive at room temperature, and is adhesive at an elevated temperature above room temperature.

Abstract: A pressure-activated membrane switch and methods of use are provided. The pressure-activated membrane switch includes a first electrically-conductive membrane, and a second electrically-conductive membrane. Contact between the first electrically-conductive membrane and the second electrically-conductive membrane is configured to cause an electrical circuit, of which the switch is a part, to close. The pressure-activated membrane switch further includes a plurality of spacers dispersed between the first electrically-conductive membrane and the second electrically-conductive membrane, and one or more columns positioned on an outer surface of the second electrically-conductive membrane.