Abstract: A semiconductor package device includes a first die having a first surface and a second surface opposite to the first surface, and a first adhesive layer disposed on the first surface of the first die. The semiconductor package device further includes an encapsulant layer encapsulating the first die and the first adhesive layer, and a first conductive via disposed in the first adhesive layer and electrically connected to the first die.

Abstract: Techniques are described for forecasting and dynamic routing of incoming routing service requests in a service environment that includes one or more call centers. Implementations apply a doubly stochastic modeling technique to modeling call volumes, call wait times, calling handling times, and/or other parameters in a service environment that includes one or more call centers that include multiple skill codes for the service representatives. By simultaneously modeling on different time scales, such as modeling both inter-day and intra-day correlations, implementations are able to provide an analysis that exploits more of the structure in the data compared to traditional techniques. Implementations can also integrate in other types of time series for other effects that may impact the call volume or other parameters in a service environment, such as exogenous and/or anomalous variables that are independent of other inter-day and/or intra-day trends exhibited in the data.

Abstract: A method for operating an energy storage device with at least one first and at least one second energy storage element in a motor vehicle, wherein the first and the second energy storage elements are connected in series to provide a nominal voltage of the energy storage device, wherein when a charging condition indicated for charging an energy storage device by a motor vehicle-independent energy source as fulfilled, the first and the second energy storage elements are connected in parallel to the motor vehicle-independent energy source, wherein a charging voltage is provided by the motor vehicle-independent energy source for charging the energy storage device, which is lower than the nominal voltage of the energy storage device with a connection in series of the first and of the second energy storage element.

Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.

Abstract: There is provided a method of making a hollow fiber. The method includes mixing, in a first solvent, a plurality of nanostructures, one or more first polymers, and a fugitive polymer which is dissociable from the nanostructures and the one or more first polymers, to form an inner-volume portion mixture. The method further includes mixing, in a second solvent, one or more second polymers to form an outer-volume portion mixture, and spinning the inner-volume portion mixture and the outer-volume portion mixture to form a precursor fiber. The method further includes heating the precursor fiber to oxidize the precursor fiber and to change a molecular-bond structure of the precursor fiber, and during heating, extracting the fugitive polymer from the inner-volume portion mixture. The method further includes obtaining the hollow fiber with the inner-volume portion having the nanostructures and the first polymers, and with the outer-volume portion having the second polymers.

Abstract: Described herein is a system, method of use and Self Retracting Lifeline (SRL) apparatus using a system that governs a dynamic response between members causing a halt in relative motion between the members. Magnetic interactions, eddy current drag forces and centrifugal and/or inertial forces may provide various mechanisms of governing movement.

Abstract: A cartridge droplet dosage device with a cartridge (1) and an actuation element (2), whereby the cartridge (1) includes a reservoir body (3), a cladding (5) and a plug (6), characterized in that a fluid groove (9) projects from the reservoir body (3) into an inner tube valve area (11), whereby the fluid groove (9) is releasable either by the yielding of a sealing rib (12) and/or by the yielding of a part of the cladding (5).

Abstract: A composite article includes a low surface energy polymer layer, a poly(meth)acrylate layer, an epoxide layer, and a hydrolytically resistant layer. The poly(meth)acrylate layer is disposed on and in direct contact with the low surface energy polymer layer and includes the reaction product of at least one acrylate that is polymerized in the presence of an organoborane initiator, such that the poly(meth)acrylate includes boron. The epoxide layer is disposed on and in direct contact with the poly(meth)acrylate layer. The hydrolytically resistant layer is disposed on and in direct contact with the epoxide and is the reaction product of an isocyanate component and an isocyanate-reactive component reacted in the presence of a curing agent. The isocyanate-reactive component includes a polydiene polyol and the curing agent crosslinks the carbon-carbon double bonds of the polydiene polyol.

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.

Abstract: Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.

Abstract: The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

Abstract: 3D modeling of an object using textural features. Disclosed is a method and a system for 3D modeling of a 3D object adapted to be inserted in or worn by a patient. The 3D modeling applies information of one or more features from an acquired 2D digital representation including textural data of the location where the 3D object is adapted to be arranged.

Abstract: An arrangement for reducing the radiation of noise from liquid-cooled transformers or chokes includes a tank having stiffeners arranged outside on the side walls of the tank, where a region situated between each stiffener is covered by a sandwich panel that is fastened to each stiffener, where each sandwich panel has a metallic wall that hermetically closes off a cavity that is filled with a composition composed of a polymer material and a filler material, where the composition has a specific weight of >2 grams per cubic centimeter.

Abstract: The invention is directed to a photovoltaic roadway assembly, to a method of assembling the photovoltaic roadway assembly, and to a method of replacing one or more photovoltaic modules in the photovoltaic roadway assembly.

Abstract: Methods and systems for transcribing a media file using a human intelligence task service and/or reinforcement learning are provided. The disclosed systems and methods provide opportunities for a segment of the input media file to be automatically re-analyzed, re-transcribed, and/or modified for re-transcription using a human intelligence task (HIT) service for verification and/or modification of the transcription results. The segment can also be reanalyzed, reconstructed, and re-transcribed using a reinforcement learning enabled transcription model.

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

Abstract: The invention relates to a gamma radiation detector that provides compensation for the parallax effect. The gamma radiation detector includes a plurality of scintillator elements, a planar optical detector array, and a pinhole collimator that includes a pinhole aperture. Each scintillator element has a gamma radiation receiving face and an opposing scintillation light output face. The gamma radiation receiving face of each scintillator element faces the pinhole aperture for generating scintillation light in response to gamma radiation received from the pinhole aperture. The scintillator elements are arranged in groups. Each group has a group axis that is aligned with the pinhole aperture and is perpendicular to the radiation receiving face of each scintillator in that group. The scintillation light output faces of each of the scintillator elements are in optical communication with the planar optical detector array.

Abstract: CeDNA vectors having linear and continuous structure can be produced in high yields and used for effective transfer and expression of a transgene. ceDNA vectors comprise an expression cassette and two different ITR sequences derived from AAV genomes in a specified order. Some ceDNA vectors provided herein further comprise cis-regulatory elements and provide high gene expression efficiencies. Further provided herein are methods and cell lines for reliable and efficient production of the linear, continuous and capsid-free DNA vectors.

Abstract: A fluid bearing for a wind turbine including a bearing housing, a plurality of bearing pads inside the bearing housing and circumferentially distributed around a longitudinal axis of the fluid bearing, a plurality of supporting structures, each supporting structure having at least a first interface detachably connected to a respective seat provided in the bearing housing and at least a second interface detachably connected to a respective bearing pad of the plurality of bearing pads, the supporting structure including an elastomer allowing tilting of the respective bearing pad parallel to the longitudinal axis, the elastomer being interposed between the respective seat and the respective bearing pad is provided.