Abstract: Systems and processes for operating a digital assistant are provided. An example process for determining a response includes, at an electronic device having one or more processors and memory, receiving a spoken input including a request, performing a semantic analysis on the spoken input, determining, based on the semantic analysis, a likelihood that the electronic device requires additional contextual data to satisfy the request, and in accordance with the determined likelihood exceeding a threshold, enabling a camera of the electronic device and determining a response to the request based on data captured by the camera of the electronic device.

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The sense strand of the dsRNA agent comprises at least one thermally destabilizing nucleotide, and at least one said thermally destabilizing nucleotide occurring at a site opposite to the seed region (positions 2-8) of the antisense strand; and the antisense strand of the dsRNA agent comprises at least two modified nucleotides that provide the nucleotide a steric bulk that is less than or equal to the steric bulk of a 2?-OMe modification, wherein said modified nucleotides are separated by 11 nucleotides in length. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.

Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.

Abstract: The present invention provides a modified RNAi agent comprising a sense strand and an antisense strand, wherein the antisense strand targets an HBV mRNA; all of the nucleotide sugars of the RNAi agent are 2?-modified; and at least one of the sense and antisense strands is conjugated to at least one targeting ligand that comprises two or more building blocks connected to a biantennary or triantennary branched linker, optionally via one or more linking groups.

Abstract: A system including one or more processors and one or more non-transitory computer-readable media storing computing instructions that, when run on the one or more processors, cause the one or more processors to perform functions including: reconfiguring a webpage as an undirected graph; identifying a cyclic dependency in the undirected graph; iterating processing one or more inferences over the cyclic dependency for each pair of the nodes of the set of the nodes; breaking one or more of edges of the undirected graph; determining, based at least in part on compatibility functions of the one or more edges remaining after breaking the one or more of the edges, a probability of the webpage having exceeded a predetermined threshold to cause a user to take an action; and sending instructions to display the webpage. Other embodiments are described.

Abstract: A method for manufacturing a rod-shaped aerosol-generating article is provided, including: arranging segments in a row along a longitudinal direction; wrapping a first sheet around at least one of the segments; and wrapping a second sheet around at least one of the segments so as to at least partially overlap the first sheet, such that upon wrapping the second sheet, an electromagnetic information marker is created, the electromagnetic information marker including a first structure provided on the first sheet and a second structure provided on the second sheet. A rod-shaped aerosol-generating article, an aerosol-generating system, and a sheet, are also provided.

Abstract: The disclosed subject matter relates to a system and method for personalizing customer experience at a retailer’s physical location in order to increase sales and customer satisfaction. The personalization is based upon classification of customer’s online interaction with the retailer. Upon detecting the customer’s presence at the retailer’s physical location, data of the customer’s online interactions is retrieved and classified based on the type of online interactions and temporal characteristics. Push content is transmitted to the customer, the push content being based upon at least the classification and data associated with retailer’s physical location.

Abstract: A method of reducing the Packet Internet Grope (PING) latency, e.g., in 5G New Radio (NR) or LTE system, is provided. When first two PING requests are received from a user equipment (UE) in uplink (UL), the UE will use Scheduling Request (SR) and Buffer Status Report (BSR) cycle to obtain UL grants for the first two PING requests. Starting from the third PING request, the size of the proactive allocation window for giving UL allocation to the PING request is uniquely configured, using a “delay timer” and a “proactive allocation window.” The delay timer is to delay the start of the proactive allocation window from the transmission time interval (TTI) in which the packet type is detected. The proactive allocation window is the number of TTIs over which the proactive allocations are given to a UE.

Abstract: A method and a system for identifying suitable participants for a proposed transaction is provided. The method includes receiving transaction-specific information that relates to a proposed transaction; determining a search term based on the transaction-specific information; retrieving, from a memory, participant-specific information that relates to at least one prospective participant with respect to the proposed transaction; applying, to the participant-specific information, a search algorithm that uses the determined search term; and using a result of the applying of the search algorithm to determine whether to offer an opportunity to participate in the proposed transaction to each of the at least one prospective participant. The search algorithm is initially applied to a first list of prospective participants, and when a number of prospective participants to which an opportunity is offered is less than a threshold number, then the search algorithm is applied to a broader list of prospective participants.

Abstract: A system and method for content selection and presentation is disclosed. A system receives a plurality of content elements configured for presentation in at least one content container and selects one of the plurality of content elements for presentation in the at least one content container. The one of the plurality of content elements is selected by a trained selection model configured to use Thompson sampling. An interface including the selected one of the plurality of content elements is generated.

Abstract: This application relates to apparatus and methods for providing recommended items to advertise. In some examples, a computing device determines a plurality of first values for a corresponding plurality of first items based on the user's engagement with each of the first items. The computing device may then determine a subset of the plurality of first items based on the first values. The computing device may receive a search request and determine a plurality of second values for a plurality of second items based on the search request. The computing device may determine a plurality of third values for the subset of items based on the plurality of second values for the plurality of second items and the user's engagement with each of the subset of items. The computing device may determine the recommended items based on the plurality of second values and the plurality of third values.

Abstract: Methods and systems are presented for providing a container orchestration framework for facilitating development and deployment of software applications across different operating environments within an enterprise system. Upon receiving a service request for processing a set of data is received, the container orchestration framework determines one or more machines that store the set of data. Instead of processing the set of data remotely, the container orchestration framework deploys a container that encapsulates an application on the one or more machines. Each application instance running on the one or more machines are executed to process a corresponding subset of data stored on the machine locally. The container orchestration framework obtains the output data from executing the applications on each of the one or more machines, and present the output data as a response to the service request.

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Abstract: A method of assembling a connector for automotive applications, comprising the steps of: providing a cable having at least one inner conductor; connecting an elongated inner signal contact of the connector to a stripped end of the at least one inner conductor; surrounding the elongated inner signal contact by an insulating element; placing a first shielding part of the connector around a first portion of the insulating element from a first radial direction; placing a second shielding part of the connector around a second portion of the insulating element from a second radial direction generally opposite to the first radial direction; and joining the first and second shielding parts to form a shielding contact of the connector surrounding the insulating element.

Abstract: The present invention relates to a chirally-modified dsRNA agent capable of inhibiting the expression of a target gene. The sense and antisense strands of chirally-modified dsRNA agent independently or in combination comprises one or more site specificsite specific/position specific, chirally-modified internucleotide linkages.

Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The sense strand of the dsRNA agent comprises at least one thermally destabilizing nucleotide, and at least one said thermally destabilizing nucleotide occurring at a site opposite to the seed region (positions 2-8) of the antisense strand; and the antisense strand of the dsRNA agent comprises at least two modified nucleotides that provide the nucleotide a steric bulk that is less than or equal to the steric bulk of a 2?-OMe modification, wherein said modified nucleotides are separated by 11 nucleotides in length. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.

Abstract: A system and computer-implemented method for authenticating digital transactions. The method includes receiving a device registration request and a device attestation response including at least a device integrity status from a device. In response to the device registration request, the method includes providing a device registration response to the device, based on validation of the device integrity status. Further, the method includes receiving a first payment transaction request and an enrolment request from the device via an application to authenticate a second payment transaction request using a first type of authentication technique. Finally, the method includes enrolling the device to the first type of authentication technique and providing a second token to the device based on a result of the first payment transaction request, wherein the second token is used for authenticating the second payment transaction request.

Abstract: Porous metal oxide microspheres are prepared via a process comprising forming a liquid dispersion of polymer nanoparticles and a metal oxide; forming liquid droplets of the dispersion; drying the droplets to provide polymer template microspheres comprising polymer nanospheres; and removing the polymer nanospheres from the template microspheres to provide the porous metal oxide microspheres. The porous microspheres exhibit saturated colors and are suitable as colorants for a variety of end-uses.