Abstract: The present disclosure provides pharmaceutical compositions of remdesivir that may be administered by inhalation. These compositions may allow the achievement of a therapeutically effective dose of remdesivir directly to the lungs. These compositions may be used to treat one or more diseases or disorders such as a viral infection like an infection of a coronavirus.

Abstract: A radiation monitoring system includes a patient support apparatus. A radiation sensor assembly is operably coupled to the patient support apparatus. The radiation sensor assembly includes a radiation sensor and a first controller. The radiation sensor senses radiation data corresponding to a radiation dose received by a patient. A management system includes a second controller that stores a patient profile database. The second controller is communicatively coupled with the first controller. The first controller communicates the radiation data to the second controller for storage in the patient profile database to monitor the radiation dose received by the patient.

Abstract: A motor spindle including a sleeve-shaped stator, which has a first coupling receptacle and a second coupling receptacle, further including a rotor, which has a first coupling part with axial fixed bearing and a second coupling part with axial loose bearing, which are to be mounted to the respective coupling receptacle, the axial loose bearing comprising an inner ring mounted to the rotor shaft and an outer ring arranged coaxially with the inner ring and mounted to the second coupling part, wherein the second coupling part is received on the rotor shaft so as to be axially movable parallel to the rotor axis between a first functional position and a second functional position along an adjustment path and wherein for the entire adjustment path there is a first distance between a first axial surface of the inner ring and the second coupling part and there is a second distance between a second axial surface of the inner ring and the second coupling part.

Abstract: An outer contact surface element of a one-way clutch is configured to contact at least one clamping body of the one-way clutch when an inner ring of the one-way clutch rotates in a first direction. The outer contact surface element includes a hollow-cylindrical section, and at least one radially outwardly projecting lug. The outer contact surface element may also include features for connecting the outer contact surface element to a support bearing.

Abstract: A radiation monitoring system includes a patient support apparatus. A radiation sensor assembly is operably coupled to the patient support apparatus. The radiation sensor assembly includes a radiation sensor and a first controller. The radiation sensor senses radiation data corresponding to a radiation dose received by a patient. A management system includes a second controller that stores a patient profile database. The second controller is communicatively coupled with the first controller. The first controller communicates the radiation data to the second controller for storage in the patient profile database to monitor the radiation dose received by the patient.

Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10). The tensioning device (S) has a ramp (52) which is rotatable by means of a motor (12) and has a ramp track (53) extending along a helical line, wherein the ramp track (53) ascends from a first plateau along a region of inclination (S1, S2) to a second plateau and descends from the second plateau to the first plateau via a transition flank (46).

Abstract: Cyclic depsipeptide-class molecules, referred to herein as persephacins (including analogs thereof), having similarities to aureobasidin A, are described. The persephacins have antimicrobial activity, such as antifungal activity against a diverse range of clinically-relevant fungal pathogens, antiprotozoan parasite activity, and antibacterial activity, and can be used for example in treatments of difficult-to-treat ocular fungal infections at lower concentrations than natamycin. The active compounds may be combined with a secondary compound in a composition.

Abstract: A system is capable of scanning the layout of a room and a method for its usage. In a typical embodiment, the system consists of a mobile device that utilizes a distance sensor(s). The mobile device and/or sensor(s) rotate and travel around a room, providing multiple distance calculations that convert to degree arrays and obstacle arrays, mapping out the layout of the room without human presence.

Abstract: An apparatus investigates a technical device using a borescope. The apparatus has: a guide tube which is introducible through a borescope opening on the technical device to be inspected using the borescope; and a repeatedly plastically deformable carrier configured to guide a borescope head arranged at one end of the carrier. The guide tube is designed to deform the carrier during the passage of the carrier through the guide tube.

Abstract: The disclosure relates to dry powder compositions of (a) a plant-based cannabidiol (pCBD) composition, or (b) a plant-based tetrahydrocannabinol composition (pTHC); or (c) a synthetic cannabidiol composition (sCBD), or (d) a synthetic tetrahydrocannabinol composition (sTHC), or (e) a plant-based cannabidiol (pCBD) composition in combination with a a plant-based tetrahydrocannabinol composition (pTHC), or (f) a synthetic cannabidiol composition (sCBD) in combination with a synthetic tetrahydrocannabinol composition (sTHC) and their delivery to the airway of a subject using a dry powder inhaler.

Abstract: A method for producing an automobile rim made of aluminum or an aluminum alloy for a wheel of an automobile, the automobile rim having a rim well delimited on opposite sides by an outer flange and an inner flange, a hub with a center recess and a bolt hole circle as well as a rim center connecting the rim well and the hub with one another. The automobile rim is produced in one piece and continuously in a casting mold by die casting of a casting material. The automobile rim is formed during the die casting with at least one air conveying element for conveying air in the axial direction with respect to a longitudinal center axis of the automobile rim relative to an imaginary plane perpendicular to the longitudinal center axis and/or at least one surface enlargement element extending in the circumferential direction along a circular line.

Abstract: A method for producing a motor car rim made of aluminum or an aluminum alloy for a wheel of a motor vehicle. The motor car rim has a rim well delimited on opposite sides by an outer flange and an inner flange, a hub with a center recess and a pitch circle diameter, as well as a rim center connecting the rim well and the hub to one another and engaging the rim well off-center in the longitudinal section. The rim center is formed with several spokes spaced apart from one another in the circumferential direction as relates to a center longitudinal axis of the motor car rim.

Abstract: A method for producing a motor vehicle rim made of aluminum or an aluminum alloy for a motor vehicle wheel. The motor vehicle rim has a rim base delimited on opposite sides by an outer horn and an inner horn, a hub with a central recess and a hole circle and a rim center connecting the rim base and the hub to one another and acting eccentrically on the rim base in longitudinal section. The motor vehicle rim is produced in one piece and continuously in a casting mold by vacuum die casting of a casting material, wherein the motor vehicle rim has a small wall thickness of at most 15 mm at least in some regions and/or a curvature with a small radius of curvature of at most 4 mm.

Abstract: An optical fiber configured to improve the pump conversion efficiency of an L-band fiber amplifier which uses the multimode pump source. By directly absorbing multimode light including 915 nm, an active fiber core region co-doped with both erbium and ytterbium can provide gain to the L-band signals via stimulated emission. The unwanted C-band amplified spontaneous emission (ASE) light generate from this active fiber core region can be absorbed by another active fiber core region doped with erbium, then provides additional gain to the L-band signals. Active regions and cladding can be configured to match a given spatial mode of the optical signal. Signal-pump combiners with end-coupling or side coupling can be used.

Abstract: Disclosed is an echosounder configured to: a) drive the transducers of its emitting antenna to emit first and second acoustic waves having first and second frequencies, these waves being superposed over one another along an axis of superposition that is directed toward a point of the bottom of the subaquatic environment, and b) acquire an echo signal, the frequency of which is equal to the difference between the first and the second frequencies, the echosounder being configured to perform steps a) and b) a plurality of times while varying the orientation of the axis of superposition, and to determine, on the basis of the acquired echo signals, an image representative of the content of the sub-bottom of the subaquatic environment beneath each of the points. Also disclosed is an associated method for characterizing a portion of the sub-bottom of a subaquatic environment.

Abstract: A method for producing an automobile rim made of aluminum or an aluminum alloy for a wheel of an automobile, the automobile rim having a rim bed bounded on opposite sides by an outer flange and an inner flange, a hub with a center recess and a bolt circle, as well as a rim center connecting the rim bed and the hub to one another, the rim center being designed with a plurality of spokes spaced apart in the circumferential direction with respect to the longitudinal center axis of the automobile rim. The automobile rim is produced in one piece and continuously in a casting mold by die casting of a casting material, wherein the automobile rim has, at least in some areas, a low wall thickness not exceeding 15 mm.

Abstract: A method for producing an automobile rim from aluminum or an aluminum alloy for a wheel of a motor vehicle. The automobile rim has a rim well delimited on opposite sides by an outer flange and an inner flange, a hub having a center recess and a bolt hole circle, and a rim center connecting the rim well and the hub to one another. The automobile rim is produced integrally and continuously in a casting mold by die casting of a casting material. After the introduction of the casting material into the casting mold, a volume of the casting mold is reduced for post-compaction of the casting material. The invention furthermore relates to a device for producing an automobile rim.

Abstract: A method for producing a motor vehicle rim made of an aluminum alloy for a wheel of a motor vehicle, the motor vehicle rim having a rim base limited on opposite sides by an outer horn and an inner horn, a hub with a central recess and a hole circle, and a rim center connecting the rim base and the hub to one another. The motor vehicle rim is produced in one piece and continuously in a casting mold by die casting of a casting material, the casting material being the aluminum alloy.

Abstract: An outer contact surface element of a one-way clutch is configured to contact at least one clamping body of the one-way clutch when an inner ring of the one-way clutch rotates in a first direction. The outer contact surface element includes a hollow-cylindrical section, and at least one radially outwardly projecting lug. The outer contact surface element may also include features for connecting the outer contact surface element to a support bearing.