Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic—cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

Abstract: Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: A coffee puck removal device (10) to remove a coffee puck (24) from a portafilter (20) is disclosed herein. The coffee puck removal device (10) has an open compartment (22) containing the coffee puck (24), the coffee puck (24) having an exposed major outer face (26) and a major inner face (28) when the coffee puck (24) is located in the open compartment (22). The device (10) includes: a body (12) having a rim (14) surrounding an aperture (16), with the rim (14) being configured to engage the portafilter (20), with the open compartment (22) facing the body (12) to inhibit air passing between the portafilter (20) and the rim (14); and a vacuum source (30) to remove air from the aperture (16) so that air pressure applied to the major inner face (28) is greater than air pressure applied to the exposed major outer face (26) so that the coffee puck (24) is removed from the portafilter (20).

Abstract: Provided herein is a process for the preparation of (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide, intermediates thereof, and salts of the foregoing.

Abstract: A suspending agent composition comprising (i) a fast hydrating guar gum and (ii) a high molecular weight polysaccharide, wherein the suspending agent composition has a rheological coupling ratio for yield point ranging from about 1 to about 2 when placed in an aqueous solution at a concentration of equal to or less than about 0.5 grams/deciliter and a ratio of about 90 weight percent (wt. %) fast hydrating guar gum and 10 wt. % high molecular weight polysaccharide. A wellbore servicing fluid comprising the suspending agent and methods of making and using the suspending agent.

Abstract: The present inventions relate to a breeding system for the production of polyploid maize seeds, maize plants, or maize plant parts where cycles of meiosis, syngamy, and selection are used for interpopulation improvement of progenitor lines, and sexual polyploidization occurs during hybrid production by inducing clonal gamete formation in the parents that are to be crossed. Reciprocal recurrent selection can be used to inform selection of candidate maize lines that are either advanced to a gene editing or genetic modification system or crossed and selected to induce clonal gamete formation by arresting meiotic recombination and chromosome reduction. Crosses of parent maize plants bearing clonal gametes are planned and executed based upon predicted heterotic performance at the polyploid level. The final product is a homogeneous population of hybrid polyploid maize seed, or derivative thereof, bearing both parents' complete nuclear genomes.

Abstract: The present invention relates, in various embodiments, to prediction of human subject states (e.g. physiological and/or psychological and/or neurological state) via a hybrid approach, which includes elements of AI-based classification and objective physiological analysis (such as blepharometric analysis). Embodiments are described by reference to applications in driver alertness monitoring. However, it will be appreciated that the technology is not limited as such, and has application in a broader range of context. For example, the technology is applicable to prediction of physiological states other than alertness level, and to implementation environments other than driver monitoring.

Abstract: A cationic-stabilized dispersion for use in fabricating an in-mold coated article including at least one of a cationic-stabilized polyurethane dispersion, a cationic-stabilized acrylic dispersion, a cationic-stabilized polyacrylamide dispersion, a cationic-stabilized polyallylamine dispersion, a cationic-stabilized polyetheramine dispersion, and a cationic-stabilized chitosan dispersion.

Abstract: An apparatus for monitoring blood oxygen saturation of a subject is provided. The apparatus includes a unit configured for wearing on the subject's upper arm, the unit comprising first and second light sources configured to emit light of first and second wavelengths and a photodetector configured to detect light of the first and second wavelengths, where the light sources are arranged to direct light into the upper arm and the photodetector is arranged to detect light reflected from within the upper arm.

Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.

Abstract: The present inventions relate to a breeding system for the production of polyploid potato seeds, plants, or plant parts where cycles of meiosis, syngamy, and selection are used for interpopulation improvement of progenitor lines, and sexual polyploidization occurs during hybrid production by inducing clonal gamete formation in the parents that are to be crossed. Reciprocal recurrent selection can be used to inform selection of candidate potato lines that are either advanced to a gene editing or genetic modification system or crossed and selected to induce clonal gamete formation by arresting meiotic recombination and chromosome reduction. Crosses of parent plants bearing clonal gametes are planned and executed based upon predicted heterotic performance at the polyploid level. The final product is a homogeneous population of hybrid polyploid potato seed, or derivative thereof, bearing both parents' complete nuclear genomes. In some instances, the method is used to generate seedless plants.

Abstract: A surgical instrument includes an end effector having a clamp arm pivotable relative to an ultrasonic blade, an articulation section configured to deflect the end effector, an acoustic waveguide having a distal portion extending along an axis, a clamp arm closure assembly comprising a body configured to actuate in order to drive the pivoting of the clamp arm, and a clamp arm clocking assembly. The clamp arm clocking assembly is capable of driving rotation of the clamp arm about the axis relative to the ultrasonic blade between a first clocked position and a second clocked position. The clamp arm clocking assembly includes a rotating body pivotally coupled with the clamp arm, a translating drive extending through the articulation section, and a rotation driver assembly. The rotation driver is in communication with the translating driver to convert translational motion of the translating driver into rotational motion of the rotating body.

Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.

Abstract: The present disclosure relates to identifying vehicles using wireless device identifiers. In accordance with aspects of the present disclosure, a system for identifying vehicles in a parking structure includes a camera configured to capture images of an area in the parking structure where the camera captures an image containing one or more vehicle(s), a detector configured to scan for wireless device identifiers in the area, and a processing system including an electronic storage. The processing system is configured to execute instructions to access the image containing the vehicle(s) in the area and access one or more wireless device identifier(s) scanned by the detector in the area, process the image containing the vehicle(s) to extract one or more license plate identifier(s) corresponding to the vehicle(s), and store in the electronic storage at least one record associating the license plate identifier(s) with the wireless device identifier(s).

Abstract: A method for operating a frost treatment system including a first heating mat, covering a first zone and an intermediate zone of a second zone, operating alternately at a first energy level adjusted to maintain a first positive temperature on the first zone and a negative temperature on at least a part of the intermediate zone and at a second energy level adjusted to generate a positive temperature on the intermediate zone, a second heating mat covering the second zone apart from the intermediate zone and ensuring the defrosting function for the zone. This solution makes it possible to reduce the energy consumption of the first heating mat by reducing the energy level at which it is powered for most of the time. Also, an outer wall of an aircraft is provided including at least one frost treatment system operating according to this method.

Abstract: In certain embodiments an optimized derivative of the CCLc-?AS3-FB lentiviral vector termed (CCLc-mGata/ANK-CoreLCR-?AS3-FB), is provided which is capable of driving lineage-restricted expression of a beta-globin gene (e.g., an anti-sickling ?-globin like gene (?A83)). In certain embodiments the vectors described herein comprise novel defined LCR HS core sequences (HS2(˜420 bp), HS3?40 bp), HS4(˜410 bp)) which can be used to replace the putative LCR HS sequences present within the “mini-LCR” (˜3.6 kb reduced to ˜1.2 kb) to produce an “optimized mini-LCR”.

Abstract: A surgical stapling instrument. Various embodiments include an actuation system for selectively generating a plurality of control motions. A surgical end effector is operably coupled to the actuation system. The actuation system interfaces with an actuation member configured to operably engage rotatable camming members to fire staples within the end effector into forming contact with an anvil portion of the end effector.

Abstract: An electrosurgical instrument comprising a housing, a shaft extending from the housing, an end effector extending from the shaft, an articulation joint rotatably connecting the end effector to the shaft, and a wiring circuit is disclosed. The housing comprises a printed control board. The wiring circuit extends from the printed control board through the shaft and into the end effector. The wiring circuit is configured to monitor a function of the end effector and communicate the monitored function to the printed control board. The wiring circuit comprises a proximal rigid portion fixed to the shaft, a distal rigid portion fixed to the end effector, and an intermediate portion extending from the proximal rigid portion to the distal rigid portion. The intermediate portion comprises a resilient portion and a stretchable portion.

Abstract: Methods and compositions for treating subterranean formations to mitigate lost circulation are provided. The methods of the present disclosure include forming a treatment fluid including one or more geopolymer lost circulation materials; introducing the treatment fluid into at least a portion of a subterranean formation that includes at least one loss zone; activating the geopolymer lost circulation materials to form a geopolymer that imparts a thixotropic property to the treatment fluid; and allowing the treatment fluid exhibiting the thixotropic property to at least partially reduce a rate of loss associated with the loss zone.