Abstract: Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes of treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. These compounds were found to have significantly longer half-life compared to taurolidine and taurultam.

Abstract: An exemplary hearing system that is configured to assist a user in hearing includes an in-the-ear (ITE) component configured to fit at least partially within an ear canal of the user while the hearing system is worn by the user, a first sensor electrode provided on a surface of the ITE component and configured to contact, while the hearing system is worn by the user, outer ear tissue of the user, and a second sensor electrode configured to be located, while the hearing system is worn by the user, at an entrance to or outside of the ear canal of the user. The first sensor electrode and the second sensor electrode may be configured to be used to detect a physiological attribute of the user while the hearing system is worn by the user. Corresponding methods and systems are also disclosed.

Abstract: Marfan Syndrome is a pathology responsible for a high morbidity and mortality. Apart from surgery, treatment options are limited. It is therefore essential to develop new pharmacological approaches to limit aortic dilatation and/or rupture. Now, the inventors have demonstrated a critical role for TREM-1 in the pathophysiology of ascending aortopathy related to Marfan disease, In particular, the inventors showed that i) TREM-1 is expressed by macrophages in the aortic wall of Marfan patients, ii) TREM-1 is expressed by macrophages in the aortic wall of Marfan mice, and iii) TREM-1 deficiency protects against aortic rupture in a mouse model of Marfan syndrome. Blocking TREM-1 could therefore be a therapeutic approach for Marfan-related aortopathy.

Abstract: The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.

Abstract: The invention relates to, inter alia, a thick matter conveying system (10) comprising a thick matter pump (16) for conveying a thick matter; a thick matter distributing mast (18) for distributing the thick matter to be conveyed, said thick matter distributing mast (18) having a rotary mechanism (19) which can be rotated about a vertical axis and a mast assembly (40) comprising at least two mast arms (41); a substructure (30) on which the thick matter distributing mast (18) and the thick matter pump (16) are arranged, said substructure (30) comprising a support structure (31) for supporting the substructure (30) by means of at least one horizontally and/or vertically movable support leg (32); a sensor unit (11) comprising a plurality of sensors (111, 112, 113, 114, 115) for detecting a respective piece of operating information, wherein the sensor unit (11) is at least designed to detect a first piece of operating information which indicates the position of the rotary mechanism (19), a second piece of operating

Abstract: A method trains a speaker recognition unit of a hearing aid of a user, wherein the hearing aid is connected to a communication device of the user, for carrying out a remote conversation between the user of the hearing aid and a conversation partner of the user. An audio signal of the conversation partner is received by the communication device for output to the user. A speaker ID is assigned to the conversation partner, wherein a number of speech samples of the conversation partner is extracted from the audio signal. The speech samples are assigned to the speaker ID and form a training data set jointly therewith. The speaker recognition unit of the hearing aid is trained using the training data set in order to recognize the conversation partner in future.

Abstract: Provided are methods for the treatment of spinal muscular atrophy (SMA) in a fetal subject in need thereof comprising administering an amount of risdiplam to a carrier of the fetal subject. Administering the amount of risdiplam to the carrier of the fetal subject results in transplacental delivery to the fetal subject, resulting in an increase in SMN protein production.

Abstract: A pump (1) comprising a stator (4) and a rotor (6) axially and rotatably movable relative to the stator, the stator (4) comprising a piston chamber (10) comprising a radial surface (30), an inlet (3) comprising an inlet mouth (28) formed in the radial surface and an outlet (5) comprising an outlet mouth (29) formed in the radial surface, the rotor (6) comprising a piston portion (13) comprising a radial surface (16), an end face (15) and a non-axisymmetric indent (14) formed between the radial surface (16) and the end face (15) of the piston portion (13), wherein the indent (14) is arranged to overlap at least partially the inlet mouth (28) over a range of angular positions of the rotor relative to the stator corresponding to a pump intake phase, and arranged to overlap at least partially the outlet mouth (29) over a range of angular positions of the rotor relative to the stator corresponding to a pump expel phase, and wherein the radial surface (16) of the piston portion (13) is configured to close the outle

Abstract: The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: The subject invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage.

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

Abstract: The invention relates to a bottle lock for a bottle, comprising a housing part designed to enclose an upper portion of the bottle neck of the bottle to be secured, including the bottle cap of the bottle to be secured, a plurality of claws arranged in the housing part, which are designed and intended to engage non-releasably with the upper portion of the bottle neck when the bottle lock is in a secured state and to allow the bottle lock to be released and removed away from the upper portion of the bottle neck in the released state of the bottle lock, and to a locking mechanism intended to assume an unlocked state in which the bottle lock can be transferred from the secured state to the released state, and a locked state in which the bottle lock cannot be transferred from the secured state to the released state.

Abstract: The present disclosure relates to a medical condensate trap for use in external blood treatment by means of a blood treatment apparatus. The condensate trap comprises an interior; a first connection for connecting the interior in fluid communication to a gas outlet of the blood treatment apparatus; a second connection for connecting the interior in fluid communication to a gas inlet of the blood treatment apparatus; and a third connection for connecting the interior to an air port of a blood treatment device. The blood treatment device may be, for example, a blood tubing set or a blood cassette.

Abstract: The disclosure relates to a method for radially aligning wheelsets of rail vehicles relative to a coordinate system of a wheelset diagnosis tool and/or wheelset machine tool, which method can be implemented quickly with sufficient precision and comprises the following steps: a) positioning the wheelset at a working position of the tool; b) defining a tool-side coordinate system in an assumed wheel centre point of each wheel, where an X-axis adopts a vertical extent, a Y-axis adopts a horizontal extent and a Z-axis describes the resulting depth extent of the wheel; c) measuring the distance of the wheel backs with respect to one another and defining the Z-position=0 on each wheel back; d) defining a unique Z-position for each measuring point; e) positioning each measuring sensor at the specified Z-position; f) measuring the X-position of each measuring point; g) aligning the wheelset by vertically displacing one of the wheels in order to match the X-positions of the measuring points of two wheels.

Abstract: A materials handling vehicle including a battery receiving space, and a removable battery assembly, wherein: the removable battery assembly includes lateral battery faces, each including a longitudinal guide structure; the battery receiving space includes opposing retention blocks, each arranged on opposite sides of the battery receiving space, and each comprising a retention lever including a fixed end and a distal end; and the longitudinal guide structure of each lateral battery face includes a lever-receiving detent that is configured to receive the distal end of one of the retention levers.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: This invention relates to a pharmaceutical aerosol product suitable for administration by oral or nasal inhalation and its use in the treatment of respiratory diseases, in particular in the treatment of children. The aerosol composition comprises ciclesonide, ethanol and either 1, 1, 1, 2-tetrafluoroethane, or 1, 1, 1, 2, 3, 3, 3-heptafluoropropane.

Abstract: A system and method for detecting and managing electronic transactions and providing a domain specific collection of remotely callable functions in a video game environment.

Abstract: A warp-knitted textile composite has a spacer fabric that extends in a production direction and a transverse direction and has an outer flat warp-knitted fabric layer of predetermined stretchability, an inner flat warp-knitted fabric layer of lesser stretchability in the production and transverse directions than the outer layer, and spacer threads interconnecting the warp-knitted fabric layers. A decorative cover layer is attached to the outer flat warp-knitted fabric layer and is formed with compressed areas where the spacer fabric is permanently at least partially compressed for structuring the decorative cover layer.

Abstract: A method for determining machine learning training parameters is disclosed. The method can include a processor receiving a first input. The processor may receive a first response to the first input, determine a first intent, and identify a first action. The processor can then determine first trainable parameter(s) and determine whether the first trainable parameter(s) is negative or positive. Further, the processor can update a training algorithm based on the first trainable parameter(s). The processor can then receive a second input and determine a second intent for the second input. The processor can also determine a second action for the second intent and transmit the second action to a user. The processor can then determine second trainable parameter(s) and determine whether the second trainable parameter(s) is positive or negative. Finally, the processor can further update the training algorithm based on the second trainable parameter(s).