Abstract: A molded article suitable for subsequent blow-molding into a final-shaped container. The article includes a neck portion; a gate portion; and a body portion extending between the neck portion and the gate portion, at least a majority of the body portion having an overall shape which is symmetric about a body axis extending longitudinally through a center of the body portion. The body portion includes an inner exterior layer and an outer exterior layer of a first polymeric material; and a core layer of a second polymeric material disposed between the inner exterior layer and the outer exterior layer. A radial thickness or a material of the core layer is selectively varied to govern non-uniform blow molding of the molded article into the final-shaped container.

Abstract: The invention relates to a cathode for an electrochemical accumulator including a current collector, an interfacing layer, the interfacing layer being coated on the current collector, and an electrode, the electrode being formed by deposition, in particular by coating, of a first composition on the interfacing layer, the first composition having a hydrogen potential greater than or equal to 10, preferably greater than or equal to 12, the hydrogen potential being measured at a temperature of 25° C.

Abstract: There is disclosed an elastomeric styrenic block copolymer (SBC) composition comprising one or more SBCs and one or more polymers miscible with styrenic end blocks of the one or more SBCs; wherein said block copolymer composition is both physically and chemically crosslinked; wherein said chemical crosslinking comprises covalent bonds between chains of SBC and; wherein said physical crosslinking comprises non-covalent interaction between styrenic end blocks of the one or more SBCs and the one or more polymers miscible with the styrenic end blocks.

Abstract: A liquid formulation of an ophthalmic drug in a pre-filled pharmaceutical package, for example a syringe, cartridge, vial or any other vessel made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. A blister, a pouch, a bag, a tray or a tub may encompass as a secondary packaging the syringe, vial, cartridge, tube or any other vessel. The package is suitable for sterilization (e.g., surface and/or terminal sterilization) with sterilization gas residuals being minimal and/or lower than required by ISO 10993-7; and/or the stability of the ophthalmic drug is maintained, during a prolonged time period following the sterilization. The sterilization gas may be EO, propylene oxide, chlorine dioxide, nitrogen dioxide, or vaporized hydrogen peroxide (VHP), among others.

Abstract: A method for encoding a LUT defined as a lattice of vertices is disclosed. At least one value is of each vertex of the lattice. The method comprises for a current vertex: predicting the at least one value of said current vertex from another value which is for example obtained from reconstructed values of neighboring vertices; and encoding in a bitstream at least one residue computed between the at least one value of the current vertex and its prediction in a bitstream.

Abstract: A system for actuating a vacuum bottle of an electrical device, the vacuum bottle comprising a fixed electrode and a moving electrode that is mobile along a longitudinal axis between a closed position and an open position. The actuating system comprises an adjusting nut that is rotatably mobile about the longitudinal axis and driven by a drive device to perform an opening movement of the moving electrode, and an adjusting screw engaging with the adjusting nut in order to vary the moment when the drive device drives the moving electrode. The moving electrode is constrained to translate along the longitudinal axis with the adjusting screw, but is free to rotate relative to the adjusting screw, and the rotation of the adjusting screw is limited by blocking means.

Abstract: A steering controller includes processing circuitry. The processing circuitry is configured to execute an operation process for calculating a torque command value corresponding to a sum of an amount by which the steering-side operation amount is converted into the torque required for the electric motor and an amount by which the steerable wheel-side operation amount is converted into the torque required for the electric motor and operate a drive circuit of the electric motor to adjust the torque of the electric motor to the torque command value.

Abstract: The present disclosure relates to computer-implemented methods, software, and systems for using augmented reality-based operations to interact with and analyze real estate property, including modifications and additions to the interior of the property. One example method includes receiving, from an augmented reality-enabled application, a request identifying at least one digital improvement associated with a particular real estate property. A set of characteristics associated with the at least one digital improvement are identified, and a response including at least a portion of the identified set of characteristics associated with the at least one digital improvement and a digital object representing the at least one digital improvement is transmitted to the augmented reality-enabled application.

Abstract: A low-cost process is provided to render lignocellulosic biomass accessible to cellulase enzymes, to produce fermentable sugars. Some variations provide a process to produce ethanol from lignocellulosic biomass (such as sugarcane bagasse or corn stover), comprising introducing a lignocellulosic biomass feedstock to a single-stage digestor; exposing the feedstock to a reaction solution comprising steam or liquid hot water within the digestor, to solubilize the hemicellulose in a liquid phase and to provide a cellulose-rich solid phase; refining the cellulose-rich solid phase, together with the liquid phase, in a mechanical refiner, thereby providing a mixture of refined cellulose-rich solids and the liquid phase; enzymatically hydrolyzing the mixture in a hydrolysis reactor with cellulase enzymes, to generate fermentable sugars; and fermenting the fermentable sugars to produce ethanol. Many alternative process configurations are described.

Abstract: An electrical active unit (100) for generating a physical effect such as heat, cold or light emission, with a particular application to a temperature regulation system for regulating the temperature of a body, or to a light emission system to be worn by such a portion of a body. The electrical active unit (100) comprises a textile support (102) supporting: an active element (101) adapted for generating said physical effect; at least one electrical connection point (104) adapted to be connected to a power source and a controlling unit, and located on said active element (101); a sensor (106) adapted for being connected to the power source and the controlling unit, such that the electrical active unit may be connected to the power source and the controlling unit via the connection point in order to allow the powering of the active element by the power source and the activation/deactivation of said active element by the controlling unit depending on data sensed by the sensor.

Abstract: The present disclosure provides a surfactant formulation for use in treating and recovering fossil fluid from a subterranean formation. The surfactant formulation includes a nonionic surfactant, organic acid selected from citric acid, diglycolic acid, glycolic acid and a salt thereof and injection water. The surfactant formulation may be injected into one or more injection wells located within the subterranean formation and fossil fluids can then be subsequently recovered from one or more producing wells.

Abstract: Methods, devices, systems, and kits are provided that buffer the time spaced glucose signals in a memory, and when a request for real time glucose level information is detected, transmit the buffered glucose signals and real time monitored glucose level information to a remotely located device, process a subset of the received glucose signals to identify a predetermined number of consecutive glucose data points indicating an adverse condition such as an impending hypoglycemic condition, confirm the adverse condition based on comparison of the predetermined number of consecutive glucose data points to a stored glucose data profile associated with the adverse condition, where confirming the adverse condition includes generating a notification signal when the impending hypoglycemic condition is confirmed, and activate a radio frequency (RF) communication module to wirelessly transmit the generated notification signal to the remotely located device only when the notification signal is generated.

Abstract: The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is O5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)—C(O)OH, 5) CF2—C(O)OH, or 6) C(O)—C(O)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.

Abstract: The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.

Abstract: A first set of signal data is received. Generative machine learning models are trained based on the first set of signal data. The generative machine learning models include at least a first model trained to identify a first signal component and a second model trained to identify a second signal component. An incoming mixed signal data stream is dynamically separated into a clean signal component and a noise signal component by running the generative machine learning models.

Abstract: Device for conveying picked mushrooms (1), wherein this device comprises several openings (4) into which the mushrooms (1) are placeable, and comprises one or several displacement means configured to move these openings (4) from a picking zone to a removing zone where the mushrooms (1) placed into the openings (4) are removable, wherein this device comprises several conveying modules (5) which each comprise one or several said openings (4), and the displacement means at least comprise a first conveying unit (6a, 6b), (60a, 60b) for moving the conveying modules (5) to an intermediate point, and a second conveying unit (7), which joins to the first conveying unit (6a, 6b), (60a, 60b) at the location of the intermediate point, for moving the conveying modules (5) from the intermediate point to the removing zone.

Abstract: Inventors have evaluated the effects of the FLT3 inhibitors on morphine analgesic potency, on tolerance to morphine analgesia and on morphine-induced mechanical pain hypersensitivity. When the FLT3 inhibitor was administered together with morphine, the amount of analgesic effect was higher than that produced by morphine alone. Repeated administration of morphine induced a progressive decrease in morphine-induced analgesia as showed by the decreased percentage of MPE in control animals. Intrathecal pre-treatment with an FLT3 inhibitor reduced the decrease in morphine analgesia. The administration of FLT3 inhibitors completely prevented both the development of morphine-induced pain hypersensitivity and morphine-revealed latent pain sensitization. Accordingly, the invention relates to an FLT3 inhibitor for increasing the efficacy of an opioid for its analgesic effect, and hereby reducing the opioid dose while maintaining the opioid efficacy in a subject suffering from pain in need thereof.

Abstract: The present invention relates to an APJ receptor agonist for use in the treatment or the prevention of diabetes.

Abstract: An injection device for injecting medicament in a patient includes a syringe coupled to a housing and radially retained by a retaining rib. A needle guard is slideably coupled to the housing and spring biased in a distal direction by a return spring. A ram is slideably coupled to the housing and spring biased in the distal direction by a main spring. An initial position is defined by a retaining arm being disposed in the longitudinal path of the ram preventing firing. A released position is defined by the retaining arm being clear from the longitudinal path of the ram allowing the ram to extend distally. A locked position is defined by the retaining arm being disposed in the longitudinal path of the ram and a lock arm of the ram being disposed in the longitudinal path of the needle guard preventing the needle guard from being retracted.

Abstract: An adjustable guide apparatus for a turbine, comprising a bearing ring with a plurality of guide vanes, wherein the guide vanes are rotatably mounted on the bearing ring with the aid of guide vane shafts, wherein in order to position the guide vane, the guide vane shaft is allocated an adjusting lever which engages in a rotatable rotating ring of the adjustable guide apparatus, and wherein, in order to be held in an exhaust gas guiding section of the turbine, the adjustable guide apparatus has a support ring, and wherein the support ring serves to mount the rotating ring. The rotating ring is radially and/or axially guided with the aid of at least one guiding element, wherein the guiding element is received on the support ring. Furthermore, the invention relates to a turbine with an adjustable guide apparatus and to an exhaust turbocharger.