Abstract: The present invention relates in general to bacterial cells having a genetic alteration that results in increased expression of a protein of interest and methods of making and using such cells. Aspects of the present invention include Gram positive microorganisms, such as Bacillus species, having a genetic alteration that modifies activity of a protein encoded by the ykf operon and results in enhanced expression of a protein of interest.

Abstract: Computer system and methods for optimally controlling the behavior of an industrial process, in accordance with plant operating goals, without requiring a complicated trial and error process. The system and methods enable configuring optimization preference and optimization priority for key manipulated variables (MVs) of the industrial process. The system and methods translate the configured optimization preference and optimization priority for each key MV into prioritized economic objective functions. The system and methods calculate a set of normalized cost factors for use in a given prioritized economic functions based on a model gain matrix of manipulated variables and controlled variables of the industrial process.

Abstract: The present invention relates to methods for the alkylene oxide-free preparation of compositions comprising polyetherols using one or more alkylene carbonates as reactants. The polyetherol compositions prepared according to the invention ideally do not comprise carbonate or comprise almost no carbonate. The present invention also comprises the use of alkylene carbonate for preparing polyetherols or compositions comprising polyetherols and polyetherols or compositions comprising polyetherols prepared by the method according to the invention.

Abstract: Forming a proximal anastomosis on an aortic wall includes method and instrumentation and apparatus for forming an aortic puncture and inserting into the vessel through the puncture a fluid-impervious sealing element with a protruding retainer. An anastomosis of a graft vessel over the puncture is partially completed with the retainer of the sealing element protruding through the partial anastomosis. The retainer facilitates removal of the sealing element from the partial anastomosis prior to completion of the procedure.

Abstract: The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.

Abstract: The present invention includes methods and a system for treating a mass of contaminated media using ammonia. The methods include determining the amount of ammonia required for treatment using various calculation methods and combining the ammonia with air or another carrier gas to create a gas mixture. The methods and system utilize at least one injection well inserted into the contaminated media to deliver the gas mixture over a period ranging from approximately 1 week to approximately 8 weeks.

Abstract: The invention relates to immunoassays, methods for carrying out immunoassays, immunoassay kits and methods for manufacturing immunoassay kits. In particular, the invention has relevance to capillary (especially microcapillary) immunoassay technology.

Abstract: It is an object to provide a power semiconductor module having a case shared for base plates of different sizes and having a high-stability base plate. The power semiconductor module according to the present invention includes: a base plate; an insulating substrate disposed on a first main surface of the base plate; a semiconductor chip disposed on an insulating substrate; a case for enclosing the base plate except a second main surface of the base plate facing the first main surface, the insulating substrate, and the semiconductor chip; and a spacer provided between the outer periphery of the base plate and the inner periphery of the case and in contact with both. The spacer has a bonding surface with a side surface of the base plate and the first main surface in the contact with the outer periphery of the base plate.

Abstract: A method for forming an immune-tolerant site, and a method for attracting immunosuppressive cells, comprising contacting an agent comprising SEK-1005 (Ser, 3-hydroxy-N-[2-hydroxy-1-oxo-2-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl-propyl]-Leu-Pip(hexahydro-3-pyridazinecarbonyl)-N-hydroxy-Ala-N-methyl-Phe-Pip-rho-lactone) and/or fibroblast growth factor (FGF) with a site in the body tissue.

Abstract: Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described.

Abstract: A seal mechanism that is provided with an annular resin seal lip which is disposed coaxially with a shaft and is brought into contact with a circumferential surface of the shaft. The seal mechanism is provided with a stopper that is provided in a metallic housing surrounding the shaft and is disposed between the shaft and a portion of the seal lip other than the edge portion coming into direct contact with the shaft while spaced apart from the circumferential surface of the shaft. The stopper is made of a material having a thermal expansion coefficient smaller than that of a material of which the seal lip is formed, and an axis of the seal lip is caused to correspond to an axis of the shaft by coming into contact with the seal lip which is reduced in diameter at the time of cooling.

Abstract: A motor controller includes an H-bridge circuit, a switching-element driving circuit, a motor-current detection circuit, a sample hold circuit executing a sample hold of an output of the motor-current detection circuit at every half period and outputting the output of the motor-current detection circuit as a first signal and a second signal, according to a PWM output timing of the switching-element driving circuit, and a motor-current calculation circuit selecting a signal that is larger between the first signal and the second signal as a selection signal, calculating a value of the selection signal as an absolute value of a motor current, determining a current direction based on a relation between the selection signal and a PWM output signal at a sample timing that the selection signal is obtained.

Abstract: Provided are systems, methods, and computer-readable media for providing search results having contacts from a user's social graph are provided herein. A search query is received from a user of client computer, and a point of interest responsive to the search query is determined. A person associated with the point of interest is identified, and a relationship in a social graph between the person and the user is identified. A search result that includes the point of interest and information about the person in the user's social graph associated with the point of interest is generated, and the search result is transmitted over a network to the client computer.

Abstract: A motor control apparatus controlling current feeding and a rotational direction of a motor includes: four bridge-circuit switches between a high and low potential lines; two current feeding line switches connected through the motor between a first and second nodes in series to arrange two parasitic diodes facing each other; a pull-up resistor between the high potential line and a third node; a pull-down resistor between the low potential line and a fourth node to interpose the motor between the third and fourth nodes; a protective diode blocking current; and a fault diagnostic device having: a driver turning on or off the switches; and a voltage determinator determining suitability of a first and second voltages and performing initial fault diagnosis for at least one of the switches.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer-readable storage medium, for providing content. A method includes receiving a request for an advertisement to be displayed in a slot associated with a third-party content site; identifying a relevant advertisement to be provided in the slot; determining information to be included in an annotation associated with the advertisement, the annotation including customized information to be presented along with the advertisement; providing the advertisement responsive to the request including providing the annotation along with a control for re-publishing the advertisement along with the relevant advertisement; receiving user input selecting the control and designating the advertisement for re-publishing to a group, the group being designated by the user; and targeting additional content to the group based on the received user input.

Abstract: A coherent extreme ultraviolet (XUV) radiation source is provided that includes a non-linear optical conversion material solid substrate disposed for nonlinear conversion of infrared (IR) coherent radiation into XUV coherent radiation, where the solid substrate includes an IR coherent radiation region, and an XUV coherent radiation waveguide region, where the IR coherent radiation region is optically coupled to the XUV coherent radiation waveguide region, where the XUV coherent radiation converted from the IR coherent radiation by the non-linear optical conversion material propagates in and outputs from the XUV coherent radiation waveguide region.

Abstract: The invention relates to an aircraft (10) having a system for measuring a static reference pressure in flight, which system comprises: a pressure sensor (22) connected to the rear portion of the aircraft by a cable (16) and associated with a pressure intake (24) that is located, in flight, in an undisturbed zone downstream from the aircraft, the pressure signal (22) being suitable firstly for measuring a pressure coming from the pressure intake (24) and secondly for transmitting a signal representative of the measured pressure, e.g. an electric signal, to the aircraft; and a system (34) on board the aircraft, which system is suitable for determining a pressure measurement firstly from the transmitted signal and secondly from a position of the pressure sensor (22) relative to the aircraft (10). Pressure is measured dynamically while the aircraft is climbing or descending.

Abstract: A process for the inhibition of particulate emission during friction of heat-treated iron ore pellets includes the following steps: a) removal of heat-treated iron ore pellets at a temperature of 200° C.; and b) spraying of an alcohol by-product on pellets. The use of an alcohol by-product as an inhibitor of particulate emission is further described, with the alcohol by-product being sprayed on heat-treated iron ore pellets, which can partially or completely replace water during the handling, stacking, loading, and unloading of materials such as pellets, granules, fines, and other products from iron ore and other minerals. This process significantly reduces the emission of particulates in the an operational area.

Abstract: A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof: the process comprising the reaction of a carbamate of Formula (II?): Formula (I?): with a primary or secondary amine of the formula R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

Abstract: An apparatus designs an animation expressing a transition of display forms of an object. A reception unit receives an operation for setting key frames in the animation at one or more time points on a time axis displayed on a screen, the time axis corresponding to the animation, and instructs a display form of the object at each of the set key frames. The reception unit receives, in a state when one or more key frames are set on the time axis and a display form of the object is instructed at each of the set key frames, an instruction for reflecting a display form of the object instructed to a first key frame of an already set one or more key frames as a display form of the object at a second key frame set on the time axis. A display control unit displays indicators representing the key frames.