Abstract: The present invention relates to a heteroaryl derivative compound and a use thereof. Since the heteroaryl derivative of the present invention exhibits excellent inhibitory activity against EGFR, the heteroaryl derivative can be usefully used as a therapeutic agent for EGFR-associated diseases.

Abstract: According to the present disclosure, by a simple operation of pressing the press-fitting block with the pressing part, a press-fitting force of the press-fitting block is automatically released at a predetermined time after the needle part penetrates a skin layer, due to the release of the press-fitting force of the press-fitting block, a practitioner can easily determine a. time to detach and separate the needle part, due to guiding of the time to detach and separate the needle part, even an unskilled person can easily use the microneedle, by a uniform amount of drug being injected into patients, the same therapeutic effect can be given to the patients, and in particular, by the needle part being promptly removed after the drug of the needle part is injected into the skin layer, there is no concern about the needle part staying in the skin layer for an excessive amount of time.

Abstract: The present invention relates to a moisture and oxygen barrier laminate with improved durability and flexibility. According to the present invention, there is provided a laminate, comprising: an inorganic barrier layer and a protective layer sequentially formed on one surface of a transparent substrate, wherein the protective layer includes an organic copolymer containing a repeating unit derived from a siloxane compound. The laminate according to the present invention can maintain excellent interlayer adhesion even when deformation such as bending is applied, thereby exhibiting excellent moisture and oxygen barrier properties.

Abstract: Proposed is a modular augment, and, more specifically, a modular augment in which an additional unit is separably coupled to a center unit so as to selectively couple the additional unit to the center unit according to the degree of a patient's bone loss so that the degree of bone reinforcement can be easily adjusted, and thus a manufacturer is capable of covering various types of patients even though the types of units are minimized, thereby reducing manufacturing costs, the number of products to be prepared for surgery by a user such as a hospital is remarkably reduced, thereby preventing the unnecessary costs and facilitating inventory management, and a patient can receive an optimal augment that is appropriate for the patient' condition.

Abstract: A method for operating a memory includes determining to perform an error correction operation; determining whether to perform an error correction operation; generating an internal address when the error correction operation is performed; reading data from memory cells that are selected based on the internal address and an error correction code corresponding to the data; performing an error correction operation on the data based on the error correction code to produce an error-corrected data; writing the error-corrected data and an error correction code corresponding to the error-corrected data into the memory cells; determining one or more regions among regions in the memory as a repair-requiring region based on an error detected when the error correction operation is performed; receiving a first command; backing up the data and the error correction code into a redundant region in response to the first command; and repairing the repair-requiring region with the redundant region.

Abstract: A method for managing an application executed in a user terminal according to an embodiment of this disclosure includes executing a launcher application on the user terminal, displaying a first application list within a first GUI of the launcher application, installing, in the user terminal, a first application selected by a user from applications included on the first application list, displaying a second application list within a second GUI of the launcher application and executing a second application selected by the user from applications included on the second application list.

Abstract: A method for operating a memory includes determining to perform an error correction operation; determining whether to perform an error correction operation; generating an internal address when the error correction operation is performed; reading data from memory cells that are selected based on the internal address and an error correction code corresponding to the data; performing an error correction operation on the data based on the error correction code to produce an error-corrected data; writing the error-corrected data and an error correction code corresponding to the error-corrected data into the memory cells; determining one or more regions among regions in the memory as a repair-requiring region based on an error detected when the error correction operation is performed; receiving a first command; backing up the data and the error correction code into a redundant region in response to the first command; and repairing the repair-requiring region with the redundant region.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: An artificial knee joint includes a tibial component implanted into the proximal end of a tibia, and a bearing component coupled to the tibial component, in which the tibial component includes an interference prevention portion capable of preventing interference with the bearing component when the bearing component is inserted diagonally and the bearing component includes a protrusion coupled to the interference prevention portion.

Abstract: A method for operating a memory includes determining to perform an error correction operation; determining whether to perform an error correction operation; generating an internal address when the error correction operation is performed; reading data from memory cells that are selected based on the internal address and an error correction code corresponding to the data; performing an error correction operation on the data based on the error correction code to produce an error-corrected data; writing the error-corrected data and an error correction code corresponding to the error-corrected data into the memory cells; determining one or more regions among regions in the memory as a repair-requiring region based on an error detected when the error correction operation is performed; receiving a first command; backing up the data and the error correction code into a redundant region in response to the first command; and repairing the repair-requiring region with the redundant region.

Abstract: Disclosed is a pedestal apparatus having an antenna attached thereto capable of biaxial motion. The pedestal apparatus according to one embodiment may comprise: a body; a first drive unit, arranged on the lower part of the body, for transmitting driving power; a second drive unit, arranged on the lower part of the body, for transmitting driving power; a first drive gear arranged on the upper part of the body and receiving driving power from the first drive unit; a second drive gear arranged on the upper part of the body opposite the first drive gear, and receiving driving power from the second drive unit; and a driven gear which rotates by receiving driving power from the first and second drive gears, and to which an antenna is connected, wherein the antenna can move biaxially in accordance with the rotational directions of the first and second drive gears.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: A knee joint implant that prevents hyperextension includes a femoral component having an anterior surface with reference to the lowermost point of a convex condyle, the anterior surface being configured to have different curvature radii in respective sections thereof, and a bearing component having an anterior surface with reference to the lowermost point of a concave articular surface, the anterior surface being configured to have different curvature radii in respective sections, so that when an extended knee is about to be hyperextended, the convex condyle of the femoral component slides toward the anterior side and is brought into contact with a plurality of points of the concave articular surface of the bearing component, thereby producing resistance so as to suppress hyperextension exceeding a design range due to behavioral habits, a decrease in muscle mass, and the like of the patient.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: A knee joint implant that prevents hyperextension includes a femoral component having an anterior surface with reference to the lowermost point of a convex condyle, the anterior surface being configured to have different curvature radii in respective sections thereof, and a bearing component having an anterior surface with reference to the lowermost point of a concave articular surface, the anterior surface being configured to have different curvature radii in respective sections, so that when an extended knee is about to be hyperextended, the convex condyle of the femoral component slides toward the anterior side and is brought into contact with a plurality of points of the concave articular surface of the bearing component, thereby producing resistance so as to suppress hyperextension exceeding a design range due to behavioral habits, a decrease in muscle mass, and the like of the patient.

Abstract: An artificial knee joint includes a tibial component implanted into the proximal end of a tibia, and a bearing component coupled to the tibial component, in which the tibial component includes an interference prevention portion capable of preventing interference with the bearing component when the bearing component is inserted diagonally and the bearing component includes a protrusion coupled to the interference prevention portion.

Abstract: Disclosed is a pedestal apparatus having an antenna attached thereto capable of biaxial motion. The pedestal apparatus according to one embodiment may comprise: a body; a first drive unit, arranged on the lower part of the body, for transmitting driving power; a second drive unit, arranged on the lower part of the body, for transmitting driving power; a first drive gear arranged on the upper part of the body and receiving driving power from the first drive unit; a second drive gear arranged on the upper part of the body opposite the first drive gear, and receiving driving power from the second drive unit; and a driven gear which rotates by receiving driving power from the first and second drive gears, and to which an antenna is connected, wherein the antenna can move biaxially in accordance with the rotational directions of the first and second drive gears.

Abstract: Provided is a peptide, which has an anti-inflammatory activity and an activity for promoting osteogenic differentiation, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3. And provided is a peptide, which has a hair growth promoting activity, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. A peptide formed from the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, according to the present invention, consequently shows an anti-inflammatory activity by inhibiting an inflammatory cytokine expression and proliferation of inflammatory cells, and consequently promotes osteogenic differentiation by increasing phosphorylation of PI3K, Smad1, Smad5 and Smad8, which contribute to osteogenesis, and by increasing ALP, OPG and BSP expressions.

Abstract: A peptide which is formed from an amino acid sequence selected from the group comprising amino acid sequences of SEQ ID NO: 1 to SEQ ID NO: 3, according to the present invention, has osteoclast differentiation and activation inhibition and is highly effective for preventing or treating bone diseases related to the destruction of the bone. A peptide, according to the present invention, reduces expression of cathepsin K and TRAP related to osteoclast differentiation, inhibits nuclear translocation of NF-kB, and ultimately inhibits osteoclast differentiation. Provided is a composition, for preventing or treating bone diseases, comprising the peptide.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).