Abstract: According to the present disclosure, by a simple operation of pressing the press-fitting block with the pressing part, a press-fitting force of the press-fitting block is automatically released at a predetermined time after the needle part penetrates a skin layer, due to the release of the press-fitting force of the press-fitting block, a practitioner can easily determine a. time to detach and separate the needle part, due to guiding of the time to detach and separate the needle part, even an unskilled person can easily use the microneedle, by a uniform amount of drug being injected into patients, the same therapeutic effect can be given to the patients, and in particular, by the needle part being promptly removed after the drug of the needle part is injected into the skin layer, there is no concern about the needle part staying in the skin layer for an excessive amount of time.

Abstract: A method for managing an application executed in a user terminal according to an embodiment of this disclosure includes executing a launcher application on the user terminal, displaying a first application list within a first GUI of the launcher application, installing, in the user terminal, a first application selected by a user from applications included on the first application list, displaying a second application list within a second GUI of the launcher application and executing a second application selected by the user from applications included on the second application list.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: Disclosed is a pedestal apparatus having an antenna attached thereto capable of biaxial motion. The pedestal apparatus according to one embodiment may comprise: a body; a first drive unit, arranged on the lower part of the body, for transmitting driving power; a second drive unit, arranged on the lower part of the body, for transmitting driving power; a first drive gear arranged on the upper part of the body and receiving driving power from the first drive unit; a second drive gear arranged on the upper part of the body opposite the first drive gear, and receiving driving power from the second drive unit; and a driven gear which rotates by receiving driving power from the first and second drive gears, and to which an antenna is connected, wherein the antenna can move biaxially in accordance with the rotational directions of the first and second drive gears.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: Disclosed is a pedestal apparatus having an antenna attached thereto capable of biaxial motion. The pedestal apparatus according to one embodiment may comprise: a body; a first drive unit, arranged on the lower part of the body, for transmitting driving power; a second drive unit, arranged on the lower part of the body, for transmitting driving power; a first drive gear arranged on the upper part of the body and receiving driving power from the first drive unit; a second drive gear arranged on the upper part of the body opposite the first drive gear, and receiving driving power from the second drive unit; and a driven gear which rotates by receiving driving power from the first and second drive gears, and to which an antenna is connected, wherein the antenna can move biaxially in accordance with the rotational directions of the first and second drive gears.

Abstract: Provided is a peptide, which has an anti-inflammatory activity and an activity for promoting osteogenic differentiation, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3. And provided is a peptide, which has a hair growth promoting activity, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. A peptide formed from the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, according to the present invention, consequently shows an anti-inflammatory activity by inhibiting an inflammatory cytokine expression and proliferation of inflammatory cells, and consequently promotes osteogenic differentiation by increasing phosphorylation of PI3K, Smad1, Smad5 and Smad8, which contribute to osteogenesis, and by increasing ALP, OPG and BSP expressions.

Abstract: A peptide which is formed from an amino acid sequence selected from the group comprising amino acid sequences of SEQ ID NO: 1 to SEQ ID NO: 3, according to the present invention, has osteoclast differentiation and activation inhibition and is highly effective for preventing or treating bone diseases related to the destruction of the bone. A peptide, according to the present invention, reduces expression of cathepsin K and TRAP related to osteoclast differentiation, inhibits nuclear translocation of NF-kB, and ultimately inhibits osteoclast differentiation. Provided is a composition, for preventing or treating bone diseases, comprising the peptide.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: A peptide comprising an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, shows proliferation and differentiation promotion of osteoblast and proliferation and activation promotion of periodontal ligament fibroblast. A peptide, according to the present invention, increases BMP signaling such as SMAD1/5/8 phosphorylation and increases the growth of osteoblast and the expression of a differentiation marker such as COL1A1, BSP and ALP, thereby ultimately showing osteoblast activation. A peptide, according to the present invention, promotes the growth of periodontal ligament fibroblast by means of PI3K and Akt phosphorylation and increases the expression of an activation marker such as COL1A1 and DSPP, thereby ultimately showing periodontal tissue regeneration activation. Provided are a composition for preventing or treating bone diseases and a composition for preventing or treating periodontal diseases, the compositions comprising the aforementioned peptide.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (CON), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: A peptide which is formed from an amino acid sequence selected from the group comprising amino acid sequences of SEQ ID NO: 1 to SEQ ID NO: 3, according to the present invention, has osteoclast differentiation and activation inhibition and is highly effective for preventing or treating bone diseases related to the destruction of the bone. A peptide, according to the present invention, reduces expression of cathepsin K and TRAP related to osteoclast differentiation, inhibits nuclear translocation of NF-kB, and ultimately inhibits osteoclast differentiation. Provided is a composition, for preventing or treating bone diseases, comprising the peptide.

Abstract: A peptide comprising an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, shows proliferation and differentiation promotion of osteoblast and proliferation and activation promotion of periodontal ligament fibroblast. A peptide, according to the present invention, increases BMP signaling such as SMAD1/5/8 phosphorylation and increases the growth of osteoblast and the expression of a differentiation marker such as COL1A1, BSP and ALP, thereby ultimately showing osteoblast activation. A peptide, according to the present invention, promotes the growth of periodontal ligament fibroblast by means of PI3K and Akt phosphorylation and increases the expression of an activation marker such as COL1A1 and DSPP, thereby ultimately showing periodontal tissue regeneration activation. Provided are a composition for preventing or treating bone diseases and a composition for preventing or treating periodontal diseases, the compositions comprising the aforementioned peptide.

Abstract: Provided is a peptide, which has an anti-inflammatory activity and an activity for promoting osteogenic differentiation, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3. And provided is a peptide, which has a hair growth promoting activity, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. A peptide formed from the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, according to the present invention, consequently shows an anti-inflammatory activity by inhibiting an inflammatory cytokine expression and proliferation of inflammatory cells, and consequently promotes osteogenic differentiation by increasing phosphorylation of PI3K, Smad1, Smad5 and Smad8, which contribute to osteogenesis, and by increasing ALP, OPG and BSP expressions.

Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).

Abstract: The present invention relates to a mixed metal oxide catalyst in which a hydrotalcite precursor containing an alkali metal is impregnated or intercalated with a nonprecious metal, a method of manufacturing the same, and a method of decomposing nitrogen oxide using the mixed metal oxide catalyst. The mixed metal oxide catalyst has excellent catalytic activity because it can decompose NOx, N2O or a mixture thereof even at low temperature, and is economical because it does not use a precious metal.

Abstract: Disclosed is a brightness enhancing film, including a multilayered thin film wherein a plurality of first thin film layers which are optically anisotropic and a plurality of second thin film layers which are optically isotropic are alternately stacked, the multilayered thin film including a first wavelength reflection region which reflects a wavelength of 160˜451 nm, a second wavelength reflection region which reflects a wavelength of 451˜836 nm, and a third wavelength reflection region which reflects a wavelength of 836˜1040 nm, and a thickness of each of the first and second thin film layers in the first and second wavelength reflection regions is linearly increased from the short wavelength reflection side toward the long wavelength reflection side, and a thickness of each of the first and second thin film layers in the third wavelength reflection region is nonlinearly increased from the short wavelength reflection side toward the long wavelength reflection side.

Abstract: Disclosed is a brightness enhancing film, including a multilayered thin film wherein a plurality of first thin film layers which are optically anisotropic and a plurality of second thin film layers which are optically isotropic are alternately stacked, the multilayered thin film including a first wavelength reflection region which reflects a wavelength of 160˜451 nm, a second wavelength reflection region which reflects a wavelength of 451˜836 nm, and a third wavelength reflection region which reflects a wavelength of 836˜1040 nm, and a thickness of each of the first and second thin film layers in the first and second wavelength reflection regions is linearly increased from the short wavelength reflection side toward the long wavelength reflection side, and a thickness of each of the first and second thin film layers in the third wavelength reflection region is nonlinearly increased from the short wavelength reflection side toward the long wavelength reflection side.

Abstract: Disclosed is a luminance enhancement film which is suitable for use in a display and includes a multilayered thin film and a uniaxially drawn film formed on one surface of the multilayered thin film.