Abstract: The present invention provides Wnt pathway agonists and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of diseases.

Abstract: The present application provides, in some aspects, methods of identifying a condensate of interest associated with a el disease. Also provided are methods of identifying a marker for identifying a condensate of interest associated with a disease. In other aspects, provided herein are methods of identifying a therapeutic agent useful for treating a disease via the identified condensate of interest.

Abstract: A system for treating a plurality of adjacent wells having casing includes a wireline, perforating equipment, and a fiber-optic interrogator. The wireline has at least one optical fiber disposed along its length. At least one optical fiber is configured as a distributed acoustic sensor. The perforating equipment includes a perforating gun that can couple to a termination of the wireline. Run downhole on the wireline, the perforating gun can perforate the casing. The fiber-optic interrogator is configured to couple to another termination of the wireline. The fiber-optic interrogator is configured to interrogate the at least one optical fiber for distributed acoustic sensing. The wireline deployed in a well with the perforating gun can remain in the well, while an adjacent well is stimulated to produce hydraulic fracture. During the stimulation, the fiber-optic wireline is used for distributed acoustic sensing during the fracture operation of the adjacent well.

Abstract: Disclosed herein are compositions and methods comprising a composition for light filtering. An example composition comprises a plurality of metal nanoparticles, at least a portion of the plurality of metal nanoparticles having an anisotropic shape; and a stabilizing mechanism disposed to selectively couple with at least a portion of the plurality of metal nanoparticles, wherein the composition exhibits a peak light filtering value in the range of about 600 nm to about 850 nm.

Abstract: A green tape composition includes at least one Li-garnet ceramic powder; at least one excess lithium source; at least one dispersant; at least one binder; and at least one plasticizer, such that a porosity of the green tape composition is <10 vol. %. A method includes dispersing at least one lithium garnet powder and at least one excess lithium source in a predetermined ratio in an organic solvent to form a garnet suspension; adding at least one dispersant, at least one binder, and at least one plasticizer to the garnet suspension; milling the garnet suspension; and de-airing under vacuum, such that a porosity of the green tape composition is <10 vol. %.

Abstract: A system comprising a causal convolutional neural network to autoregressively generate a succession of values of a data item conditioned upon previously generated values of the data item. The system includes support memory for a set of support data patches each of which comprises an encoding of an example data item. A soft attention mechanism attends to one or more patches when generating the current item value. The soft attention mechanism determines a set of scores for the support data patches, for example in the form of a soft attention query vector dependent upon the previously generated values of the data item. The soft attention query vector is used to query the memory. When generating the value of the data item at a current iteration layers of the causal convolutional neural network are conditioned upon the support data patches weighted by the scores.

Abstract: An integrated circuit structure includes an aluminum pad layer on a dielectric stack, a passivation layer covering the aluminum pad layer, and an aluminum shield layer including aluminum routing patterns disposed directly above an embedded memory area and embedded in the dielectric stack. The aluminum shield layer is electrically connected to the uppermost copper layer through a plurality of tungsten vias. The plurality of tungsten vias is embedded in the dielectric stack.

Abstract: The present disclosure provides tissue-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in targeted tissues.

Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: A method of applying an environmental barrier coating and an environmental barrier coating. The method includes applying a high apparent density powder via a high temperature and high velocity (HTHV) process. The high apparent density powder comprises at least one of rare earth silicates; mullite or alkaline silicate.

Abstract: An optical proximity sensor includes a housing, an optical emitter, and an optical detector. A first light guide disposed in a first chimney of the housing is configured to direct light from the optical emitter through the first chimney towards a target location. A second light guide disposed in a second chimney of the housing is configured to direct a returned portion of the light emitted from the optical emitter through the second chimney towards the optical detector.

Abstract: In various aspects and embodiments, the present disclosure provides methods for making glycosylated products, as well as bacterial cells and uridine diphosphate (UDP)-dependent glycosyltransferase (UGT) enzymes useful for the same. In other aspects and embodiments, the disclosure provides methods for high yield and/or high purity recovery of such glycoside products from microbial cultures or cell free reactions. In various aspects and embodiments, the disclosure provides for whole cell bioconversion processes involving the glycosylation of a desired substrate, and/or the recovery of the glycosylated product at high yield and/or high purity.

Abstract: Disclosed embodiments relate to natural language processing. Techniques can include receiving input text, extracting, from the input text, at least one modifier and aspect pair, receiving data from a knowledgebase, based on the at least one modifier and aspect pair and commonsense data, generate one or more premise embeddings, convert the input text into tokens, generating at least one vector for one or more of the tokens based on an analysis of the tokens, combine the at least one vector with the one or more premise embeddings to create at least one combined vector, and analyze the at least one combined vector wherein the analysis generates an output indicative of a feature of the input text.

Abstract: Methods are described for driving an electro-optic display having a plurality of display pixels. Each of the display pixels is associated with a display transistor. The method includes the following steps in order. A first voltage is applied to a first display transistor associated with a first display pixel of the plurality of display pixels. The first voltage is applied during at least one frame of a driving waveform. A second voltage is applied to the first display transistor associated with the first display pixel. The second voltage has a non-zero amplitude less than the first voltage and is applied during the last frame of the driving waveform. The amplitude of the second voltage is based on a voltage offset value and a sum of remnant voltages each frame of the driving waveform contributes to the first display pixel when the first voltage is applied to the first display transistor.

Abstract: A battery electrode includes a first metal foil, a second metal foil, and a thermoplastic polymer layer between the first metal foil and the second metal foil. The battery electrode also includes a first coating adjacent to the first metal foil such that the first metal foil is between the thermoplastic polymer layer and the first coating. The battery electrode also includes a second coating adjacent to the second metal foil such that the second metal foil is between the thermoplastic polymer layer and the second coating.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: In an embodiment, an electronic device includes a display and processing circuitry. The display includes a plurality of pixels arranged in a plurality of rows, wherein a first grouping of the plurality of rows displays image content during a first portion of an image frame, and wherein a second grouping of the plurality of rows displays image content during a second portion of the image frame. The processing circuitry is operatively coupled to the display and determines a velocity associated with the image content displayed by the first grouping of the plurality of rows moving across the display and adjusts a position of the image content displayed by the second grouping of the plurality of rows during the second portion of the image frame.

Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

Abstract: Methods, apparatus, and systems related to light detection and ranging (LIDAR) are described. In one example aspect, a LIDAR apparatus includes a light emitter configured to generate, according to a first electrical pulse signal, a pulse light signal. The first electrical pulse signal comprises a first set of non-uniformly spaced pulses. The apparatus includes a receiver configured to convert returned light signals from the object into electrical signals and a filtering subsystem in communication with the receiver, configured to receive the electrical signals from the receiver and remove a point from a set of points representing at least a partial surface of the object as noise by determining whether there is a coherence between the point and corresponding neighboring points of the point along at least a first direction and a second direction of the set of points.