Abstract: The present disclosure relates to IL 12 receptor agonists with improved therapeutic profiles.

Abstract: In one implementation, a system for broadcasting on-duty adventure opportunities among computing devices includes an adventure management computer system to transmit (a) push notifications to selected mobile computing devices related to activated on-duty adventure opportunities and (b) local beacon signal identifiers for mobile-to-mobile beacon signal transmissions for the activated on-duty adventure opportunities, a guide mobile computing device to locally broadcast information for the on-duty adventure opportunity, and a participant mobile computing device (i) to detect the local beacon signals with the local beacon signal identifier for the on-duty adventure opportunity, (ii) to obtain the adventure information for the on-duty adventure opportunity from the adventure management computer system, and (iii) to reserve the on-duty adventure opportunity with the adventure management computer system.

Abstract: A work machine comprises of a cab, a battery, an auxiliary operations system, a cab occupant sensor and a controller. The auxiliary operations system is operatively coupled to the battery. The cab occupant sensor is operable to sense data associated with an occupancy of the cab by an operator. The control is communicatively coupled to the cab occupant sensor and comprises of a processor, and a memory having a power conserving algorithm thereon. The processor is operable to execute a power conserving algorithm to identify a cab inoccupancy condition from data related to an occupancy of the cab, and automatically initiates a low power mode by derating the auxiliary operations system a first degree when the cab inoccupancy condition is fulfilled.

Abstract: A solar cell, and methods of fabricating said solar cell, are disclosed. The solar cell can include a first emitter region over a substrate, the first emitter region having a perimeter around a portion of the substrate. A first conductive contact is electrically coupled to the first emitter region at a location outside of the perimeter of the first emitter region.

Abstract: In one implementation, a computer-implemented method includes receiving, at a computer system, a request for outdoor adventures that satisfy one or more criteria; accessing a centralized data repository of outdoor adventures that are provided by a plurality of different guides; identifying, by the computer system, one or more outdoor adventures based on a comparison of the one or more criteria to data associated with the outdoor adventures; generating code that includes information for the one or more outdoor adventures, the code being generated for execution or interpretation on the client computing device; and transmitting the code to the client computing device, wherein the client computing device is programmed to automatically execute or interpret the code upon receipt so as to present a graphical user interface presenting the one or more outdoor adventures and a selectable feature to reserve at least a portion of the one or more adventures.

Abstract: A gyroscopic roll stabilizer for a boat includes an enclosure mounted to a gimbal for rotation about a gimbal axis and configured to maintain a below-ambient pressure, and a flywheel assembly including a flywheel and flywheel shaft, with the flywheel assembly rotatably mounted inside the enclosure for rotation about a flywheel axis. The gyroscopic roll stabilizer also includes a motor operative to rotate the flywheel assembly and disposed inside the enclosure. A motor cooling circuit is configured to transfer heat away from the motor. The motor cooling circuit has a closed fluid pathway for recirculating cooling fluid therein. The fluid pathway includes a fluid channel jointly defined by the motor and the enclosure and having the cooling fluid therein. The gyroscopic roll stabilizer is configured to transfer heat away from the motor to the cooling fluid. Related methods are also disclosed.

Abstract: In one light-based computing method, a first light representing a first numerical input, a second light representing a second numerical input, and a third light representing an output command are received. The first and second lights are comingled. The output light sum of the numerical inputs is based on sensing the amplitude of the comingled light. In another light-based computing method, non-binary values are associated with corresponding light amplitudes. A main light containment area comingles two or more lights inside it. Each of the two or more lights has an amplitude associated with a non-binary value. After sensing light in a secondary light containment area, the resultant light amplitude of the comingled light is detected and becomes the basis for the result of the calculation.

Abstract: A method includes: accessing objects, generated by a set of sources, representing attributes of assets, affiliated with a computer network, including a set of endpoint devices and a first application; partitioning the objects into object groups including a first object group representing the first application; aggregating objects in the first object group into a first user container representing the first application during the first time interval; and, in response to selection of the first application at an operator portal: generating a visualization representing a subset of endpoint devices, in the set of endpoint devices, on which the first application is installed during the first time interval based on a set of attributes, exhibited by the first application during the first time interval, contained in the first application container; and rendering the visualization at the operator interface.

Abstract: A method and system for applying colored dental adhesive and a high-resolution decal to the surface of a person's tooth. The colored dental adhesive is formed by combining dental adhesive with a food grade colorant. The high-resolution decal is formed by printing a design on a paper substrate. Before application of the colored dental adhesive, the tooth is cleaned and etched with a phosphoric acid compound. The colored dental adhesive is applied to the surface of a tooth. The decal is then placed on colored dental adhesive, and the colored dental adhesive is cured. Additional layers of dental adhesive may be applied on top of the decal.

Abstract: Disclosed embodiments may include a system for testing application resiliency. The system may receive first data associated with a plurality of microservices within a microservice architecture. The system may generate a graphical user interface (GUI) configured to display the first data and an icon associated with each of the plurality of microservices. The system may receive, via the GUI, a selection of the icon associated with a first microservice of the plurality of microservices. The system may transmit a call via an Application Programming Interface (API), from the first microservice to further microservice(s) of the plurality of microservices. The system may receive, via the GUI, a request to transmit a simulated Hypertext Transfer Protocol (HTTP) error response code from the further microservice(s) to the first microservice, transmit the simulated HTTP error response code from the further microservice(s) to the first microservice, and monitor a response from the first microservice.

Abstract: In one implementation, a computer-implemented method includes receiving, at a computer system, a request for outdoor adventures that satisfy one or more criteria; accessing a centralized data repository of outdoor adventures that are provided by a plurality of different guides; identifying, by the computer system, one or more outdoor adventures based on a comparison of the one or more criteria to data associated with the outdoor adventures; generating code that includes information for the one or more outdoor adventures, the code being generated for execution or interpretation on the client computing device; and transmitting the code to the client computing device, wherein the client computing device is programmed to automatically execute or interpret the code upon receipt so as to present a graphical user interface presenting the one or more outdoor adventures and a selectable feature to reserve at least a portion of the one or more adventures.

Abstract: A light-based apparatus has an input device, accepting two or more numerical inputs and an output command. It has a logic unit that receives the two numerical inputs from the input device, and is adapted to combine various lights, in amplitudes based on the respective values of the numerical inputs, to produce an output light sum representing a sum of the two numerical inputs. The logic unit also has an output sensing circuit to sense the output light sum. The logic unit is responsive to the output command to output a value representing the output light sum. The device uses a computing method that includes comingling light from multiple sources, at the same time, in a light containment area to provide comingled light. The method includes using light amplitude sensing circuitry to sense an amplitude of the comingled light, outputting an arithmetic sum, based on the amplitude of the comingled light, without using a binary computer to compute the arithmetic sum.

Abstract: A method includes: accessing objects, generated by a set of sources, representing attributes of assets, affiliated with a computer network, including a set of endpoint devices and a first application; partitioning the objects into object groups including a first object group representing the first application; aggregating objects in the first object group into a first user container representing the first application during the first time interval; and, in response to selection of the first application at an operator portal: generating a visualization representing a subset of endpoint devices, in the set of endpoint devices, on which the first application is installed during the first time interval based on a set of attributes, exhibited by the first application during the first time interval, contained in the first application container; and rendering the visualization at the operator interface.

Abstract: An endoscope has an improved chip-on-tip configuration that includes both a first configuration of source illumination fibers and a second plurality of source illumination fibers, along with a camera chip. The combination of the camera chip and the source illumination fibers on the tip of the endoscope results in endoscopes with reduced size and weight.

Abstract: A battery electrode includes a first metal foil, a second metal foil, and a thermoplastic polymer layer between the first metal foil and the second metal foil. The battery electrode also includes a first coating adjacent to the first metal foil such that the first metal foil is between the thermoplastic polymer layer and the first coating. The battery electrode also includes a second coating adjacent to the second metal foil such that the second metal foil is between the thermoplastic polymer layer and the second coating.

Abstract: Improved yields of melanin are obtained by incubating, in an optimized media with a disodium tyrosine substrate, a culture of Vibrio natriegens expressing a heterologous tyrosinase gene at a temperature of about 30° C.

Abstract: A method includes: accessing objects, generated by a set of sources, representing attributes of assets, affiliated with a computer network, including a set of endpoint devices and a first application; partitioning the objects into object groups including a first object group representing the first application; aggregating objects in the first object group into a first user container representing the first application during the first time interval; and, in response to selection of the first application at an operator portal: generating a visualization representing a subset of endpoint devices, in the set of endpoint devices, on which the first application is installed during the first time interval based on a set of attributes, exhibited by the first application during the first time interval, contained in the first application container; and rendering the visualization at the operator interface.

Abstract: A method includes: accessing objects, generated by a set of sources, representing attributes of users affiliated with a computer network; partitioning the objects into object groups, each object group representing a particular user; for each object group, aggregating objects in the object group into a user container, in a set of user containers, representing a user during the first time interval; generating a manifest of users affiliated with the computer network during the first time interval based on the set of user containers; and, in response to selection of a first user in the manifest of users at an operator portal: generating a visualization representing a set of attributes exhibited by the first user during the first time interval.

Abstract: A method and system for applying colored dental adhesive and a high-resolution decal to the surface of a person's tooth. The colored dental adhesive is formed by combining dental adhesive with a food grade colorant. The high-resolution decal is formed by printing a design on a paper substrate. Before application of the colored dental adhesive, the tooth is cleaned and etched with a phosphoric acid compound. The colored dental adhesive is applied to the surface of a tooth. The decal is then placed on colored dental adhesive, and the colored dental adhesive is cured. Additional layers of dental adhesive may be applied on top of the decal.

Abstract: A magnetic shape memory (MSM) microfluidic device may include a flexible membrane positioned between a channel and an MSM element. The MSM element may engage the flexible membrane to deform the channel at portions of the flexible membrane that are adjacent to non-contracted portions of the MSM element. The flexible membrane may prevent contact between a fluid within the channel and the MSM element. Magnetic field components may be applied to the MSM element and moved along the MSM element enable fluidic flow within the channel while. The device may include an upper portion including the flexible membrane and a lower portion including the MSM element. The upper portion may be interchangeable with additional upper portions.