Abstract: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample.

Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.

Abstract: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample.

Abstract: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample.

Abstract: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample.

Abstract: Imaging is carried out using multiple views (e.g., from a single monolithic device) to generate an image. According to an example embodiment, a scene is imaged using disjoint sensors beyond a designated focal plane to obtain multiple views of common points in the focal plane. For the common points, the multiple views are processed to compute a depth of field, and the computed depth of field to generate an image.

Abstract: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample.

Abstract: A new adaptive pixel architecture, folded-multiple-capture (FMC), integrates synchronous self-reset and multiple capture schemes and advantageously eliminates the requirement of a high-frame-rate sensor array, which is essential for conventional image sensors with high dynamic range. The FMC comprises a per-pixel analog-front-end (AFE), a fine analog-digital convertor (ADC) stage, and a digital-signal-processor/controller (DSPC) stage. The AFE performs programmable gain control, synchronous self-reset, sample-and-hold, and enables disturbance detection. In the AFE, a comparator compares an integrator output with a threshold voltage and produces a binary sequence accordingly. The ADC utilizes the binary sequence and the folded multiple capture signals to estimate photocurrent.

Abstract: A new adaptive pixel architecture, folded-multiple-capture (FMC), integrates synchronous self-reset and multiple capture schemes and advantageously eliminates the requirement of a high-frame-rate sensor array, which is essential for conventional image sensors with high dynamic range. The FMC comprises a per-pixel analog-front-end (AFE), a fine analog-digital convertor (ADC) stage, and a digital-signal-processor/controller (DSPC) stage. The AFE performs programmable gain control, synchronous self-reset, sample-and-hold, and enables disturbance detection. In the AFE, a comparator compares an integrator output with a threshold voltage and produces a binary sequence accordingly. The ADC utilizes the binary sequence and the folded multiple capture signals to estimate photocurrent.

Abstract: Motion/Saturation detection system and method for synthesizing high dynamic range motion blur free images from multiple captures, the system and method utilizing photocurrent estimation to reduce read noise and enhance dynamic range at the low illumination end, saturation detection to enhance dynamic range at the high illumination end, and motion blur detection to ensure the photocurrent estimation is not corrupted by motion. Motion blur detection also makes it possible to extend exposure time and to capture more images, which can be used to further enhance dynamic range at the low illumination end. The present invention operates completely locally, making it well suited for single chip digital camera implementations.

Abstract: The dynamic range and the noise immunity of a digital imaging system are increased by basing an estimate of the illumination on a sensor on a series of measurements of the accumulated illumination at intervals within an exposure period. The measuring may occur destructively, or alternatively the photocurrent of the sensor may continue to accumulate over the exposure period. The estimate may use statistical signal processing of the measurements, based on various noise models and various optimization criteria. The estimate may be computed recursively over the multiplicity of measurements, using a set of recursive values that may include but is not limited to the estimated illumination, a current weighting coefficient, a variance of the current measurement and a variance over the series of measurements.

Abstract: A method for improving SNR without reducing dynamic range in a CMOS video sensor system under low illumination is described, wherein the CMOS video sensor system employing self-reset DPS architecture includes pixel level A/D conversion and wherein each DPS pixels is capable of resetting itself whenever a corresponding diode reaches saturation during integration time, the method comprising the steps of eliminating global frame reset for the self-reset DPS pixels, capturing and storing a plurality of frames, extending integration time beyond frame readout time, and generating frame images using one or more previously stored frames.

Abstract: A method for forming an application specific integrated circuit, comprises receiving a circuit design for the application specific integrated circuit from a designer; performing an initial place and route layout of the circuit design which leaves a group of buffer modules unused, based upon a partially predesigned integrated circuit, in which the partially predesigned integrated circuit includes a plurality of logic modules and a plurality of buffer modules uniformly distributed amongst the logic modules; evaluating load and timing characteristics for the initial place and route layout of the circuit design; and integrating buffer modules from the group of unused buffer modules into the circuit design, based on the load and timing characteristics evaluated.

Abstract: A CMOS DPS image sensor architecture for improving SNR and dynamic range is presented. The CMOS DPS architecture includes self-reset digital pixels capable of collecting more charge than the physical well capacity. A method for improving SNR without reducing dynamic range in a CMOS video sensor system under low illumination is described, wherein the CMOS video sensor system employing self-reset DPS architecture includes pixel level A/D conversion and wherein each DPS pixels is capable of resetting itself whenever a corresponding diode reaches saturation during integration time.

Abstract: A gate array in accordance with the invention includes a matrix of function blocks capable of being configured to implement combinational, sequential, and memory modes of operation, as well as providing tri-state drivers and buffers in useful numbers. The function block includes a logic circuit with a first bit storage unit, which is selectively configurable to behave as combinational logic or to store a first bit, and a second bit storage unit, which is also selectively configurable to behave as combinational logic or to store a second bit. The matrix of function blocks in accordance with the invention is also useful to properly distribute clocks throughout the gate array.

Abstract: A gate array in accordance with the invention includes a matrix of function blocks capable of being configured to implement combinational, sequential, and memory modes of operation, as well as providing tri-state drivers and buffers in useful numbers. The function block includes a logic circuit with a first bit storage unit, which is selectively configurable to behave as combinational logic or to store a first bit, and a second bit storage unit, which is also selectively configurable to behave as combinational logic or to store a second bit. The matrix of function blocks in accordance with the invention is also useful to properly distribute clocks throughout the gate array.

Abstract: A functional block for a CMOS circuit within the core of an integrated circuit chip and a method of making the same is disclosed. The functional block uses both thick and thin gate oxide transistors which reduces the leakage current and increases the voltage swing while permitting the device scaling in circuits made in CMOS technology. Within the functional block, the distance between a thick oxide transistor and a thin oxide transistor is chosen based on a transistor stability criterion. The thick and thin oxide transistors can be connected to identical or different voltage sources. Further, a transistor within a functional block can be chosen to be thick or thin oxide transistor based on a leakage current threshold or a voltage swing threshold.

Abstract: The dynamic range and the noise immunity of a digital imaging system are increased by basing an estimate of the illumination on a sensor on a series of measurements of the accumulated illumination at intervals within an exposure period. The measuring may occur destructively, or alternatively the photocurrent of the sensor may continue to accumulate over the exposure period. The estimate may use statistical signal processing of the measurements, based on various noise models and various optimization criteria. The estimate may be computed recursively over the multiplicity of measurements, using a set of recursive values that may include but is not limited to the estimated illumination, a current weighting coefficient, a variance of the current measurement and a variance over the series of measurements.

Abstract: Motion/Saturation detection system and method for synthesizing high dynamic range motion blur free images from multiple captures, the system and method utilizing photocurrent estimation to reduce read noise and enhance dynamic range at the low illumination end, saturation detection to enhance dynamic range at the high illumination end, and motion blur detection to ensure the photocurrent estimation is not corrupted by motion. Motion blur detection also makes it possible to extend exposure time and to capture more images, which can be used to further enhance dynamic range at the low illumination end. The present invention operates completely locally, making it well suited for single chip digital camera implementations.

Abstract: A method for improving SNR without reducing dynamic range in a CMOS video sensor system under low illumination is described, wherein the CMOS video sensor system employing self-reset DPS architecture includes pixel level A/D conversion and wherein each DPS pixels is capable of resetting itself whenever a corresponding diode reaches saturation during integration time, the method comprising the steps of eliminating global frame reset for the self-reset DPS pixels, capturing and storing a plurality of frames, extending integration time beyond frame readout time, and generating frame images using one or more previously stored frames.