Abstract: Disclosed herein are therapeutic use of isoform-specific, context-permissive inhibitors of TGF?1 in the treatment of disease that involve TGF?1 dysregulation.

Abstract: A device may receive information associated with an entity. The information may include a first resource and a second resource. The first resource may be associated with a first file type, and the second resource may be associated with a second file type that is different than the first file type. The first resource may be associated with a first source, and the second resource may be associated with a second source that is different than the first source. The device may extract a plurality of attributes associated with the entity based on the information. The device may implement a natural language processing technique to extract the plurality of attributes. The device may associate the plurality of attributes with a plurality of elements based on extracting the plurality of attributes. The device may provide information that identifies the plurality of elements and the plurality of attributes to permit and/or cause an action to be performed.

Abstract: Disclosed herein are immunoglobulins, such as antibodies, and antigen binding portions thereof, that specifically bind complexes of GARP-TGF?1, LTBP1-TGF?1, LTBP3-TGF?1, and/or LRRC33-TGF?1. The application also provides methods of use of these immunoglobulins for, for example, inhibiting TGF?1 activity, and treating subjects suffering from TGF?1-related disorders, such as cancer and fibrosis.

Abstract: A system for reconciliation comprises a determination engine to determine whether data is structured or unstructured, a data structuring engine to structure the data, and a rule extraction engine to determine relations between pairs of values of a first set and a second set of data. The system further comprises a matching engine to generate a confidence score for each pair of the values, a categorization engine to classify the pairs of values into matched pairs and unmatched pairs, a validation engine to validate matching and classification of the pairs based on a user feedback, and a learning engine to store details pertaining to the validation of the matching and the classification over a period of time. The learning engine forwards the details to the rule extraction engine and the categorization engine to determine the relations between subsequent pairs of values and classify the pairs based on the stored details.

Abstract: An apparatus for delivering therapeutic electrostimulation across a tissue surface includes a current source, a low current component adapted to contact the tissue surface, a first electrode assembly electrically connected to the current source and supported by the low current component, a second electrode assembly electrically connected to the current source and supported by the low current component and a conductive fluid supported by the low current component for facilitating a flow of electric current across the tissue surface. At least one of the first and second electrodes assemblies includes at least one of a magnetic electrode, a high current component and a non-current component.

Abstract: Disclosed herein are therapeutic use of isoform-specific, context-permissive inhibitors of TGF?1 in the treatment of disease that involve TGF?1 dysregulation.

Abstract: An electrode assembly for neuro-cranial stimulation includes an electrode, a conductive gel, and an adapter including an interior compartment for positioning the electrode relative to the adapter and for receiving and retaining the conductive gel. The conductive gel contacts the electrode along an electrode-gel interface. An orifice at one end of the interior compartment and adjacent to a positioning surface of the adapter for positioning the electrode assembly against a skin surface of a user enables the conductive gel is able to contact the skin surface of the user to define a gel-skin interface, such that a minimum distance between the electrode-gel interface and the gel-skin interface is maintained between 0.25 cm and 1.3 cm. An electrode assembly mounting apparatus is provided for adjustably positioning a plurality of electrode assemblies against target positions on the cranium.

Abstract: In some embodiments of the present disclosure, systems and methods for effecting a physiological effect are provided. In some embodiments, a system is provided which comprises a plurality of current sources, where each current source having a positive output and a negative output and each being configured to provide a first current. The system may also include a plurality of stimulating electrodes electrically connected with the plurality of current sources such that at least a pair of the stimulating electrodes share at least one output of at least one of the plurality of current sources. The stimulating electrodes may be configured to provide electrical energy to tissue of a patient at the first current. The system may further include at least one sentinel electrode, and a first voltage monitor configured to monitor a first voltage across the at least one sentinel electrode and at least one of the plurality of stimulating electrodes.

Abstract: An apparatus for delivering therapeutic electrostimulation across a tissue surface includes a current source, a low current component adapted to contact the tissue surface, a first electrode assembly electrically connected to the current source and supported by the low current component, a second electrode assembly electrically connected to the current source and supported by the low current component and a conductive fluid supported by the low current component for facilitating a flow of electric current across the tissue surface. At least one of the first and second electrodes assemblies includes at least one of a magnetic electrode, a high current component and a non-current component.

Abstract: A method includes coupling electrodes to a patient's head and identifying whether any of the electrodes form a functional set, such that a desired therapeutic effect is achieved when the two or more electrodes deliver a total amount of current to the patient regardless of what portion of the total amount of current each respective electrode carries. One or more constant current sources are provided, each having a supply and return terminal, which supply and return equal amounts of current at any given time. The constant current source(s) are coupled to the electrodes in such a manner that each supply terminal and each return terminal is coupled to no more than the electrodes of a single one of the functional sets, if any, or to a single one of the electrodes not included in one of the functional sets.

Abstract: There is provided method and apparatus for enhancing focality of neurocranial electrostimulation, including: providing a first plurality of electrodes having at least one electrode; providing a second plurality of electrodes having at least two electrodes; locating the first and the second plurality of electrodes on cranium of a subject and supplying electric current of opposite polarities to the first and the second plurality of electrodes. At least one electrode of the first plurality of electrodes is surrounded by at least two electrodes of the second plurality of electrodes. The enhanced focal stimulation may be used to treat ailments or augment cognitive performance. There are also provided methods for treating brain related ailments and performance augmentation.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for developing transcranial electrical stimulation protocols are disclosed. In one aspect, a method includes forming a first array of electrodes and optimizing a plurality of electrode parameters within the first array of electrodes to achieve a desired physiological response; identifying one or more electrodes within the optimized first array that have relatively low current compared to the remaining electrodes in the first array; removing the identified low current electrodes from the first array to form a second array of electrodes, wherein the number of electrodes in the second array is less than the number of electrodes in the first array and optimizing a plurality of electrode parameters with the second array of electrodes to achieve a desired physiological response.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for developing transcranial electrical stimulation protocols are disclosed. In one aspect, a method includes forming a first array of electrodes and optimizing a plurality of electrode parameters within the first array of electrodes to achieve a desired physiological response; identifying one or more electrodes within the optimized first array that have relatively low current compared to the remaining electrodes in the first array; removing the identified low current electrodes from the first array to form a second array of electrodes, wherein the number of electrodes in the second array is less than the number of electrodes in the first array and optimizing a plurality of electrode parameters with the second array of electrodes to achieve a desired physiological response.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for developing transcranial electrical stimulation protocols are disclosed. In one aspect, a method includes the actions of accepting an image model of target tissue, obtaining a forward model having a first electrode configuration and first electrical stimulation parameters based on electrical stimulation of the target tissue, accepting electrode configuration changes or electrical stimulation parameter changes resulting in a second electrode configuration or second electrical stimulation parameters, determining an optimized tissue model using a least square methodology and based on the second electrode configuration or second electrical stimulation parameter changes, comparing the optimized tissue model with a desired outcome, and providing a confirmation of the optimized model with the desired outcome.

Abstract: A method includes coupling electrodes to a patient's head and identifying whether any of the electrodes form a functional set, such that a desired therapeutic effect is achieved when the two or more electrodes deliver a total amount of current to the patient regardless of what portion of the total amount of current each respective electrode carries. One or more constant current sources are provided, each having a supply and return terminal, which supply and return equal amounts of current at any given time. The constant current source(s) are coupled to the electrodes in such a manner that each supply terminal and each return terminal is coupled to no more than the electrodes of a single one of the functional sets, if any, or to a single one of the electrodes not included in one of the functional sets.

Abstract: An electrode assembly for neuro-cranial stimulation includes an electrode, a conductive gel, and an adapter including an interior compartment for positioning the electrode relative to the adapter and for receiving and retaining the conductive gel. The conductive gel contacts the electrode along an electrode-gel interface. An orifice at one end of the interior compartment and adjacent to a positioning surface of the adapter for positioning the electrode assembly against a skin surface of a user enables the conductive gel is able to contact the skin surface of the user to define a gel-skin interface, such that a minimum distance between the electrode-gel interface and the gel-skin interface is maintained between 0.25 cm and 1.3 cm. An electrode assembly mounting apparatus is provided for adjustably positioning a plurality of electrode assemblies against target positions on the cranium.

Abstract: There is provided method and apparatus for enhancing focality of neurocranial electrostimulation, including: providing a first plurality of electrodes having at least one electrode; providing a second plurality of electrodes having at least two electrodes; locating the first and the second plurality of electrodes on cranium of a subject and supplying electric current of opposite polarities to the first and the second plurality of electrodes. At least one electrode of the first plurality of electrodes is surrounded by at least two electrodes of the second plurality of electrodes. The enhanced focal stimulation may be used to treat ailments or augment cognitive performance. There are also provided methods for treating brain related ailments and performance augmentation.