Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.

Abstract: A wheel bearing unit includes a wheel hub, a first rolling-element bearing, and a fastener assembly, and the fastener assembly is formed separately from the wheel hub and is spaced from an axial end of the wheel hub. The fastener assembly secures at least one component of the rolling-element bearing against falling out of the wheel hub away from a center of mass of the wheel bearing unit, and the fastener assembly contacts the wheel hub.

Abstract: The invention relates to a sensor element for detecting at least one analyte in a body fluid or in a body tissue, particularly for determining at least one metabolite concentration in a body fluid. The sensor element comprises an implantable, one-piece shaped body, which comprises a sensor end and a coupling end. The shaped body comprises, in the area of the sensor end, at least one sensor area, which comprises at least one sensor material. The sensor material changes at least one optically measurable property in the presence of the analyte. The shaped body also has at least one optically transparent coupling part, which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area and the coupling end. In the sensor area, the shaped body has at least one optically transparent matrix material, and the analyte can at least partially diffuse through the matrix material to the sensor material. The sensor material is embedded in the matrix material.

Abstract: A method for manufacturing a rolling-element bearing assembly includes providing a first bearing ring, a second bearing ring and rolling-elements, rotating the first bearing ring relative to the second bearing ring and joining the first bearing ring, the second bearing ring and the rolling elements while the first bearing ring is rotating relative to the second bearing ring. The method additionally includes connecting one of the bearing rings to a bearing ring of another rolling-element bearing or to a spacer while the first bearing ring is rotating relative to the second bearing ring.

Abstract: The present invention relates to sintered balls comprising tungsten carbide (WC) and partially stabilized zirconium oxide, nX:ZrO2,, and to powder mixtures and green bodies for the production thereof, and to methods for the production of the green bodies and the sintered balls. The sintered balls have high densities, high wear resistance and a long service life.

Abstract: A wheel bearing unit includes a wheel hub, a first rolling-element bearing, and a fastener assembly, and the fastener assembly is formed separately from the wheel hub and is spaced from an axial end of the wheel hub. The fastener assembly secures at least one component of the rolling-element bearing against falling out of the wheel hub away from a center of mass of the wheel bearing unit, and the fastener assembly contacts the wheel hub.

Abstract: A method and an apparatus for determining at least one smoothed data point (tk, sk) within a stream of data points {ti, si} with 1?i?z, k<z is disclosed. Herein, the stream of data points {ti, si} is consecutively acquired in a manner that a data point (ti, si) is acquired after an acquisition of a preceding data point (ti-1, si-1), wherein each data point (ti, si) comprises a valid value or an invalid value or a missing value for the signal si at a time ti. Herein, the signal si at the time ti comprises physical, chemical, biological, environmental, and/or technical data acquired by means of a technical set-up. According to the method, a set of data points is provided, wherein for each smoothed data point (tk, sk) a smoothing set is created. For each smoothed data point (tk, sk), trailing data resulting from large gaps are removed until it is verified whether the smoothing set comprises a minimal number of data points.

Abstract: The present invention relates to sintered balls comprising tungsten carbide (WC) and partially stabilized zirconium oxide, nX:ZrO2,, and to powder mixtures and green bodies for the production thereof, and to methods for the production of the green bodies and the sintered balls. The sintered balls have high densities, high wear resistance and a long service life.

Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.

Abstract: The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.

Abstract: A method for manufacturing a rolling-element bearing assembly includes providing a first bearing ring, a second bearing ring and rolling-elements, rotating the first bearing ring relative to the second bearing ring and joining the first bearing ring, the second bearing ring and the rolling elements while the first bearing ring is rotating relative to the second bearing ring. The method additionally includes connecting one of the bearing rings to a bearing ring of another rolling-element bearing or to a spacer while the first bearing ring is rotating relative to the second bearing ring.

Abstract: The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.

Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

Abstract: An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).

Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.

Abstract: A bearing assembly includes a first bearing comprising a first inner ring and a second bearing comprising a second inner ring. A sleeve-shaped spacer is disposed between and axially separates the first and second inner rings. An adhesive connects the spacer to the first and second inner rings.

Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.

Abstract: The present invention generally relates to a method for coating ophthalmic lenses, preferably contact lenses, more preferably silicone hydrogel contact lenses. In particular, the present invention is directed to a method for forming a coating comprising a polyionic material on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user.

Abstract: A self-service device (1), specifically an automated teller machine, account statement printer, and/or information or transaction terminal, with a base housing (2), an operator interface (3), an input device for identification cards (9), a magnetic interference unit (8) and one or more additional components (4, 5, 6) where the magnetic interference unit (8) is configured as a coil enclosing the input and/or output device for identification cards (9).

Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.