Abstract: An injector for transcutaneously introducing a sensor into a patient, including a cannula, a sensor arranged in the cannula, a base element, a sliding element arranged displaceably on the base element in an injection direction, for transcutaneously introducing the cannula having the sensor into the patient in an injection operation. The cannula has a slot in a longitudinal direction of the cannula. The injector has a holding element arranged displaceably on the base element that, in an ejection operation, prevents the sensor from being pulled out as the cannula is withdrawn, by engaging in a distal end region of the sensor through the slot into the cannula. The holding element and/or base element have at least one fixing arrangement to automatically lock the holding element on the base element when the cannula is introduced transcutaneously into the patient. A method for transcutaneously introducing a sensor into a patient is also provided.

Abstract: An injector for transcutaneously introducing a sensor into a patient, including a cannula, a base element, a sliding element arranged displaceably on the base element, for transcutaneously introducing the cannula into the patient in an injection direction, and including an ejection element for automatically pulling the cannula out of the patient counter to the injection direction by the ejection element in an ejection operation. The injector has a locking element for the ejection element such that, in a delivery state, the ejection element is lockable in an energy-charged state, and the sliding element and the locking element are configured to interact indirectly or directly in order, in an injection state, when the cannula is introduced transcutaneously into the patient, to release the locking of the ejection element in order automatically to start the ejection operation.

Abstract: A method and an apparatus for determining at least one smoothed data point (tk, sk) within a stream of data points {ti, si} with 1?i?z, k<z is disclosed. Herein, the stream of data points {ti, si} is consecutively acquired in a manner that a data point (ti, si) is acquired after an acquisition of a preceding data point (ti?1, si?1), wherein each data point (ti, si) comprises a valid value or an invalid value or a missing value for the signal si at a time ti. Herein, the signal si at the time ti comprises physical, chemical, biological, environmental, and/or technical data acquired by means of a technical set-up. According to the method, a set of data points is provided, wherein for each smoothed data point (tk, sk) a smoothing set is created. For each smoothed data point (tk, sk), trailing data resulting from large gaps are removed until it is verified whether the smoothing set comprises a minimal number of data points.

Abstract: An arrangement for operating a biosensor emitting radiation includes an excitation light source, which generates at least one excitation radiation for the biosensor; a coupling fiber, at the entry surface of which the excitation radiation is coupled in; an optical Y-coupler, including an excitation arm, which is connected to the exit surface of the coupling fiber, a detector arm, which is connected to an optical detector, and a sensor foot, which can be connected to the biosensor. The excitation arm has a conical shape. The radiation axis of the excitation arm includes an angle in the range of 5° to 70° with the main radiation axis of the detector arm. The diameter of the excitation arm at the connecting point to the detector arm is less than two thirds the diameter of the detector arm. An arrangement for determining the glucose content blood is also provided.

Abstract: A system for analyzing a patient using a transcutaneous sensor, having a base unit for attaching to the patient, an injector, releasably connectable to the base unit, for the transcutaneous insertion of the sensor into the patient, and a detection unit, releasably connectable to the base unit, for generating measurement data by the sensor. The base unit has a holding device which is configured to cooperate with the injector and detection unit such that, in a detection configuration with the detection unit arranged on the base unit, a contact pressure is applied to the sensor by the holding device for frictional fixing, and in an injection configuration with the injector arranged on the base unit, a lower contact pressure than in the detection configuration is applied to the sensor by the holding device.

Abstract: We have modified a commercially-available adherent cell culture bioreactor, developing a new sampling manifold configuration and new way of taking samples to reduce contamination risk.

Abstract: A method and an apparatus for determining at least one smoothed data point (tk, sk) within a stream of data points {ti, si} with 1?i?z, k<z is disclosed. Herein, the stream of data points {ti, si} is consecutively acquired in a manner that a data point (ti, si) is acquired after an acquisition of a preceding data point (ti-1, si?1), wherein each data point (ti, si) comprises a valid value or an invalid value or a missing value for the signal si at a time ti. Herein, the signal si at the time ti comprises physical, chemical, biological, environmental, and/or technical data acquired by means of a technical set-up. According to the method, a set of data points is provided, wherein for each smoothed data point (tk, sk) a smoothing set is created. For each smoothed data point (tk, sk), trailing data resulting from large gaps are removed until it is verified whether the smoothing set comprises a minimal number of data points.

Abstract: A can for an electrolytic capacitor is disclosed. In an embodiment a can for an electrolytic capacitor includes a bottom including a first area and a second area, wherein the first area is recessed relative to the second area at an outer surface of the bottom of the can.

Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.

Abstract: A system for analyzing a patient using a transcutaneous sensor, having a base unit for attaching to the patient, an injector, releasably connectable to the base unit, for the transcutaneous insertion of the sensor into the patient, and a detection unit, releasably connectable to the base unit, for generating measurement data by the sensor. The base unit has a holding device which is configured to cooperate with the injector and detection unit such that, in a detection configuration with the detection unit arranged on the base unit, a contact pressure is applied to the sensor by the holding device for frictional fixing, and in an injection configuration with the injector arranged on the base unit, a lower contact pressure than in the detection configuration is applied to the sensor by the holding device.

Abstract: An injector for cm 11transcutaneously introducing a sensor into a patient, including a cannula, a sensor arranged in the cannula, a base element, a sliding element arranged displaceably on the base element in an injection direction, for transcutaneously introducing the cannula having the sensor into the patient in an injection operation. The cannula has a slot in a longitudinal direction of the cannula. The injector has a holding element arranged displaceably on the base element that, in an ejection operation, prevents the sensor from being pulled out as the cannula is withdrawn, by engaging in a distal end region of the sensor through the slot into the cannula. The holding element and/or base element have at least one fixing arrangement to automatically lock the holding element on the base element when the cannula is introduced transcutaneously into the patient. A method for transcutaneously introducing a sensor into a patient is also provided.

Abstract: An injector for transcutaneously introducing a sensor into a patient, including a cannula, a base element, a sliding element arranged displaceably on the base element, for transcutaneously introducing the cannula into the patient in an injection direction, and including an ejection element for automatically pulling the cannula out of the patient counter to the injection direction by the ejection element in an ejection operation. The injector has a locking element for the ejection element such that, in a delivery state, the ejection element is lockable in an energy-charged state, and the sliding element and the locking element are configured to interact indirectly or directly in order, in an injection state, when the cannula is introduced transcutaneously into the patient, to release the locking of the ejection element in order automatically to start the ejection operation.

Abstract: We have modified a commercially-available adherent cell culture bioreactor, developing a new sampling manifold configuration and new way of taking samples to reduce contamination risk.

Abstract: We have modified a commercially-available adherent cell culture bioreactor in several ways to increase productivity of cultured cells, while decreasing contamination risk. We found that modifying a commercially-available adherent cell culture bioreactor to provide for slower cell culture medium flow unexpectedly and dramatically increases the productivity of the cultured adherent cells. We also developed a new sampling manifold configuration and new way of taking samples, to reduce contamination risk.

Abstract: The invention relates to a sensor element for detecting at least one analyte in a body fluid or in a body tissue, particularly for determining at least one metabolite concentration in a body fluid. The sensor element comprises an implantable, one-piece shaped body, which comprises a sensor end and a coupling end. The shaped body comprises, in the area of the sensor end, at least one sensor area, which comprises at least one sensor material. The sensor material changes at least one optically measurable property in the presence of the analyte. The shaped body also has at least one optically transparent coupling part, which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area and the coupling end. In the sensor area, the shaped body has at least one optically transparent matrix material, and the analyte can at least partially diffuse through the matrix material to the sensor material. The sensor material is embedded in the matrix material.

Abstract: A method and an apparatus for determining at least one smoothed data point (tk, sk) within a stream of data points {ti, si} with 1?i?z, k<z is disclosed. Herein, the stream of data points {ti, si} is consecutively acquired in a manner that a data point (ti, si) is acquired after an acquisition of a preceding data point (ti-1, si-1), wherein each data point (ti, si) comprises a valid value or an invalid value or a missing value for the signal si at a time ti. Herein, the signal si at the time ti comprises physical, chemical, biological, environmental, and/or technical data acquired by means of a technical set-up. According to the method, a set of data points is provided, wherein for each smoothed data point (tk, sk) a smoothing set is created. For each smoothed data point (tk, sk), trailing data resulting from large gaps are removed until it is verified whether the smoothing set comprises a minimal number of data points.

Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.

Abstract: The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.

Abstract: The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.

Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.