Patents by Inventor Achim Muller
Achim Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8647271Abstract: An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).Type: GrantFiled: May 23, 2008Date of Patent: February 11, 2014Assignee: Eyesense AGInventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
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Publication number: 20140024060Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.Type: ApplicationFiled: December 13, 2011Publication date: January 23, 2014Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
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Patent number: 8632255Abstract: A bearing assembly includes a first bearing comprising a first inner ring and a second bearing comprising a second inner ring. A sleeve-shaped spacer is disposed between and axially separates the first and second inner rings. An adhesive connects the spacer to the first and second inner rings.Type: GrantFiled: June 16, 2010Date of Patent: January 21, 2014Assignee: Aktiebolaget SKFInventors: Rico Dittmar, Thilo Louis Beck, Gerhard Haas, Michael Kummert, Achim Müller, Bernd Stephan, Arno M. Stubenrauch, Peter Volpert, Thomas Will
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Publication number: 20130337468Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.Type: ApplicationFiled: December 13, 2011Publication date: December 19, 2013Inventors: Achim Müller, Peter Herberchtsmeier, Monika Knuth, Katharina Nikolaus
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Patent number: 8460743Abstract: The present invention generally relates to a method for coating ophthalmic lenses, preferably contact lenses, more preferably silicone hydrogel contact lenses. In particular, the present invention is directed to a method for forming a coating comprising a polyionic material on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user.Type: GrantFiled: March 16, 2009Date of Patent: June 11, 2013Assignee: Novartis AGInventors: Achim Müller, Katharina Schmid
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Patent number: 8452363Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.Type: GrantFiled: July 23, 2007Date of Patent: May 28, 2013Assignee: Eyesense AGInventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh, Roman Gruler
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Patent number: 8452361Abstract: An ocular sensor (110) is proposed for verification of at least one analyte in an eye fluid. The ocular sensor (110) is composed of at least one sensor material which is designed to change at least one optical characteristic in the presence of the at least one analyte. Furthermore, the ocular sensor (110) comprises at least one sensor chip which has at least one integrated optical detector (122) for verification of the optical characteristic. A measurement system (166) is also proposed for verification of at least one analyte in an eye fluid, which measurement system (166) comprises an ocular sensor (110) according to the invention as well as an evaluation unit (168) which is designed to interchange information with the sensor chip (118).Type: GrantFiled: January 14, 2008Date of Patent: May 28, 2013Assignee: Eyesense AGInventor: Achim Müller
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Publication number: 20120258551Abstract: The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.Type: ApplicationFiled: October 25, 2010Publication date: October 11, 2012Inventors: Peter Herbrechtsmeier, Achim Müller, Monika Knuth, Katharina Nikolaus
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Patent number: 8206622Abstract: The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the microspheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.Type: GrantFiled: February 22, 2005Date of Patent: June 26, 2012Assignee: EyeSense AGInventors: Stefan Kammermeier, Till Merkel, Katharina Schmid, Achim Müller
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Publication number: 20120156361Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.Type: ApplicationFiled: February 23, 2012Publication date: June 21, 2012Inventors: Achim Müller, Monika Knuth, Ralf Pasternack, Jens Zotzel, Christine Reiff
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Patent number: 8147897Abstract: A method for making an article comprising a core material and a coating thereon, the method comprising the steps of: (a) providing the core material; (b) applying one or more layers of a crosslinkable polycationic material, wherein the polycationic material is a reaction product of: (i) an epoxide of formula (I) wherein X equals bromo, chloro, iodo, or cyano, and R1, R2, R3, R4, independently of one another, are selected from the group consisting of hydrogen, linear or branched C1-C6-alkyl, and linear or branched C1-C6-alkyl which is substituted with halogen, and (ii) a polymer having repeating units comprising one or more secondary or tertiary amine group(s); (c) applying one or more layers of a polyanionic material; and (d) cross-linking the layers of polyelectrolytes formed by steps (b) and (c).Type: GrantFiled: February 6, 2008Date of Patent: April 3, 2012Assignee: Novartis AGInventors: Maria Gonzalez Ferreiro, Lutz Kröhne, Achim Müller, Katharina Schmid, Andreas Voigt
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Patent number: 8142835Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.Type: GrantFiled: January 21, 2009Date of Patent: March 27, 2012Assignee: Novartis AGInventors: Achim Müller, Monika Knuth, Ralf Pasternack, Jens Zotzel, Christine Reiff
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Patent number: 8057041Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.Type: GrantFiled: July 23, 2007Date of Patent: November 15, 2011Assignee: EyeSense AGInventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh, Roman Gruler
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Publication number: 20110230835Abstract: The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.Type: ApplicationFiled: October 2, 2009Publication date: September 22, 2011Applicant: EyeSense AGInventors: Achim Müller, Peter Herbrechtsmeier
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Publication number: 20110224514Abstract: The invention relates to a sensor element (110) for detecting at least one analyte in a body fluid or in a body tissue (130), particularly for determining at least one metabolite concentration in a body fluid. The sensor element (110) comprises an implantable, one-piece shaped body (112), which comprises a sensor end (114) and a coupling end (116). The shaped body (112) comprises, in the area of the sensor end (114), at least one sensor area (118), which comprises at least one sensor material (122). The sensor material (122) changes at least one optically measurable property in the presence of the analyte. The shaped body (112) also has at least one optically transparent coupling part (120), which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area (118) and the coupling end (116).Type: ApplicationFiled: October 2, 2009Publication date: September 15, 2011Applicant: EyeSense AGInventors: Achim Müller, Peter Herbrechtsmeier
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Publication number: 20110033147Abstract: A bearing assembly includes a first bearing comprising a first inner ring and a second bearing comprising a second inner ring. A sleeve-shaped spacer is disposed between and axially separates the first and second inner rings. An adhesive connects the spacer to the first and second inner rings.Type: ApplicationFiled: June 16, 2010Publication date: February 10, 2011Applicant: AKTIEBOLAGET SKFInventors: Rico Dittmar, Thilo Beck, Gerhard Haas, Michael Kummert, Achim Müller, Bernd Stephen, Arno Stubenrauch, Peter Volpert, Thomas Will
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Publication number: 20100331634Abstract: An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).Type: ApplicationFiled: May 23, 2008Publication date: December 30, 2010Applicant: Eyesense AGInventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
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Patent number: 7858337Abstract: The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.Type: GrantFiled: March 3, 2008Date of Patent: December 28, 2010Assignee: Novartis AGInventors: Achim Müller, Monika Knuth, Katharina Schmid, Ralf Pasternack, Jens Zotzel, Kai Oertel, Christine Reiff, geb. Schmitt, Hans-Lothar Fuchsbauer
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Publication number: 20100249548Abstract: An ocular sensor (110) is proposed for verification of at least one analyte in an eye fluid. The ocular sensor (110) is composed of at least one sensor material which is designed to change at least one optical characteristic in the presence of the at least one analyte. Furthermore, the ocular sensor (110) comprises at least one sensor chip which has at least one integrated optical detector (122) for verification of the optical characteristic. A measurement system (166) is also proposed for verification of at least one analyte in an eye fluid, which measurement system (166) comprises an ocular sensor (110) according to the invention as well as an evaluation unit (168) which is designed to interchange information with the sensor chip (118).Type: ApplicationFiled: January 14, 2008Publication date: September 30, 2010Inventor: Achim Müller
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Patent number: 7772286Abstract: The present invention relates to a copolymer, which is the reaction product of (a) a first prepolymer, comprising a bioactive moiety and at least one radically polymerizable group, and (b) a second prepolymer which is a polyvinyl alcohol having a weight average molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprises from 0.5 to 80% structural units of formula (I) wherein: R is alkylene having up to 8 carbon atoms, R1 is hydrogen or alkyl having up to seven carbon atoms, and R2 is an olefinically unsaturated, electron-attracting copolymerizable radical.Type: GrantFiled: February 27, 2004Date of Patent: August 10, 2010Assignee: Eyesense AGInventors: Achim Müller, Roland Schmieder, Katharina Schmid